JP2008546376A - Scn1a遺伝子における変異を検出することによっててんかんを診断および処置するための方法 - Google Patents

Scn1a遺伝子における変異を検出することによっててんかんを診断および処置するための方法 Download PDF

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JP2008546376A
JP2008546376A JP2008516076A JP2008516076A JP2008546376A JP 2008546376 A JP2008546376 A JP 2008546376A JP 2008516076 A JP2008516076 A JP 2008516076A JP 2008516076 A JP2008516076 A JP 2008516076A JP 2008546376 A JP2008546376 A JP 2008546376A
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scn1a
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epilepsy
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ジョン, チャールズ マレイ,
ルイーズ ハーキン,
サミュエル, フランク ベルコヴィック,
イングリッド アイリーン シェッファー,
スティーヴン ペトロウ,
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バイオノミックス リミテッド
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    • C07ORGANIC CHEMISTRY
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    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2857Seizure disorders; Epilepsy

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JP2008516076A 2005-06-16 2006-06-16 Scn1a遺伝子における変異を検出することによっててんかんを診断および処置するための方法 Pending JP2008546376A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2005903146A AU2005903146A0 (en) 2005-06-16 Methods for the diagnosis and treatment of epilepsy
PCT/AU2006/000841 WO2006133508A1 (en) 2005-06-16 2006-06-16 Methods of treatment, and diagnosis of epilepsy by detecting mutations in the scn1a gene

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JP2008546376A true JP2008546376A (ja) 2008-12-25
JP2008546376A5 JP2008546376A5 (https=) 2009-07-30

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US (1) US20100088778A1 (https=)
EP (1) EP1904630A4 (https=)
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CA (1) CA2612180A1 (https=)
NZ (1) NZ564892A (https=)
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JP2011188837A (ja) * 2010-03-16 2011-09-29 Hirosaki Univ リーシークエンスdnaチップおよび最適抗てんかん薬決定方法
JP2013535958A (ja) * 2010-06-23 2013-09-19 カッパーアールエヌエー,インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット(SCNA)に対する天然アンチセンス転写物の阻害によるSCNA関連疾患の治療
US8916743B2 (en) 2010-01-29 2014-12-23 National University Corporation Okayama University Method for assessment of potential for development of dravet syndrome and use thereof
JP2016136949A (ja) * 2009-08-20 2016-08-04 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 抗p2x7受容体抗体およびその断片
JP2021525865A (ja) * 2018-05-29 2021-09-27 エボゲン,インコーポレーテッド 非てんかん性発作/発作なし/心因性非てんかん性発作に対するてんかん性発作の評価および処置のためのバイオマーカーおよび方法

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JP2005501536A (ja) * 2001-07-18 2005-01-20 バイオノミックス リミテッド イオンチャネルにおける変異
AU2003904154A0 (en) 2003-08-07 2003-08-21 Bionomics Limited Mutations in ion channels
AU2003901425A0 (en) * 2003-03-27 2003-04-10 Bionomics Limited A diagnostic method for epilepsy
JP5540343B2 (ja) * 2007-11-06 2014-07-02 国立大学法人 岡山大学 小児てんかん患者における急性脳炎または急性脳症の罹患リスク判定データの取得方法およびその利用
JP5608863B2 (ja) * 2007-12-28 2014-10-15 公立大学法人横浜市立大学 新生児期〜乳児期発症の難治性てんかんの検出方法
TWI734935B (zh) * 2011-06-24 2021-08-01 美商可娜公司 上調電壓門控鈉離子通道第I型α次單元(SCN1A)之表現及/或功能之反義寡核苷酸及其用途
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
CN107111673B (zh) 2014-09-29 2021-03-23 周格尼克斯国际有限公司 控制药物分配的控制系统
JP2018531975A (ja) 2015-10-30 2018-11-01 ピーティーシー セラピューティクス,インコーポレーテッド てんかんの治療方法
WO2017106377A1 (en) * 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
WO2017112701A1 (en) 2015-12-22 2017-06-29 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
ES3024232T3 (en) 2015-12-22 2025-06-04 Zogenix International Ltd Fenfluramine compositions and methods of preparing the same
SG11201900975XA (en) 2016-08-24 2019-03-28 Zogenix International Ltd Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same
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CN106719436A (zh) * 2016-12-20 2017-05-31 郑州伊美诺生物技术有限公司 一种制备单克隆抗体的小鼠模型建立方法
US11492345B2 (en) 2017-02-13 2022-11-08 Praxis Precision Medicines, Inc. Compounds and their methods of use
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US20200085838A1 (en) * 2017-05-16 2020-03-19 Praxis Precision Medicines, Inc. Methods of treating epilepsy and neurodevelopmental disorders
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KR102318434B1 (ko) 2017-08-25 2021-11-01 스톡 테라퓨틱스, 인크. 병태 및 질환 치료용 안티센스 올리고머
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
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EP3806834A4 (en) * 2018-05-25 2022-07-27 The Florey Institute of Neuroscience and Mental Health DYNAMIC CLAMPS AND METHODS OF USE THEREOF
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Cited By (9)

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Publication number Priority date Publication date Assignee Title
JP2016136949A (ja) * 2009-08-20 2016-08-04 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 抗p2x7受容体抗体およびその断片
JP2018023396A (ja) * 2009-08-20 2018-02-15 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 抗p2x7受容体抗体およびその断片
US8916743B2 (en) 2010-01-29 2014-12-23 National University Corporation Okayama University Method for assessment of potential for development of dravet syndrome and use thereof
JP2011188837A (ja) * 2010-03-16 2011-09-29 Hirosaki Univ リーシークエンスdnaチップおよび最適抗てんかん薬決定方法
JP2013535958A (ja) * 2010-06-23 2013-09-19 カッパーアールエヌエー,インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット(SCNA)に対する天然アンチセンス転写物の阻害によるSCNA関連疾患の治療
JP2017000158A (ja) * 2010-06-23 2017-01-05 カッパーアールエヌエー,インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット(SCNA)に対する天然アンチセンス転写物の阻害によるSCNA関連疾患の治療
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JP2021525865A (ja) * 2018-05-29 2021-09-27 エボゲン,インコーポレーテッド 非てんかん性発作/発作なし/心因性非てんかん性発作に対するてんかん性発作の評価および処置のためのバイオマーカーおよび方法

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CA2612180A1 (en) 2006-12-21
WO2006133508A1 (en) 2006-12-21
EP1904630A4 (en) 2009-10-21
US20100088778A1 (en) 2010-04-08
EP1904630A1 (en) 2008-04-02
NZ564892A (en) 2011-10-28

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