JP2009511892A - 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド - Google Patents

抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Download PDF

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Publication number
JP2009511892A
JP2009511892A JP2008535094A JP2008535094A JP2009511892A JP 2009511892 A JP2009511892 A JP 2009511892A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2009511892 A JP2009511892 A JP 2009511892A
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Japan
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variable domain
antibody
chain variable
light chain
heavy chain
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JP2008535094A
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Japanese (ja)
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JP2009511892A5 (https=
Inventor
ジェスパーズ，ローラン
クルーブ，ジャスパー
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ドマンティス リミテッド
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Priority claimed from GB0520644A external-priority patent/GB0520644D0/en
Priority claimed from GB0521140A external-priority patent/GB0521140D0/en
Application filed by ドマンティス リミテッド filed Critical ドマンティス リミテッド
Publication of JP2009511892A publication Critical patent/JP2009511892A/ja
Publication of JP2009511892A5 publication Critical patent/JP2009511892A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008535094A 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Pending JP2009511892A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0520644A GB0520644D0 (en) 2005-10-11 2005-10-11 Antibody polypeptide library screening and selected antibody polypeptides
GB0521140A GB0521140D0 (en) 2005-10-18 2005-10-18 Antibody polypeptide library screening and selected antibody polypeptides
PCT/GB2006/003781 WO2007042809A2 (en) 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides

Publications (2)

Publication Number Publication Date
JP2009511892A true JP2009511892A (ja) 2009-03-19
JP2009511892A5 JP2009511892A5 (https=) 2009-10-22

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ID=37943170

Family Applications (1)

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JP2008535094A Pending JP2009511892A (ja) 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド

Country Status (6)

Country Link
US (1) US20100168393A1 (https=)
EP (1) EP1951754A2 (https=)
JP (1) JP2009511892A (https=)
AU (1) AU2006300951A1 (https=)
CA (1) CA2625222A1 (https=)
WO (1) WO2007042809A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法

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US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
AU2020201002B2 (en) * 2008-06-25 2022-04-07 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
PL2307458T3 (pl) * 2008-06-25 2018-08-31 Esbatech, An Alcon Biomedical Research Unit Llc Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała
KR102050040B1 (ko) 2008-06-25 2019-11-28 에스바테크 - 어 노바티스 컴파니 엘엘씨 ＴＮＦα를 저해하는 안정한 가용성 항체
MX2012006560A (es) 2009-12-08 2012-10-05 Abbott Gmbh & Co Kg Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal.
UY33679A (es) 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles
EP2670779B1 (en) * 2011-02-01 2017-08-02 Bac Ip B.V. Antigen-binding protein directed against epitope in the ch1 domain of human igg antibodies
EP3369746A1 (en) 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
CN107814845B (zh) * 2016-09-14 2021-02-09 浙江特瑞思药业股份有限公司 新的抗pd-1纳米抗体及其应用
CN107857816B (zh) * 2017-10-17 2020-11-06 北京大学 一种抗干扰素α-2b纳米抗体及其应用
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CA3105448A1 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
GB2595980B (en) * 2019-01-04 2023-06-14 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
CN119039441A (zh) 2019-02-21 2024-11-29 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
GB2599228B (en) 2019-02-21 2024-02-07 Marengo Therapeutics Inc Multifunctional molecules that bind to T cell related cancer cells and uses thereof
AU2020416273A1 (en) 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
AU2022298665A1 (en) * 2021-06-22 2024-01-04 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interactions and signaling
CN116239687B (zh) * 2021-12-22 2026-03-24 北京世纪沃德生物科技有限公司 一种crp驼源单域抗体及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ＥｒｂＢ２抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
WO2004016782A1 (ja) * 2002-08-16 2004-02-26 The University Of Tokyo 複数の蛋白質の間の相互作用を測定する方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ＥｒｂＢ２抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
US9598501B2 (en) 2010-02-16 2017-03-21 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法
US9834615B2 (en) 2010-08-16 2017-12-05 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies
US9926382B2 (en) 2010-08-16 2018-03-27 Novimmune S.A. Methods for the generation of multispecific and multivalent antibodies
US10597465B2 (en) 2010-08-16 2020-03-24 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies

Also Published As

Publication number Publication date
WO2007042809A3 (en) 2007-07-19
WO2007042809A2 (en) 2007-04-19
CA2625222A1 (en) 2007-04-19
AU2006300951A1 (en) 2007-04-19
US20100168393A1 (en) 2010-07-01
EP1951754A2 (en) 2008-08-06

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