JP2009225781A - カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法 - Google Patents

カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法 Download PDF

Info

Publication number
JP2009225781A
JP2009225781A JP2008155901A JP2008155901A JP2009225781A JP 2009225781 A JP2009225781 A JP 2009225781A JP 2008155901 A JP2008155901 A JP 2008155901A JP 2008155901 A JP2008155901 A JP 2008155901A JP 2009225781 A JP2009225781 A JP 2009225781A
Authority
JP
Japan
Prior art keywords
glycoprotein
sugar chain
producing
antibody
silk gland
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008155901A
Other languages
English (en)
Japanese (ja)
Inventor
Masahiro Tomita
正浩 冨田
Atsushi Hirabayashi
淳 平林
Shinichi Nakakita
慎一 中北
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neosilk Co Ltd
NIPPN Corp
Original Assignee
Nippon Flour Mills Co Ltd
Neosilk Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Flour Mills Co Ltd, Neosilk Co Ltd filed Critical Nippon Flour Mills Co Ltd
Priority to JP2008155901A priority Critical patent/JP2009225781A/ja
Priority to PCT/JP2009/002715 priority patent/WO2009150858A1/ja
Priority to US12/997,333 priority patent/US20110203009A1/en
Publication of JP2009225781A publication Critical patent/JP2009225781A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/60—New or modified breeds of invertebrates
    • A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fodder In General (AREA)
JP2008155901A 2008-02-29 2008-06-13 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法 Pending JP2009225781A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008155901A JP2009225781A (ja) 2008-02-29 2008-06-13 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法
PCT/JP2009/002715 WO2009150858A1 (ja) 2008-06-13 2009-06-15 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法
US12/997,333 US20110203009A1 (en) 2008-02-29 2009-06-15 Method for producing glycoprotein characterized by sugar chain structure by using silkworm

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008050319 2008-02-29
JP2008155901A JP2009225781A (ja) 2008-02-29 2008-06-13 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013211286A Division JP5893597B2 (ja) 2008-02-29 2013-10-08 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法

Publications (1)

Publication Number Publication Date
JP2009225781A true JP2009225781A (ja) 2009-10-08

Family

ID=41241940

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008155901A Pending JP2009225781A (ja) 2008-02-29 2008-06-13 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法
JP2013211286A Expired - Fee Related JP5893597B2 (ja) 2008-02-29 2013-10-08 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013211286A Expired - Fee Related JP5893597B2 (ja) 2008-02-29 2013-10-08 カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法

Country Status (2)

Country Link
US (1) US20110203009A1 (https=)
JP (2) JP2009225781A (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011040565A1 (ja) 2009-09-30 2011-04-07 Kato Yukinari 抗ポドプラニン抗体、及び抗ポドプラニン抗体を含む医薬組成物
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
WO2012118176A1 (ja) * 2011-03-03 2012-09-07 日本製粉株式会社 フィブリノゲンを産生するトランスジェニックカイコ
JP2016082962A (ja) * 2014-04-25 2016-05-19 公益財団法人野口研究所 糖鎖切断抗体の製造方法及び均一糖鎖抗体
JP2016192937A (ja) * 2015-04-01 2016-11-17 シスメックス株式会社 糖タンパク質の製造方法および糖タンパク質
WO2017135452A1 (ja) * 2016-02-05 2017-08-10 国立大学法人大阪大学 哺乳動物型糖鎖付加遺伝子組換えカイコ
WO2018179302A1 (ja) 2017-03-30 2018-10-04 国立大学法人東北大学 抗ポドプラニン抗体
EP4549574A2 (en) 2016-03-08 2025-05-07 National Cancer Center Japan Anti-tmem-180 antibody, anticancer drug and cancer testing method

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2528892T3 (es) * 2012-07-30 2015-02-13 Nbe-Therapeutics Llc Identificación mediada por trasposición de proteínas de unión o funcionales específicas
WO2020090747A1 (ja) 2018-10-29 2020-05-07 株式会社免疫生物研究所 抗ｈｉｖ抗体及びその製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003325188A (ja) * 2002-03-06 2003-11-18 Toray Ind Inc サイトカイン遺伝子組換えカイコおよびそのタンパク質の製造方法
JP2006109772A (ja) * 2004-10-15 2006-04-27 Hiroshima Industrial Promotion Organization カイコでの組換えタンパク質製造のためのポリヌクレオチド
JP2006137739A (ja) * 2004-09-27 2006-06-01 National Institute Of Agrobiological Sciences カイコ中部絹糸腺特異的遺伝子発現系を利用したタンパク質の製造方法
WO2007046439A1 (ja) * 2005-10-18 2007-04-26 National Institute Of Agrobiological Sciences 抗体を産生するトランスジェニックカイコとその製造方法
JP2007228814A (ja) * 2006-02-27 2007-09-13 Toray Ind Inc 外来タンパク質の発現用遺伝子カセットおよび外来タンパク質の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070067855A1 (en) * 2003-10-28 2007-03-22 Chesapeake Perl, Inc. Production of human glycosylated proteins in transgenic insects

