JP2009503020A - 肥満症の治療におけるフリバンセリンの使用 - Google Patents
肥満症の治療におけるフリバンセリンの使用 Download PDFInfo
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- JP2009503020A JP2009503020A JP2008524499A JP2008524499A JP2009503020A JP 2009503020 A JP2009503020 A JP 2009503020A JP 2008524499 A JP2008524499 A JP 2008524499A JP 2008524499 A JP2008524499 A JP 2008524499A JP 2009503020 A JP2009503020 A JP 2009503020A
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- obesity
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- flibanserin
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| EP05016867 | 2005-08-03 | ||
| PCT/EP2006/064825 WO2007014929A1 (en) | 2005-08-03 | 2006-07-31 | Use of flibanserin in the treatment of obesity |
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| US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
| US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
| PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
| CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| EA200802208A1 (ru) * | 2006-05-09 | 2009-04-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Применение флибансерина для лечения расстройств полового влечения в постклимактерический период |
| EP2037927B1 (en) * | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibanserin for the treatment of urinary incontinence and related diseases |
| EP2043648A1 (en) * | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Use of flibanserin for the treatment of sexual disorders in females |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| AR062320A1 (es) | 2006-08-14 | 2008-10-29 | Boehringer Ingelheim Int | Formulaciones de flibanserina y metodo para fabricarlas |
| WO2008022932A2 (en) * | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| US8722682B2 (en) * | 2006-12-20 | 2014-05-13 | Sprout Pharmaceuticals, Inc. | Sulfated benzimidazolone derivatives having mixed serotonin receptor affinity |
| WO2008090742A1 (ja) * | 2007-01-23 | 2008-07-31 | National University Corporation Hokkaido University | 眼疾患モデル用非ヒト動物 |
| CL2008002693A1 (es) * | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
| CN104039753B (zh) | 2011-12-30 | 2016-09-14 | 雷维瓦药品公司 | 苯基环烷基甲胺衍生物的组合物、合成以及使用方法 |
| US9146807B2 (en) | 2012-12-04 | 2015-09-29 | Sandisk Technologies Inc. | Bad column handling in flash memory |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10278948B1 (en) | 2015-09-03 | 2019-05-07 | Tian Xia | Method for transnasal delivery of anticonvulsant and therapeutic treatments |
| CN115300627B (zh) * | 2021-05-08 | 2024-01-26 | 中南大学湘雅医院 | 钠-葡萄糖共转运蛋白2抑制剂的应用、一种药物组合物及其应用 |
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| JP2004517937A (ja) * | 2001-01-29 | 2004-06-17 | 大塚製薬株式会社 | 5−ht1a受容体サブタイプ作動薬 |
Family Cites Families (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3096248A (en) | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
| US3406178A (en) | 1964-02-04 | 1968-10-15 | Monsanto Chem Australia Ltd | Preparation of 2-substituted benzimidazoles |
| US3406189A (en) | 1965-08-12 | 1968-10-15 | American Home Prod | Aminopregnanes |
| US3362956A (en) | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| US4200641A (en) | 1976-12-21 | 1980-04-29 | Janssen Pharmaceutica, N.V. | 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives |
| DK251079A (da) | 1978-06-20 | 1979-12-21 | Synthelabo | Fremgangsmaade til fremstilling af phenylpiperazinderivater |
| DE3000979A1 (de) | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
| DE3126703A1 (de) | 1981-07-07 | 1983-01-27 | Dr. Karl Thomae Gmbh, 7950 Biberach | Bromhexin-retardform und verfahren zu ihrer herstellung |
| JPS58134033A (ja) | 1982-02-02 | 1983-08-10 | Fujisawa Pharmaceut Co Ltd | 医薬組成物 |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| IE58370B1 (en) | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| HUT43600A (en) | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
| DE3620643A1 (de) | 1985-06-22 | 1987-01-22 | Sandoz Ag | Thiazole, ihre herstellung und verwendung |
