JP2009013146A - Diabetes treating composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a novel diabetes treating therapeutic agent attaining an excellent diabetes treating effect under a condition without strict dietary restriction. <P>SOLUTION: The diabetes treating composition of the invention is a hair growth substance containing as an effective ingredient at least one member selected from processed half-ripe soybeans, an extract of processed half-ripe soybeans, Polygonum multiflorum, an extract of Polygonum multiflorum, processed Polygonum multiflorum, an extract of processed Polygonum multiflorum, soybeans and an extract of soybeans, and preferably, containing as an effective ingredient processed half-ripe soybeans and/or an extract of processed half-ripe soybeans, and at least one member selected from the group consisting of processed Polygonum multiflorum and an extract of processed Polygonum multiflorum. The processed half-ripe soybeans are obtained by heat-treating soybeans within a range of eliminating the raw taste of the soybeans but not leading to powderization due to overheating of the soybeans, and the processed Polygonum multiflorum is obtained by impregnating raw Polygonum multiflorum with an extract of black soybeans and liquors. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a composition for treating diabetes that is extremely effective and safe for diabetes.

  Diabetes is a terrible disease that causes various disorders throughout the body, and it is estimated that there are approximately 7.4 million patients in the country. The causes of diabetes include aging, inheritance and stress, and excessive eating and drinking. The treatment of diabetes consists of three pillars: diet, exercise, and pharmacotherapy. There are two types of drug therapy: oral therapy using oral hypoglycemic drugs and insulin therapy in which insulin is injected.

  In internal therapy, nateglinide and α-glucosidase inhibitors such as antihyperglycemic drugs are generally used. However, while these drugs have been pointed out to be unsatisfactory for their purpose, some cases have side effects that cause hypoglycemia with sweating, tremors, dizziness, and helplessness. Insulin injection therapy is the last hand of diabetes treatment. Unfortunately, this insulin injection therapy is associated with various risks and side effects such as hypoglycemia, weight gain, insulin resistance, insulin allergy, and insulin edema. Clinical practice avoids the use of this insulin therapy whenever possible.

  As described above, since there are various problems in the treatment of diabetes, development of a therapeutic drug for diabetes having a new mechanism of action is currently demanded.

  Therefore, natural plants with few side effects have attracted attention, and clinical researches such as herbs such as herbs, mountain medicine (sanyaku), natural pollen, and kakkon are being promoted in Japan and overseas. In addition, the blood glucose lowering effect of Turdukudami, which is a constituent of the present application, has also been confirmed. (Special Table 2002-526379 gazette, "Chokuyaku Dictionary"). However, the achievements so far have not solved the weakness of natural plants.

  In addition, soybean water-soluble polysaccharides (Japanese Patent Laid-Open No. 2006-52191), soy lecithin (Japanese Patent No. 3545760), soy protein (Japanese Patent No. 3589673), soy protein concentrate (Japanese Patent No. 3524096) Research reports of soy protein isolate (Japanese Patent No. 3040477), proteinaceous carrier made of soybean powder (Japanese Patent No. 2927835), and the like.

  In any of the conventional treatment methods, dietary restrictions are a prerequisite. This strict dietary restriction becomes a reality that is difficult to overcome in clinical practice, and becomes a barrier to diabetes treatment. Please cite the words of Professor Masato Kasuga, the incumbent director of the Japanese Diabetes Society, who has experienced difficulties in treating diabetes as a clinician. “The percentage of outpatients with good blood glucose control is only 40%. Because no matter how much new treatments are available, many people lose their appetite and eat.” (Quoted from the Ministry of Education, Culture, Sports, Science and Technology's homepage (https://www.genome-sci.jp/modules/contents2/rewrite/tc_62.html), download date is June 18, 2007). This clinical experience suggests the importance of new therapeutic agents that can maintain their effects even under loose diet control. However, at present, such a therapeutic agent has not yet been discovered.

JP-T-2002-526379 JP 2006-52191 A Japanese Patent No. 3545760 Japanese Patent No. 3589673 Japanese Patent No. 3524096 Japanese Patent No. 3040477 Japanese Patent No. 2927835 “Chokuyaku Dictionary”, edited by Shanghai Science and Technology Publishers, Shogakukan, published by Shogakukan Co., Ltd., May 1, 1998, first edition, third edition, page 276.

  An object of the present invention is to provide a novel therapeutic composition for diabetes that has a remarkable effect and overcomes the drawbacks of conventional therapeutic agents for diabetes.

  Further, the present invention has found that a composition of processed semi-ripe soybean (or soybean) and tsurudukudami (hereinafter referred to as “composition”) has an excellent therapeutic effect for diabetes.

  The therapeutic agent for diabetes of the present invention contains soybean and / or an extract thereof as an active ingredient.

  The therapeutic agent for diabetes of the present invention contains processed semi-ripe soybean and / or an extract thereof as an active ingredient.

  The therapeutic agent for diabetes of the present invention contains tsurudukudami and / or an extract thereof as an active ingredient.

  The therapeutic agent for diabetes of the present invention contains processed turks and / or extracts thereof as active ingredients.

  The therapeutic agent for diabetes of the present invention contains a composition and / or an extract thereof as an active ingredient.

  The therapeutic agent for diabetes of the present invention contains legumes and / or extracts thereof as active ingredients.

  The therapeutic agent for diabetes of the present invention contains a teraceae plant and / or an extract thereof as an active ingredient.

  The method for processing processed half-boiled soybean of the present invention is a method in which raw soybean is used as a raw material and heat is applied.

  The turd kudami of the present invention is a method in which raw turd kudami, boiled black soybean solution and yellow liquor are mixed and heated for a long time.

