JP2009507912A5 - - Google Patents
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- Publication number
- JP2009507912A5 JP2009507912A5 JP2008530635A JP2008530635A JP2009507912A5 JP 2009507912 A5 JP2009507912 A5 JP 2009507912A5 JP 2008530635 A JP2008530635 A JP 2008530635A JP 2008530635 A JP2008530635 A JP 2008530635A JP 2009507912 A5 JP2009507912 A5 JP 2009507912A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 2
- -1 -CF 3 1 Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- RBCHFMNWLAVRPO-INIZCTEOSA-N (3s)-3-[(2-phenylphenyl)methoxy]pyrrolidine Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1CO[C@H]1CCNC1 RBCHFMNWLAVRPO-INIZCTEOSA-N 0.000 claims 1
- GYGMDXJUPWUIKS-ZDUSSCGKSA-N (3s)-3-[[2-(2,3-difluorophenyl)-5-fluorophenyl]methoxy]pyrrolidine Chemical compound C=1C(F)=CC=C(C=2C(=C(F)C=CC=2)F)C=1CO[C@H]1CCNC1 GYGMDXJUPWUIKS-ZDUSSCGKSA-N 0.000 claims 1
- YVUZTTOQUJABBE-ZDUSSCGKSA-N (3s)-3-[[2-(2,3-difluorophenyl)phenyl]methoxy]pyrrolidine Chemical compound FC1=CC=CC(C=2C(=CC=CC=2)CO[C@@H]2CNCC2)=C1F YVUZTTOQUJABBE-ZDUSSCGKSA-N 0.000 claims 1
- ZJUXDISIBQHQIX-AWEZNQCLSA-N (3s)-3-[[2-(2,4-difluorophenyl)-5-fluorophenyl]methoxy]pyrrolidine Chemical compound FC1=CC(F)=CC=C1C1=CC=C(F)C=C1CO[C@@H]1CNCC1 ZJUXDISIBQHQIX-AWEZNQCLSA-N 0.000 claims 1
- XBUBHMYDYOIPGD-AWEZNQCLSA-N (3s)-3-[[2-(2,4-difluorophenyl)phenyl]methoxy]pyrrolidine Chemical compound FC1=CC(F)=CC=C1C1=CC=CC=C1CO[C@@H]1CNCC1 XBUBHMYDYOIPGD-AWEZNQCLSA-N 0.000 claims 1
- WCOVTUQVMUPPBA-UQKRIMTDSA-N (3s)-3-[[2-(2,4-difluorophenyl)phenyl]methoxy]pyrrolidine;hydrochloride Chemical compound Cl.FC1=CC(F)=CC=C1C1=CC=CC=C1CO[C@@H]1CNCC1 WCOVTUQVMUPPBA-UQKRIMTDSA-N 0.000 claims 1
- OAQUTYQPGHBFRF-INIZCTEOSA-N (3s)-3-[[2-(4-fluorophenyl)phenyl]methoxy]pyrrolidine Chemical compound C1=CC(F)=CC=C1C1=CC=CC=C1CO[C@@H]1CNCC1 OAQUTYQPGHBFRF-INIZCTEOSA-N 0.000 claims 1
- QZDLXDGUELPWKB-KRWDZBQOSA-N (3s)-3-[[2-(4-methylphenyl)phenyl]methoxy]pyrrolidine Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1CO[C@@H]1CNCC1 QZDLXDGUELPWKB-KRWDZBQOSA-N 0.000 claims 1
- BEPFSQFEFIYIMZ-AWEZNQCLSA-N (3s)-3-[[5-fluoro-2-(2-fluorophenyl)phenyl]methoxy]pyrrolidine Chemical compound C=1C(F)=CC=C(C=2C(=CC=CC=2)F)C=1CO[C@H]1CCNC1 BEPFSQFEFIYIMZ-AWEZNQCLSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004957 naphthylene group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 0 C*c1c(*)c(*)c(*)c(O*)c1* Chemical compound C*c1c(*)c(*)c(*)c(O*)c1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71670605P | 2005-09-13 | 2005-09-13 | |
| PCT/IB2006/002457 WO2007031828A2 (en) | 2005-09-13 | 2006-09-04 | Therapeutic pyrrolidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507912A JP2009507912A (ja) | 2009-02-26 |
| JP2009507912A5 true JP2009507912A5 (enExample) | 2009-10-22 |
Family
ID=37688316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530635A Withdrawn JP2009507912A (ja) | 2005-09-13 | 2006-09-04 | 治療用のピロリジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090215857A1 (enExample) |
| EP (1) | EP1931653A2 (enExample) |
| JP (1) | JP2009507912A (enExample) |
| CA (1) | CA2622222A1 (enExample) |
| WO (1) | WO2007031828A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5405571B2 (ja) | 2008-07-24 | 2014-02-05 | セラヴァンス， インコーポレーテッド | ３−（フェノキシフェニルメチル）ピロリジン化合物 |
