JP2009511892A - 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド - Google Patents

抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Download PDF

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JP2009511892A
JP2009511892A JP2008535094A JP2008535094A JP2009511892A JP 2009511892 A JP2009511892 A JP 2009511892A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2009511892 A JP2009511892 A JP 2009511892A
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variable domain
antibody
chain variable
light chain
heavy chain
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Japanese (ja)
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JP2009511892A5 (https=
Inventor
ジェスパーズ，ローラン
クルーブ，ジャスパー
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ドマンティス リミテッド
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Priority claimed from GB0520644A external-priority patent/GB0520644D0/en
Priority claimed from GB0521140A external-priority patent/GB0521140D0/en
Application filed by ドマンティス リミテッド filed Critical ドマンティス リミテッド
Publication of JP2009511892A publication Critical patent/JP2009511892A/ja
Publication of JP2009511892A5 publication Critical patent/JP2009511892A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008535094A 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Pending JP2009511892A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0520644A GB0520644D0 (en) 2005-10-11 2005-10-11 Antibody polypeptide library screening and selected antibody polypeptides
GB0521140A GB0521140D0 (en) 2005-10-18 2005-10-18 Antibody polypeptide library screening and selected antibody polypeptides
PCT/GB2006/003781 WO2007042809A2 (en) 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides

Publications (2)

Publication Number Publication Date
JP2009511892A true JP2009511892A (ja) 2009-03-19
JP2009511892A5 JP2009511892A5 (https=) 2009-10-22

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ID=37943170

Family Applications (1)

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JP2008535094A Pending JP2009511892A (ja) 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド

Country Status (6)

Country Link
US (1) US20100168393A1 (https=)
EP (1) EP1951754A2 (https=)
JP (1) JP2009511892A (https=)
AU (1) AU2006300951A1 (https=)
CA (1) CA2625222A1 (https=)
WO (1) WO2007042809A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法

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ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
CN104004094B (zh) * 2008-06-25 2017-09-22 艾斯巴技术-诺华有限责任公司 使用通用抗体构架进行的兔抗体的人源化
MX345039B (es) 2008-06-25 2017-01-16 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles que inhiben el tnfa.
AU2020201002B2 (en) * 2008-06-25 2022-04-07 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
CN102656190A (zh) 2009-12-08 2012-09-05 雅培股份有限两合公司 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
WO2012105833A1 (en) * 2011-02-01 2012-08-09 Bac Ip B.V. Antigen-binding protein directed against epitope in the ch1 domain of human igg antibodies
NZ714482A (en) 2012-01-27 2017-08-25 Abbvie Inc Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
CN107814845B (zh) * 2016-09-14 2021-02-09 浙江特瑞思药业股份有限公司 新的抗pd-1纳米抗体及其应用
CN107857816B (zh) * 2017-10-17 2020-11-06 北京大学 一种抗干扰素α-2b纳米抗体及其应用
EP3737692A4 (en) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
GB2595980B (en) * 2019-01-04 2023-06-14 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
CN116234829A (zh) 2020-01-03 2023-06-06 马伦戈治疗公司 抗tcr抗体分子及其用途
EP4341298A4 (en) * 2021-06-22 2025-04-16 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR DETECTING AND REGULATING FIBRONECTIN-INTEGRIN INTERACTIONS AND SIGNALING
CN114195891B (zh) * 2021-12-22 2023-05-12 北京世纪沃德生物科技有限公司 一种crp驼源单域抗体及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ＥｒｂＢ２抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
US20060252028A1 (en) * 2002-08-16 2006-11-09 Hiroshi Ueda Method of assaying interaction between proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ＥｒｂＢ２抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
US9598501B2 (en) 2010-02-16 2017-03-21 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法
US9834615B2 (en) 2010-08-16 2017-12-05 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies
US9926382B2 (en) 2010-08-16 2018-03-27 Novimmune S.A. Methods for the generation of multispecific and multivalent antibodies
US10597465B2 (en) 2010-08-16 2020-03-24 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies

Also Published As

Publication number Publication date
EP1951754A2 (en) 2008-08-06
AU2006300951A1 (en) 2007-04-19
US20100168393A1 (en) 2010-07-01
WO2007042809A3 (en) 2007-07-19
CA2625222A1 (en) 2007-04-19
WO2007042809A2 (en) 2007-04-19

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