JP2008540552A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008540552A5 JP2008540552A5 JP2008511301A JP2008511301A JP2008540552A5 JP 2008540552 A5 JP2008540552 A5 JP 2008540552A5 JP 2008511301 A JP2008511301 A JP 2008511301A JP 2008511301 A JP2008511301 A JP 2008511301A JP 2008540552 A5 JP2008540552 A5 JP 2008540552A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic composition
- composition according
- brimonidine
- administered
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims description 8
- 229960003679 brimonidine Drugs 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 6
- 238000012377 drug delivery Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims 14
- 239000007943 implant Substances 0.000 claims 5
- 229920002988 biodegradable polymer Polymers 0.000 claims 3
- 239000004621 biodegradable polymer Substances 0.000 claims 3
- 210000001508 eye Anatomy 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000005252 bulbus oculi Anatomy 0.000 claims 1
- 239000004067 bulking agent Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000003161 choroid Anatomy 0.000 claims 1
- 230000004406 elevated intraocular pressure Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 229940023490 ophthalmic product Drugs 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67977105P | 2005-05-10 | 2005-05-10 | |
| PCT/US2006/018019 WO2006122165A2 (en) | 2005-05-10 | 2006-05-09 | Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011209152A Division JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540552A JP2008540552A (ja) | 2008-11-20 |
| JP2008540552A5 true JP2008540552A5 (OSRAM) | 2011-06-16 |
Family
ID=37397258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511301A Pending JP2008540552A (ja) | 2005-05-10 | 2006-05-09 | 増大した前部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2011209152A Pending JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2014156852A Pending JP2015013863A (ja) | 2005-05-10 | 2014-07-31 | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011209152A Pending JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2014156852A Pending JP2015013863A (ja) | 2005-05-10 | 2014-07-31 | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7931909B2 (OSRAM) |
| EP (2) | EP3656374A1 (OSRAM) |
| JP (3) | JP2008540552A (OSRAM) |
| AU (1) | AU2006244083A1 (OSRAM) |
| BR (1) | BRPI0608978A2 (OSRAM) |
| CA (1) | CA2603069C (OSRAM) |
| ES (1) | ES2798259T3 (OSRAM) |
| WO (1) | WO2006122165A2 (OSRAM) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| WO2007011743A2 (en) | 2005-07-14 | 2007-01-25 | Lipothera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| WO2007037849A2 (en) * | 2005-09-16 | 2007-04-05 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
| US20070203144A1 (en) * | 2006-01-17 | 2007-08-30 | Allergan, Inc. | Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals |
| PL2077830T3 (pl) * | 2006-10-17 | 2013-04-30 | Lithera Inc | Sposoby, kompozycje i formulacje do leczenia orbitopatii tarczycowej |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US8492334B2 (en) * | 2007-06-21 | 2013-07-23 | Yale University | Sustained intraocular delivery of drugs from biodegradable polymeric microparticles |
| US20090081277A1 (en) * | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
| GB0724558D0 (en) * | 2007-12-15 | 2008-01-30 | Sharma Anant | Optical correction |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| AU2009246520B2 (en) | 2008-05-12 | 2012-04-19 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095506B2 (en) * | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US8034813B2 (en) | 2008-11-18 | 2011-10-11 | Bausch & Lomb Incorporated | Polymorphs of brimonidine pamoate |
| US9636255B2 (en) | 2009-02-13 | 2017-05-02 | Dose Medical Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| WO2010118340A1 (en) * | 2009-04-09 | 2010-10-14 | University Of Medicine And Dentistry Of New Jersey | Treatment of cutaneous hemangioma |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| EP3412260B1 (en) | 2009-05-18 | 2020-08-26 | Dose Medical Corporation | Drug eluting ocular implant |
| WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| US8299079B2 (en) * | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| AU2010314990B2 (en) | 2009-11-09 | 2015-10-01 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| US8492557B2 (en) | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
| US9370444B2 (en) | 2010-10-12 | 2016-06-21 | Emmett T. Cunningham, JR. | Subconjunctival conformer device and uses thereof |
| US8915877B2 (en) | 2010-10-12 | 2014-12-23 | Emmett T. Cunningham, JR. | Glaucoma drainage device and uses thereof |
| EP2654715B1 (en) | 2010-11-24 | 2017-01-25 | Dose Medical Corporation | Drug eluting ocular implant |
| EP2646012A4 (en) | 2010-11-24 | 2014-12-10 | Neothetics Inc | MONOTHERAPEUTIC FORMULATIONS OF SELECTIVE, LIPOPHILIC AND PROLONGED BETA AGONISTS AND METHODS OF COSMETIC TREATMENT OF SILHOUETTE ADPOSITY AND REINFORCEMENT |
| CN108383828A (zh) | 2010-12-16 | 2018-08-10 | 阿勒根公司 | 作为趋化因子受体调节剂的新的1,2-双-磺酰胺衍生物 |
| AU2011344148B2 (en) | 2010-12-16 | 2017-04-27 | Allergan, Inc. | Phosphorous derivatives as chemokine receptor modulators |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| US8580817B2 (en) | 2011-02-11 | 2013-11-12 | Allergan, Inc. | 1-(1-OXO-1,2,3,4-tetrahydroisoquinolin-7-YL)urea derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| US8653299B2 (en) | 2011-03-17 | 2014-02-18 | Allergan, Inc. | Dihydronaphthalene and naphthalene derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| AU2012340806B2 (en) | 2011-11-21 | 2017-10-19 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases |
| US20130190324A1 (en) * | 2011-12-23 | 2013-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Topical ocular drug delivery |
| WO2013116186A1 (en) | 2012-01-30 | 2013-08-08 | Allergan, Inc. | Brimonidine for treating visual disorders mediated by central visual projections from the eye |
| PL3345899T3 (pl) | 2012-03-01 | 2020-07-27 | Allergan, Inc. | Pochodne benzofurano-2-sulfonoamidu jako modulatory receptorów chemokin |
| KR20150058510A (ko) | 2012-09-27 | 2015-05-28 | 알레간 인코포레이티드 | 단백질의 지속된 방출을 위한 생물분해성 약물 전달 시스템 |
| CN105142710A (zh) | 2013-01-15 | 2015-12-09 | 科罗拉多州立大学董事会,公司实体 | 泪腺系统给药装置 |
| US20140234389A1 (en) | 2013-02-15 | 2014-08-21 | Allergan, Inc. | Sustained drug delivery implant |
| ES2708563T3 (es) | 2013-03-12 | 2019-04-10 | Allergan Inc | Derivados de sulfonamida como moduladores de receptores de quimiocinas |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| KR20150143439A (ko) | 2013-03-15 | 2015-12-23 | 알레간 인코포레이티드 | 무스카린성 효능제 |
| WO2015084869A1 (en) | 2013-12-02 | 2015-06-11 | Allergan, Inc. | Benzothiophene sulfonamides derivatives as chemokine receptor modulators |
| KR101587483B1 (ko) * | 2014-03-28 | 2016-01-21 | 동아대학교 산학협력단 | 미토콘드리아성 복합체 ⅰ 저해제를 유효성분으로 함유하는 증식성 유리체망막병증의 예방 또는 치료용 약학적 조성물 |
| US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| SG11201700777VA (en) | 2014-08-04 | 2017-02-27 | Nuevolution As | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11857461B2 (en) | 2015-11-23 | 2024-01-02 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system for drug delivery |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| WO2017201255A1 (en) | 2016-05-20 | 2017-11-23 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal drug delivery device |
| EP4520828A3 (en) | 2016-11-15 | 2025-07-09 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| WO2018125930A1 (en) * | 2016-12-27 | 2018-07-05 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| EP3710008A4 (en) * | 2017-11-14 | 2021-08-25 | The Schepens Eye Research Institute, Inc. | RUNX1 INHIBITION FOR THE TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND DISEASES ASSOCIATED WITH EPITHELIAL-MESENCHYMAL TRANSITION |
| WO2020041340A1 (en) * | 2018-08-21 | 2020-02-27 | Allergan, Inc. | The use of alpha-2-adrenergic receptor agonists for improving vision |
| AU2020302924A1 (en) | 2019-06-27 | 2022-02-17 | Layerbio, Inc. | Ocular device delivery methods and systems |
| US11685727B2 (en) | 2019-12-20 | 2023-06-27 | Nuevolution A/S | Compounds active towards nuclear receptors |
