JP2009513150A - シグナリングアッセイ及び株化細胞 - Google Patents

シグナリングアッセイ及び株化細胞 Download PDF

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Publication number
JP2009513150A
JP2009513150A JP2008538163A JP2008538163A JP2009513150A JP 2009513150 A JP2009513150 A JP 2009513150A JP 2008538163 A JP2008538163 A JP 2008538163A JP 2008538163 A JP2008538163 A JP 2008538163A JP 2009513150 A JP2009513150 A JP 2009513150A
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Prior art keywords
cell
agent
protein
localization
fusion protein
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Japanese (ja)
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JP2009513150A5 (https=
Inventor
スタッブス,サイモン・エル・ジェイ
ハザー,キャサリン
ロス,サンドラ
パワーズ,デイビッド
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ジーイー・ヘルスケア・ユーケイ・リミテッド
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Publication of JP2009513150A publication Critical patent/JP2009513150A/ja
Publication of JP2009513150A5 publication Critical patent/JP2009513150A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
JP2008538163A 2005-10-28 2006-10-26 シグナリングアッセイ及び株化細胞 Pending JP2009513150A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73136405P 2005-10-28 2005-10-28
PCT/US2006/060251 WO2007094867A2 (en) 2005-10-28 2006-10-26 Cell-based p38 mapk translocation assay

Publications (2)

Publication Number Publication Date
JP2009513150A true JP2009513150A (ja) 2009-04-02
JP2009513150A5 JP2009513150A5 (https=) 2009-11-12

Family

ID=38371953

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008538163A Pending JP2009513150A (ja) 2005-10-28 2006-10-26 シグナリングアッセイ及び株化細胞

Country Status (4)

Country Link
US (1) US20080227131A1 (https=)
EP (1) EP1941044A2 (https=)
JP (1) JP2009513150A (https=)
WO (1) WO2007094867A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015019637A (ja) * 2013-07-22 2015-02-02 オリンパス株式会社 サバイビンについての細胞解析方法、並びにそれを利用した癌の解析方法および薬効のスクリーニング方法
JP2019510754A (ja) * 2016-03-01 2019-04-18 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化tau及びp38ガンマの使用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190381500A1 (en) * 2018-06-14 2019-12-19 Daisuke Takagi Cell contained container and cell contained container producing method, and cell chip

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001522454A (ja) * 1997-04-07 2001-11-13 バイオイメージ エイ/エス 細胞応答への影響に関する定量情報の抽出方法
US20050118663A1 (en) * 2003-07-30 2005-06-02 Irm Llc Methods and compositions for modulating cell proliferation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001522454A (ja) * 1997-04-07 2001-11-13 バイオイメージ エイ/エス 細胞応答への影響に関する定量情報の抽出方法
US20050118663A1 (en) * 2003-07-30 2005-06-02 Irm Llc Methods and compositions for modulating cell proliferation

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015019637A (ja) * 2013-07-22 2015-02-02 オリンパス株式会社 サバイビンについての細胞解析方法、並びにそれを利用した癌の解析方法および薬効のスクリーニング方法
JP2019510754A (ja) * 2016-03-01 2019-04-18 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化tau及びp38ガンマの使用
JP7040774B2 (ja) 2016-03-01 2022-03-23 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化tau及びp38ガンマの使用
JP2022078192A (ja) * 2016-03-01 2022-05-24 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化tau及びp38ガンマの使用
JP7496627B2 (ja) 2016-03-01 2024-06-07 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化tau及びp38ガンマの使用

Also Published As

Publication number Publication date
WO2007094867A2 (en) 2007-08-23
WO2007094867A3 (en) 2008-01-17
EP1941044A2 (en) 2008-07-09
US20080227131A1 (en) 2008-09-18

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