JP2009215191A - 神経損傷治療剤及び神経損傷治療方法 - Google Patents

神経損傷治療剤及び神経損傷治療方法 Download PDF

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JP2009215191A
JP2009215191A JP2008058447A JP2008058447A JP2009215191A JP 2009215191 A JP2009215191 A JP 2009215191A JP 2008058447 A JP2008058447 A JP 2008058447A JP 2008058447 A JP2008058447 A JP 2008058447A JP 2009215191 A JP2009215191 A JP 2009215191A
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gene
cells
cell
pluripotent stem
differentiated
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JP2009215191A5 (enExample
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Sakayuki Okano
栄之 岡野
Masaya Nakamura
雅也 中村
Kazuhiko Tsuji
収彦 辻
Shinya Yamanaka
伸弥 山中
Kyoko Miura
恭子 三浦
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Keio University
Kyoto University NUC
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Priority to JP2008058447A priority Critical patent/JP2009215191A/ja
Priority to EP08790758A priority patent/EP2263705A4/en
Priority to PCT/JP2008/061845 priority patent/WO2009110113A1/ja
Publication of JP2009215191A publication Critical patent/JP2009215191A/ja
Publication of JP2009215191A5 publication Critical patent/JP2009215191A5/ja
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2008058447A 2008-03-07 2008-03-07 神経損傷治療剤及び神経損傷治療方法 Pending JP2009215191A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008058447A JP2009215191A (ja) 2008-03-07 2008-03-07 神経損傷治療剤及び神経損傷治療方法
EP08790758A EP2263705A4 (en) 2008-03-07 2008-06-30 THERAPEUTIC AGENT AGAINST NERVE INJURY AND METHOD FOR TREATING NERVE INJURY
PCT/JP2008/061845 WO2009110113A1 (ja) 2008-03-07 2008-06-30 神経損傷治療剤及び神経損傷治療方法

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JP2008058447A JP2009215191A (ja) 2008-03-07 2008-03-07 神経損傷治療剤及び神経損傷治療方法

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JP2009215191A true JP2009215191A (ja) 2009-09-24
JP2009215191A5 JP2009215191A5 (enExample) 2011-05-06

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EP (1) EP2263705A4 (enExample)
JP (1) JP2009215191A (enExample)
WO (1) WO2009110113A1 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015098962A1 (ja) 2013-12-25 2015-07-02 東亞合成株式会社 多能性幹細胞から内胚葉系細胞への分化誘導方法
JP2017192401A (ja) * 2009-10-16 2017-10-26 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
US10113613B2 (en) 2013-09-17 2018-10-30 Hiedkazu Atari Planetary gear mechanism and power transmission member thereof
JP2019520079A (ja) * 2016-07-06 2019-07-18 クリスパー セラピューティクス アクチェンゲゼルシャフト 疼痛関連障害を処置するための物質及び方法
US10421944B2 (en) 2015-09-29 2019-09-24 Toagosei Co. Ltd. Method for producing neural stem cells using synthetic peptide
US11359180B2 (en) 2015-04-28 2022-06-14 Toagosei Co., Ltd. Method for producing myocardial cells using synthetic peptide
WO2023171808A1 (ja) 2022-03-11 2023-09-14 慶應義塾 脊髄損傷治療剤
US11801313B2 (en) 2016-07-06 2023-10-31 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
WO2024053721A1 (ja) 2022-09-08 2024-03-14 慶應義塾 急性期から亜急性期までを対象とする脊髄損傷治療剤

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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WO2011074690A1 (en) * 2009-12-14 2011-06-23 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
WO2012112603A1 (en) * 2011-02-14 2012-08-23 University Of Utah Research Foundations Constructs and methods for generating induced pluri potent stem ( ips) cells
US9228204B2 (en) 2011-02-14 2016-01-05 University Of Utah Research Foundation Constructs for making induced pluripotent stem cells

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US20050042749A1 (en) * 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
JP4901471B2 (ja) 2004-02-19 2012-03-21 国立大学法人京都大学 体細胞核初期化物質のスクリーニング方法
WO2006093276A1 (ja) * 2005-03-04 2006-09-08 Kyoto University 心臓組織由来の多能性幹細胞
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
US20090252711A1 (en) * 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells

