JP2008536865A5 - - Google Patents
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- Publication number
- JP2008536865A5 JP2008536865A5 JP2008506765A JP2008506765A JP2008536865A5 JP 2008536865 A5 JP2008536865 A5 JP 2008536865A5 JP 2008506765 A JP2008506765 A JP 2008506765A JP 2008506765 A JP2008506765 A JP 2008506765A JP 2008536865 A5 JP2008536865 A5 JP 2008536865A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- egfr
- pharmaceutical
- analog
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 23
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 18
- 229930003448 Vitamin K Natural products 0.000 claims 17
- 235000019168 vitamin K Nutrition 0.000 claims 17
- 239000011712 vitamin K Substances 0.000 claims 17
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 17
- 229940046010 vitamin k Drugs 0.000 claims 17
- 102000001301 EGF receptor Human genes 0.000 claims 16
- 108060006698 EGF receptor Proteins 0.000 claims 16
- 235000012711 vitamin K3 Nutrition 0.000 claims 9
- 239000011652 vitamin K3 Substances 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 229940122907 Phosphatase inhibitor Drugs 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 208000010201 Exanthema Diseases 0.000 claims 6
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims 6
- 201000005884 exanthem Diseases 0.000 claims 6
- 235000019175 phylloquinone Nutrition 0.000 claims 6
- 239000011772 phylloquinone Substances 0.000 claims 6
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims 6
- 229960001898 phytomenadione Drugs 0.000 claims 6
- 206010037844 rash Diseases 0.000 claims 6
- 238000011282 treatment Methods 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 4
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 4
- 206010028124 Mucosal ulceration Diseases 0.000 claims 4
- 206010040943 Skin Ulcer Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 238000011123 anti-EGFR therapy Methods 0.000 claims 4
- 230000030609 dephosphorylation Effects 0.000 claims 4
- 238000006209 dephosphorylation reaction Methods 0.000 claims 4
- 229940116977 epidermal growth factor Drugs 0.000 claims 4
- 208000025865 Ulcer Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 238000011200 topical administration Methods 0.000 claims 3
- 231100000397 ulcer Toxicity 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 229960005395 cetuximab Drugs 0.000 claims 2
- 208000014834 chemotherapy-induced oral mucositis Diseases 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 231100000046 skin rash Toxicity 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108010048999 Transcription Factor 3 Proteins 0.000 claims 1
- 102100038313 Transcription factor E2-alpha Human genes 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical group C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67156305P | 2005-04-15 | 2005-04-15 | |
| PCT/US2006/014158 WO2006113479A2 (en) | 2005-04-15 | 2006-04-12 | Vitamin k for prevention and treatment of skin rash secondary to anti-egfr therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196249A Division JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536865A JP2008536865A (ja) | 2008-09-11 |
| JP2008536865A5 true JP2008536865A5 (https=) | 2009-05-28 |
Family
ID=37115750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506765A Withdrawn JP2008536865A (ja) | 2005-04-15 | 2006-04-12 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
| JP2012196249A Expired - Fee Related JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196249A Expired - Fee Related JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7745494B2 (https=) |
| EP (3) | EP2494965A3 (https=) |
| JP (2) | JP2008536865A (https=) |
| KR (1) | KR101332869B1 (https=) |
| AT (1) | ATE492275T1 (https=) |
| AU (1) | AU2006236633B2 (https=) |
| CA (2) | CA2603785C (https=) |
| CY (1) | CY1111786T1 (https=) |
| DE (1) | DE602006019074D1 (https=) |
| DK (1) | DK1871353T3 (https=) |
| ES (1) | ES2358528T3 (https=) |
| PT (1) | PT1871353E (https=) |
| WO (1) | WO2006113479A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR101332869B1 (ko) * | 2005-04-15 | 2013-11-25 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 항-ｅｇｆｒ 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 ｋ |
| EP2043685B1 (en) * | 2006-07-03 | 2015-12-23 | Genmab A/S | Prevention of rash in patients undergoing anti-egfr therapy |
| US8815953B2 (en) | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| WO2010005989A1 (en) * | 2008-07-09 | 2010-01-14 | Edison Pharmaceuticals, Inc. | Dermatological compositions with anti-aging and skin even-toning properties |
