|
US6812327B1
(en)
|
1996-10-25 |
2004-11-02 |
Human Genome Sciences, Inc. |
Neutrokine-alpha polypeptides
|
|
US8212004B2
(en)
|
1999-03-02 |
2012-07-03 |
Human Genome Sciences, Inc. |
Neutrokine-alpha fusion proteins
|
|
WO2002094852A2
(en)
|
2001-05-24 |
2002-11-28 |
Zymogenetics, Inc. |
Taci-immunoglobulin fusion proteins
|
|
US7833529B1
(en)
|
1999-01-07 |
2010-11-16 |
Zymogenetics, Inc. |
Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
|
|
US20030095967A1
(en)
|
1999-01-25 |
2003-05-22 |
Mackay Fabienne |
BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
|
|
DK1666052T3
(da)
*
|
2000-02-16 |
2011-09-12 |
Genentech Inc |
Anti-APRIL monoklonalt antistof og dets anvendelse til behandling af en immum-relateret sygdom eller cancer
|
|
US7879328B2
(en)
|
2000-06-16 |
2011-02-01 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to B lymphocyte stimulator
|
|
CN1279055C
(zh)
*
|
2000-06-16 |
2006-10-11 |
人体基因组科学有限公司 |
免疫特异性结合BLyS的抗体
|
|
WO2002016411A2
(en)
|
2000-08-18 |
2002-02-28 |
Human Genome Sciences, Inc. |
Binding polypeptides and methods based thereon
|
|
UA83458C2
(uk)
*
|
2000-09-18 |
2008-07-25 |
Байоджен Айдек Ма Інк. |
Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
|
|
AU2002230659A1
(en)
*
|
2000-11-07 |
2002-05-21 |
Zymogenetics Inc. |
Human tumor necrosis factor receptor
|
|
US20040170997A1
(en)
*
|
2001-02-28 |
2004-09-02 |
Shinji Irie |
Traf3-binding b-cell-specific receptor
|
|
AU2002311976A1
(en)
|
2001-05-24 |
2002-12-03 |
Human Genome Sciences, Inc. |
Antibodies against tumor necrosis factor delta (april)
|
|
US20050070689A1
(en)
*
|
2001-08-03 |
2005-03-31 |
Genentech, Inc. |
Taci and br3 polypeptides and uses thereof
|
|
US7112410B1
(en)
|
2001-08-29 |
2006-09-26 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor TR21 and methods based thereon
|
|
WO2003024991A2
(en)
*
|
2001-09-21 |
2003-03-27 |
Amgen Inc. |
Tall-1 receptor molecules and uses thereof
|
|
US7344843B2
(en)
*
|
2001-11-29 |
2008-03-18 |
Serono Genetics Institute S.A. |
Agonists and antagonists of prolixin for the treatment of metabolic disorders
|
|
WO2003055509A1
(en)
*
|
2001-12-26 |
2003-07-10 |
Genset S.A. |
Agonists and antagonists of bromix for the treatment of metabolic disorders
|
|
AU2003222664A1
(en)
*
|
2002-04-18 |
2003-11-03 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
|
US20050276812A1
(en)
|
2004-06-01 |
2005-12-15 |
Genentech, Inc. |
Antibody-drug conjugates and methods
|
|
US20050043516A1
(en)
*
|
2002-07-25 |
2005-02-24 |
Genentech, Inc. |
TACI antibodies and uses thereof
|
|
CA2520097C
(en)
|
2003-03-28 |
2014-10-07 |
Biogen Idec Ma Inc. |
Truncated baff receptors
|
|
US20050163775A1
(en)
*
|
2003-06-05 |
2005-07-28 |
Genentech, Inc. |
Combination therapy for B cell disorders
|
|
DK1631313T3
(en)
*
|
2003-06-05 |
2015-06-15 |
Genentech Inc |
Combination therapy for b cell disorders
|
|
CN1938046B
(zh)
|
2003-11-06 |
2014-03-19 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
EP1586585A1
(de)
*
|
2004-04-14 |
2005-10-19 |
F. Hoffmann-La Roche Ag |
Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
WO2007106436A2
(en)
*
|
2006-03-10 |
2007-09-20 |
Mallinckrodt Inc. |
Photoactive compounds and compositions and uses thereof
|
|
WO2007019573A2
(en)
|
2005-08-09 |
2007-02-15 |
Zymogenetics, Inc. |
Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
|
|
WO2007019575A2
(en)
|
2005-08-09 |
2007-02-15 |
Zymogenetics, Inc. |
Methods for treating b-cell malignancies using taci-ig fusion molecule
|
|
WO2007142667A2
(en)
*
|
2005-10-13 |
2007-12-13 |
Human Genome Sciences, Inc. |
Treatment of patients with autoantibody positive disease
|
|
US9168286B2
(en)
|
2005-10-13 |
2015-10-27 |
Human Genome Sciences, Inc. |
Methods and compositions for use in treatment of patients with autoantibody positive disease
|
|
ES2618543T3
(es)
*
|
2005-11-23 |
2017-06-21 |
Genentech, Inc. |
Métodos y composiciones relacionados con ensayos de linfocitos B
|