  The method of using the raw swordfish can also be used for the swordfish of the present invention.

  The processed half-boiled soybean of the present invention can be processed using raw soybeans.

  As for the turd kudami of the present invention, radish cowhide which is circulated as a turd kudami in China can also be used.

  For the kudu kudaami of the present invention, related plants such as radish beef skin circulated as tsurukudaami in China can also be used.

  According to the therapeutic agent for diabetes of the present invention, an excellent therapeutic effect for diabetes can be exhibited by including the composition and / or an extract of these compositions as an active ingredient. In particular, the therapeutic agent for diabetes of the present invention has no side effects and can significantly reduce blood glucose (based on the value of HbA1c) in a short period of 1 to 3 months. In addition, there is no side effect of too low (hypoglycemia). Of particular note is the fact that these effects are not under strict dietary restrictions, but are usually obtained at the level of dietary attention. This point is extremely important for the treatment site.

  The composition for treating diabetes according to the present invention has an excellent effect for treating diabetes, and can be processed into a form of delicious food preparations such as cookies, rice crackers, rice crackers, arare, Japanese sweets, and crackers. From the meaning that it is possible to treat diabetes while eating these delicious foods and satisfying snacks, the therapeutic composition for diabetes of the present invention is considered to be a therapeutic drug for diabetes having a new mechanism of action, and is a revolutionary. It is worthy of evaluation as a therapeutic agent for diabetes.

  Hereinafter, the therapeutic agent for diabetes of the present invention will be specifically described.

  1. Materials related to the composition of the present invention

1-1, yellow soybean Yellow soybean (scientific name: Glycine max (L.) Merr.) Used as a raw material for the therapeutic agent for diabetes of the present invention is a yellow seed of a plant seed coat belonging to the leguminous soybean genus. The place of origin was China, which came to Japan in the middle part of Yayoi and has been widely cultivated since the Kamakura period.

  Soybeans can be classified into large, medium, small, and color from yellow, white, black, and green. Yellow soybeans are mainly referred to as “yellow soybeans” or “soybeans”. Many large seeds have been cultivated and used for cooking. Medium grain seeds are used for processed products such as tofu, miso and soy sauce, and small grain seeds are mainly used for natto.

  The varieties of yellow soybeans in Japan are mainly Tsurume, Yuutsuru, Toyosumume, Toyokomachi, Kariyutaka, Toyohomare, Yukihomare, Miyagi Shiromome, Tachinagaha, Otsuru, Oosuzu, Houen, Okushirome, Nakasenrei, Suzukari, Suzukogane , Suzuyutaka, Nishimurame, Tomoyutaka, Axiromome, Tachiyutaka, Fukuyutaka, Tamaurara, Murayutaka, Hatataka, Sachiyutaka, Ayakokane, Kitasumume, Sayanami, Tamamasari, Tamahomare, Suzuhime, Suzumaru Any of these varieties can be used as a raw material in the composition for treating diabetes according to the present invention.

  Soybean intake is recommended by the Ministry of Health, Labor and Welfare from 76 to 100 g per day (Ministry of Health, Labor and Welfare: “National Health Promotion Movement in the 21st Century (Healthy Japan 21)”, 2000). The amount of soybean used in the composition for treating diabetes in the present invention was only 16 grams or less per day, and a remarkable effect for treating diabetes was obtained.

  Therefore, the present invention has found that processed semi-ripe soybeans produced by the semi-ripe processing method have an excellent blood glucose lowering action.

  1-1-1. Process for producing processed half-boiled soybeans

  Raw material: Yellow soybean: 1 kilogram was used. In addition to yellow soybeans, beans of other colors are considered to be usable.

  Heating equipment: A frying pan, a household gas stove, and other cooking utensils for stirring were used. Other heating appliances can also be used. For example, household heating appliances such as open, microwave oven, toaster, and laboratory or factory for hot plates, mantle heaters, electric furnaces, rubber heaters, firewood heaters, throw-in heaters, laboratory heaters, electric stoves, etc. Although a large-sized heating apparatus is mentioned, it does not specifically limit.

  Preparation of processed half-boiled soybeans: Preheat the frying pan with a gas stove, add 1 kilogram of dried yellow soybeans, stir while continuing to heat over medium heat, turn off the fire after 3 minutes, A half-boiled soybean was obtained. Semi-mature means that the taste of yellow soybeans has been erased, but not enough heat.

1-2, Black soybean Black soybean (scientific name: Glycine max (L.) Merr.) Used as a raw material in the therapeutic agent for diabetes of the present invention is a black seed of a plant seed coat belonging to the leguminous soybean genus. In Japan, Hokkaido and Okayama Hyogo Prefecture are the main production areas. Thrombosis, hypertension, liver disease, diabetes, calculus, arthritis, diet, cancer prevention is said to be effective, in the form of black soybean tea, soy milk squeezed, bean confectionery, sweets, rice cake, miso, stew To be eaten.

1-3, yellow wine Yellow wine (fanchu) used as a raw material in the therapeutic agent for diabetes of the present invention is aged for a certain number of years (1 to several decades) mainly using glutinous rice and wheat straw as raw materials. It is a brew. Because the color is yellow (brown or scarlet), it is called “Yellow”. It is also called “old liquor” because it is aged for a long time. Introduced to Japan by Tadahide Nakagawa in the Edo period (Tadahide Nakagawa: “Seijun Kimon”, 1799). Shaoxing is one of the well-known yellow wines in Japan. The alcohol level of yellow liquor is about 14 to 20%, although there are some differences depending on the age of aging. Yellow wine is mainly used as cooking liquor in its country of origin.

