JP2008540484A5 - - Google Patents
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- JP2008540484A5 JP2008540484A5 JP2008510532A JP2008510532A JP2008540484A5 JP 2008540484 A5 JP2008540484 A5 JP 2008540484A5 JP 2008510532 A JP2008510532 A JP 2008510532A JP 2008510532 A JP2008510532 A JP 2008510532A JP 2008540484 A5 JP2008540484 A5 JP 2008540484A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- oil
- weight
- pharmaceutical composition
- fatty acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 5
- MBMBGCFOFBJSGT-KUBAVDMBSA-N Docosahexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 229960004363 doconexent Drugs 0.000 claims 4
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 230000001613 neoplastic Effects 0.000 claims 2
- 210000000133 Brain Stem Anatomy 0.000 claims 1
- 210000000481 Breast Anatomy 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 210000000936 Intestines Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 210000000496 Pancreas Anatomy 0.000 claims 1
- 210000001428 Peripheral Nervous System Anatomy 0.000 claims 1
- 210000002307 Prostate Anatomy 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002622 anti-tumorigenesis Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000002601 intratumoral Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000011682 nervous system cancer Diseases 0.000 claims 1
Claims (13)
- 腫瘍性疾患の治療のための医薬組成物を製造するための、ＤＨＡグリセリドが濃縮された油の使用であって、該油は該医薬組成物の総重量に対して７０重量％までの濃度で濃縮されており、かつそのドコサヘキサエン酸は該油中の脂肪酸の全アシル基に対して少なくとも５０％の割合である、該油の使用。
- 前記医薬組成物がエマルション形態である、請求項１に記載の使用。
- 前記濃縮油がエコサペンタエン酸を、前記油の脂肪酸の全アシル基に対して３０％までの重量百分率で含む、請求項１に記載の使用。
- 前記濃縮油が１〜７０重量％の範囲である、請求項１に記載の使用。
- 前記濃縮油が１０〜３０重量％の範囲である、請求項４に記載の使用。
- 前記ドコサヘキサエン酸が５０〜１００％の割合である、請求項１に記載の使用。
- ドコサヘキサエン酸の前記濃度が前記油中の脂肪酸の全アシル基に対して７０重量％〜９０重量％の割合である、請求項６に記載の使用。
- 前記ドコサヘキサエン酸が前記油中の全脂肪酸に対して７０重量％の割合である、請求項７に記載の使用。
- 前記エマルションの平均径が２００ｎｍ未満である、請求項２に記載の使用。
- 前記医薬組成物が非経口経路により投与される、請求項１に記載の使用。
- 前記医薬組成物が腫瘍内注射により投与される、請求項１に記載の使用。
- 前記医薬組成物が、少なくとも１種の抗腫瘍形成薬を併用して受けている患者に投与される、請求項１に記載の使用。
- 治療すべき腫瘍性疾患が、肺、前立腺、腸、乳房、膵臓、脳、中枢および末梢神経系の癌、黒色腫を含む群のうちの１つである、請求項１〜１２のいずれか一項に記載の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501141A ES2264886B1 (es) | 2005-05-12 | 2005-05-12 | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
| ESP-200501141 | 2005-05-12 | ||
| PCT/EP2006/061833 WO2006120120A1 (en) | 2005-05-12 | 2006-04-26 | Use of docosahexaenoic glycerides for the treatment of tumorous diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128247A Division JP6038841B2 (ja) | 2005-05-12 | 2014-06-23 | 腫瘍性疾患の治療のためのドコサヘキサエン酸グリセリドの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540484A JP2008540484A (ja) | 2008-11-20 |
| JP2008540484A5 true JP2008540484A5 (ja) | 2009-06-18 |
| JP5893235B2 JP5893235B2 (ja) | 2016-03-23 |
Family
ID=36809521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510532A Active JP5893235B2 (ja) | 2005-05-12 | 2006-04-26 | 腫瘍性疾患の治療のためのドコサヘキサエン酸グリセリドの使用 |
| JP2014128247A Active JP6038841B2 (ja) | 2005-05-12 | 2014-06-23 | 腫瘍性疾患の治療のためのドコサヘキサエン酸グリセリドの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128247A Active JP6038841B2 (ja) | 2005-05-12 | 2014-06-23 | 腫瘍性疾患の治療のためのドコサヘキサエン酸グリセリドの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20080207947A1 (ja) |
| EP (1) | EP1881824B1 (ja) |
| JP (2) | JP5893235B2 (ja) |
| CA (1) | CA2614192C (ja) |
| DK (1) | DK1881824T3 (ja) |
| ES (2) | ES2264886B1 (ja) |
| HK (1) | HK1113319A1 (ja) |
| IL (1) | IL187274A (ja) |
| NO (1) | NO336953B1 (ja) |
| NZ (1) | NZ563301A (ja) |
| PL (1) | PL1881824T3 (ja) |
| PT (1) | PT1881824E (ja) |
| WO (1) | WO2006120120A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
