JP2008543878A5 - - Google Patents

Info

Publication number

JP2008543878A5

JP2008543878A5 JP2008517207A JP2008517207A JP2008543878A5 JP 2008543878 A5 JP2008543878 A5 JP 2008543878A5 JP 2008517207 A JP2008517207 A JP 2008517207A JP 2008517207 A JP2008517207 A JP 2008517207A JP 2008543878 A5 JP2008543878 A5 JP 2008543878A5

Authority

JP

Japan

Prior art keywords

peptide agent

use according

terminal

amino acid

acid sequence

Prior art date

2006-06-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• 239000003795 chemical substances by application Substances 0.000 claims 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• -1 DNaseI Proteins 0.000 claims 6
• 102000001708 Protein Isoforms Human genes 0.000 claims 6
• 108010029485 Protein Isoforms Proteins 0.000 claims 6
• 239000012736 aqueous medium Substances 0.000 claims 6
• 210000004899 c-terminal region Anatomy 0.000 claims 6
• 230000004410 intraocular pressure Effects 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 5
• QQKKFVXSQXUHPI-NBVRZTHBSA-N Acidissiminol epoxide Chemical compound O1C(C)(C)C1CC(O)C(/C)=C/COC(C=C1)=CC=C1CCNC(=O)C1=CC=CC=C1 QQKKFVXSQXUHPI-NBVRZTHBSA-N 0.000 claims 3
• 108010038798 Actin Depolymerizing Factors Proteins 0.000 claims 3
• 102000015693 Actin Depolymerizing Factors Human genes 0.000 claims 3
• 108010063503 Actinin Proteins 0.000 claims 3
• 102000010825 Actinin Human genes 0.000 claims 3
• 101710138529 Depactin Proteins 0.000 claims 3
• 102000004878 Gelsolin Human genes 0.000 claims 3
• 108090001064 Gelsolin Proteins 0.000 claims 3
• 108050001408 Profilin Proteins 0.000 claims 3
• 102000011195 Profilin Human genes 0.000 claims 3
• FCHAMFUEENBIDH-UHFFFAOYSA-N Severin Natural products CC1CCC2C(C)C3CCC4(O)C(CC5C4CC(O)C6CC(CCC56C)OC(=O)C)C3CN2C1 FCHAMFUEENBIDH-UHFFFAOYSA-N 0.000 claims 3
• UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims 3
• 102100035000 Thymosin beta-4 Human genes 0.000 claims 3
• 102000050760 Vitamin D-binding protein Human genes 0.000 claims 3
• 101710179590 Vitamin D-binding protein Proteins 0.000 claims 3
• 229940087051 fragmin Drugs 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 150000003462 sulfoxides Chemical class 0.000 claims 3
• 108010079996 thymosin beta(4) Proteins 0.000 claims 3
• 108090000195 villin Proteins 0.000 claims 3
• 208000010412 Glaucoma Diseases 0.000 claims 2
• 239000003246 corticosteroid Substances 0.000 claims 2
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
• 206010013774 Dry eye Diseases 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1