CN115120697B - Tibetan medicine composition and preparation method and application thereof - Google Patents
Tibetan medicine composition and preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Diabetes (AREA)
- Insects & Arthropods (AREA)
- Endocrinology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Tibetan medicine composition, a preparation method and application thereof, belonging to the technical field of Tibetan medicines, wherein the Tibetan medicine composition comprises the following raw material medicines in parts by weight: 50-100 parts of emblic leafflower fruit, 25-50 parts of ginger, 25-50 parts of berberis bark, 12-24 parts of caltrop, 12-24 parts of cardamom, 12-24 parts of pennycress, 12-24 parts of white sandalwood, 5-10 parts of platycladi seed, 5-10 parts of mango, 5-10 parts of wild mallow and 12-24 parts of honey; the invention uses common plant medicines to form prescription medicines, eliminates the defects caused by animal medicines, mineral medicines and precious herbaceous plants, has low cost and obvious curative effect, is herbaceous plants, and has relatively low metabolic load on livers.
Description
Technical Field
The invention belongs to the technical field of Tibetan medicines, and particularly relates to a Tibetan medicine composition and a preparation method and application thereof.
Background
Diabetes is a metabolic disease characterized by hyperglycemia, which is caused by defective insulin secretion or impaired biological action, or both. The long-standing hyperglycemia can lead to various organizations. In particular chronic damage to the eyes, kidneys, heart, blood vessels, nerves, and dysfunction. The etiology of diabetes is mainly divided into two types, one is genetic factor, and type I or type II diabetes has obvious genetic heterogeneity. Type I diabetes mellitus has a plurality of DNA sites involved in the onset of disease, wherein the relationship among DQ site polymorphism in HLA antigen genes is the most intimate. Type II diabetes mellitus has found a variety of well-defined gene mutations such as insulin gene, insulin receptor gene, glucokinase gene, mitochondrial gene, etc. Secondly, the obesity caused by excessive eating and reduced physical activity is the most important environmental factor of type II diabetes, so that individuals with genetic susceptibility to type II diabetes are easy to attack. Type I diabetics have abnormal immune systems, and after infection of certain viruses, such as Coxsackie virus, rubella virus, mumps virus and the like, autoimmune reactions are easily caused, and islet B cells are destroyed.
Based on factors such as life habit, dietary structure and the like, diabetes mellitus is a common disease of the Qinghai-Tibet plateau nowadays, and the treatment means still adopt the methods of Tibetan medicines. The Tibetan medicine is mainly applied to the treatment of symptoms and improves the symptoms of patients, but little attention is paid to the treatment of organic diseases and etiology, so in clinical treatment, the Tibetan medicine can effectively improve the symptoms of emaciation, polyphagia, diuresis and polydipsia of the patients, but has no obvious or no repeatability on the change of indexes such as blood sugar and the like. The existing diabetes Tibetan medicine contains animal medicines such as bear gall, musk and the like, and mineral medicines such as slag tamarind and lapis Micae aureus and the like, so that the diabetes Tibetan medicine is difficult to continuously prepare and supply for a long time for clinic, and is not suitable for long-term administration due to the fact that the diabetes Tibetan medicine has multiple mineral medicines. Therefore, the invention provides a Tibetan medicine composition, and a preparation method and application thereof.
Disclosure of Invention
The invention provides a Tibetan medicine composition, a preparation method and application thereof, solves the technical problems that the existing animal medicine for treating diabetes is difficult to continuously prepare and supply clinic for a long time and mineral medicine is not suitable for long-term administration, and simultaneously provides a Tibetan medicine composition with low liver metabolic load.
The invention provides a Tibetan medicine composition which is characterized by comprising the following raw materials in parts by weight: 50-100 parts of emblic leafflower fruit, 25-50 parts of ginger, 25-50 parts of berberis bark, 12-24 parts of caltrop, 12-24 parts of cardamom, 12-24 parts of pennycress, 12-24 parts of white sandalwood, 5-10 parts of platycladi seed, 5-10 parts of mango, 5-10 parts of wild mallow and 12-24 parts of honey.