|
WO2007123765A2
(en)
|
2006-03-31 |
2007-11-01 |
Human Genome Sciences Inc. |
Neutrokine-alpha and neutrokine-alpha splice variant
|
|
KR20090016707A
(ko)
*
|
2006-05-15 |
2009-02-17 |
아레스 트레이딩 에스.에이. |
Ｔａｃｉｉｇ 융합 분자를 사용하여 자가면역 질병을 치료하는 방법
|
|
WO2008131242A1
(en)
|
2007-04-18 |
2008-10-30 |
Zymogenetics, Inc. |
Single chain fc, methods of making and methods of treatment
|
|
EP2233149B1
(en)
|
2007-10-16 |
2016-02-10 |
ZymoGenetics, Inc. |
Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for treatment of autoimmune disease
|
|
WO2010045261A1
(en)
*
|
2008-10-13 |
2010-04-22 |
Zymogenetics, Llc |
Single chain fc type iii interferons and methods of using same
|
|
WO2010075249A2
(en)
|
2008-12-22 |
2010-07-01 |
Genentech, Inc. |
A method for treating rheumatoid arthritis with b-cell antagonists
|
|
US9238878B2
(en)
|
2009-02-17 |
2016-01-19 |
Redwood Bioscience, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
KR20120104517A
(ko)
|
2009-09-03 |
2012-09-21 |
제넨테크, 인크. |
류마티스 관절염의 치료, 진단 및 모니터링 방법
|
|
US8470980B2
(en)
|
2009-09-09 |
2013-06-25 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
WO2011109280A1
(en)
|
2010-03-05 |
2011-09-09 |
Lerner Research Institute |
Methods and compositions to treat immune-mediated disorders
|
|
MA34277B1
(fr)
|
2010-04-15 |
2013-06-01 |
Spirogen Developments Sarl |
Pyrrolobenzodiazépines et conjugués de celles-ci
|
|
US9000130B2
(en)
|
2010-06-08 |
2015-04-07 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
WO2012074757A1
(en)
|
2010-11-17 |
2012-06-07 |
Genentech, Inc. |
Alaninyl maytansinol antibody conjugates
|
|
CN103415621A
(zh)
|
2011-01-14 |
2013-11-27 |
雷德伍德生物科技股份有限公司 |
醛标记免疫球蛋白多肽及其使用方法
|
|
EP2680884B1
(en)
|
2011-02-28 |
2018-01-17 |
F. Hoffmann-La Roche AG |
Biological markers and methods for predicting response to b-cell antagonists
|
|
LT2697257T
(lt)
*
|
2011-04-13 |
2016-12-27 |
Bristol-Myers Squibb Company |
Su fc sulieti baltymai, apimantys naujus linkerius ir išsidėstimus
|
|
RU2638806C2
(ru)
|
2011-05-12 |
2017-12-15 |
Дженентек, Инк. |
Lc-ms/ms способ мониторинга множественных реакций для выявления терапевтических антител в образцах животных с помощью каркасных сигнатурных пептидов
|
|
EA026827B1
(ru)
|
2011-10-14 |
2017-05-31 |
Медимьюн Лимитед |
Пирролбензодиазепины и их конъюгаты
|
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
|
HUE039329T2
(hu)
|
2012-10-12 |
2018-12-28 |
Adc Therapeutics Sa |
Pirrolobenzodiazepin-antitest konjugátumok
|
|
PT2906298T
(pt)
|
2012-10-12 |
2018-12-28 |
Medimmune Ltd |
Conjugados de pirrolobenzodiazepina-anticorpos
|
|
US10751346B2
(en)
|
2012-10-12 |
2020-08-25 |
Medimmune Limited |
Pyrrolobenzodiazepine—anti-PSMA antibody conjugates
|
|
US10695433B2
(en)
|
2012-10-12 |
2020-06-30 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US10736903B2
(en)
|
2012-10-12 |
2020-08-11 |
Medimmune Limited |
Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
|
|
KR101995621B1
(ko)
|
2012-10-12 |
2019-07-03 |
에이디씨 테라퓨틱스 에스에이 |
피롤로벤조디아제핀-항-cd22 항체 컨주게이트
|
|
SI2766048T1
(sl)
|
2012-10-12 |
2015-03-31 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
ES2658888T5
(es)
|
2012-12-21 |
2021-10-19 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas
|
|
US9567340B2
(en)
|
2012-12-21 |
2017-02-14 |
Medimmune Limited |
Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
|
|
CA2901941C
(en)
|
2013-03-13 |
2020-04-07 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
NZ712035A
(en)
|
2013-03-13 |
2019-06-28 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
BR112015021965B1
(pt)
|
2013-03-13 |
2022-05-03 |
Medimmune Limited |
Conjugados e compostos de pirrolobenzodiazepinas, composição farmacêutica, uso dos mesmos para o tratamento de uma doença proliferativa e método de síntese dos ditos compostos
|
|
US10442836B2
(en)
|
2013-08-12 |
2019-10-15 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
|
US9956299B2
(en)
|
2013-10-11 |
2018-05-01 |
Medimmune Limited |
