JP2008538117A5 - - Google Patents
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- Publication number
- JP2008538117A5 JP2008538117A5 JP2008504239A JP2008504239A JP2008538117A5 JP 2008538117 A5 JP2008538117 A5 JP 2008538117A5 JP 2008504239 A JP2008504239 A JP 2008504239A JP 2008504239 A JP2008504239 A JP 2008504239A JP 2008538117 A5 JP2008538117 A5 JP 2008538117A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- heteroaryl
- perfluoroalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims 58
- 125000000217 alkyl group Chemical group 0.000 claims 50
- 125000001072 heteroaryl group Chemical group 0.000 claims 47
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 37
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 37
- 125000003545 alkoxy group Chemical group 0.000 claims 33
- 229910052739 hydrogen Inorganic materials 0.000 claims 33
- 239000001257 hydrogen Substances 0.000 claims 33
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 32
- 125000000623 heterocyclic group Chemical group 0.000 claims 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 21
- 125000004104 aryloxy group Chemical group 0.000 claims 16
- 229910052725 zinc Inorganic materials 0.000 claims 13
- 239000011701 zinc Substances 0.000 claims 13
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 229910052731 fluorine Inorganic materials 0.000 claims 12
- 239000011737 fluorine Substances 0.000 claims 12
- 125000002837 carbocyclic group Chemical group 0.000 claims 11
- 125000004663 dialkyl amino group Chemical group 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- 125000002252 acyl group Chemical group 0.000 claims 10
- 125000005256 alkoxyacyl group Chemical group 0.000 claims 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 10
- 150000001768 cations Chemical class 0.000 claims 10
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 10
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 10
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 238000005984 hydrogenation reaction Methods 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 239000003610 charcoal Substances 0.000 claims 4
- 150000003751 zinc Chemical class 0.000 claims 4
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 3
- 230000002159 abnormal effect Effects 0.000 claims 3
- 239000003125 aqueous solvent Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 150000001879 copper Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000028709 inflammatory response Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004442 acylamino group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910021386 carbon form Inorganic materials 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 125000005035 acylthio group Chemical group 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000005228 aryl sulfonate group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000005518 carboxamido group Chemical group 0.000 claims 1
- -1 carboxy, amino Chemical group 0.000 claims 1
- 125000004112 carboxyamino group Chemical group [H]OC(=O)N([H])[*] 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011981 lindlar catalyst Substances 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/093,757 US7582785B2 (en) | 2002-04-01 | 2005-03-29 | Trihydroxy polyunsaturated eicosanoid derivatives |
| PCT/US2006/011222 WO2006105058A2 (en) | 2005-03-29 | 2006-03-28 | Trihydroxy polyunsaturated eicosanoid derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128022A Division JP2012162576A (ja) | 2005-03-29 | 2012-06-05 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538117A JP2008538117A (ja) | 2008-10-09 |
| JP2008538117A5 true JP2008538117A5 (enExample) | 2010-04-02 |
Family
ID=36645579
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504239A Pending JP2008538117A (ja) | 2005-03-29 | 2006-03-28 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
| JP2012128022A Pending JP2012162576A (ja) | 2005-03-29 | 2012-06-05 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
| JP2014061270A Pending JP2014122240A (ja) | 2005-03-29 | 2014-03-25 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128022A Pending JP2012162576A (ja) | 2005-03-29 | 2012-06-05 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
| JP2014061270A Pending JP2014122240A (ja) | 2005-03-29 | 2014-03-25 | トリヒドロキシポリ不飽和エイコサノイド誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7582785B2 (enExample) |
| EP (1) | EP1863753B1 (enExample) |
| JP (3) | JP2008538117A (enExample) |
| CN (1) | CN101203481A (enExample) |
| AU (1) | AU2006230136B2 (enExample) |
| BR (1) | BRPI0609767A2 (enExample) |
| CA (1) | CA2603371C (enExample) |
| MX (2) | MX2007012022A (enExample) |
| WO (1) | WO2006105058A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151299A0 (en) * | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
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| US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| DK2216318T3 (en) | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
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| US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| DE60318456T2 (de) | 2002-06-17 | 2008-12-24 | Resolvyx Pharmaceuticals, Bedford | ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHREN |
| DK2216318T3 (en) | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US20060293288A1 (en) | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| KR20150115959A (ko) * | 2007-10-12 | 2015-10-14 | 레솔빅스 파마슈티칼즈, 인코퍼레이티드 | 안과 질환의 치료를 위한 옥실리핀 화합물 |
| WO2010039531A1 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Therapeutic compounds |
| US20120122816A1 (en) * | 2009-02-05 | 2012-05-17 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for organ preservation |
| TW201039815A (en) * | 2009-04-13 | 2010-11-16 | Resolvyx Pharmaceuticals Inc | Compositions and methods for the treatment of inflammation |
-
2005
- 2005-03-29 US US11/093,757 patent/US7582785B2/en not_active Expired - Fee Related
-
2006
- 2006-03-28 MX MX2007012022A patent/MX2007012022A/es active IP Right Grant
- 2006-03-28 WO PCT/US2006/011222 patent/WO2006105058A2/en not_active Ceased
- 2006-03-28 EP EP06748789.2A patent/EP1863753B1/en not_active Not-in-force
- 2006-03-28 AU AU2006230136A patent/AU2006230136B2/en not_active Ceased
- 2006-03-28 CN CNA2006800180987A patent/CN101203481A/zh active Pending
- 2006-03-28 MX MX2014005826A patent/MX352197B/es unknown
- 2006-03-28 CA CA2603371A patent/CA2603371C/en not_active Expired - Fee Related
- 2006-03-28 JP JP2008504239A patent/JP2008538117A/ja active Pending
- 2006-03-28 BR BRPI0609767-7A patent/BRPI0609767A2/pt not_active Application Discontinuation
-
2012
- 2012-06-05 JP JP2012128022A patent/JP2012162576A/ja active Pending
-
2014
- 2014-03-25 JP JP2014061270A patent/JP2014122240A/ja active Pending
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