JP2008542435A - イルベサルタンのアルカリ土類塩水和物およびその調製 - Google Patents
イルベサルタンのアルカリ土類塩水和物およびその調製 Download PDFInfo
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- JP2008542435A JP2008542435A JP2008515246A JP2008515246A JP2008542435A JP 2008542435 A JP2008542435 A JP 2008542435A JP 2008515246 A JP2008515246 A JP 2008515246A JP 2008515246 A JP2008515246 A JP 2008515246A JP 2008542435 A JP2008542435 A JP 2008542435A
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- Prior art keywords
- irbesartan
- salt
- alkaline earth
- tetrahydrate
- preparation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Diabetes (AREA)
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- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
式:
‐イルベサルタンのナトリウム塩を水溶液中で調製し、次いで、
‐イルベサルタンの上記ナトリウム塩を水媒体中で所望のアルカリ土類金属塩に置換することを特徴とする工程により調製される。
‐残留溶媒がないこと、したがって、コスト削減と環境問題の回避;
‐上記2段階の工程では、該水溶液の滅菌が可能であること;
‐形成される塩の制御された結晶化;
‐得られる塩のろ過と乾燥の容易さ;
‐得られる塩の静電的挙動の欠如と容易な錠剤化。
イルベサルタン42.8gを、水430ml中に水酸化ナトリウム4gから調製した溶液に溶解する。この溶液を、水500ml中に塩化カルシウム11.1gから調製した溶液に注ぐ。こうして得られた反応媒質を50℃で4時間加熱した後、周囲温度まで戻す。得られた塩をろ過し、水100mlで3回すすいだ後、真空下50℃で重量が一定になるまで乾燥する。目的の塩47.1gを得る。
イルベサルタン42.8gを、水430ml中に水酸化ナトリウム4gから調製した溶液に溶解する。この溶液を、水500ml中に塩化マグネシウム9.52gから調製した溶液に注ぐ。こうして得られた反応媒質を50℃で4時間加熱した後、周囲温度まで戻す。得られた塩をろ過し、水100mlで3回洗浄した後、真空下50℃で重量が一定になるまで乾燥する。 目的の塩47.5gを得る。
Claims (6)
- 医薬的に許容されるイルベサルタンのアルカリ土類金属塩水和物。
- イルベサルタンのカルシウム塩水和物およびマグネシウム塩水和物から選択される、請求項1に記載のイルベサルタンの塩水和物。
- イルベサルタンのカルシウム塩4水和物。
- イルベサルタンのマグネシウム塩4水和物。
- 結晶形でのイルベサルタンのカルシウム塩4水和物またはマグネシウム塩4水和物。
- ‐イルベサルタンのナトリウム塩を水溶液中で調製すること、次いで、
‐イルベサルタンの前記ナトリウム塩を水媒体中で所望のアルカリ土類金属塩に置換することを特徴とする、請求項1から5のいずれか一項に記載のイルベサルタン塩水和物の調製方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0505755A FR2886642B1 (fr) | 2005-06-06 | 2005-06-06 | Sels alcalino-terreux d'irbesartan et leur preparation |
PCT/FR2006/001267 WO2006131632A1 (fr) | 2005-06-06 | 2006-06-06 | Hydrates de sels alcalino-terreux d'irbesartan et leur preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008542435A true JP2008542435A (ja) | 2008-11-27 |
Family
ID=35639476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008515246A Pending JP2008542435A (ja) | 2005-06-06 | 2006-06-06 | イルベサルタンのアルカリ土類塩水和物およびその調製 |
Country Status (17)
Country | Link |
---|---|
US (1) | US7947842B2 (ja) |
EP (1) | EP1891054A1 (ja) |
JP (1) | JP2008542435A (ja) |
KR (1) | KR20080024473A (ja) |
CN (1) | CN101248061B (ja) |
AR (1) | AR054131A1 (ja) |
AU (1) | AU2006256678A1 (ja) |
BR (1) | BRPI0610933A2 (ja) |
CA (1) | CA2610665A1 (ja) |
FR (1) | FR2886642B1 (ja) |
HK (1) | HK1123793A1 (ja) |
IL (1) | IL187723A (ja) |
MX (1) | MX2007015426A (ja) |
RU (1) | RU2401266C2 (ja) |
TW (1) | TW200716099A (ja) |
UY (1) | UY29584A1 (ja) |
WO (1) | WO2006131632A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008018843A1 (en) * | 2006-08-08 | 2008-02-14 | Ulkar Kimya Sanayi Ve Ticaret As | Process for producing useful salts form of biphenyl-tetrazole compounds |
CN111175385B (zh) * | 2018-11-12 | 2023-02-07 | 珠海润都制药股份有限公司 | 一种厄贝沙坦中厄贝沙坦同分异构体检验方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5541209A (en) * | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
JPH10279566A (ja) * | 1990-03-20 | 1998-10-20 | Sanofi Sa | N−置換複素環誘導体を含有する医薬組成物 |
JP2004504307A (ja) * | 2000-07-19 | 2004-02-12 | ノバルティス アクチエンゲゼルシャフト | バルサルタン塩 |
