WO2010132370A3 - Soluble tlt-1 for the treatment and diagnosis of sepsis - Google Patents

Soluble tlt-1 for the treatment and diagnosis of sepsis Download PDF

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Publication number
WO2010132370A3
WO2010132370A3 PCT/US2010/034263 US2010034263W WO2010132370A3 WO 2010132370 A3 WO2010132370 A3 WO 2010132370A3 US 2010034263 W US2010034263 W US 2010034263W WO 2010132370 A3 WO2010132370 A3 WO 2010132370A3
Authority
WO
WIPO (PCT)
Prior art keywords
sepsis
diagnosis
treatment
tlt
soluble
Prior art date
Application number
PCT/US2010/034263
Other languages
French (fr)
Other versions
WO2010132370A8 (en
WO2010132370A2 (en
Inventor
Daniel W. Mc Vicar
A. Valance Washington
Jessica Morales
Original Assignee
Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services filed Critical Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of WO2010132370A2 publication Critical patent/WO2010132370A2/en
Publication of WO2010132370A8 publication Critical patent/WO2010132370A8/en
Publication of WO2010132370A3 publication Critical patent/WO2010132370A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Abstract

The invention provides compositions including sTLT-1 and sTREM-1 polypeptides, the use of such polypeptides in therapeutic methods, and kits including such peptides.
PCT/US2010/034263 2009-05-11 2010-05-10 Soluble tlt-1 for the treatment and diagnosis of sepsis WO2010132370A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17724209P 2009-05-11 2009-05-11
US61/177,242 2009-05-11

Publications (3)

Publication Number Publication Date
WO2010132370A2 WO2010132370A2 (en) 2010-11-18
WO2010132370A8 WO2010132370A8 (en) 2011-08-11
WO2010132370A3 true WO2010132370A3 (en) 2011-09-29

Family

ID=42985622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/034263 WO2010132370A2 (en) 2009-05-11 2010-05-10 Soluble tlt-1 for the treatment and diagnosis of sepsis

Country Status (1)

Country Link
WO (1) WO2010132370A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
NZ602845A (en) 2010-04-08 2015-05-29 Inst Nat Sante Rech Med Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof
EP3196214B1 (en) 2012-02-15 2019-07-31 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
SI2814842T1 (en) 2012-02-15 2018-10-30 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
JP6738316B2 (en) 2014-07-17 2020-08-12 ノヴォ ノルディスク アクティーゼルスカブ Site-directed mutagenesis of TREM-1 antibody to reduce viscosity
JP7023853B2 (en) 2016-03-04 2022-02-22 アレクトル エルエルシー Anti-TREM1 antibody and its usage
JOP20190248A1 (en) 2017-04-21 2019-10-20 Amgen Inc Trem2 antigen binding proteins and uses thereof
US11155618B2 (en) 2018-04-02 2021-10-26 Bristol-Myers Squibb Company Anti-TREM-1 antibodies and uses thereof
MX2021012365A (en) 2019-04-17 2021-11-17 Novo Nordisk As Bispecific antibodies.
CN113755580B (en) * 2021-09-13 2023-10-27 中国医学科学院阜外医院 Pharmaceutical intervention target for treating and/or relieving lymphedema and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040180409A1 (en) * 2003-03-16 2004-09-16 Mcvicar Daniel TLT-1, a novel platelet-associated receptor and uses therefor
US20080131423A1 (en) * 2006-12-04 2008-06-05 Government Of The Us, As Represented By The Secretary, Dept. Of Health And Human Services Anti-TREM-like transcript-1 (TLT-1) antibodies, methods and compositions
WO2009141359A1 (en) * 2008-05-23 2009-11-26 Pronota N.V. New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040180409A1 (en) * 2003-03-16 2004-09-16 Mcvicar Daniel TLT-1, a novel platelet-associated receptor and uses therefor
US20080131423A1 (en) * 2006-12-04 2008-06-05 Government Of The Us, As Represented By The Secretary, Dept. Of Health And Human Services Anti-TREM-like transcript-1 (TLT-1) antibodies, methods and compositions
WO2009141359A1 (en) * 2008-05-23 2009-11-26 Pronota N.V. New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FORD J W ET AL: "TREM and TREM-like receptors in inflammation and disease", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB, vol. 21, no. 1, 1 February 2009 (2009-02-01), pages 38 - 46, XP026104157, ISSN: 0952-7915, [retrieved on 20090221], DOI: DOI:10.1016/J.COI.2009.01.009 *
GATTIS JAMES L ET AL: "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 281, no. 19, 27 February 2006 (2006-02-27), pages 13396 - 13403, XP002589901, ISSN: 0021-9258, [retrieved on 20060501], DOI: DOI:10.1074/JBC.M600489200 *
LU YEN-TA ET AL: "Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1)", HYBRIDOMA, LIEBERT, NEW YORK, NY, US, vol. 25, no. 1, 1 February 2006 (2006-02-01), pages 20 - 26, XP002539976, ISSN: 0272-457X, DOI: DOI:10.1089/HYB.2006.25.20 *
MORALES JESSICA ET AL: "Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization", BLOOD COAGULATION & FIBRINOLYSIS, RAPID COMMUNICATIONS, OXFORD, OXFORD, GB, vol. 21, no. 3, 1 April 2010 (2010-04-01), pages 229 - 236, XP009135455, ISSN: 0957-5235 *
WASHINGTON A VALANCE ET AL: "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets", BLOOD, vol. 104, no. 4, 15 August 2004 (2004-08-15), pages 1042 - 1047, XP002627253, ISSN: 0006-4971 *
WASHINGTON A VALANCE ET AL: "TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 119, no. 6, 11 May 2009 (2009-05-11), pages 1489 - 1501, XP002589557, ISSN: 0021-9738, DOI: DOI:10.1172/JC136175 *

Also Published As

Publication number Publication date
WO2010132370A8 (en) 2011-08-11
WO2010132370A2 (en) 2010-11-18

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