JP2009504135A5 - - Google Patents
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- Publication number
- JP2009504135A5 JP2009504135A5 JP2008510166A JP2008510166A JP2009504135A5 JP 2009504135 A5 JP2009504135 A5 JP 2009504135A5 JP 2008510166 A JP2008510166 A JP 2008510166A JP 2008510166 A JP2008510166 A JP 2008510166A JP 2009504135 A5 JP2009504135 A5 JP 2009504135A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic composition
- mammal
- virus
- protein
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000001225 therapeutic Effects 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2R,4R,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Polymers C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 241000710831 Flavivirus Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-Methionine Natural products CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 206010047461 Viral infection Diseases 0.000 claims 1
- 208000001756 Virus Disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 229920000023 polynucleotide Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
Claims (9)
- 配列番号1のアミノ酸配列からなるオリゴアデニレートシンセターゼ1タンパク質であって、1位のメチオニンが欠失しており、162位のアミノ酸がグリシンである、タンパク質。
- 哺乳動物におけるウイルス感染を治療または哺乳動物における癌を治療するための治療組成物であって、薬学的に許容される担体と、請求項1に記載のオリゴアデニレートシンセターゼ1タンパク質とを含む、組成物。
- 前記ウイルスがフラビウイルスである、請求項2に記載の治療組成物。
- 前記ウイルスがC型肝炎ウイルスである、請求項2に記載の治療組成物。
- 哺乳動物における癌を治療するための治療組成物であって、請求項1に記載のポリペプチドを、薬学的に許容される担体と共に含む、組成物。
- 前記癌が前立腺癌である、請求項5に記載の治療組成物。
- 治療化合物がキットの一部として提供される、請求項2に記載の治療組成物。
- キットが、治療組成物の使用に関する1以上の指示書または治療組成物の使用に関する規制当局の認可を示す標識もしくは挿入物を含む、請求項7に記載の治療組成物。
- 請求項1に記載のタンパク質をコードするポリヌクレオチド。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67768005P | 2005-05-04 | 2005-05-04 | |
US60/677,680 | 2005-05-04 | ||
PCT/US2006/016983 WO2006119363A2 (en) | 2005-05-04 | 2006-05-03 | Mutations in oas1 genes |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009504135A JP2009504135A (ja) | 2009-02-05 |
JP2009504135A5 true JP2009504135A5 (ja) | 2011-05-12 |
JP5303728B2 JP5303728B2 (ja) | 2013-10-02 |
Family
ID=37113984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008510166A Expired - Fee Related JP5303728B2 (ja) | 2005-05-04 | 2006-05-03 | Oas1遺伝子内の突然変異 |
Country Status (19)
Country | Link |
---|---|
US (4) | US20060275802A1 (ja) |
EP (4) | EP2314675B1 (ja) |
JP (1) | JP5303728B2 (ja) |
KR (3) | KR20140109510A (ja) |
CN (2) | CN101203604A (ja) |
AU (1) | AU2006242152B2 (ja) |
BR (1) | BRPI0611454A2 (ja) |
CA (1) | CA2607575A1 (ja) |
HK (1) | HK1209454A1 (ja) |
IL (1) | IL187079A (ja) |
MX (1) | MX2007013765A (ja) |
NO (1) | NO20076126L (ja) |
NZ (1) | NZ563785A (ja) |
PH (1) | PH12014500829A1 (ja) |
RU (2) | RU2465328C2 (ja) |
SG (2) | SG175656A1 (ja) |
UA (1) | UA95446C2 (ja) |
WO (1) | WO2006119363A2 (ja) |
ZA (1) | ZA200710521B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2267154A1 (en) | 2003-10-23 | 2010-12-29 | Illumigen Biosciences, Inc. | Oligoadenylate synthetase |
UA95446C2 (ru) | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
US20080038753A1 (en) * | 2006-08-01 | 2008-02-14 | Illumigen Biosciences, Inc. | Pharmaceutical manufacturing methods |
EP2531856A4 (en) | 2010-02-05 | 2013-07-10 | Translational Genomics Res Inst | METHODS AND KITS USED TO CLASSIFY ADRENOCORTICAL CARCINOMA |