1-4, Tsurudukudami (also referred to as “what necklace” or “kashu”)
As a raw material for the therapeutic agent for diabetes according to the present invention, tsurudokudami is a dried product of the genus Polygonum multiflorum chumb. (Latin name: Polygoni Multifluor Radix.). It was listed in “Kaiho Honso” in the Chinese era. The dried tuber is called “raw rice neck” and the heat-treated one is called “mature rice neck”.

  Turudukudami is a component of diantrons such as emodin, rhein, aloe-emodin, chrysophanol, physcion, 2,3,5,4-tetrahydrostilbene-2-O-β-D-glucoside, 3-methyl-1,6,8-tri. -Hydroxyanthraquinone, 2,6-dihydroxy-benzoic acid, 1,2-propandiol-1- (4-hydroxy-phenyl), emodin-8-O-β-D-glucoside, 8-O-β-D-glucoside, chrysophanol 8-O-β-D-glucopyranoside, torography 8-O-β-D-glucopyranos ide, aloe-emodin 8-O-β-D-glucopyranoside, chrysophanol 8-O-β-D- (6′-O-malonyl) glucopyranoside, (+)-lyonilesinol-3α-O-β-Dracopy, 2,3,4 ', 5-tetrahydroxy-trans-stilbene-2-O-β-D-glucopyranoside, 2,3,4', 5-tetrahydroxy-trans-stilbene-2,3-di-O-β- D-glucopyranide, Mindole-3- (L-α-amino-α-hydroxypropionate), cireorosein, Megalate, anthracuino It contains Ca, Fe, Cu, K, Mn, Zn and P, which are higher than the average plant content, as components such as nes, sennoside A, and sennoside B, and further as a component feature of cashew.

  Turdockami has anthraquinone substances, so when ingested raw, feces may become loose, or mild diarrhea or diarrhea may occur. For this reason, tsurudukudami is usually used after being processed into mature kudukudami.

  Mature tsurudukudami has a nourishing tonic. It is used for the treatment of tinnitus, gray hair, insomnia, poor sperm development, weakness of the legs and legs, hyperlipidemia, chronic hepatitis, and nervous breakdown. In recent years, taking the serum cholesterol lowering action, its intake as a health food has been widely spread in China and Europe and America.

  The phenomenon of raising blood sugar once in the 1970s was confirmed in the 1970s, and its blood glucose lowering action was recognized (Non-patent Document 1). However, it is not used as a hypoglycemic agent because its effectiveness is weak and a remarkable effect has not been obtained in clinical practice.

1-4-1, Processed Turk Kudami In the present invention, black soybeans and yellow liquor were used to produce “processed tuldok dami” in order to sufficiently bring out the blood glucose lowering action of the tsurukudami and to eliminate the diarrhea action. The manufacturing method will be specifically described below, but is not limited thereto.

1-4-1-1, Material Black soybean: 1 kilogram. Yellow liquor: 2.5 liters (trade name "Fuzhou Elder Sake", Fuzhou Shuzo, Fuzhou City, China. Other alcoholic beverages, or other alcohols, ethanol and other solvents can also be used). Raw swordfish: 10 kilograms (produced by Shandong Province, China, procured by Heiwa Prefectural Hospital).

1-4-1-2, operating procedures:
Procedure 1, 5 liters of water was put into 1 kilogram of black soybeans, and boiled for 3 hours on low heat to obtain 1 liter of hot water extract. A second extraction was performed in the same manner to obtain a 1.5 liter hot water extract.

  Step 2, 2.5 liters of the hot water extract obtained and 2.5 liters of yellow liquor are mixed, added to 10 kilograms of fresh turd kudami, and heated by a hot water method. Heat until soaked. This process takes about 10 hours.

  Procedure 3, heated tsurudukudami was dried by a natural drying method.

  Such a crumpled duck is called “processed crumpled duck”. Other methods capable of achieving the purpose of soaking black soybean extract solution and yellow liquor in raw tsurudukudami can also be used. It is not limited to the method mentioned here.

  It has been found that the invention of the present application expresses an excellent antihyperglycemic action by ingestion by blending processed turd kudami and processed semi-yellow soybean.

1-4-2, Radish Beef Skin Dishes (Scientific name: Cynanchum bungei Decne.) Is mainly produced in Shandong Province, China, and has not been confirmed to be native in Japan. Plants of different bases such as Cynanchuum auricularum Royle (Asclepiadaceae), Asclepias hasta Bunge. Enum. , Cynanchum hastum Lamarck, Symphyoglossum hastum (Bunge) Turczaninow, Vincetoxicum hastum (Bunge) Kuntze. Is effective as a radish cowhide and is distributed in the medicinal plant market in small quantities. These plants, related plants of these plants, or plants having similar components can also be used as tsurudokudami.

  Radish cowhide contains Bungeide A, Bungeide B, Bungeide C, Bungeide D, Blumenol, (-) Leucanthemil, β-Sitosterol glucoside, 4-Hydroxyacetophenol, C component.

1-5, Formulation with Other Substances The subjects who participated in the examples of the present invention did not perform dietary restrictions such as calorie management or prohibition of intake of sweets, lifestyle improvement, or the like. In addition, there was no restriction on the intake of food and favorite foods. Thus, the ability to treat diabetes under normal conditions has shown that the composition of the present invention can be further blended with all food ingredients and medicines. In some cases, it is considered possible to enhance the effect of treating diabetes by further blending.

  For example, with foodstuffs or extracts thereof that improve physical health, natural medicinal products (medicinal plants, or medicinal animals, or medicinal minerals) or extracts thereof, Japanese and Chinese medicine formulations, western medicine or other compounds Formulation is mentioned. The invention is not particularly limited to this.