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JPN6012059893; Ｔａｋａｈａｓｈｉ　Ｋ　ａｎｄ　Ｙａｍａｎａｋａ　Ｓ．: 'Ｉｎｄｕｃｔｉｏｎ　ｏｆ　ｐｌｕｒｉｐｏｔｅｎｔ　ｓｔｅｍ　ｃｅｌｌｓ　ｆｒｏｍ　ｍｏｕｓｅ　ｅｍｂｒｙｏｎｉｃ　ａｎｄ　ａｄｕｌｔ　ｆｉｂｒｏｂｌａｓｔ　ｃｕｌｔｕｒｅｓ　ｂｙ　ｄｅｆｉｎｅｄ　ｆａ' Ｃｅｌｌ Ｖｏｌ．１２６　Ｎｏ．４, 20060810, ｐｐ．６６３-６７６ *
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Cited By (27)

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JP2024138390A (ja) * 2009-10-16 2024-10-08 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
JP2017192401A (ja) * 2009-10-16 2017-10-26 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
JP7160855B2 (ja) 2009-10-16 2022-10-25 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
JP2019110912A (ja) * 2009-10-16 2019-07-11 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
US12195762B2 (en) 2009-10-16 2025-01-14 The Scripps Research Institute Induction of pluripotent cells
JP2022185128A (ja) * 2009-10-16 2022-12-13 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
JP2020167994A (ja) * 2009-10-16 2020-10-15 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
US11046933B2 (en) 2009-10-16 2021-06-29 The Scripps Research Institute Induction of pluripotent cells
JP7520083B2 (ja) 2009-10-16 2024-07-22 ザ スクリプス リサーチ インスティテュート 多能性細胞の誘導法
US10113613B2 (en) 2013-09-17 2018-10-30 Hiedkazu Atari Planetary gear mechanism and power transmission member thereof
WO2015098962A1 (ja) 2013-12-25 2015-07-02 東亞合成株式会社 多能性幹細胞から内胚葉系細胞への分化誘導方法
US10100284B2 (en) 2013-12-25 2018-10-16 Toagosei Co. Ltd. Method for inducing differentiation of pluripotent stem cells into endodermal cells
US11359180B2 (en) 2015-04-28 2022-06-14 Toagosei Co., Ltd. Method for producing myocardial cells using synthetic peptide
US10421944B2 (en) 2015-09-29 2019-09-24 Toagosei Co. Ltd. Method for producing neural stem cells using synthetic peptide
JP7548696B2 (ja) 2016-07-06 2024-09-10 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
US11801313B2 (en) 2016-07-06 2023-10-31 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
JP7429264B2 (ja) 2016-07-06 2024-02-07 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
JP2024028643A (ja) * 2016-07-06 2024-03-04 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
US11459587B2 (en) 2016-07-06 2022-10-04 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
JP2022132353A (ja) * 2016-07-06 2022-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
JP2019520079A (ja) * 2016-07-06 2019-07-18 クリスパー セラピューティクス アクチェンゲゼルシャフト 疼痛関連障害を処置するための物質及び方法
JP7719222B2 (ja) 2016-07-06 2025-08-05 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
US12442020B2 (en) 2016-07-06 2025-10-14 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
WO2023171808A1 (ja) 2022-03-11 2023-09-14 慶應義塾 脊髄損傷治療剤
KR20240162494A (ko) 2022-03-11 2024-11-15 각고호우징 게이오기주크 척수 손상 치료제
WO2024053721A1 (ja) 2022-09-08 2024-03-14 慶應義塾 急性期から亜急性期までを対象とする脊髄損傷治療剤
KR20250058766A (ko) 2022-09-08 2025-04-30 각고호우징 게이오기주크 급성기부터 아급성기까지를 대상으로 하는 척수 손상 치료제

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WO2009110113A1 (ja) 2009-09-11
EP2263705A4 (en) 2013-01-23

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