| GB8601160D0 (en) | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
| US5036088A (en) | 1986-06-09 | 1991-07-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents, compositions and use |
| JPH0784462B2 (ja) | 1986-07-25 | 1995-09-13 | 日清製粉株式会社 | ベンゾイミダゾ−ル誘導体 |
| US4968508A (en) | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
| US4792452A (en) | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| GB8830312D0 (en) | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| US4954503A (en) | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| AU8629691A (en) | 1990-08-09 | 1992-03-02 | Massachusetts Institute Of Technology | Method for treating the premenstrual or late luteal phase syndrome |
| DE69129839T2 (de) | 1990-08-24 | 1999-02-11 | Shin-Etsu Chemical Co., Ltd., Tokio/Tokyo | Beschichtungsbase für einen pharmazeutischen film und verfahren zur herstellung derselben |
| NZ241613A (en) | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
| SE9100860D0 (sv) | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | New use |
| FR2675800A1 (fr) | 1991-04-26 | 1992-10-30 | Rhone Poulenc Rorer Sa | Derives heterocycliques antiserotonines leur preparation et les medicaments les contenant. |
| FI934894A7 (fi) | 1991-05-07 | 1993-11-05 | Merck & Co Inc | Fibrinogeenireseptorin antagonisteja |
| IT1251144B (it) | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| DE4216364A1 (de) | 1991-12-14 | 1993-11-25 | Thomae Gmbh Dr K | Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5225417A (en) | 1992-01-21 | 1993-07-06 | G. D. Searle & Co. | Opioid agonist compounds |
| US5492907A (en) | 1992-12-09 | 1996-02-20 | The United States Of America As Represented By The Department Of Health & Human Services | Antipsychotic composition and method of treatment |
| EP0696919B1 (en) | 1993-04-05 | 2002-01-30 | Competitive Technologies, Inc. | Diagnosis and treatment of erectile dysfunction |
| FR2707294B1 (fr) | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
| GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| MX9606450A (es) | 1994-06-14 | 1997-03-29 | Pfizer | Derivados de bencimidazolona. |
| UA42781C2 (uk) | 1994-08-23 | 2001-11-15 | Смітклайн Бічем Плц | Фармацевтичний препарат, який містить ібупрофен та кодеїн, і спосіб його приготування |
| ES2204932T3 (es) | 1994-09-12 | 2004-05-01 | Eli Lilly And Company Limited | Moduladores serotonergicos. |
| JPH08143476A (ja) | 1994-11-18 | 1996-06-04 | Japan Tobacco Inc | 薬物放出制御膜及び固形製剤 |
| FR2727682A1 (fr) | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5883094A (en) | 1995-04-24 | 1999-03-16 | Pfizer Inc. | Benzimidazolone derivatives with central dopaminergic activity |
| US5854290A (en) | 1995-09-21 | 1998-12-29 | Amy F. T. Arnsten | Use of guanfacine in the treatment of behavioral disorders |
| US6083947A (en) | 1996-01-29 | 2000-07-04 | The Regents Of The University Of California | Method for treating sexual dysfunctions |
| GB9613423D0 (en) | 1996-06-26 | 1996-08-28 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5916916A (en) | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| ZA979937B (en) | 1996-11-06 | 1999-05-18 | Sharmatek Inc | Delayed delivery system for acid-sensitive drugs |
| JP2001504851A (ja) | 1996-12-02 | 2001-04-10 | メルク シヤープ エンド ドーム リミテツド | 性的機能不全の治療のためのnk−1受容体拮抗薬の使用 |
| US5859246A (en) | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
| GB9706089D0 (en) | 1997-03-24 | 1997-05-14 | Scherer Ltd R P | Pharmaceutical composition |
| US20040023948A1 (en) | 1997-03-24 | 2004-02-05 | Green Richard David | Fast-dispersing dosage form containing 5-HT1 agonists |
| AU729912B2 (en) | 1997-06-11 | 2001-02-15 | Warner Chilcott Company, Llc | Film-coated tablet for improved upper gastrointestinal tract safety |
| DE69815003T2 (de) | 1997-09-10 | 2004-04-01 | Takeda Chemical Industries, Ltd. | Stabilisierte pharmazeutische Zusammensetzung |