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Rishi, persimmon, persimmon, persimmon, persimmon licorice, akaishi fat, glaze, Yamato glaze, Ogata glaze, red persimmon, serpentine, sasan, north sasan, car forer, car forerunner, sha Insects, comforters, Shujitsuko, mokuchi yellow, shredded sand, ginger, ginger, ginger, pine oil, wheat, rice bran, sone, hemp, moth, Korenen, younger brother cut grass,

Squid flower, gold and silver flower, water syrup, Sudoku, bean drum, incense drum, bullshit, green vine, blue ginseng, red ginseng, stone root, stone matsuko, stone pericarp, stone decision, gypsum, sarcophagus, bone bone, Gelatin, Senzaku grass, all

Whirling flower, assembly, senbei, river lion, grass, horned sashimi, horned horned cocoon, cocoon, tusks cocoon, mulberry cocoon, mulberry seed, cocoon ear, cocoon, old cocoon, grass moth, mulberry white Skin, mulberry leaves, mulberry leaves, mulberry leaves, lateral cocoon leaves, sugi, soba, daikon incense, dai yellow, nishikimon dai yellow, daiko, radish grass, radish seeds, arabiko, daiseki stone, large green leaves, Daegu, jujube, large belly skin, Kotobuki, Sawaran, Sawaran, turmeric, brackish gold, cod root bark, dansang, light bamboo leaves, bamboo leaves, dandelion roots, 蒲 英 英 根, bamboo basket, chikujo, bamboo ginseng, bamboo Leaves, mom, tea leaves, earthenware, scented incense, chopsticks, Tsutomu Satoshi, persimmon, crust, tsuchiakebi, dotsutsukusa, turf, tsurudukudami root, what neck moth, tsuruna, hamasensha, teilexi, heavenly yellow, heavenly bamboo yellow, Tennansei, Tenma, Tenjinmi, Tenjintsuru, Tenkitsuru, Tenmon Fuyu, Togashi, Tokachi, Yamato Toki, Fuyu Toshi, Kara Sesame, Lantern, Lantern Grass, Ginseng, Sword Bean, Cordyceps, Tang Active, peach seed, orange peel, medicinal product, assembly, dope root, dodge fruit, solitary life, tang dokki, fish carp grass, dodomi, juyaku, cocoon paste, tochino fruit, Tochu, dotsutsukusa, doboshi, mountain return, Dobetsu, Bekko, Bird-stopping (Tritomaraz), Megi, Tonburi, Gyoko, Nazuna, Natsume, White sword beans,

Meat Juyo, Meat Beans, Nishiki, Nukako, Niwakoko, Nikotoko, Carrot, Ginseng, Raw Ginseng, Raw Blind Ginseng, White Ginseng, Ginseng, Ninfu, Natsunomu, Miomatsuko, Ratty Mochi, Sadako, Shellfish Mother, river shell mother, river shell, malt, white lion, coconut, white birch, white skin, bald eagle, white peach blossom, white sword bean, white south heaven, south heavenly fruit, white white beans, white beans, barley winter, open side Mumon winter, 巴戟 天, ruptured paper, ladle, radish, lotus seeds, octagon, oak incense, light load, pigeons, cocoon pigeons, hanamotsu, hub grass, konji hub tea, Hamasensha , Beach windbreak, persimmon, semi-summer, banzakuro leaves, guava leaves, half-branches, meteorite foliage, guava leaves, coral sea, great sea lion, plate indigo root, hikai, cluster amaryllis, cluster amaryllis roots, toads, longevity grass, mustache carrot , Rhinoceros, dried leaves,

Hill, Minamata, Yuzuha, Yuzu, Udon Bonsai, Kashiwa, Tsuji, Tsujitsuko, Becko, Dobetsu, Crimson, Scarlet, Prevention, Sone, Helminth, Windproof, Scarlet Yellow, Sumo (Box) , 蒲 英 英 根, complement bone oil, ruptured paper, peony skin, oysters, camellia, hemp, mashed yellow, mackerel, macri, seaweed, asakojin, matababi vine, heavenly tree vine, matatabi fruit, Heavenly tree seeds, wormwood, pine nuts, sea matsuko, pine needles, matsufuji, matsuyani, pine oil, vinegar, mitsuen flower, beeswax, bleached beeswax, milobaran, eggplant, no flower fruit, fig fruit, no flower fruit leaves, fig leaf , Eyes tree, tour tree, cotton candy Chen, bandit, tree street, tree tsuko, wood tempura, matabite berry mass, wood cocoon, wood incense, peach leaf, gate moth, horsetail, sprayed, profit Satoshi, Masutomo Jin, Masu Mother Grass, Yakko, Yagami Ran, Yatsume Ran, Bear Gall, Under the Snow, Lily Leaf, Lily Root, Lily, Yokuinin, Sagebrush, Nagiha, Raimaru, Rinko, Raku , Luo Han Fruit, Luo Zhuang, Lee Neskin, Longan, Ms. Liu Yong, Keel, Magnesium Sulfate, Dragon Gall, Liang, Kora, Mung Bean, Ganoderma, Ream, Rengen Grass, Kakidoshi, Lotus Japanese cypress, deer crab, dew beehive, alleyway, samurai activity, safflower, beef dragon yellow, deer gauze maru, shiongo, uchida herbal medicine plaster, uchida bath agent, yunnan kisei, yunnan katamakin, yunnan Tanachi, Ginseng, Reishi, Ganoderma extract, Agaricus processed food, Uchida's precious chitosan, Chida's new kaiho ionized calcium, Sleeveless, Honey, pearl barley, pearl barley processed food, Pu'er tea, konji potato leaves, For example, candy pearl barley, tochu tea, and megsurinoki tea. In addition, any of the Chinese medicines listed in the “Chūshoku University Dictionary” (Shanghai Science and Technology Publishers, Shogakukan, published by Shogakukan Co., Ltd., 1998) can be mentioned.

