JP2009191079A - 育毛剤用添加剤及び育毛剤組成物 - Google Patents
育毛剤用添加剤及び育毛剤組成物 Download PDFInfo
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- JP2009191079A JP2009191079A JP2009134744A JP2009134744A JP2009191079A JP 2009191079 A JP2009191079 A JP 2009191079A JP 2009134744 A JP2009134744 A JP 2009134744A JP 2009134744 A JP2009134744 A JP 2009134744A JP 2009191079 A JP2009191079 A JP 2009191079A
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- hair
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- growing agent
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Abstract
Description
さらに、本発明によれば、組成物全量基準で、上記薬効成分であるミノキシジルの含有量が0.05〜2重量%であり、上記育毛剤用添加剤の含有量が0.02〜2重量%であることを特徴とする上記の育毛剤組成物が提供される。
本発明の育毛剤用添加剤は、次の一般式(I):
上記一般式(I)の式中、R1の一つ以上は炭素原子数6〜30のアルキル基又は−YO(C2H4O)a(C3H6O)bR3で表される基であることが必須である。残りのR1の好ましいものはメチル基、エチル基、フェニル基又は(R2)3SiO−で表される基であるが、特に好ましくはメチル基または(CH3)3SiO−である。
R2は炭素原子数1〜5のアルキル基またはアリール基を表すが、好ましくは炭素原子数1〜3のアルキル基であり、特にはメチル基である。
R3は水素原子あるいは炭素数1〜6のアルキル基又はアセトキシ基を表すが、好ましくは水素原子、メチル基、ブチル基である。
Yの好ましい例としては−CH2CH2CH2−、−CH2CH(CH3)CH2−が挙げられ、特には−CH2CH2CH2−が好ましい。
mは平均で1〜50であることが必須であるが、好ましくは1〜5である。
a及びbはそれぞれ平均で0〜50の数を示し、a+b≧2であるが、好ましくはaは2〜20、bは0〜10である。
で表されるものが好ましい。
具体的には下記式で表される化合物1〜化合物3が好ましいものとして挙げられる。
化合物1
上記の薬効成分、溶剤及び育毛剤用添加剤、更に必要に応じてその他添加剤からなる育毛剤組成物もまた、本発明の一形態である。
表1(実施例1、2は参考例)に示した処方で、ミノキシジルに、他の成分を配合し、無水エタノールおよび精製水で全量を100mlとし、撹拌溶解してローションタイプの外用剤を調製した。
C3H系マウス(雄性、7週齢)10匹を一群とし、各群の動物について、その背部の2×3cmの範囲をバリカンで除毛し試験に供した。表1の処方の各々にそれぞれ個別の群の動物を割り当て、その除毛部に1日1回、0.2mlずつ20日間塗布した。
試験に使用した動物の体毛は黒色で、除毛部の皮膚の色は茶色であり、その毛の成長と共に灰色から黒色に色調が変化することから、毛の色の黒さの程度を肉眼により、0:発毛が全く認められない、1:発毛している、2:硬毛が生え揃っている、3:硬毛が正常の約50%生えている、4:硬毛が正常の約70%生えている、5:硬毛が正常のほぼ100%生えている、の6段階で評価した。結果を表1に示した。
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JPH07196462A (ja) * | 1993-12-06 | 1995-08-01 | Dow Corning Corp | 揮発性アルキルメチルシリコーンを含む髪用スタイリング助剤 |
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JPH07196462A (ja) * | 1993-12-06 | 1995-08-01 | Dow Corning Corp | 揮発性アルキルメチルシリコーンを含む髪用スタイリング助剤 |
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