CN1548421A (zh) * | 2003-05-22 | 2004-11-24 | 上海医药工业研究院 | 替米沙坦盐及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
SI21849A (sl) * | 2004-07-29 | 2006-02-28 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Priprava hidrokloridnih soli tetrazolskega derivata |
-
2005
- 2005-06-06 FR FR0505755A patent/FR2886642B1/fr not_active Expired - Fee Related
-
2006
- 2006-06-02 AR ARP060102315A patent/AR054131A1/es not_active Application Discontinuation
- 2006-06-05 TW TW095119885A patent/TW200716099A/zh unknown
- 2006-06-06 RU RU2007149526/04A patent/RU2401266C2/ru not_active IP Right Cessation
- 2006-06-06 JP JP2008515246A patent/JP2008542435A/ja active Pending
- 2006-06-06 EP EP06764732A patent/EP1891054A1/fr not_active Withdrawn
- 2006-06-06 CN CN2006800198798A patent/CN101248061B/zh not_active Expired - Fee Related
- 2006-06-06 KR KR1020077028374A patent/KR20080024473A/ko not_active Application Discontinuation
- 2006-06-06 BR BRPI0610933-0A patent/BRPI0610933A2/pt not_active IP Right Cessation
- 2006-06-06 CA CA002610665A patent/CA2610665A1/fr not_active Abandoned
- 2006-06-06 MX MX2007015426A patent/MX2007015426A/es active IP Right Grant
- 2006-06-06 AU AU2006256678A patent/AU2006256678A1/en not_active Abandoned
- 2006-06-06 WO PCT/FR2006/001267 patent/WO2006131632A1/fr active Application Filing
- 2006-06-07 UY UY29584A patent/UY29584A1/es unknown
-
2007
- 2007-11-28 IL IL187723A patent/IL187723A/en not_active IP Right Cessation
- 2007-12-05 US US11/950,555 patent/US7947842B2/en active Active
-
2009
- 2009-02-18 HK HK09101566.3A patent/HK1123793A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10279566A (ja) * | 1990-03-20 | 1998-10-20 | Sanofi Sa | N−置換複素環誘導体を含有する医薬組成物 |
US5541209A (en) * | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
JP2004504307A (ja) * | 2000-07-19 | 2004-02-12 | ノバルティス アクチエンゲゼルシャフト | バルサルタン塩 |
CN1548421A (zh) * | 2003-05-22 | 2004-11-24 | 上海医药工业研究院 | 替米沙坦盐及其制备方法 |
Non-Patent Citations (4)
Title |
---|
BERGE,S.M.,ET AL, JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, JPN6009014198, 1977, pages 1 - 19, ISSN: 0002209359 * |
化学実験操作法 上巻, JPN6009015192, 1963, pages 377 - 379, ISSN: 0002486068 * |
新製剤学, JPN6012022297, 25 April 1984 (1984-04-25), pages 102 - 103, ISSN: 0002486069 * |
監訳者 長瀬博: "34章 塩形成による水溶性有機化合物の調製", 最新 創薬化学 下巻, JPN6012019949, 15 August 1998 (1998-08-15), pages 347 - 365, ISSN: 0002209358 * |
Also Published As
Publication number | Publication date |
---|---|
FR2886642A1 (fr) | 2006-12-08 |
MX2007015426A (es) | 2008-02-19 |
AU2006256678A1 (en) | 2006-12-14 |
EP1891054A1 (fr) | 2008-02-27 |
UY29584A1 (es) | 2007-01-31 |
BRPI0610933A2 (pt) | 2010-08-03 |
AR054131A1 (es) | 2007-06-06 |
CN101248061A (zh) | 2008-08-20 |
KR20080024473A (ko) | 2008-03-18 |
US20080096944A1 (en) | 2008-04-24 |
US7947842B2 (en) | 2011-05-24 |
FR2886642B1 (fr) | 2008-05-30 |
RU2401266C2 (ru) | 2010-10-10 |
RU2007149526A (ru) | 2009-07-20 |
WO2006131632A1 (fr) | 2006-12-14 |
CA2610665A1 (fr) | 2006-12-14 |
TW200716099A (en) | 2007-05-01 |
IL187723A (en) | 2011-06-30 |
IL187723A0 (en) | 2008-08-07 |
HK1123793A1 (en) | 2009-06-26 |
CN101248061B (zh) | 2011-08-24 |
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