  The Kampo preparations and extracts or granules produced from natural plants, animals, or minerals are not particularly limited, and examples thereof include the following types. Tsumura hot water, Tsumura hot water Kagawa hot pepper, Otsuji hot spring, Anchu-san, Jumi-detoxicated hot water, Hachimi-jio-maru, Dai-saiko-yu, Sho-saiko-yu, Saiko-Kei-do, Saiko-Kei-do Karui-yu, Saiko-ka-ryo-ryo oyster hot water , Semi-Summer Hot Spring, Huangren Detox, Semi-Summer Hot Spring, Gojosan, Katsueka Hot Spring, Shosei Ryuyu, Hakuho Hakuyu, Shohanka Kayu, Shofusan, Toki San, kamisansan, katsushikamaru, katsushika dragon bone oyster bath, maoyu, oshitsuka kanyu, barontoyu, shinbuyu, kureyu, ginseng, daikon peony, and white tiger carrot Hot springs, Shigyakusan, Kibo already hot springs, Hansaku Shirakaba Tenma hot springs, Toki four hot springs Kuga ginger hot springs, 苓 Katsura hot springs, Sachu hot springs, Hochuekki hot springs, Rikkunshi hot springs, Katsue hot springs, Shichimono Shimo-yu, Choto-san, Juzen-taiho-yu, Tsuren-en-yu, Jun-in-to, Yokuinin-to, Ryokyoku-san, Yokukan-san, Myokan-kanshi-to, Gojo-san, Gosei-san, Kiyokami Fufu-to, Jiju-wan, Katsueka Kayaku-yu, Momonuclear Kiyu, Fufutsu Seiki, Gokansan炙 Amakusa-yu, Kikisu-yu, Sanso-drink, Megami-san, Shakuyaku-kanzo-yu, Akane-drink, Koso-san, Yotsumono-yu, Ganmu-Otsuchi-yu, Shibaku-to-yu, Jijo-jiki-yu, Syoji-ko-yu, Ryobi Chokoku-to, Toki Kyo-en-yu, Aso-kanto, Heigasaku-san, Saiko-sei-Kyoto-yu, Nichien-yu, Keieda-jinjin-yu, Yokukan-san-ka-sen-summer, Daio-kanzo-to, Mystic-yu, Toki-drink , Rokumi-maru, Futaba-yu, Jitsu-zukuri, Seiryo-yu, Hot-boiled hot-spring, Shiyin-jibyo-yu, Shiyin-hoten-yu, Gotora-yu, Saiboku-yu, Daifufu-yu, Hakuen-kenchu-yu, Koken Nakayu, Daikenchuyu, Sasa-yu, Toki-yu, soju-jin-yu, kaisen-sei-lung-yu, tsuden-san, yunkei-yu, ox-sha-jinki-maru, ginseng-yoei-yu, kosa-saiyu Efficacy, Seishin Renko Drinking, Sakai-yu Gomono Hot Spring, San-Hou Sakai-yu, Saiba-yu, Gaspo-yu, Sakai-drinking Semi-Summer Hot Spring, Gojo-san, Sakai Amyu , Houren-yu, Sanmono-koyu-yu, Dyu-san-yu-yu, Tokiken-chu-yu, Kawacha-san-san, Katsushika-maruka, Asako-jinmaru, hemp Tsukushi Hot Spring, Keishi-yu, Daisho-ki-yu, Keieda-ka-Da-yu, Inchinkou-yu, Seikatsu-Kai-to, Kamiki-Spa-yu, Kikyo-to, Shiunko, Herbal Koujin, Herbal Medicine Shuji Bushi, and Metalite , Astat cream, Astat solution, Astat ointment, Shin phase, Tokon syrup, flat stomach powder, hot and cold drinks, gorei powder, sardine sung lung hot water, anti-alcoholic hot springs, saiko kuryu oyster hot water, mystic hot water, Hofutsu Seiki-san, Huangren-yu, Saiko-Kei-Dai-yu, Ryokyo-Kai-yu, Saiko-Kei-do, Dai-saiko-to, Ma-Akan-Ashiishi-yu, Kakkon-Yu, Saiko-Kei-Kyo-to, Cho-to-san, Mao-Ama Hot water, Kakkon Yukagawa hot spring, Sankoenshin-yu, Tsukuyu, Kibo already hot water, Toki four reversal Kure ginger hot spring, Yokukan Sanka Chen-skin summer, Toki medicinal powder, Rikkunshi hot water, Katsura Edaka Ryubon Oyster Hot Spring, Jumi-Kotobuchi Hot Spring, Semi-Summer Koboku Hot Spring, Ryu Gyotsu Liver Hot Spring, Hot Discontinuation Hot Spring, Hot Wash Drinking, Hou Ren Hot Spring, Loosening Constant Pain Hot Spring, Yokukan Sanka Chen Skin Hot Summer Hot Spring, in order Blood temperature hot water , Ryu-Gonjyo-to, Taiyo-San-no-yu, Yokkayaku-to, Unmusume-ta-to, Hot-discontinued-pain-tablet, Keieda-yu, Xiaoyang-table, Moisture clarified tablet, Warm refresher, Yeangshun tablet, Kosei Ryuyu, Seisei St. Ken Tablets, Huang Renyu, Gomi Risui Tablets, Hochu Reversion Tablets, Seong Heng Hot Lock, Huang Ren Detoyu, Ryujin Jun Seiki Tablets, Shuang San Seok Tablets, Feng Shui Water Tablets , Tianchi Tsutsugi Lock, Semi-backed Yoyo Tablets, Shiso Jiayu Tablets, Unlocked Samurai Tablets, Sotsujinto, Nintoku Anjun Tablets, Taiyosou Ryoyu, Kakkonyu Kagawa Hotan, Four Medicines , Mumon Fuyuto, Minghua Junshin Tablets, Shakuyakukanzoto, Rikirishinko Tablets, Semi-Summer Koboku-yu, Chorento-yu, Omo-ryo Yeo-ju, Nakashou Ken-wa Tablets, Hanatsuo Shinshin-to, Huang-maru , Huangren detoxification circle, ginseng ginseng semi-summer circle, blood-breathing round, Katsushida Karasuma, Katsura Kaka Daihokumaru, Sanoh Maru, Daikanmaru, Momokashikimaru, Asako Jinmaru, Rinaka Maru, Rokumi Maru, Hachimaru, Annaka-san, Kamisan-san, Shofu-san, Tsutsu-san, Tokiyaku-san, Dyu-san, Hirakusan-san, Ninjin-yoei-to, Dai Licorice, Kami Kisyu, Toki Yakusan, Hochuekki-to, Hachimi-jio-maru, Sho-saiko-yu, Juzen-dai-so-yu, Saiko-yu, Saiko-Kei-eda, Gojo-san, Kei-sha-Kan-maru , Katsueka Kasetsuyu, Kamisansan, Kakkonto, and Houren Detox.

