CN101223150B - (s)-1-氰基丁-2-基(s)-1-(3-(3-(3-甲氧基-4-(*唑-5-基)苯基)脲基)苯基)乙基氨基甲酸酯的多晶型 - Google Patents

(s)-1-氰基丁-2-基(s)-1-(3-(3-(3-甲氧基-4-(*唑-5-基)苯基)脲基)苯基)乙基氨基甲酸酯的多晶型 Download PDF

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CN101223150B
CN101223150B CN2006800260110A CN200680026011A CN101223150B CN 101223150 B CN101223150 B CN 101223150B CN 2006800260110 A CN2006800260110 A CN 2006800260110A CN 200680026011 A CN200680026011 A CN 200680026011A CN 101223150 B CN101223150 B CN 101223150B
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phenyl
bottle
polymorphic
evaporation
solution
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CN101223150A (zh
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T·A·布里瑟
P·沃拉赫瓦
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2006800260110A 2005-05-26 2006-05-25 (s)-1-氰基丁-2-基(s)-1-(3-(3-(3-甲氧基-4-(*唑-5-基)苯基)脲基)苯基)乙基氨基甲酸酯的多晶型 Expired - Fee Related CN101223150B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68464405P 2005-05-26 2005-05-26
US60/684,644 2005-05-26
PCT/US2006/020256 WO2006127909A2 (en) 2005-05-26 2006-05-25 Polymorphic forms of (s)-1-cyanobutan-2-yl (s)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl) phenyl) ureido) phenyl) ethylcarbamate

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CN101223150A CN101223150A (zh) 2008-07-16
CN101223150B true CN101223150B (zh) 2012-12-12

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CN2006800260110A Expired - Fee Related CN101223150B (zh) 2005-05-26 2006-05-25 (s)-1-氰基丁-2-基(s)-1-(3-(3-(3-甲氧基-4-(*唑-5-基)苯基)脲基)苯基)乙基氨基甲酸酯的多晶型

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US (2) US7504515B2 (cg-RX-API-DMAC10.html)
EP (1) EP1902040A2 (cg-RX-API-DMAC10.html)
JP (1) JP2009505945A (cg-RX-API-DMAC10.html)
CN (1) CN101223150B (cg-RX-API-DMAC10.html)
AU (1) AU2006249921A1 (cg-RX-API-DMAC10.html)
CA (1) CA2609511A1 (cg-RX-API-DMAC10.html)
NZ (1) NZ564252A (cg-RX-API-DMAC10.html)
WO (1) WO2006127909A2 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009505945A (ja) 2005-05-26 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態
WO2015102019A2 (en) * 2013-12-30 2015-07-09 Msn Laboratories Private Limited Process for the preparation of polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofuran carboxamide hydrochloride
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301802B6 (cs) * 1999-03-19 2010-06-30 Vertex Pharmaceuticals Incorporated Deriváty mocoviny jako inhibitory IMPDH a farmaceutické prostredky s jejich obsahem
US7943593B2 (en) * 2002-12-06 2011-05-17 Vertex Pharmaceuticals Incorporated Compositions comprising inhibitors of IMPDH enzyme
JP2009505945A (ja) 2005-05-26 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態

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JP2009505945A (ja) 2009-02-12
CN101223150A (zh) 2008-07-16
WO2006127909A2 (en) 2006-11-30
US7504515B2 (en) 2009-03-17
CA2609511A1 (en) 2006-11-30
AU2006249921A1 (en) 2006-11-30
WO2006127909A3 (en) 2007-03-29
NZ564252A (en) 2011-04-29
US20070099972A1 (en) 2007-05-03
US20090170915A1 (en) 2009-07-02
EP1902040A2 (en) 2008-03-26
US7829723B2 (en) 2010-11-09

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