Pyrrolobenzodiazepine—antibody conjugates
|
|
WO2015052532A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
US9950078B2
(en)
|
2013-10-11 |
2018-04-24 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
PE20161394A1
(es)
|
2013-12-16 |
2017-01-06 |
Genentech Inc |
Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco
|
|
JP6671292B2
(ja)
|
2013-12-16 |
2020-03-25 |
ジェネンテック， インコーポレイテッド |
ペプチド模倣化合物及びその抗体−薬物コンジュゲート
|
|
CN105828840B
(zh)
|
2013-12-16 |
2020-08-04 |
基因泰克公司 |
1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚二聚体抗体-药物缀合物化合物及使用和治疗方法
|
|
WO2016037644A1
(en)
|
2014-09-10 |
2016-03-17 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
JP6622293B2
(ja)
|
2014-09-12 |
2019-12-18 |
ジェネンテック， インコーポレイテッド |
アントラサイクリンジスルフィド中間体、抗体−薬物複合体、及び方法
|
|
KR20170052600A
(ko)
|
2014-09-12 |
2017-05-12 |
제넨테크, 인크. |
시스테인 가공된 항체 및 콘주게이트
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EA201790359A1
(ru)
|
2014-09-17 |
2017-08-31 |
Дженентек Инк. |
Пирролобензодиазепины и их конъюгаты, связанные дисульфидной связью с антителами
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
BR112017011111A2
(pt)
|
2014-11-25 |
2017-12-26 |
Adc Therapeutics Sa |
conjugados de pirrolobenzodiazepina-anticorpo
|
|
CN107206101B
(zh)
|
2014-12-03 |
2021-06-25 |
基因泰克公司 |
季铵化合物及其抗体-药物缀合物
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
MA43345A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
MA45326A
(fr)
|
2015-10-20 |
2018-08-29 |
Genentech Inc |
Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
WO2017165734A1
(en)
|
2016-03-25 |
2017-09-28 |
Genentech, Inc. |
Multiplexed total antibody and antibody-conjugated drug quantification assay
|
|
WO2017189432A1
(en)
|
2016-04-26 |
2017-11-02 |
R.P. Scherer Technologies, Llc |
Antibody conjugates and methods of making and using the same
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
ES2858151T3
(es)
|
2016-05-20 |
2021-09-29 |
Hoffmann La Roche |
Conjugados de PROTAC-anticuerpo y procedimientos de uso
|
|
EP3465221B1
(en)
|
2016-05-27 |
2020-07-22 |
H. Hoffnabb-La Roche Ag |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
|
US10639378B2
(en)
|
2016-06-06 |
2020-05-05 |
Genentech, Inc. |
Silvestrol antibody-drug conjugates and methods of use
|
|
CN109689111B
(zh)
|
2016-08-11 |
2024-04-05 |
基因泰克公司 |
吡咯并苯并二氮杂䓬前药及其抗体缀合物
|
|
CN110139674B
(zh)
|
2016-10-05 |
2023-05-16 |
豪夫迈·罗氏有限公司 |
制备抗体药物缀合物的方法
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
BR112019016373B1
(pt)
|
2017-02-08 |
2022-01-25 |
Medimmune Limited |
Conjugado anticorpo-fármaco que se liga ao axl, composição e composição farmacêutica que compreende o mesmo e uso terapêutico do dito conjugado
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
PT3612537T
(pt)
|
2017-04-18 |
2022-08-29 |
Medimmune Ltd |
Conjugados de pirrolobenzodiazepina
|
|
JP7408396B2
(ja)
|
2017-04-20 |
2024-01-05 |
アーデーセー セラピューティクス ソシエテ アノニム |
併用療法
|
|
US11124818B2
(en)
|
2017-05-09 |
2021-09-21 |
Cyano Biotech Gmbh |
Method for modifying microcystins and nodularins
|
|
US11512114B2
(en)
|
2017-05-09 |
2022-11-29 |
Cyano Biotech Gmbh |
Modified microcystins and nodularins
|
|
AU2018285562B2
(en)
|
2017-06-14 |
2024-01-18 |
Adc Therapeutics Sa |
Dosage regimes for the administration of an anti-CD19 ADC
|
|
EA039276B1
(ru)
|
2017-08-18 |
2021-12-27 |
Медимьюн Лимитед |
Пирролобензодиазепиновые конъюгаты
|
|
IL302943A
(en)
|
2017-09-20 |
2023-07-01 |
Ph Pharma Co Ltd |
Thylanstatin analogs
|
|
EP3687287B1
(en)
*
|
2017-09-29 |
2023-07-12 |
Regeneron Pharmaceuticals, Inc. |
Rodents expressing humanized c1q complex
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
|
WO2020086858A1
(en)
|
2018-10-24 |
2020-04-30 |
Genentech, Inc. |
Conjugated chemical inducers of degradation and methods of use
|
|
EP3894427A1
(en)
|
2018-12-10 |
2021-10-20 |
Genentech, Inc. |
Photocrosslinking peptides for site specific conjugation to fc-containing proteins
|
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|