| US20100029784A1 (en) * | 2008-07-30 | 2010-02-04 | Hinman Andrew W | Naphthoquinone compositions with anti-aging, anti-inflammatory and skin even-toning properties |
| JP5765634B2 (ja) | 2008-10-21 | 2015-08-19 | スレッシュホールド ファーマシューティカルズ， インコーポレイテッド | 低酸素活性化型プロドラッグを用いるがんの処置 |
| US20120114745A1 (en) * | 2009-06-26 | 2012-05-10 | Nam-Mew Pui | Method for treating or ameliorating mucocutaneous or ocular toxicities |
| ITPD20100090A1 (it) * | 2010-03-22 | 2011-09-23 | Sanitas Farmaceutici S R L | Formulazione topica per il trattamento di eruzioni cutanee, in particolare conseguenti a trattamenti con farmaci anti egfr |
| CN103347505B (zh) | 2011-02-14 | 2015-02-04 | J-制油株式会社 | 皮肤胶原蛋白增强剂 |
| EP2712613B1 (en) * | 2012-09-28 | 2017-02-08 | Pharmadab d.o.o. | Vitamin K1 and uses thereof |
| US9421297B2 (en) | 2014-04-02 | 2016-08-23 | Adhezion Biomedical, Llc | Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides |
| EP3250180B1 (en) | 2015-01-27 | 2026-03-11 | Lesaffre et Compagnie | Pharmaceutical composition comprising vitamin k2 for use in the treatment or prevention of melanoma |
| WO2019114705A1 (zh) | 2017-12-13 | 2019-06-20 | 上海小午医药科技有限公司 | 一种用于预防或治疗与egfr被抑制相关疾病的方法 |
| CN111989095A (zh) | 2018-04-16 | 2020-11-24 | 上海岸阔医药科技有限公司 | 预防或治疗肿瘤疗法副作用的方法 |
| JP2023132190A (ja) * | 2022-03-10 | 2023-09-22 | 学校法人福岡大学 | ケモカインｃｃｌ５発現抑制剤 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA84119A (en) | 1903-11-06 | 1903-12-01 | Edward M. Haymaker | Cover and strainer for milk pails |
| CA91784A (en) | 1904-10-05 | 1905-02-28 | William Stevenson | Dining and billiard table |
| US3155031A (en) | 1962-03-16 | 1964-11-03 | Babco Products Inc | Printing and digital coding machine |
| US4294852A (en) * | 1973-11-01 | 1981-10-13 | Johnson & Johnson | Skin treating compositions |
| DE3060165D1 (en) | 1979-03-08 | 1982-03-11 | Hoffmann La Roche | Process for the stereospecific preparation of compounds of the vitamin k1- and k2-series, as well as new starting materials for the process |
| JPS6025918A (ja) * | 1983-07-25 | 1985-02-08 | Ajinomoto Co Inc | 脂溶性薬物含有水性液 |
| DE3406497A1 (de) * | 1984-02-23 | 1985-09-05 | Mueller Bernhard Willi Werner | Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung |
| DE3514724A1 (de) | 1985-04-24 | 1986-10-30 | Albin F. Dr. 4200 Oberhausen Jereb | Salbe zur verbeugung und behandlung von augen- und hauterkrankungen |
| JPS62294636A (ja) | 1986-05-21 | 1987-12-22 | Eisai Co Ltd | ２−メチル−１，４−ナフトキノンの製造法 |
| US5180747A (en) * | 1989-02-28 | 1993-01-19 | Nisshin Flour Milling Co., Ltd. | Stabilized fat-soluble vitamin compositions |
| ZA902066B (en) | 1989-04-14 | 1990-12-28 | Minnesota Mining & Mfg | Solid gel external drug delivery system |
| US4966779A (en) * | 1989-12-21 | 1990-10-30 | Basf Corporation | Stable, water miscible emulsion comprising a fat-soluble vitamin |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5155031A (en) | 1990-06-07 | 1992-10-13 | Posner Barry I | Use of pervanadate as an inhibitor of phosphotyrosine phosphatase |
| FR2672288B1 (fr) | 1991-02-06 | 1993-04-23 | Oreal | Nouveaux amides dipeptidiques derivant de la glycyl-serine, utilisables, notamment dans des compositions cosmetiques, pharmaceutiques ou alimentaires. |
| DE4141351A1 (de) * | 1991-12-14 | 1993-06-17 | Basf Ag | Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung |
| US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5643765A (en) | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| CA2117412A1 (en) | 1993-07-26 | 1995-01-27 | Eisai Co., Ltd. | Preparation process of naphthoquinone derivative and intermediate for the preparation thereof |
| US5510391A (en) | 1993-10-22 | 1996-04-23 | Mayapple Holdings, Llc | Method of treating blood vessel disorders of the skin using vitamin K |
| FR2719219B1 (fr) * | 1994-05-02 | 1996-06-21 | Rocher Yves Biolog Vegetale | Composition cosmétique ou pharmaceutique à usage topique comprenant des vésicules lipidiques. |
| US5637741A (en) | 1994-09-27 | 1997-06-10 | Kuraray Co., Ltd. | Process for producing 2-methyl-1,4-naphthoquinone |
| JPH09143042A (ja) * | 1995-11-24 | 1997-06-03 | Lion Corp | 口腔用組成物 |
| AU2804297A (en) | 1996-04-22 | 1997-11-12 | Advanced Polymer Systems Inc. | Method of and composition for treating disorders of the skin using vitamin k |
| KR0178456B1 (ko) * | 1996-04-25 | 1999-05-15 | 김흥기 | 2-메틸-1,4-나프토퀴논(비타민 k3)의 제조방법 |