The invention also provides a preparation method of the Tibetan medicine composition, which is characterized by comprising the following steps:
s1, pretreatment of medicinal materials
Removing cores of fructus Phyllanthi, mashing, sprinkling semen Avenae Nudae wine uniformly, and drying in shade; soaking rhizoma Zingiberis recens in semen Avenae Nudae wine, decocting with semen Rhododendri Simsii, rhizoma Zingiberis recens, fructus Piperis Longi, and drying in shade for 15 min; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; uniformly sprinkling highland barley wine on the white sandalwood, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparation
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing the raw material powder in a mixer according to the dosage of claim 1 to obtain mixed powder;
cleaning semen Platycladi, removing impurities, adding water, boiling, decocting with slow fire for 25-35min, decocting with slow fire for 45-60min, filtering to obtain decoction, adding Mel into the filtrate, decocting with slow fire for 35-45min, adding mixed medicinal powder after the filtrate is changed in temperature, mixing, and concentrating until water content is 10% -15%, to obtain Tibetan medicinal composition.
Preferably, the Tibetan medicine composition is prepared into an oral medicine dosage form.
Preferably, the Tibetan medicine composition is prepared into pills, and the specific preparation method comprises the following steps: dividing the mixed powder II into pills, drying in the shade, placing into a sugar coating machine, adding gelatin paste, sequentially adding talcum powder, gelatin syrup and medicinal active carbon after the surface of the pills is uniformly wetted, and adding monosaccharide paste to obtain the pills.
Preferably, in S1, the feed liquid ratio of the phyllanthus emblica to the highland barley wine is 1g: 10-20 ml.
Preferably, in S1, the feed liquid ratio of ginger to highland barley wine is 1g: 20-30 ml; the mass ratio of the ginger to the primula, the ginger, the long pepper and the pepper is 1:1:1:1:0.5.
Preferably, in S1, the feed liquid ratio of the white sandalwood to the highland barley wine is 1g: 10-20 ml.
Preferably, in S2, the working parameters of the mixer are: the mixing rotating speed is 20-25 r/min, and the mixing time is 18-25 min.
Preferably, the mass of each pill is 3% -5% of gelatin paste, the mass of talcum powder is 2% -3.75%, the mass of medicinal active carbon is 2% -4.25%, the mass of gelatin syrup is 4%, and the mass of single syrup is 65%.
The Tibetan medicine composition is applied to the preparation of the medicine for treating diabetes.
Compared with the prior art, the invention has the beneficial effects that:
the prescription of the invention is proper in compatibility, and the nature and the taste of the medicines complement each other; according to the invention, four raw material medicines with kidney tonifying and dehumidifying effects, namely cardamom, pennycress, caltrop, mango and wild mallow, can improve kidney functions so as to relieve or eliminate frequent urination and keep essence required by human bodies to control organism emaciation, diabetics often have thirst, the Tibetan medicine considers that thirst should be given with heat-clearing medicines, and the white sandalwood and platycladi seed with heat-clearing and fire-reducing effects are added in the formula, and the seven medicines are used as ministerial medicines in the compatibility; ginger has the effects of promoting qi and dredging collaterals, and Tibetan medicine considers that diabetes is a comprehensive disease of multiple systems and viscera of the whole body due to excessive bacon and fat, failing to be converted into essence required by human body, mixed into urine and discharged out of the body. The absorption and elimination of essence are related to the function of 'long', and when 'long' is disordered, the absorption and elimination of essence can be disturbed, so that the ginger can not only improve the absorption of essence, but also improve the efficacy utilization of medicines, and the absorbed medicines permeate into focus to treat diseases, thereby being the medicine; the honey is used by guiding medicines of bacon in the Tibetan medicine compatibility, plays a role in traction of medicine effect, has the effect of improving medicine effect utilization of medicines to treat diseases, and is also a guiding medicine. In addition, phyllanthus emblica is used as a monarch drug, and can simultaneously regulate kidney function and control blood sugar concentration. The berberis skin is added in the compatibility of medicines as an adjuvant drug to assist in reducing the blood sugar concentration; the invention is mainly used for treating emaciation, polyphagia, diuresis, polydipsia and other diseases caused by diabetes, effectively reducing blood sugar concentration, and has obvious curative effect and safety on various diabetes without adverse reaction.
