JP2008539787A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008539787A5 JP2008539787A5 JP2008512445A JP2008512445A JP2008539787A5 JP 2008539787 A5 JP2008539787 A5 JP 2008539787A5 JP 2008512445 A JP2008512445 A JP 2008512445A JP 2008512445 A JP2008512445 A JP 2008512445A JP 2008539787 A5 JP2008539787 A5 JP 2008539787A5
- Authority
- JP
- Japan
- Prior art keywords
- barrier
- permeable material
- cells
- chamber
- microporous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cells Anatomy 0.000 claims 24
- 239000000463 material Substances 0.000 claims 24
- 239000012530 fluid Substances 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 210000003494 Hepatocytes Anatomy 0.000 claims 4
- 230000001464 adherent Effects 0.000 claims 4
- 230000002496 gastric Effects 0.000 claims 4
- 210000001519 tissues Anatomy 0.000 claims 4
- 210000004369 Blood Anatomy 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 239000012229 microporous material Substances 0.000 claims 3
- 210000000941 Bile Anatomy 0.000 claims 2
- 102100004728 CDH1 Human genes 0.000 claims 2
- 101700016900 CDH1 Proteins 0.000 claims 2
- 210000004072 Lung Anatomy 0.000 claims 2
- 230000036740 Metabolism Effects 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 230000035786 metabolism Effects 0.000 claims 2
- 230000000275 pharmacokinetic Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000000013 Bile Ducts Anatomy 0.000 claims 1
- 210000001218 Blood-Brain Barrier Anatomy 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 102000004162 Claudin-1 Human genes 0.000 claims 1
- 108090000600 Claudin-1 Proteins 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 230000036826 Excretion Effects 0.000 claims 1
- 102100015924 GJB1 Human genes 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- 210000004324 Lymphatic System Anatomy 0.000 claims 1
- 108090000304 Occludin Proteins 0.000 claims 1
- 102000003940 Occludin Human genes 0.000 claims 1
- 102000000591 Tight Junction Proteins Human genes 0.000 claims 1
- 108010002321 Tight Junction Proteins Proteins 0.000 claims 1
- 210000002700 Urine Anatomy 0.000 claims 1
- -1 ZO-1 Proteins 0.000 claims 1
- 230000035507 absorption Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 102000015735 beta Catenin Human genes 0.000 claims 1
- 108060000903 beta Catenin Proteins 0.000 claims 1
- 102000024070 binding proteins Human genes 0.000 claims 1
- 108091007650 binding proteins Proteins 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000003633 blood substitute Substances 0.000 claims 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims 1
- 108040002558 cell adhesion mediator activity proteins Proteins 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 230000004087 circulation Effects 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229960005188 collagen Drugs 0.000 claims 1
- 108010015416 connexin 32 Proteins 0.000 claims 1
- 210000002249 digestive system Anatomy 0.000 claims 1
- 230000035510 distribution Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 239000011368 organic material Substances 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 230000003169 placental Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 101710040918 shg Proteins 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 230000002485 urinary Effects 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68213105P | 2005-05-18 | 2005-05-18 | |
| PCT/US2006/018951 WO2007021343A2 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539787A JP2008539787A (ja) | 2008-11-20 |
| JP2008539787A5 true JP2008539787A5 (zh) | 2009-08-06 |
Family
ID=37758004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512445A Pending JP2008539787A (ja) | 2005-05-18 | 2006-05-17 | 生物学的な障壁を有する薬物動態学ベース培養システム |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1891201A4 (zh) |
| JP (1) | JP2008539787A (zh) |
| CN (1) | CN101223268A (zh) |
| CA (1) | CA2607965A1 (zh) |
| WO (1) | WO2007021343A2 (zh) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2278338B1 (en) | 2002-05-09 | 2020-08-26 | The University of Chicago | Device and method for pressure-driven plug transport and reaction |
| US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| WO2007081386A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| WO2009015390A2 (en) * | 2007-07-26 | 2009-01-29 | University Of Chicago | Co-incuating confined microbial communities |
| WO2009039378A2 (en) | 2007-09-19 | 2009-03-26 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures for biomedical applications |
| JP5579620B2 (ja) * | 2008-01-10 | 2014-08-27 | ヒューレル コーポレーション | 免疫システムモデリング・デバイスおよび方法 |
| US8622987B2 (en) | 2008-06-04 | 2014-01-07 | The University Of Chicago | Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
| CN102124096B (zh) | 2008-07-16 | 2014-10-22 | 儿童医疗中心有限公司 | 具有微通道的器官模仿装置及其使用和制造方法 |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP2411148B1 (en) | 2009-03-23 | 2018-02-21 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| AU2010229490B2 (en) | 2009-03-24 | 2015-02-12 | University Of Chicago | Slip chip device and methods |
| US8906644B2 (en) | 2009-08-26 | 2014-12-09 | The University Of Tokyo | Method for culture of hepatocytes |