  In addition, it can be formulated with food and ingredients.

  Western medicine includes all medicines approved for use by the Ministry of Health and Welfare in Japan.

  1-6, when using an extract of the composition

  Further, as an active ingredient of the composition for treating diabetes according to the present invention, an extract extracted from the composition with a solvent, or a dried product obtained by drying the extract may be used.

  In addition, the composition and / or the extract thereof concentrated and dried can be dissolved again in water or a polar solvent, or purification treatment such as decolorization, deodorization, and desalting can be performed without impairing these physiological functions. Alternatively, it may be used in the therapeutic agent for diabetes of the present invention after fractionation by column chromatography or the like. The composition and / or the extract thereof and the processed product (or fraction) thereof may be lyophilized after each treatment (or fraction) and dissolved in a solvent at the time of use, or a vesicle such as a liposome. Or may be encapsulated in a microcapsule or the like.

  Next, the preparation method of the extract of a composition is demonstrated below.

  When preparing an extract of the composition, a raw composition may be used. However, in consideration of extraction efficiency, it is preferable to perform extraction after processing such as chopping, drying, and pulverization. The extraction can be performed by immersing in an extraction solvent, or using a supercritical fluid or a subcritical fluid. When an extraction solvent is used, the extraction solvent may be stirred or homogenized in the extraction solvent in order to increase extraction efficiency. The extraction temperature is preferably in the range of, for example, about 5 ° C. to a temperature of the extraction solvent pour point + 10 ° C. or lower. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is preferably about 1 minute to about 14 days, for example.

  Although it does not specifically limit as a kind of extraction solvent, For example, water and an organic solvent are mentioned. Examples of the organic solvent include methanol, ethanol, 1-propanol, 2-propanol, n-butanol, s-butanol, t-butanol, and other lower alcohols, ethylene gericol, 1,3- Polyhydric alcohols such as butylene gel, propylene gel, dipropylene glycol and glycerin, ethers such as diethyl ether and dipropyl ether, esters such as butyl acetate and ethyl acetate, acetone and ethyl Ketones such as methyl ketone, organic acids such as formic acid and acetic acid, dimethyl sulfoxide, acetonitrile, tetrahydrofuran, dioxane, phenols, and other lipophilic organic solvents (eg, chloroform, pentane, hexane, cyclohexane, benzene, toluene, xylene and Vegetable oils such as rapeseed oil) Rukoto can, can be selected and used one or at least two of them. Of these, water or ethanol is preferable from the viewpoint of safety. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, a propylene, ethanol, methanol, ammonia.

  2. Effect

  The therapeutic agent for diabetes of the present invention has an excellent therapeutic effect for diabetes by containing a composition of processed semi-ripe soybeans and processed turks and / or extracts of these compositions as active ingredients. In particular, according to the antidiabetic agent of the present invention, by containing these compositions and / or extracts thereof as active ingredients, blood sugar is reduced to a normal threshold (HbA1c) without strict dietary restriction within 1 to 3 months. Can be stabilized as an index).

  On the other hand, conventional anti-diabetic agents have side effects that are insufficient or too effective (cause hypoglycemia if they are too effective), or that cause weight gain, edema, and heart failure like insulin.

  Of particular note, strict dietary restrictions are required for conventional therapeutic agents for diabetes to stabilize their therapeutic effects. In reality, about 60% of all patients were unsuccessful in their treatment, such as being unable to maintain their dietary restrictions because they lost their appetite and could not maintain their therapeutic effects. (Previous paragraph [0007], by Professor Masato Kasuga, the current President of the Japanese Diabetes Society). On the other hand, the present invention is considered to be an innovative therapeutic agent, which is an essential difference from conventional antidiabetic agents and that it can provide a stable therapeutic effect without strict dietary restriction. .

  In addition, from the previous research documents in [0005], [0006] and [0043], it has been found that such an effect cannot be manifested even when used alone. Therefore, in order to obtain a stable therapeutic effect without performing the strict dietary restriction discovered in the present invention, a specific formulation such as the composition of the present invention is necessary and presupposed.