The invention uses common plant medicines to form prescription medicines, eliminates the defects caused by animal medicines, mineral medicines and precious herbaceous plants, has low cost and obvious curative effect, is herbaceous plants, and has relatively low metabolic load on livers.
Detailed Description
In order that those skilled in the art will better understand the technical scheme of the present invention, the present invention will be further described with reference to specific examples and clinical data, but the examples are not intended to limit the present invention.
Example 1
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 50 parts of emblic leafflower fruit, 25 parts of ginger, 25 parts of berberis bark, 12 parts of caltrop, 12 parts of cardamom, 12 parts of pennycress, 12 parts of white sandalwood, 5 parts of platycladi seed, 5 parts of mango, 5 parts of wild sunflower and 12 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine in a ratio of 10ml, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 20ml of highland barley wine, cooking with the materials including Rhododendron cerasus, rhizoma Zingiberis recens, fructus Piperis Longi and fructus Piperis at a mass ratio of 1:1:1:0.5 for 15min, cleaning, and drying in shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine in a ratio of 10ml, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 20r/min and the mixing time was 18min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 25min, decocting with slow fire for 45min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 35min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 10%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
According to the mass of each pill, the dosage of gelatin paste is 3%, the dosage of talcum powder is 2%, the dosage of medicinal active carbon is 2%, the dosage of gelatin syrup is 4%, and the dosage of single syrup is 65%.
Example 2
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 100 parts of emblic leafflower fruit, 50 parts of ginger, 50 parts of berberis bark, 24 parts of caltrop, 24 parts of cardamom, 24 parts of pennycress, 24 parts of sandalwood, 10 parts of platycladi seed, 10 parts of mango, 10 parts of wild sunflower and 24 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine into 20ml of the mixture, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 30ml of highland barley wine, cooking with the raw materials of rhododendron, ginger, long pepper and pepper in a mass ratio of 1:1:1:0.5 for 15min, washing and drying in the shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine into 20ml of the mixture, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 25r/min and the mixing time was 25min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, adding water, boiling, decocting with slow fire for 35min, decocting with slow fire for 60min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 45min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 15%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 5% of the gelatin paste, 3.75% of talcum powder, 4.25% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 3
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 75 parts of emblic leafflower fruit, 38 parts of ginger, 38 parts of berberis bark, 18 parts of caltrop, 18 parts of cardamom, 18 parts of pennycress, 18 parts of sandalwood, 7.5 parts of platycladi seed, 7.5 parts of mango, 7.5 parts of wild mallow and 18 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine into 15ml of the mixture, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 25ml of highland barley wine, cooking with the materials including Rhododendron cerasus, rhizoma Zingiberis recens, fructus Piperis Longi and fructus Piperis at a mass ratio of 1:1:1:0.5 for 15min, cleaning, and drying in shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine into 15ml of the mixture, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder I;
the working parameters of the mixer are as follows: the mixing speed was 22r/min and the mixing time was 21min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, adding water, boiling, decocting with slow fire for 30min, decocting with slow fire for 50min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 40min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 12%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 4% of gelatin paste, 2.5% of talcum powder, 3% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 4
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 65 parts of emblic leafflower fruit, 31 parts of ginger, 31 parts of berberis bark, 15 parts of caltrop, 15 parts of cardamom, 15 parts of pennycress, 15 parts of sandalwood, 6.5 parts of platycladi seed, 6.5 parts of mango, 6.5 parts of wild mallow and 15 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine into 17ml of the mixture, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 22ml of highland barley wine, cooking with the raw materials of rhododendron, ginger, long pepper and pepper in a mass ratio of 1:1:1:0.5 for 15min, washing and drying in the shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine into 12ml of the mixture, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 23r/min and the mixing time was 19min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 27min, decocting with slow fire for 55min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 38min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 14%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 3.5% of gelatin paste, 3% of talcum powder, 2.5% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 5
