JP2009505945A5 - - Google Patents
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- Publication number
- JP2009505945A5 JP2009505945A5 JP2008513710A JP2008513710A JP2009505945A5 JP 2009505945 A5 JP2009505945 A5 JP 2009505945A5 JP 2008513710 A JP2008513710 A JP 2008513710A JP 2008513710 A JP2008513710 A JP 2008513710A JP 2009505945 A5 JP2009505945 A5 JP 2009505945A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- evaporation
- fast
- composition
- substantially pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 12
- 238000001704 evaporation Methods 0.000 claims 11
- 230000008020 evaporation Effects 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 10
- 238000010583 slow cooling Methods 0.000 claims 5
- 238000001816 cooling Methods 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- -1 3-methoxy-4- (oxazol-5-yl) phenyl Chemical group 0.000 claims 2
- 229910002483 Cu Ka Inorganic materials 0.000 claims 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- PHZYZQWQIQMLBY-UHFFFAOYSA-N acetonitrile;propan-1-ol Chemical compound CC#N.CCCO PHZYZQWQIQMLBY-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 1
- GNWXVOQHLPBSSR-UHFFFAOYSA-N oxolane;toluene Chemical compound C1CCOC1.CC1=CC=CC=C1 GNWXVOQHLPBSSR-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68464405P | 2005-05-26 | 2005-05-26 | |
| PCT/US2006/020256 WO2006127909A2 (en) | 2005-05-26 | 2006-05-25 | Polymorphic forms of (s)-1-cyanobutan-2-yl (s)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl) phenyl) ureido) phenyl) ethylcarbamate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009505945A JP2009505945A (ja) | 2009-02-12 |
| JP2009505945A5 true JP2009505945A5 (cg-RX-API-DMAC10.html) | 2009-07-09 |
Family
ID=37076080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513710A Pending JP2009505945A (ja) | 2005-05-26 | 2006-05-25 | （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7504515B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1902040A2 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2009505945A (cg-RX-API-DMAC10.html) |
| CN (1) | CN101223150B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2006249921A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2609511A1 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ564252A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006127909A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009505945A (ja) | 2005-05-26 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態 |
| WO2015102019A2 (en) * | 2013-12-30 | 2015-07-09 | Msn Laboratories Private Limited | Process for the preparation of polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofuran carboxamide hydrochloride |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ301802B6 (cs) * | 1999-03-19 | 2010-06-30 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny jako inhibitory IMPDH a farmaceutické prostredky s jejich obsahem |
| US7943593B2 (en) * | 2002-12-06 | 2011-05-17 | Vertex Pharmaceuticals Incorporated | Compositions comprising inhibitors of IMPDH enzyme |
| JP2009505945A (ja) | 2005-05-26 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態 |
-
2006
- 2006-05-25 JP JP2008513710A patent/JP2009505945A/ja active Pending
- 2006-05-25 CN CN2006800260110A patent/CN101223150B/zh not_active Expired - Fee Related
- 2006-05-25 EP EP06771179A patent/EP1902040A2/en not_active Withdrawn
- 2006-05-25 CA CA002609511A patent/CA2609511A1/en not_active Abandoned
- 2006-05-25 AU AU2006249921A patent/AU2006249921A1/en not_active Abandoned
- 2006-05-25 WO PCT/US2006/020256 patent/WO2006127909A2/en not_active Ceased
- 2006-05-25 NZ NZ564252A patent/NZ564252A/en not_active IP Right Cessation
- 2006-05-25 US US11/440,891 patent/US7504515B2/en not_active Expired - Fee Related
-
2009
- 2009-02-04 US US12/365,424 patent/US7829723B2/en not_active Expired - Lifetime