  The product of the present invention has the effect of recovering the neurosensory with reduced function (Patent No. 3830960 “Hair-growth substance”, item [0099]). Therefore, it was suggested that the composition of the present invention can directly treat each complication of diabetes, at least neurological disorder complication. On the other hand, conventional anti-diabetic agents function only to prevent the occurrence of diabetic complications indirectly due to the effect of lowering blood glucose.

  3. Composition amount

  The composition and blending amount of the composition of the present invention are shown as follows, but are not limited thereto. The weight of the processed half-boiled soybean in the composition is preferably 1 to 99% by weight based on the total weight. It is preferable that the weight of the mulberry beetle in the composition is 0.1 to 99% by weight based on the total weight.

  The blending amount of the composition and / or the extract thereof in the present invention can be adjusted depending on the form of the therapeutic agent for diabetes (for example, foods and beverages such as cookies, bread, rice crackers, powders, and drinks). It is preferable that it is 1-100 weight% with respect to the total weight of.

  4. Aspects of composition for treating diabetes

  The composition of the present invention can be taken in a pulverized state. Or it can also ingest, after adding additives, such as a sweetener, in the grind | pulverized state. Or, confectionery such as cookies, Japanese confectionery such as rice crackers, sheep crab, baked potatoes, Chinese confectionery such as moon cake and dumplings, or Chinese food ingredients, or daily food such as bread, noodles, rice balls Can be processed and ingested. In the experiment of the present invention, a pulverized product of the composition was used.

  Or, for example, it may be in the form of tablets, capsules, powders, fine granules, granules and the like. In addition, rice cakes, juices, liquids, syrups and drinks are also included.

  Along with the composition which is an active ingredient and / or an extract thereof, a binder, an excipient, a swelling agent, a lubricant, a sweetener, a flavoring agent and the like can be used. Here, the tablets can also be coated with shellac or sugar. In addition, the capsule may further contain a liquid carrier such as fats and oils in the above material. Syrups and drinks may contain sweeteners, preservatives, pigment flavors and the like.

  The therapeutic agent for diabetes of the present invention is preferably taken once to several times a day. In the study of the present invention, it was taken twice a day as an intake in the early morning fasting and intake before going to bed at night.

  In addition, the therapeutic agent for diabetes of the present invention may be used in combination with another drug or compound having a blood glucose lowering action (or effect), another plant, or an extract of the plant, as long as the effect of the invention is not impaired. .

  5. Examples

  EXAMPLES Hereinafter, although this invention is demonstrated further more concretely based on an Example, this invention is not limited to these Examples.

5-1, Participants in the experiment Participating in this experiment were five subjects (4 men and 1 woman) from 46 to 67 years old. All participants took the composition to solve the problem of hair loss and thinning hair. Regarding the use of the composition, I explained its merit and risk as a hair restorer and got consent.

5-2, Diabetes mode of experimental participants All of these participants had fasting blood glucose of 7.8 mmol / L (140 mg / dl) or more (1998 WHO diagnostic reference value), and these high The glycemic state lasted for 3 to 10 years. During this time, some experimental participants were receiving antihyperglycemic treatment at the hospital, but the ideal therapeutic effect was not obtained. The detailed situation of each participant is as follows.

  Experiment participant A: Age 45 years old, male, affected 3 years, blood glucose level before taking was 9.0 mmol / L. Experiment participant B: Age 52 years, female, affected years 3 years, blood glucose level before taking was 10.6 mmol / L. Experiment participant C: Age 56 years old, male, affected years 5 years, blood glucose level before taking was 16.0 mmol / L. Experimental participant D: Age 59 years old, male, affected years 10 years, blood glucose level before taking was 13.4 mmol / L. Experiment participant E: Age 67 years old, male, affected for more than 10 years, blood glucose level before taking was 12.1 mmol / L. Experiment participants B and E are taking antihyperglycemic drugs (English name: l-phenethyl-biguanid).

  The age of disease is the number of years diagnosed with diabetes by blood test.

  5-3, Dosage and administration frequency

  The composition was taken twice a day, once before going to bed at night and once before early breakfast. It was 8g / time, 2 times / day, 16g / day in total. The dose period was 3-4 months.

  Participants in the experiment took the composition because of hair problems and did not comment on diabetes at all. Of course, they did not request the participants to dietary restrictions or calorie management. In addition, the experiment participants themselves were not aware of diabetes treatment, so they did not change their eating style.

  The following present invention

5-4. Evaluation of diabetes treatment effect Blood glucose levels often fluctuate due to dietary effects. Therefore, in order to evaluate the effect of treating diabetes in the present invention, highly reliable HbA1c was used in addition to the blood glucose level. HbA1c is data indicating an average state of blood glucose levels during the past one to two months, and is widely used for evaluation of therapeutic effects.

  The obtained blood glucose level data was statistically tested using the Student's t test method. The test calculation process was performed by Microsoft Excel 2003. The risk rate was significant at 5% or less.

5-5, Evaluation time point When 3 months had elapsed after taking the composition (less than 4 months), blood glucose level and HbA1c were measured. (None of the experimental participants had tested HbA1c before taking the composition.)

5-6, result Experiment participant A: The blood glucose level after taking was 6.3 mmol / L, and HbA1c was 5.4%.
Experiment participant B: The blood glucose level after taking was 6.9 mmol / L, and HbA1c was 4.9%.
Experiment participant C: The blood glucose level after administration was 8.3 mmol / L, and HbA1c was 6.6%.
Experiment participant D: The blood glucose level after administration was 7.7 mmol / L, and HbA1c was 7.2%.
Experiment participant E: The blood glucose level after administration was 5.9 mmol / L, and HbA1c was 6.8%.

