JP2008546777A5 - - Google Patents
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- Publication number
- JP2008546777A5 JP2008546777A5 JP2008518219A JP2008518219A JP2008546777A5 JP 2008546777 A5 JP2008546777 A5 JP 2008546777A5 JP 2008518219 A JP2008518219 A JP 2008518219A JP 2008518219 A JP2008518219 A JP 2008518219A JP 2008546777 A5 JP2008546777 A5 JP 2008546777A5
- Authority
- JP
- Japan
- Prior art keywords
- gemcitabine
- pharmaceutically acceptable
- acceptable salt
- cancer
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- SDUQYLNIPVEERB-QPPQHZFASA-N Gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 4
- 229960005277 gemcitabine Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 108010005144 Bevacizumab Proteins 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 208000009956 Adenocarcinoma Diseases 0.000 claims 1
- 101700046422 IFNA Proteins 0.000 claims 1
- 229960003685 Imatinib mesylate Drugs 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- QDLHCMPXEPAAMD-QAIWCSMKSA-N Wortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 claims 1
- 239000003145 cytotoxic factor Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002471 spleen cancer Diseases 0.000 claims 1
Claims (7)
- 脾臓癌、リンパ腺癌、前立腺癌、頭部および頚部癌、ならびに黒色腫から選択される癌の進行を、阻害し、根絶し、もしくは停止させ、または反転させるための医薬を製造するための、治療上有効量の下記式（Ｉ）によって表される治療上有効量の化合物、またはその薬学的に許容可能な塩の使用。
- 前記化合物は単独で送達されるかまたは癌を治療するために使用される１以上の他の化合物と組合わせられる、請求項１に記載の使用。
- 前記他の化合物が、メシル酸イマチニブ、ヒドロシキウレア、ＩＦＮ−α、細胞傷害性因子、ゲンフィタニブ、ゲムシタビン、ベバシズマブ、およびワートマニン、またはその薬学的に許容可能な塩から選択される、請求項２に記載の使用。
- 前記他の化合物がゲムシタビンである、請求項３に記載の使用。
- 前記他の化合物がゲムシタビンおよびベバシズマブである、請求項３に記載の使用。
- 膵臓癌の進行を、阻害し、根絶し、もしくは停止させ、または反転させるための医薬を製造するための、治療上有効量の下記式（Ｉ）の化合物またはその薬学的に許容可能な塩の使用であって、ゲムシタビンまたはその薬学的に許容可能な塩と組合わせられる、使用。
- さらに、ベバシズマブまたはその薬学的に許容可能な塩と組合わせられる、請求項６に記載の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69367105P | 2005-06-24 | 2005-06-24 | |
| PCT/US2006/023063 WO2007001839A2 (en) | 2005-06-24 | 2006-06-13 | 4-anilino-3-quinolinecarbonitriles for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008546777A JP2008546777A (ja) | 2008-12-25 |
| JP2008546777A5 true JP2008546777A5 (ja) | 2009-07-30 |
Family
ID=37575124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518219A Pending JP2008546777A (ja) | 2005-06-24 | 2006-06-13 | 癌の治療のための４−アニリノ−３−キノリンカルボニトリル |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070010527A1 (ja) |
| EP (1) | EP1893209A2 (ja) |
| JP (1) | JP2008546777A (ja) |
| KR (1) | KR20080027275A (ja) |
| CN (1) | CN101252931A (ja) |
| AR (1) | AR057403A1 (ja) |
| AU (1) | AU2006262591A1 (ja) |
| BR (1) | BRPI0611977A2 (ja) |
| CA (1) | CA2610209A1 (ja) |
| CR (1) | CR9539A (ja) |
| EC (1) | ECSP078015A (ja) |
| GT (1) | GT200600268A (ja) |
| IL (1) | IL187792A0 (ja) |
| MX (1) | MX2007016542A (ja) |
| NI (1) | NI200700323A (ja) |
| NO (1) | NO20076075L (ja) |
| PE (1) | PE20070323A1 (ja) |
| RU (1) | RU2007143434A (ja) |
| TW (1) | TW200730177A (ja) |
| WO (1) | WO2007001839A2 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007005462A1 (en) | 2005-07-01 | 2007-01-11 | Wyeth | Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarb-onitrile and methods of preparing the same |
| WO2013187967A1 (en) | 2012-06-15 | 2013-12-19 | Institute For Cancer Research D/B/A The Research Institute Of Fox Case Cancer Center ("Fox Chase Cancer Center") | Sensitization of cancer cells to dna damage by inhibiting kinases essential for dna damage checkpoint control |
| WO2017134679A1 (en) * | 2016-02-03 | 2017-08-10 | Msn Laboratories Private Limited | Novel crystalline polymorphs of 4-[(2.4-dichioro-5-methoxvphenvl)aniinol- 6-methoxv-7-13-(4-methyl-l-piperazinvl)propoxvl-3-quinolinecarbonitrile and process for preparation thereof |
| CN107433391B (zh) * | 2017-07-03 | 2020-01-17 | 武汉逸飞激光设备有限公司 | 一种基于图像识别的焊接校准方法及系统 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6432979B1 (en) * | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
| US6384051B1 (en) * | 2000-03-13 | 2002-05-07 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
| EP1680119A1 (en) * | 2003-11-06 | 2006-07-19 | Wyeth | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml) |
-
2006
- 2006-06-13 RU RU2007143434/14A patent/RU2007143434A/ru not_active Application Discontinuation
- 2006-06-13 JP JP2008518219A patent/JP2008546777A/ja active Pending
- 2006-06-13 CA CA002610209A patent/CA2610209A1/en not_active Abandoned
- 2006-06-13 EP EP06773093A patent/EP1893209A2/en not_active Withdrawn
- 2006-06-13 AU AU2006262591A patent/AU2006262591A1/en not_active Abandoned
- 2006-06-13 KR KR1020077030196A patent/KR20080027275A/ko not_active Application Discontinuation
- 2006-06-13 MX MX2007016542A patent/MX2007016542A/es not_active Application Discontinuation
- 2006-06-13 WO PCT/US2006/023063 patent/WO2007001839A2/en active Application Filing
- 2006-06-13 BR BRPI0611977-8A patent/BRPI0611977A2/pt not_active IP Right Cessation
- 2006-06-13 CN CNA2006800223605A patent/CN101252931A/zh active Pending
- 2006-06-22 US US11/473,540 patent/US20070010527A1/en not_active Abandoned
- 2006-06-22 GT GT200600268A patent/GT200600268A/es unknown
- 2006-06-22 PE PE2006000716A patent/PE20070323A1/es not_active Application Discontinuation
- 2006-06-22 TW TW095122482A patent/TW200730177A/zh unknown
- 2006-06-23 AR ARP060102728A patent/AR057403A1/es not_active Application Discontinuation
-
2007
- 2007-11-22 CR CR9539A patent/CR9539A/es not_active Application Discontinuation
- 2007-11-27 NO NO20076075A patent/NO20076075L/no not_active Application Discontinuation
- 2007-11-29 IL IL187792A patent/IL187792A0/en unknown
- 2007-12-14 NI NI200700323A patent/NI200700323A/es unknown
- 2007-12-14 EC EC2007008015A patent/ECSP078015A/es unknown
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