| US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ， インコーポレイテッド | デジタル検体分析 |
| EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP3412778A1 (en) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| CA2828110C (en) * | 2011-02-28 | 2020-03-31 | President And Fellows Of Harvard College | Cell culture system |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| EP2714970B1 (en) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
| CN102643742B (zh) * | 2012-04-18 | 2013-06-05 | 西安建筑科技大学 | 一种自养菌动力学参数测量装置及测量方法 |
| US9528082B2 (en) | 2012-07-25 | 2016-12-27 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
| WO2014120772A1 (en) | 2013-01-29 | 2014-08-07 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| EP3254008B1 (en) | 2015-02-04 | 2018-12-26 | The Charles Stark Draper Laboratory, Inc. | Actuated valve or pump for microfluidic devices |
| NL2015130B1 (en) * | 2015-07-09 | 2017-02-01 | Mimetas B V | Barrier function measurements. |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| CN105385598B (zh) * | 2015-11-30 | 2017-12-29 | 赵明光 | 人脑动静脉畸形生物力学模型及其体外构建方法 |
| CN105950461B (zh) * | 2016-07-20 | 2017-10-24 | 江苏瑞明生物科技有限公司 | 单细胞纳米精准给药系统 |
| EP4253956A3 (en) * | 2016-10-14 | 2023-12-06 | Wake Forest University Health Sciences | Multi-organ "body on a chip" apparatus utilizing a common media |
| AU2018283184B2 (en) * | 2017-06-14 | 2021-08-19 | EMULATE, Inc. | Effects of space travel on human brain cells |
| SG11201913177YA (en) | 2017-08-31 | 2020-01-30 | Philip Morris Products Sa | Cell culture plate, devices and methods for in vitro exposure |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
| US6001585A (en) * | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
| DE69903800T2 (de) * | 1998-03-18 | 2003-10-02 | Massachusetts Institute Of Technology, Cambridge | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
| CA2445458C (en) * | 2001-04-25 | 2016-12-13 | Cornell Research Foundation, Inc. | Devices and methods for pharmacokinetic-based cell culture system |
| JP3853195B2 (ja) * | 2001-10-29 | 2006-12-06 | 株式会社ルネサステクノロジ | 半導体装置 |
| JP2005523717A (ja) * | 2002-05-01 | 2005-08-11 | マサチューセッツ インスティテュート オブ テクノロジー | 生化学的過程の迅速なスクリーニングおよび分析のための微小発酵槽 |
| JP4118102B2 (ja) * | 2002-08-26 | 2008-07-16 | 独立行政法人科学技術振興機構 | 半透膜付き細胞培養マイクロチャンバー |
| JP4370082B2 (ja) * | 2002-08-26 | 2009-11-25 | 独立行政法人科学技術振興機構 | 神経細胞培養マイクロチャンバー |
| JP4607432B2 (ja) * | 2003-05-12 | 2011-01-05 | 高木産業株式会社 | 細胞又は組織の培養装置 |
| WO2005033263A1 (en) * | 2003-10-01 | 2005-04-14 | Athena Capital Partners, Llc | Circulating flow device for assays of cell cultures, cellular components and cell products |
-
2006
- 2006-05-17 CA CA002607965A patent/CA2607965A1/en not_active Abandoned
- 2006-05-17 CN CN 200680025975 patent/CN101223268A/zh active Pending
- 2006-05-17 EP EP06813188A patent/EP1891201A4/en not_active Withdrawn
- 2006-05-17 JP JP2008512445A patent/JP2008539787A/ja active Pending
- 2006-05-17 WO PCT/US2006/018951 patent/WO2007021343A2/en active Application Filing
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008539787A5 (zh) | ||
| US20240182868A1 (en) | Organ Chips And Uses Thereof | |
| Xie et al. | h-FIBER: microfluidic topographical hollow fiber for studies of glomerular filtration barrier | |
| Virumbrales-Muñoz et al. | Microfluidic lumen-based systems for advancing tubular organ modeling | |
| Varone et al. | A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it | |
| US11059041B2 (en) | In vitro epithelial models comprising lamina propria-derived cells | |
| Nalayanda et al. | An open-access microfluidic model for lung-specific functional studies at an air-liquid interface | |
| Hosic et al. | Rapid prototyping of multilayer microphysiological systems | |
| KR20170090519A (ko) | 조작된 간 조직, 그의 어레이, 및 그의 제조 방법 | |
| Gonçalves et al. | Recent trends of biomaterials and biosensors for organ-on-chip platforms | |
| Rahimnejad et al. | Engineered biomimetic membranes for organ-on-a-chip | |
| EP3383996A1 (en) | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof | |
| JP6626884B2 (ja) | 細胞層のインビトロ産生および培養デバイスのための半製品、および細胞層のインビトロ産生および培養デバイス | |
| Lee et al. | Cellular hydrogel biopaper for patterned 3D cell culture and modular tissue reconstruction | |
| Kwak et al. | Rapid multilayer microfabrication for modeling organotropic metastasis in breast cancer | |
| JP2022093597A (ja) | 細胞培養装置および細胞培養方法 | |
| CN102140422A (zh) | 用于控制不同种细胞相互作用的装置、其制备方法及用途 | |
| US20130236972A1 (en) | Liver Sinusoid Model | |
| Nishikawa et al. | Accurate evaluation of hepatocyte metabolisms on a noble oxygen-permeable material with low sorption characteristics | |
| Kim et al. | Recent Advances in Gut‐and Gut–Organ‐Axis‐on‐a‐Chip Models | |
| Murphy et al. | Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine | |
| CN113174332A (zh) | 仿生肾器官芯片结构和仿生肝肾芯片结构 | |
| Moghaddam et al. | Recent advances and future prospects of functional organ-on-a-chip systems | |
| Bhagat et al. | Cultivating human tissues and organs over lab-on-a-chip models: Recent progress and applications | |
| CN111655837B (zh) | 实施模拟体内稳态微生理系统的血液和尿液回路的新型微流体装置 |