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 90 parts of emblic leafflower fruit, 44 parts of ginger, 44 parts of berberis bark, 21 parts of caltrop, 21 parts of cardamom, 21 parts of pennycress, 21 parts of sandalwood, 9 parts of platycladi seed, 9 parts of mango, 9 parts of wild sunflower and 21 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine into 17ml of the mixture, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 28ml of highland barley wine, cooking with the materials including Rhododendron cerasus, rhizoma Zingiberis recens, fructus Piperis Longi and fructus Piperis at a mass ratio of 1:1:1:0.5 for 15min, cleaning, and drying in shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine into 17ml of the mixture, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 21r/min and the mixing time was 20min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 32min, decocting with slow fire for 47min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 42min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 11%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 4.5% of gelatin paste, 3.25% of talcum powder, 3.5% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 6
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 60 parts of emblic leafflower fruit, 28 parts of ginger, 28 parts of berberis bark, 13.5 parts of caltrop, 13.5 parts of cardamom, 13.5 parts of pennycress, 13.5 parts of white sandalwood, 6 parts of platycladi seed, 6 parts of mango, 6 parts of wild sunflower and 13.5 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g:13.5ml of liquid is added with highland barley wine uniformly sprayed and dried in the shade; ginger according to 1g:23.5ml of the highland barley wine is soaked in the highland barley wine, and then is cooked for 15min together with the rhododendron primrose, the ginger, the long pepper and the pepper according to the mass ratio of 1:1:1:0.5, and is cleaned and dried in the shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g:13.5ml of liquid is added with highland barley wine uniformly sprayed and dried in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 24r/min and the mixing time was 22min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 29min, decocting with slow fire for 52min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 36min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 13%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 4% of gelatin paste, 3.5% of talcum powder, 4% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 7
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 70 parts of emblic leafflower fruit, 41 parts of ginger, 41 parts of berberis bark, 16.5 parts of caltrop, 16.5 parts of cardamom, 16.5 parts of pennycress, 16.5 parts of white sandalwood, 7 parts of platycladi seed, 7 parts of mango, 7 parts of wild sunflower and 16.5 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g:18.5ml of liquid is added with highland barley wine uniformly sprayed and dried in the shade; ginger according to 1g: soaking highland barley wine in a feed liquid ratio of 26.5ml, cooking for 15min together with the rhododendron primrose, ginger, long pepper and pepper according to a mass ratio of 1:1:1:0.5, washing and drying in the shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g:18.5ml of liquid is added with highland barley wine uniformly sprayed and dried in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 22r/min and the mixing time was 23min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 33min, decocting with slow fire for 58min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 39min, changing temperature of the filtered decoction, adding the mixed powder of S2, mixing, concentrating until water content is 10%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 4.5% of gelatin paste, 3.25% of talcum powder, 3% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
Example 8
The Tibetan medicine composition comprises the following raw material medicines in parts by weight: 85 parts of emblic leafflower fruit, 47 parts of ginger, 47 parts of berberis bark, 19.5 parts of caltrop, 19.5 parts of cardamom, 19.5 parts of pennycress, 19.5 parts of white sandalwood, 8.5 parts of platycladi seed, 8.5 parts of mango, 8.5 parts of wild sunflower and 19.5 parts of honey.
The preparation method of the Tibetan medicine composition comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of phyllanthus emblica and mashing according to 1g: adding highland barley wine into 16ml of the mixture, sprinkling uniformly, and drying in the shade; ginger according to 1g: soaking 21ml of highland barley wine, cooking with the raw materials of rhododendron, ginger, long pepper and pepper in a mass ratio of 1:1:1:0.5 for 15min, washing and drying in the shade; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; the white sandalwood is prepared from 1g: adding highland barley wine into 16ml of the mixture, sprinkling uniformly, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials;
s2, preparing medicinal powder
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; mixing all the raw material medicine powder in a mixer according to the formula amount to obtain mixed medicine powder;
the working parameters of the mixer are as follows: the mixing speed was 24r/min and the mixing time was 24min.