| SE9703375D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | A new combination |
| CH692199A8 (fr) | 1997-10-09 | 2002-06-14 | Cermol S.A. | Composes pyridiques et compositions pharmaceutique |
| JP3724157B2 (ja) | 1997-10-30 | 2005-12-07 | コニカミノルタホールディングス株式会社 | 映像観察装置 |
| FR2775188B1 (fr) | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
| AU753479B2 (en) | 1998-05-19 | 2002-10-17 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| WO1999059584A1 (en) | 1998-05-20 | 1999-11-25 | Schering Corporation | Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction |
| EP1077704A4 (en) | 1998-05-21 | 2002-01-30 | Lilly Co Eli | COMBINATION THERAPY FOR TREATING DEPRESSION |
| US20020151543A1 (en) | 1998-05-28 | 2002-10-17 | Sepracor Inc. | Compositions and methods employing R (-) fluoxetine and other active ingredients |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US6068846A (en) | 1998-08-05 | 2000-05-30 | Melaleuca, Incorporated | Methods and materials for treating depression and mood disorder |
| EP0982030A3 (en) | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
| UA67802C2 (uk) | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
| AU1738900A (en) | 1998-11-19 | 2000-06-05 | Nortran Pharmaceuticals Inc. | Serotonin ligands as pro-erectile compounds |
| US6680071B1 (en) | 1999-03-03 | 2004-01-20 | R. P. Scherer Technologies, Inc. | Opioid agonist in a fast dispersing dosage form |
| WO2000063193A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
| AU5259100A (en) | 1999-04-28 | 2000-11-10 | Respiratorius Ab | Medicament |
| IT1312310B1 (it) | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| US6579968B1 (en) | 1999-06-29 | 2003-06-17 | Palatin Technologies, Inc. | Compositions and methods for treatment of sexual dysfunction |
| US20030055070A1 (en) | 1999-07-01 | 2003-03-20 | Wilma Harrison | Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of selective serotonin reuptake inhibitor (SSR) induced sexual dysfunction |
| US6346548B1 (en) | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
| IT1313625B1 (it) | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
| DE19961334A1 (de) | 1999-12-17 | 2001-06-21 | Roehm Gmbh | Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere |
| NZ520975A (en) | 2000-02-24 | 2004-03-26 | Upjohn Co | New drug combinations containing a norepinephrine reuptake inhibitor and an antimuscarinic agent for treating nervous system disorders |
| US20030207890A1 (en) * | 2001-02-23 | 2003-11-06 | Collier Robert J | Compounds with 5-ht1a activity useful for treating disorders of the outer retina |
| AP2001002196A0 (en) | 2000-06-28 | 2002-12-21 | Pfizer Prod Inc | Melanocortin receptor ligands. |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| US20020052370A1 (en) | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| MXPA03002329A (es) | 2000-09-19 | 2003-10-15 | Boehringer Ingelheim Pharma | Nuevos derivados de bencimidazolona que muestran afinidad por los receptores de serotonina y dopamina. |
| US6586435B2 (en) | 2000-09-19 | 2003-07-01 | Boehringer Ingelheim Pharma Kg | Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors |
| US6521623B1 (en) | 2000-09-19 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
| AU2002223528A1 (en) | 2000-09-19 | 2002-04-02 | Boeringer Ingelheim Pharma Gmbh & Co. Kg | New n, n'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
| ES2284727T3 (es) | 2000-11-22 | 2007-11-16 | Abbott Laboratories | Agonistas selectivos del receptor de dopamina d4 para tratar disfuncion sexual. |
| GB0105893D0 (en) | 2001-03-09 | 2001-04-25 | Pfizer Ltd | Pharmaceutically active compounds |
| GB0106446D0 (en) | 2001-03-15 | 2001-05-02 | Vernalis Res Ltd | Chemical compounds |
| HRP20030751A2 (en) | 2001-03-28 | 2005-08-31 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad |
| DK1256343T3 (da) | 2001-05-11 | 2006-10-30 | Juergen K Dr Beck | Flibanserin til behandlingen af extrapyramidale bevægelseslidelser |