| JP2021098692A (ja) | 2019-12-20 | 2021-07-01 | ヌエヴォリューション・アクティーゼルスカブNuevolution A/S | 核内受容体に対して活性の化合物 |
| JP7713954B2 (ja) | 2020-03-31 | 2025-07-28 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
| MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| US20230301993A1 (en) * | 2020-08-21 | 2023-09-28 | Vyluma Inc. | Low-Dose Ophthalmic Compositions and Methods |
| WO2022040622A1 (en) * | 2020-08-21 | 2022-02-24 | Oculotherapy, Llc | Methods of neuroprotection and uses thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| JPS58126435U (ja) | 1982-02-19 | 1983-08-27 | オリンパス光学工業株式会社 | Ttlオ−トストロボ用絞り制御回路 |
| US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| WO1995003009A1 (en) * | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US6369116B1 (en) | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| AU738338B2 (en) | 1997-08-11 | 2001-09-13 | Allergan, Inc. | Sterile bioerodible implant device with improved biocompatability and method |
| US6242442B1 (en) * | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| AUPQ496500A0 (en) | 2000-01-06 | 2000-02-03 | University Of Sydney, The | Kit |
| AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| WO2002043785A2 (en) | 2000-11-29 | 2002-06-06 | Oculex Pharmaceuticals, Inc. | Intraocular implants for preventing transplant rejection in the eye |
| US20030114460A1 (en) * | 2001-12-14 | 2003-06-19 | Allergan Sales, Inc. | Pharmaceutical conjugates with enhanced pharmacokinetic characteristics |
| ES2326471T3 (es) | 2002-03-18 | 2009-10-13 | Novartis Ag | Composicion de uso topico que comprende un ciclofructano, un vehiculo y un farmaco. |
| US20070042951A1 (en) * | 2003-10-08 | 2007-02-22 | Allergan, Inc. | Pharmaceutical compositions comprising alpha-2-adrenergics and trefoil factor family peptides |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
-
2006
- 2006-05-02 US US11/416,929 patent/US7931909B2/en active Active
- 2006-05-09 EP EP20150705.0A patent/EP3656374A1/en not_active Withdrawn
- 2006-05-09 JP JP2008511301A patent/JP2008540552A/ja active Pending
- 2006-05-09 BR BRPI0608978-0A patent/BRPI0608978A2/pt not_active IP Right Cessation
- 2006-05-09 CA CA2603069A patent/CA2603069C/en active Active
- 2006-05-09 EP EP06752463.7A patent/EP1879553B1/en active Active
- 2006-05-09 WO PCT/US2006/018019 patent/WO2006122165A2/en not_active Ceased
- 2006-05-09 AU AU2006244083A patent/AU2006244083A1/en not_active Abandoned
- 2006-05-09 ES ES06752463T patent/ES2798259T3/es active Active
-
2007
- 2007-12-03 US US11/949,750 patent/US20080112922A1/en not_active Abandoned
- 2007-12-03 US US11/949,751 patent/US20080112923A1/en not_active Abandoned
-
2011
- 2011-09-26 JP JP2011209152A patent/JP2012046530A/ja active Pending
-
2014
- 2014-07-31 JP JP2014156852A patent/JP2015013863A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008540552A5 (OSRAM) | ||
| JP5696121B2 (ja) | α−2アドレナリン受容体アゴニスト含有生分解性眼内インプラント | |
| JP6700348B2 (ja) | 持続型薬物送達インプラント | |
| AU2007223057B2 (en) | Ocular therapy using sirtuin-activating agents | |
| Nanjawade et al. | RETRACTED: In situ-forming hydrogels for sustained ophthalmic drug delivery | |
| US20130071349A1 (en) | Biodegradable polymers for lowering intraocular pressure | |
| KR20070083941A (ko) | 중합체 전달 조성을 갖는 눈 전달 | |
| JP2012046530A (ja) | 増大した前眼部クリアランス速度を有するα−2アドレナリン受容体アゴニストを用いる眼科治療 | |
| TW200826943A (en) | Intraocular drug delivery systems | |
| JP2009511632A (ja) | 後区組織に選択的に浸透するグルココルチコイド誘導体を用いた眼治療 | |
| JP2009535422A5 (OSRAM) | ||
| JP2013126997A (ja) | β−アドレナリン受容体拮抗薬を含む持続放出眼内インプラント | |
| JP2007535367A (ja) | エストラジオール誘導体またはエストラトポン誘導体を含有する徐放性眼内インプラント、ならびに関連する製造法 | |
| CN101437478A (zh) | 聚合送递制剂的眼部送递 | |
| US20150141348A1 (en) | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | |
| JP2024167340A (ja) | コーティング眼用インプラント | |
| AU2011239238B2 (en) | Ocular therapy using sirtuin-activating agents | |
| Rajput et al. | Processed Excipients in Ocular Drug Delivery | |
| Bhanu Malhotra et al. | Ocular drug delivery systems. | |
| Robinson | Degradable Polymer Constructs Delivering AG1478 to Promote Axon Regeneration in the Mature Mammalian Central Nervous System |