S3, preparing pills
Cleaning semen Platycladi, removing impurities, boiling with water, decocting with slow fire for 26min, decocting with slow fire for 53min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 44min, adding the mixed powder of S2 after the filtered decoction is changed in temperature, mixing, concentrating until water content is 15%, separating into pills, drying in the shade, placing into sugar coating machine, adding gelatin paste, moistening the surface of the pill uniformly, sequentially adding pulvis Talci, gelatin syrup, and medicinal active carbon, and adding monosaccharide paste to obtain pill.
The mass of each pill is 4.5% of gelatin paste, 3.5% of talcum powder, 4% of medicinal active carbon, 4% of gelatin syrup and 65% of single syrup.
The Tibetan medicine compositions of examples 1 to 8 have similar performance, and the following example 8 is only an example, and the Tibetan medicine compositions are used for treating diabetes and detecting the effect thereof; 541 diabetics taking a doctor from 2018, 09 to 2020, 10 and the like in the hospital are selected, and the distribution of the conditions of the diabetics is shown in Table 1. The study protocol had been approved by the institutional ethics committee's review, and subjects all signed informed consent prior to group entry.
Table 1 table of conditions for diabetics
1. Tibetan diagnostic criteria
According to the diagnosis and treatment standard of 150 Tibetan medical diseases (2021, sichuan national publishing company) mainly compiled by Tibetan autonomous region Tibetan medical stadium, the Chinese medical herbs have the advantages of diuresis, polydipsia, polyphagia, weight wasting, sleepiness, dyspepsia, inappetence, fever in the palms and soles, dry mouth, dry tongue, thick tongue fur and superficial and slow pulse.
2. Experimental method
The pill prepared in the embodiment 8 of the invention is taken with warm water, and the medicine comprises the following components: namely, in the above example 8, 85 parts of emblic leafflower fruit, 47 parts of ginger, 47 parts of berberis bark, 19.5 parts of caltrop, 19.5 parts of cardamom, 19.5 parts of pennycress, 19.5 parts of sandalwood, 8.5 parts of platycladi seed, 8.5 parts of mango, 8.5 parts of wild sunflower and 19.5 parts of honey; the pill has a weight of 1g, 3 pills each time, and is taken with warm water 2 times a day. The treatment course of use is as follows: 3 courses (12 days per course).
Notice that: patients are prohibited from spicy and greasy food during the treatment period, take care of rest, avoid staying up all night, develop good living habits and keep the mood smooth.
3. Therapeutic effect criterion
The curative effect standard refers to the Tibetan medical common disease clinical diagnosis and treatment guide. Clinical cure: the main symptoms and indexes disappear or obviously decrease, and no uncomfortable feeling exists; the effect is shown: the clinical symptoms completely disappear, the fasting blood glucose is less than 6.6mmol/L, and the postprandial blood glucose is less than 8.2mmol/L for 2 h; the method is effective: clinical symptoms are relieved, fasting blood glucose is less than 8.5mmol/L, and postprandial blood glucose is less than 10.8mmol/L for 2 h; invalidation: clinical symptoms and blood sugar are not obviously changed and even aggravated. Total effective rate = significant rate + effective rate.
4. Experimental results
4.1 typical case Effect
(1) Only a certain man, 53 years old, is in urban Guangdong area in the Tibet autonomous region Lhasa, has the symptoms of diuresis, polyphagia, and more than five months, has fasting blood sugar of 8.4mmol/L, and is accompanied with somnolence, debilitation, weight loss, and the like. After 3 treatment courses of the pill prepared in the embodiment 8 of the invention, patients are obviously improved in somnolence, hypodynamia, diuresis, polyphagia, polydipsia and the like, fasting blood glucose is reduced to 6.3mmol/L, the fasting blood glucose is a reinforcing curative effect, 1 treatment course is used again, and no disease is caused after three months of stopping the pill.