| WO2010120910A1 (en) * | 2009-04-15 | 2010-10-21 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| RU2535669C2 (ru) | 2009-07-13 | 2014-12-20 | Тереванс, Инк. | 3-феноксиметилпирролидиновые соединения |
| JP5714580B2 (ja) | 2009-07-21 | 2015-05-07 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ３−フェノキシメチルピロリジン化合物 |
| WO2012051103A1 (en) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Serotonin reuptake inhibitors |
| WO2012075239A1 (en) | 2010-12-03 | 2012-06-07 | Theravance, Inc. | Serotonin reuptake inhibitors |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| JP5975081B2 (ja) | 2013-09-30 | 2016-08-23 | ダイキン工業株式会社 | 含フッ素ビアリール化合物の製造方法 |
| PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| US5202330A (en) * | 1985-06-03 | 1993-04-13 | E. R. Squibb & Sons, Inc. | 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters |
| US4855301A (en) * | 1986-10-09 | 1989-08-08 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters |
| US5037820A (en) * | 1990-06-29 | 1991-08-06 | Merck & Co., Inc. | Carbapenem antibacterial agents |
| US5247074A (en) * | 1990-10-09 | 1993-09-21 | Merck & Co., Inc. | (2-substituted phenyl) carbapenems |
| US5914328A (en) * | 1992-10-09 | 1999-06-22 | Abbott Laboratories | Heterocyclic ether compounds useful in controlling neurotransmitter release |
| US5948793A (en) * | 1992-10-09 | 1999-09-07 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release |
| US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| WO1996036633A1 (en) * | 1995-05-17 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
| US6437138B1 (en) * | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| TW577875B (en) * | 1997-01-31 | 2004-03-01 | Shionogi & Co | Pyrrolidine derivatives with inhibitory activity for phospholipase A2 |
| US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| WO2000009480A1 (en) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| US20020151712A1 (en) * | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| WO2002044181A1 (en) * | 2000-12-01 | 2002-06-06 | Bristol-Myers Squibb Company | Hydantoin compounds useful as anti-inflammatory agents |
| US6603000B2 (en) * | 2001-07-11 | 2003-08-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis for heteroarylamine compounds |
| WO2003020699A2 (en) * | 2001-08-30 | 2003-03-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6927293B2 (en) * | 2001-08-30 | 2005-08-09 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6806279B2 (en) * | 2001-12-17 | 2004-10-19 | Sunesis Pharmaceuticals, Inc. | Small-molecule inhibitors of interleukin-2 |
| GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| US7659305B2 (en) * | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
| EP1628970A2 (en) * | 2003-04-30 | 2006-03-01 | The Institutes of Pharmaceutical Discovery, LLC | Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
| US7619096B2 (en) * | 2003-06-11 | 2009-11-17 | Eli Lilly And Company | 3-Aminopyrrolidines as inhibitors of monoamine uptake |
-
2006
- 2006-08-29 US US12/066,740 patent/US20090215857A1/en not_active Abandoned
- 2006-09-04 EP EP06795438A patent/EP1931653A2/en not_active Withdrawn
- 2006-09-04 JP JP2008530635A patent/JP2009507912A/ja not_active Withdrawn
- 2006-09-04 WO PCT/IB2006/002457 patent/WO2007031828A2/en not_active Ceased
- 2006-09-04 CA CA002622222A patent/CA2622222A1/en not_active Abandoned