| US6627646B2 (en) | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| CA2453609C (en) | 2001-07-18 | 2010-05-04 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
| WO2003011396A1 (en) | 2001-07-30 | 2003-02-13 | Neotherapeutics, Inc. | Tetrahydroindolone and purine derivatives linked to arylpiperazines |
| US7183410B2 (en) | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| RS50742B (sr) | 2001-08-02 | 2010-08-31 | Bidachem S.P.A. | Stabilni polimorf flibanserina, postupak za njegovo dobijanje u industrijskim razmerama i njegova primena za pripremanje lekova |
| DE10138273A1 (de) | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Arzneimittel mit neuroprotektiver Wirkung |
| US20030060475A1 (en) | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
| HUP0202719A3 (en) | 2001-08-21 | 2006-01-30 | Pfizer Prod Inc | Pharmaceutical compositions for the treatment of female sexual dysfunctions |
| DE10149674A1 (de) | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| DE10209982A1 (de) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
| HRP20041092B1 (hr) | 2002-05-22 | 2013-05-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Novi farmaceutski pripravci flibanserina |
| US20040048877A1 (en) | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
| CA2529857A1 (en) | 2002-07-30 | 2004-02-05 | Peter Migaly | Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions |
| US20040116532A1 (en) | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| US20040132697A1 (en) | 2002-11-06 | 2004-07-08 | Pfizer Inc. | Treatment of female sexual dysfunction |
| US20040147581A1 (en) | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| US20040193452A1 (en) | 2003-01-06 | 2004-09-30 | Laura Berman | Method and system for computerized sexual function assessment of female users |
| WO2004069339A1 (en) | 2003-01-29 | 2004-08-19 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| US20050037983A1 (en) | 2003-03-11 | 2005-02-17 | Timothy Dinan | Compositions and methods for the treatment of depression and other affective disorders |
| US20050065158A1 (en) | 2003-07-16 | 2005-03-24 | Pfizer Inc. | Treatment of sexual dysfunction |
| WO2005007166A1 (en) | 2003-07-16 | 2005-01-27 | Pfizer Limited | Treatment of sexual dysfunction |
| MXPA06002731A (es) | 2003-09-11 | 2006-06-05 | Xenoport Inc | Tratamiento y/o prevencion de incontinencia urinaria utilizando profarmacos de analogos de gaba. |
| WO2005044238A1 (en) | 2003-11-07 | 2005-05-19 | Ranbaxy Laboratories Limited | Modified release solid dosage form of amphetamine salts |
| US20050239798A1 (en) | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
| BRPI0510074A (pt) | 2004-04-22 | 2007-10-16 | Boehringer Ingelheim Int | composições farmacêuticas para o tratamento de distúrbios sexuais ii |
| US20060014757A1 (en) * | 2004-07-14 | 2006-01-19 | Boehringer Ingelheim Pharmaceuticals | Method for the treatment of anorexia nervosa |
| US20060025420A1 (en) | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
| EP1789048A1 (en) | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Method for the treatment of attention deficit hyperactivity disorder |
| WO2006096439A2 (en) | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
| US20060211685A1 (en) | 2005-03-04 | 2006-09-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
| CA2599937A1 (en) | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
| WO2006119884A2 (en) | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
| US20060258640A1 (en) | 2005-05-13 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Use of Flibanserin in the treatment of chronic pain |
| WO2006125041A1 (en) | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
| CA2608363A1 (en) | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
| CA2578626C (en) | 2005-06-27 | 2011-07-19 | Biovail Laboratories International S.R.L. | Modified-release formulations of a bupropion salt |
| PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