(2) Some women with a certain rope, 62 years old, and people in mountain south city of Tibetan autonomous area have urination, eating and drinking more than August, and have fasting blood glucose of 9.3mmol/L, and are accompanied with symptoms of somnolence, debilitation, dysphoria, weight loss and the like. After 3 treatment courses of the pill prepared in the embodiment 8 of the invention, patients are obviously improved in somnolence, hypodynamia, diuresis, polyphagia, polydipsia and the like, fasting blood glucose is reduced to 7.1mmol/L, the fasting blood glucose is a reinforcing curative effect, and after 2 treatment courses, the symptoms of the patients completely disappear, and the patients are not ill after three months of drug withdrawal.
(3) When a certain woman, 47 years old, people in the Tibetan and autonomous area, changdu city, have the symptoms of diuresis, polyphagia, polydipsia for more than one year, fasting blood sugar of 11.7mmol/L, and symptoms such as hypodynamia, dry mouth, fever, weight loss, hyperlipidemia and the like. After 3 treatment courses of the pill prepared in the embodiment 8 of the invention, the debilitation, dry mouth, fever, diuresis, polyphagia, polydipsia and the like of a patient are obviously improved, the fasting blood glucose is reduced to 8.6mmol/L, the pill is used for radically treating diabetes, the patient continues to use for 2 treatment courses, the symptoms of the patient completely disappear, the fasting blood glucose is reduced to 6.4mmol/L, the curative effect is enhanced, the patient stops taking the pill after 1 treatment course, and the patient does not see the disease after three months.
According to statistics, according to the curative effect judgment standard, 193 patients with obvious effect, 315 patients with effective effect and 33 patients with ineffective effect in the treated patients with the ages of 29-75 years old, and the total effective rate is 93.91%.
4.2 adverse reactions
541 patients follow up in the treatment period, and the subjects do not have adverse reactions such as fever, allergy and the like.
In conclusion, the traditional Chinese medicine composition disclosed by the invention has an exact curative effect on treating diabetes, can effectively relieve clinical symptoms and physical signs, has no adverse reaction in the use process, is good in safety, and is worthy of clinical popularization and application.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (4)
1. The Tibetan medicine composition for treating diabetes is characterized by comprising the following raw materials in parts by weight: 50-100 parts of emblic leafflower fruit, 25-50 parts of ginger, 25-50 parts of berberis bark, 12-24 parts of caltrop, 12-24 parts of cardamom, 12-24 parts of pennycress, 12-24 parts of white sandalwood, 5-10 parts of platycladi seed, 5-10 parts of mango, 5-10 parts of wild mallow and 12-24 parts of honey;
the preparation method of the Tibetan medicine composition for treating diabetes comprises the following steps:
s1, pretreatment of medicinal materials
Removing cores of fructus Phyllanthi, mashing, sprinkling semen Avenae Nudae wine uniformly, and drying in shade; soaking rhizoma Zingiberis recens in semen Avenae Nudae wine, decocting with semen Rhododendri Simsii, rhizoma Zingiberis recens, fructus Piperis Longi, and drying in shade for 15 min; parching fructus Tribuli until the thorn is disappeared, and drying in the shade after the color is yellowish; sun-drying herba Capsellae, parching to dark yellow, and drying in shade; uniformly sprinkling highland barley wine on the white sandalwood, and drying in the shade; peeling fructus Mangifera Indicae, removing core, slicing, parching to deep yellow surface, and drying in shade; removing impurities from cortex Berberidis Amurensis and herba Abutili respectively, and drying in the shade; taking cardamon seed, mashing and drying in the shade; respectively obtaining all pretreatment raw medicinal materials; the feed liquid ratio of the phyllanthus emblica to the highland barley wine is 1g: 10-20 ml; the feed liquid ratio of the ginger to the highland barley wine is 1g: 20-30 ml; the mass ratio of the ginger to the primula, the ginger, the long pepper and the pepper is 1:1:1:1:0.5;
s2, preparation
Grinding the pretreated raw medicinal materials in the step S1 into fine powder respectively, and sieving the fine powder with a 100-mesh sieve to obtain powder of each raw medicinal material; according to the weight parts of the raw materials in the Tibetan medicine composition, the raw material powder is mixed in a mixer to obtain mixed medicinal powder; the working parameters of the mixer are as follows: the mixing rotating speed is 20-25 r/min, and the mixing time is 18-25 min;
cleaning semen Platycladi, removing impurities, adding water, boiling, decocting with slow fire for 25-35min, decocting with slow fire for 45-60min, filtering to obtain decoction, pouring Mel into the filtered decoction, decocting with slow fire for 35-45min, adding mixed medicinal powder after the filtered decoction is changed in temperature, mixing, and concentrating until water content is 10% -15%, to obtain Tibetan medicinal composition.