| CN103211807A (zh) * | 2005-07-08 | 2013-07-24 | Dsmip资产公司 | 用于治疗痴呆和前痴呆相关病症的多不饱和脂肪酸 |
| ES2277557B1 (es) | 2005-12-21 | 2008-07-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
| US9265745B2 (en) * | 2005-12-21 | 2016-02-23 | Brudy Technology S.L. | Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| TWI448290B (zh) * | 2007-12-19 | 2014-08-11 | Prometic Biosciences Inc | 與健擇他濱（ｇｅｍｃｉｔａｂｉｎｅ）組合用於胰臟癌之治療的中等鏈長脂肪酸、鹽類及三酸甘油酯 |
| WO2011103512A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha free fatty acid emulsions |
| US20110200644A1 (en) * | 2010-02-18 | 2011-08-18 | Martek Biosciences Corporation | DHA Ester Emulsions |
| WO2011103514A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha triglyceride emulsions |
| KR101643259B1 (ko) * | 2010-07-26 | 2016-07-27 | 후지필름 가부시키가이샤 | 유지 함유 조성물 및 그것을 포함하는 경구제제 |
| HUE046885T2 (hu) | 2013-04-22 | 2020-03-30 | Smartfish As | Halolajat és dzsúzt tartalmazó készítmény alkalmazása rák kezelésére és/vagy utókezelésére |
| KR101665253B1 (ko) | 2015-06-19 | 2016-10-25 | 순천향대학교 산학협력단 | 도코사헥사에노산 및 트리아신 씨를 포함하는 것을 특징으로 하는 자궁내막암 치료 및 예방용 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3721137A1 (de) * | 1987-06-26 | 1989-01-05 | Dietl Hans | Fettemulsion zur intravenoesen anwendung |
| US5147854A (en) * | 1990-05-22 | 1992-09-15 | Hoffmann-La Roche Inc. | Tgf-b compositions and method |
| JP2572692B2 (ja) * | 1991-07-24 | 1997-01-16 | ボーソー油脂 株式会社 | ドコサヘキサエン酸トリグリセリドの製造法 |
| JPH05139968A (ja) * | 1991-11-14 | 1993-06-08 | Sagami Chem Res Center | メダラシン活性促進剤 |
| JPH0616548A (ja) * | 1992-06-30 | 1994-01-25 | Sagami Chem Res Center | 組織異常増殖抑制剤 |
| JPH06116585A (ja) * | 1992-10-09 | 1994-04-26 | Kanegafuchi Chem Ind Co Ltd | 油脂の精製方法 |
| JP3526632B2 (ja) * | 1994-08-22 | 2004-05-17 | 旭化成ケミカルズ株式会社 | 高度不飽和脂肪酸含有油脂 |
| JPH1057086A (ja) * | 1996-08-20 | 1998-03-03 | Asahi Chem Ind Co Ltd | 高濃度ドコサヘキサエン酸モノグリセリドの製造方法 |
| EP1214067A1 (en) * | 1999-09-09 | 2002-06-19 | EFA Sciences Llc | Methods for treating cell proliferative disorders including cancer |
| JP2002180082A (ja) * | 2000-12-11 | 2002-06-26 | Maruha Corp | 摂取物 |
| US20040052837A1 (en) * | 2002-06-27 | 2004-03-18 | William Stillwell | Lipid conjugated anti-cancer drugs and methods of use thereof |
| ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
-
2005
- 2005-05-12 ES ES200501141A patent/ES2264886B1/es active Active
-
2006
- 2006-04-26 JP JP2008510532A patent/JP5893235B2/ja active Active
- 2006-04-26 PT PT06754856T patent/PT1881824E/pt unknown
- 2006-04-26 ES ES06754856.0T patent/ES2531599T3/es active Active
- 2006-04-26 EP EP06754856.0A patent/EP1881824B1/en active Active
- 2006-04-26 NZ NZ563301A patent/NZ563301A/en not_active IP Right Cessation
- 2006-04-26 PL PL06754856T patent/PL1881824T3/pl unknown
- 2006-04-26 CA CA2614192A patent/CA2614192C/en not_active Expired - Fee Related
- 2006-04-26 DK DK06754856.0T patent/DK1881824T3/en active
- 2006-04-26 WO PCT/EP2006/061833 patent/WO2006120120A1/en not_active Application Discontinuation
- 2006-04-26 US US11/913,994 patent/US20080207947A1/en not_active Abandoned
-
2007
- 2007-11-08 IL IL187274A patent/IL187274A/en active IP Right Grant
- 2007-12-11 NO NO20076382A patent/NO336953B1/no not_active IP Right Cessation
-
2008
- 2008-07-29 HK HK08108365.2A patent/HK1113319A1/xx not_active IP Right Cessation
-
2009
- 2009-08-31 US US12/550,780 patent/US9271954B2/en active Active
-
2014
- 2014-06-23 JP JP2014128247A patent/JP6038841B2/ja active Active
-
2016
- 2016-01-25 US US15/005,181 patent/US20170333381A9/en not_active Abandoned
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