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003325188A (ja) * 2002-03-06 2003-11-18 Toray Ind Inc サイトカイン遺伝子組換えカイコおよびそのタンパク質の製造方法
JP2006137739A (ja) * 2004-09-27 2006-06-01 National Institute Of Agrobiological Sciences カイコ中部絹糸腺特異的遺伝子発現系を利用したタンパク質の製造方法
JP2006109772A (ja) * 2004-10-15 2006-04-27 Hiroshima Industrial Promotion Organization カイコでの組換えタンパク質製造のためのポリヌクレオチド
WO2007046439A1 (ja) * 2005-10-18 2007-04-26 National Institute Of Agrobiological Sciences 抗体を産生するトランスジェニックカイコとその製造方法
JP2007228814A (ja) * 2006-02-27 2007-09-13 Toray Ind Inc 外来タンパク質の発現用遺伝子カセットおよび外来タンパク質の製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6009032512; 第３１回日本分子生物学会年会・第８１回日本生化学会合同大会　講演要旨集，　２００８．１１．２０，　ｐ．　５１１（２Ｐ-１４５５） *
JPN6009032514; 繊維研究所研究報告，　２００３．０３．３０，　ｎｏ．　６，　ｐ．　１-８ *
JPN6013014086; 第２７回　日本分子生物学会年会　プログラム・講演要旨集 , 2004, ｐ．１０１６　（３ＰＢ-５３４） *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011040565A1 (ja) 2009-09-30 2011-04-07 Kato Yukinari 抗ポドプラニン抗体、及び抗ポドプラニン抗体を含む医薬組成物
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
KR20130119932A (ko) 2010-10-15 2013-11-01 니홍 케미칼 리써치 가부시키가이샤 당사슬의 비환원 말단이 만노오스 잔기인 당 단백질의 제조 방법
WO2012118176A1 (ja) * 2011-03-03 2012-09-07 日本製粉株式会社 フィブリノゲンを産生するトランスジェニックカイコ
JP2012182995A (ja) * 2011-03-03 2012-09-27 Nippon Flour Mills Co Ltd フィブリノゲンを産生するトランスジェニックカイコ
EP2682464A4 (en) * 2011-03-03 2014-10-22 Immuno Biological Lab Co Ltd TRANSGENIC FIBRINOGEN-PRODUCING SILK ROBUST
US9447167B2 (en) 2011-03-03 2016-09-20 Immuno-Biological Laboratories Co., Ltd Fibrinogen-producing transgenic silkworm
JP2016082962A (ja) * 2014-04-25 2016-05-19 公益財団法人野口研究所 糖鎖切断抗体の製造方法及び均一糖鎖抗体
JP2016192937A (ja) * 2015-04-01 2016-11-17 シスメックス株式会社 糖タンパク質の製造方法および糖タンパク質
WO2017135452A1 (ja) * 2016-02-05 2017-08-10 国立大学法人大阪大学 哺乳動物型糖鎖付加遺伝子組換えカイコ
EP4549574A2 (en) 2016-03-08 2025-05-07 National Cancer Center Japan Anti-tmem-180 antibody, anticancer drug and cancer testing method
WO2018179302A1 (ja) 2017-03-30 2018-10-04 国立大学法人東北大学 抗ポドプラニン抗体

Also Published As

Publication number Publication date
JP2014012024A (ja) 2014-01-23
JP5893597B2 (ja) 2016-03-23
US20110203009A1 (en) 2011-08-18

Similar Documents

Publication Publication Date Title
JP5893597B2 (ja) カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法
US9550834B2 (en) Method for preparing glycan-hydrolyzed antibody, and homogeneous glycosylated antibody
Iizuka et al. Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons
ES2601882T3 (es) Procedimiento para controlar la actividad de una molécula inmunofuncional
Brooks Protein glycosylation in diverse cell systems: implications for modification and analysis of recombinant proteins
JP2003512076A (ja) 植物における哺乳類型グリコシレーション
KR20030081312A (ko) 항체 조성물을 생산하는 세포
KR20130002987A (ko) 개변 항체 조성물
JP2017502694A (ja) 下流タンパク質グリコリモデリングのための基質として用いられる脱グリコシル化組換えタンパク質のインビボでの産生方法
JP2008538926A (ja) 切断可能なリンカーを有する一本鎖抗体
WO2021244255A1 (zh) 一种冠状病毒s蛋白rbd糖蛋白的制备方法及其应用
CA2637947A1 (en) Production of proteins carrying oligomannose or human-like glycans in yeast and methods of use thereof
Cérutti et al. Lepidopteran cells, an alternative for the production of recombinant antibodies?
Lai et al. Potential application of Leishmania tarentolae as an alternative platform for antibody expression
JP2017522040A (ja) シアリル化が改善されたＦｃを有するバリアントを作製するための方法
US20250313646A1 (en) Glycoengineered antibodies
Rendić et al. Towards abolition of immunogenic structures in insect cells: characterization of a honey-bee (Apis mellifera) multi-gene family reveals both an allergy-related core α1, 3-fucosyltransferase and the first insect Lewis-histo-blood-group-related antigen-synthesizing enzyme
WO2009150858A1 (ja) カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法
US20210189002A1 (en) Recombinant organisms and methods for producing glycomolecules with high glycan occupancy
US20210087540A1 (en) Recombinant organisms and methods for producing glycomolecules with low sulfation
CN111440225B (zh) 一种采用Ala-Gln调控抗体半乳糖基化水平的方法
US20150210777A1 (en) Glycoprotein
Kendler et al. N-glycan core tri-fucosylation requires Golgi α-mannosidase III activity that impacts nematode growth and behavior
Mizutani et al. Genetic modification of a chicken expression system for the galactosylation of therapeutic proteins produced in egg white
US20180251569A1 (en) Expression of modified glycoproteins and glycopeptides

Legal Events

Date Code Title Description
RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20100827

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100828

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110513

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20110513

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20110514

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130524

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130709