  The blood glucose level after taking was statistically significantly lower than before taking (t = 5.8, p <0.005), and it was found that the composition had an effect of lowering the blood glucose level.

  None of the above-mentioned blood glucose levels were below the blood glucose standard value range (4.4 to 6.0 mmol / L), and thus the composition was found not to cause hypoglycemia.

  About HbA1c, it was not measured before taking and it seemed impossible to compare. However, this HbA1c is the average state of blood glucose level in the past 1 to 2 months (there are many literatures for 2 to 3 months) This is an empirical index indicating that the therapeutic effect of diabetes can be determined only by this index. Such a determination method is commonly used in Japanese clinical practice.

  The value of HbA1c for healthy individuals is 6.5% or less, and a desirable value is 4.3 to 5.8%. (If the HbA1c value is multiplied by 1.67, the approximate blood glucose level of mmol / L is converted). According to the judgment guidelines of the Japan Diabetes Association, in the case of a diabetic patient, if it is 7.0% or less, it is determined that the blood glucose level has been cleanly controlled for the past 1 to 2 months and a good therapeutic effect is obtained.

  From HbA1c, it was found that all the participants in the experiment had recovered to the normal threshold and were stable for the past 1 to 2 months, that is, 2 to 1 month after taking the composition. It was. Although HbA1c of experiment participant D was 7.2%, it was interpreted that a large therapeutic result was obtained considering the change from 8% before conversion (converted by the method of [0096]). Is done. Moreover, such an effect is also a result which is not obtained even if taking the blood glucose-lowering drug (experiment participants B and E).

  From the above results, it was proved that the composition of the present invention has a very high therapeutic effect for diabetes.

  As described in the background art, it has been discovered that soybeans and tsurudukudami have a therapeutic effect on diabetes. It was the originality of the present invention that the therapeutic effect was obtained under the conditions where dietary restrictions and calorie management were not required ([0088]) by combining these two plants. It is also a fundamental difference from antidiabetic drugs. This feature clears the difficulty of “strict appetite restriction” that has not been overcome in clinical practice at a certain level.

  In addition, no side effects were observed during the period of taking the composition of the present invention. If you think about it, soybeans (yellow soybeans and black soybeans) had a long edible history in Japanese food culture, including natto and tofu, and their safety was well proven. Yellow liquor also has a history of drinking in China for over 3000 years and in Japan for over 200 years, and it has been well proven that a proper amount of drinking has a positive effect on health. Tsurudokudami has a history of over 1000 years as a “beneficial agent” (a technical term for a tonic medicine that is gentle on the body) in China, and no side effects were observed. In recent years, the serum cholesterol lowering effect of tsurudukudami was discovered and widely used for the treatment and prevention of adult diseases. The Japanese Ministry of Health and Welfare also recognized the medicinal value of mature tsurukudami and recorded it as “Kashuu” in the “Japanese Pharmacopoeia”, allowing it to be used in Japan. Thus, the composition of the present invention was found to be safe.

  From the above results, it has been clarified that the composition can obtain a remarkable and stable blood glucose lowering effect under conditions where strict dietary restriction is not performed. The composition has also been found to be safe.

  Moreover, it can be processed into a delicious food form while having a remarkable blood glucose lowering effect. In addition, the composition of the present invention has a novelty that has never been achieved when it can be treated while satisfying the appetite of patients with this food-type anti-diabetic agent. Therefore, it was proved that the composition of the present invention has a value not found in conventional therapeutic agents for diabetes.

  The composition in this invention can be processed into the form of food-drinks. It can also be stored at room temperature for medium to long term (1 to 2 years). The raw materials can also be procured from the secondary market. Therefore, industrial use is possible.

Claims (6)

Soy and / or soy extract;
A therapeutic agent for diabetes, comprising as an active ingredient at least one selected from the group consisting of tsurudukudami, tsurudukudami extract, processed tsudukudami and processed tsudukudami extract. Processed soft-boiled soybean and / or processed soft-boiled soybean extract;
A therapeutic agent for diabetes, comprising as an active ingredient at least one selected from the group consisting of tsurudukudami, tsurudukudami extract, processed tsudukudami and processed tsurudukutami extract. For the extract of soybean a part by weight and soybean b part by weight (where a and b are 0 or more satisfying the relationship of a + b = 100),
C. Durcum c, p. D., C. D. E., C. D. E. And f. C. D, e and f are 0 or more satisfying the relationship of 3.ltoreq.c + d + e + f.ltoreq.100. The diabetes therapeutic agent according to claim 1, which is formulated at a ratio of (number). For an extract of g parts by weight of processed half-ripe soybeans and h parts by weight of processed half-ripe soybeans (where g and h are 0 or more satisfying the relationship g + h = 100),
C. Durcum c, p. D., C. D. E., C. D. E. And f. C. D, e and f are 0 or more satisfying the relationship of 3.ltoreq.c + d + e + f.ltoreq.100. The therapeutic agent for diabetes according to claim 2, which is formulated at a ratio of (number). Plants belonging to legumes and / or plant extracts belonging to legumes;
A therapeutic agent for diabetes, comprising as an active ingredient at least one selected from the group consisting of a plant belonging to a seed and an extract of a plant belonging to a seed. For i parts by weight of plants belonging to legumes and j parts by weight of plant extracts belonging to legumes (where i and j are 0 or more satisfying the relationship of i + j = 100),
It is blended at a ratio of k parts by weight of plants belonging to the family Taceae and 1 part by weight of plant extracts belonging to the family Taceae (where k and l are 0 or more satisfying the relationship 3 ≦ k + l ≦ 100). The diabetes therapeutic agent of Claim 5 characterized by these.