| HU227490B1 (en) | 2005-08-26 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Sustained release pharmaceutical preparation containing carvedilol |
| US20080275082A1 (en) | 2005-09-30 | 2008-11-06 | Jeffrey Brum | Pharmaceutical Composition |
| CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| US20070123540A1 (en) | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
| US20070105869A1 (en) | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| NZ569984A (en) | 2006-01-27 | 2011-06-30 | Eurand Inc | Drug delivery systems comprising weakly basic drugs and organic acids |
| EP1988898A2 (en) | 2006-02-18 | 2008-11-12 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin |
| CA2642101A1 (en) | 2006-02-20 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of urinary incontinence |
| JP2009528322A (ja) | 2006-02-28 | 2009-08-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フリバンセリンによる弁膜性心疾患の治療又は予防 |
| EA200802208A1 (ru) | 2006-05-09 | 2009-04-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Применение флибансерина для лечения расстройств полового влечения в постклимактерический период |
| EP2037927B1 (en) | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibanserin for the treatment of urinary incontinence and related diseases |
| CA2657045A1 (en) | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Combinations of flibanserin with caffeine, process for their preparation and use thereof as medicaments |
| EP2043648A1 (en) | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Use of flibanserin for the treatment of sexual disorders in females |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| AR062320A1 (es) | 2006-08-14 | 2008-10-29 | Boehringer Ingelheim Int | Formulaciones de flibanserina y metodo para fabricarlas |
| WO2008022932A2 (en) | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| US8722682B2 (en) | 2006-12-20 | 2014-05-13 | Sprout Pharmaceuticals, Inc. | Sulfated benzimidazolone derivatives having mixed serotonin receptor affinity |
| EP2129400A2 (en) | 2007-03-28 | 2009-12-09 | Boehringer Ingelheim International GmbH | Pharmaceutical compositions comprising flibanserin and a further agent in the treatment of sexual disorders |
| US8486452B2 (en) | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
-
2006
- 2006-07-31 PL PL06764270T patent/PL1912650T3/pl unknown
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- 2006-07-31 US US11/997,567 patent/US8227476B2/en active Active
- 2006-07-31 WO PCT/EP2006/064825 patent/WO2007014929A1/en not_active Ceased
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2012
- 2012-07-16 US US13/550,062 patent/US8785458B2/en active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004517937A (ja) * | 2001-01-29 | 2004-06-17 | 大塚製薬株式会社 | 5−ht1a受容体サブタイプ作動薬 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6012032649; CHAOULOFF,F. et al: 'Hyperinsulinemia of the genetically obese (fa/fa) rat is decreased by a low dose of the 5-HT1A recep' Eur J Pharmacol Vol.147, No.1, 1988, p.111-8 * |
| JPN6012032650; BORSINI,F. et al: 'Behavioral effects of flibanserin (BIMT 17)' Pharmacol Biochem Behav Vol.64, No.1, 1999, p.137-46 * |
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| EP1912650B1 (en) | 2017-08-30 |
| CA2617546A1 (en) | 2007-02-08 |
| ES2646326T3 (es) | 2017-12-13 |
| EP1912650A1 (en) | 2008-04-23 |
| EP1912650B8 (en) | 2017-10-18 |
| US10874668B2 (en) | 2020-12-29 |
| PL1912650T3 (pl) | 2018-01-31 |
| US8785458B2 (en) | 2014-07-22 |
| US20130079355A1 (en) | 2013-03-28 |
| WO2007014929A1 (en) | 2007-02-08 |
| US20210069185A1 (en) | 2021-03-11 |
| US8227476B2 (en) | 2012-07-24 |
| US20160136161A1 (en) | 2016-05-19 |
| CA2617546C (en) | 2014-07-15 |
| US20180015084A1 (en) | 2018-01-18 |
| US9730927B2 (en) | 2017-08-15 |
| US20080242678A1 (en) | 2008-10-02 |
| US20190282566A1 (en) | 2019-09-19 |
| US20150072994A1 (en) | 2015-03-12 |
| US10335407B2 (en) | 2019-07-02 |
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