CN103536900B (zh) * | 2012-07-16 | 2017-06-16 | 江苏豪森药业集团有限公司 | 含有促红细胞生成素模拟肽的药物组合物 |
WO2016164216A1 (en) * | 2015-04-09 | 2016-10-13 | Isp Investments Inc. | Method of cosmetic treatment to protect the skin from pollution and improve skin regeneration |
CN106483282B (zh) * | 2016-09-29 | 2018-08-31 | 北京世纪沃德生物科技有限公司 | 一种抗原稳定剂及其制备方法与应用 |
WO2020041500A1 (en) * | 2018-08-21 | 2020-02-27 | Georgia State University Research Foundation, Inc. | Treatment of flavivirus infections in humans using mus musculus resistant 2'-5' oligoadenylate synthetase 1b |
US20230083751A1 (en) * | 2019-12-30 | 2023-03-16 | Nanjing GenScript Biotech Co., Ltd. | Method For Constructing Gene Mutation Library |
CN114409744B (zh) * | 2022-03-29 | 2022-10-04 | 深圳吉诺因生物科技有限公司 | Hpv抗原表位及其鉴定方法、应用 |
WO2023245177A2 (en) * | 2022-06-17 | 2023-12-21 | The University Of Chicago | Targeted nanomedicine for treating lung disorders |
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-
2006
- 2006-03-05 UA UAA200713492A patent/UA95446C2/ru unknown
- 2006-05-03 RU RU2007144986/10A patent/RU2465328C2/ru not_active IP Right Cessation
- 2006-05-03 KR KR1020147023680A patent/KR20140109510A/ko not_active Application Discontinuation
- 2006-05-03 EP EP10184942.0A patent/EP2314675B1/en not_active Not-in-force
- 2006-05-03 MX MX2007013765A patent/MX2007013765A/es active IP Right Grant
- 2006-05-03 CN CNA2006800220895A patent/CN101203604A/zh active Pending
- 2006-05-03 BR BRPI0611454-7A patent/BRPI0611454A2/pt not_active IP Right Cessation
- 2006-05-03 NZ NZ563785A patent/NZ563785A/xx not_active IP Right Cessation
- 2006-05-03 US US11/416,790 patent/US20060275802A1/en not_active Abandoned
- 2006-05-03 EP EP20140189399 patent/EP2860246A1/en not_active Withdrawn
- 2006-05-03 SG SG2011076403A patent/SG175656A1/en unknown
- 2006-05-03 KR KR20077028236A patent/KR101476844B1/ko not_active IP Right Cessation
- 2006-05-03 CA CA002607575A patent/CA2607575A1/en active Pending
- 2006-05-03 KR KR1020137015261A patent/KR20130084323A/ko not_active Application Discontinuation
- 2006-05-03 EP EP10183486A patent/EP2295552A3/en not_active Withdrawn
- 2006-05-03 AU AU2006242152A patent/AU2006242152B2/en not_active Ceased
- 2006-05-03 EP EP06758989A patent/EP1877550A2/en not_active Withdrawn
- 2006-05-03 JP JP2008510166A patent/JP5303728B2/ja not_active Expired - Fee Related
- 2006-05-03 WO PCT/US2006/016983 patent/WO2006119363A2/en active Application Filing
- 2006-05-03 CN CN201310157513.9A patent/CN103642898A/zh active Pending
- 2006-05-03 SG SG10201502945PA patent/SG10201502945PA/en unknown
-
2007
- 2007-01-01 ZA ZA200710521A patent/ZA200710521B/xx unknown
- 2007-11-01 IL IL187079A patent/IL187079A/en not_active IP Right Cessation
- 2007-11-27 NO NO20076126A patent/NO20076126L/no unknown
-
2008
- 2008-10-09 US US12/248,810 patent/US8030046B2/en not_active Expired - Fee Related
-
2011
- 2011-07-11 US US13/180,132 patent/US8951768B2/en not_active Expired - Fee Related
- 2011-10-03 HK HK15110007.3A patent/HK1209454A1/xx unknown
-
2012
- 2012-07-30 RU RU2012132651/10A patent/RU2012132651A/ru not_active Application Discontinuation
- 2012-11-14 US US13/676,928 patent/US9163222B2/en not_active Expired - Fee Related
-
2014
- 2014-04-14 PH PH12014500829A patent/PH12014500829A1/en unknown
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