2. The Tibetan medicine composition for treating diabetes according to claim 1, wherein the Tibetan medicine composition is prepared into an oral dosage form.
3. The Tibetan medicine composition for treating diabetes according to claim 2, wherein the Tibetan medicine composition is prepared into pills by the following specific preparation method: drying the Tibetan medicine composition in the shade, placing into a sugar coating machine, adding gelatin paste, sequentially adding talcum powder, gelatin syrup and medicinal active carbon after the surface of the pill is uniformly wetted, and then adding monosaccharide paste to obtain the pill;
according to the mass of each pill, the dosage of gelatin paste is 3% -5%, the dosage of talcum powder is 2% -3.75%, the dosage of medicinal active carbon is 2% -4.25%, the dosage of gelatin syrup is 4%, and the dosage of single syrup is 65%.
4. Use of a Tibetan medicine composition for treating diabetes according to claim 1 in the preparation of a medicament for treating diabetes.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005068128A (en) * | 2003-08-01 | 2005-03-17 | Soda Aromatic Co Ltd | alpha-GLUCOSIDASE INHIBITOR |
| JP2009013146A (en) * | 2007-07-02 | 2009-01-22 | Takehito Kono | Diabetes treating composition |
| CN104127816A (en) * | 2014-07-28 | 2014-11-05 | 西藏自治区藏医院 | Pharmaceutical composition for treating diabetes mellitus, and preparation method and application thereof |
| CN108567955A (en) * | 2017-03-08 | 2018-09-25 | 成都中医药大学 | A kind of pharmaceutical composition and preparation method thereof of prevention diabetic nephropathy |
| CN111388628A (en) * | 2020-04-15 | 2020-07-10 | 次仁 | Application of Tibetan medicine composition in preparing medicine for preventing and treating hyperlipidemia and diabetes |
| DE202022102826U1 (en) * | 2022-05-21 | 2022-06-15 | Bhaskar Jyoti | Composition of an ethnomedical antidepressant energy drink |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005068128A (en) * | 2003-08-01 | 2005-03-17 | Soda Aromatic Co Ltd | alpha-GLUCOSIDASE INHIBITOR |
| JP2009013146A (en) * | 2007-07-02 | 2009-01-22 | Takehito Kono | Diabetes treating composition |
| CN104127816A (en) * | 2014-07-28 | 2014-11-05 | 西藏自治区藏医院 | Pharmaceutical composition for treating diabetes mellitus, and preparation method and application thereof |
| CN108567955A (en) * | 2017-03-08 | 2018-09-25 | 成都中医药大学 | A kind of pharmaceutical composition and preparation method thereof of prevention diabetic nephropathy |
| CN111388628A (en) * | 2020-04-15 | 2020-07-10 | 次仁 | Application of Tibetan medicine composition in preparing medicine for preventing and treating hyperlipidemia and diabetes |
| DE202022102826U1 (en) * | 2022-05-21 | 2022-06-15 | Bhaskar Jyoti | Composition of an ethnomedical antidepressant energy drink |
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