| SE9601665D0 (sv) * | 1996-04-30 | 1996-04-30 | Bioglan Ab | Biologically active composition |
| US6110891A (en) * | 1996-06-21 | 2000-08-29 | Alizyme Therapeutics Ltd. | Lectin compositions and uses thereof |
| DE19642359A1 (de) * | 1996-10-14 | 1998-04-16 | Basf Ag | Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung |
| US5916749A (en) | 1996-12-13 | 1999-06-29 | Incyte Pharmaceuticals, Inc. | Human phosphatase inhibitor protein |
| US6426078B1 (en) * | 1997-03-17 | 2002-07-30 | Roche Vitamins Inc. | Oil in water microemulsion |
| US6599513B2 (en) * | 1997-05-27 | 2003-07-29 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6372234B1 (en) * | 1997-05-27 | 2002-04-16 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6576660B1 (en) * | 1997-10-31 | 2003-06-10 | Arch Development Corporation | Methods and compositions for regulation of 5-α-reductase activity |
| US6696484B2 (en) * | 1997-10-31 | 2004-02-24 | University Of Chicago Office Of Technology And Intellectual Property | Method and compositions for regulation of 5-alpha reductase activity |
| US6013665A (en) * | 1997-12-16 | 2000-01-11 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
| CA2329160A1 (en) * | 1998-06-11 | 1999-12-16 | University Of Medicine & Dentistry Of New Jersey | Wound treatment through inhibition of adenosine diphosphate ribosyl transferase |
| US6207176B1 (en) * | 1998-09-14 | 2001-03-27 | National Starch And Chemical Investment Holding Corporation | Starch based adhesives for skin cleaning tape |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US6187822B1 (en) * | 1999-06-11 | 2001-02-13 | University Of Medicine & Dentistry Of Nj | Wound treatment through inhibition of adenosine diphosphate ribosyl transferase |
| US6524594B1 (en) * | 1999-06-23 | 2003-02-25 | Johnson & Johnson Consumer Companies, Inc. | Foaming oil gel compositions |
| US7927612B2 (en) * | 2000-01-19 | 2011-04-19 | Baofa Yu | Combinations and methods for treating neoplasms |
| DE10003786A1 (de) | 2000-01-28 | 2001-08-02 | Merck Patent Gmbh | Galenische Formulierung |
| JP2003525243A (ja) * | 2000-02-28 | 2003-08-26 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 炎症性疾患の治療のための組成物及び方法 |
| WO2001067896A2 (de) | 2000-03-17 | 2001-09-20 | Basf Aktiengesellschaft | Verfahren zur herstellung öliger suspensionen wasserlöslicher vitamine |
| MXPA02009176A (es) * | 2000-03-20 | 2004-08-12 | Pfizer Prod Inc | Tratamiento combinado con factor de crecimiento de queratinocito e inhibidor del factor de crecimiento epidermico. |
| US20040047852A1 (en) * | 2001-03-02 | 2004-03-11 | Kennedy Thomas Preston | Method of treating cancer |
| US20020040011A1 (en) | 2000-06-01 | 2002-04-04 | Brown Dennis M. | Naphthoquinone compositions and uses thereof |
| PL342071A1 (en) | 2000-08-18 | 2001-02-12 | Szolomicka Orfinger Irena | Cosmetic cream |
| GB0022079D0 (en) | 2000-09-08 | 2000-10-25 | Inst Of Molecul & Cell Biology | Novel protein tyrosine phosphatase inhibitor |
| US7094431B2 (en) * | 2000-10-12 | 2006-08-22 | Mickey L. Peshoff | Method of healing skin wounds in mammals and a composition therefor |
| US6660306B2 (en) * | 2000-10-12 | 2003-12-09 | Mickey L. Peshoff | Wound healing compound |
| US6774100B2 (en) * | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
| KR100560092B1 (ko) * | 2000-12-15 | 2006-03-10 | 파트릭 프랑케 | 저알레르기성 및 비자극성 피부 보호 제제 |
| EP1214930B1 (en) | 2000-12-15 | 2004-03-31 | Patrick Dr. Franke | Hypoallergenic and non-irritant skin care formulations |
| US6780439B2 (en) * | 2001-03-06 | 2004-08-24 | J. Ronald Wilk | Wound treatment solution and method for using same |
| US6579994B2 (en) | 2001-03-29 | 2003-06-17 | Council Of Scientific And Industrial Research | Process for preparation of 2-Methyl-1,4-naphthoquinone |
| AU2002361550A1 (en) * | 2001-07-20 | 2003-04-22 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US6812220B2 (en) | 2001-08-29 | 2004-11-02 | University Of British Columbia | Pharmaceutical compositions and methods relating to fucans |
| US20070238697A1 (en) * | 2001-08-29 | 2007-10-11 | University Of British Columbia | Pharmaceutical compositions and methods relating to fucans |
| US8156471B2 (en) * | 2001-11-09 | 2012-04-10 | Oracle International Corporation | Multi-language execution method |
| US7405188B2 (en) * | 2001-12-12 | 2008-07-29 | Wsp Chemicals & Technology, Llc | Polymeric gel system and compositions for treating keratin substrates containing same |
| JP4502641B2 (ja) * | 2002-01-24 | 2010-07-14 | ティルタン ファーマ リミテッド | 抗癌組み合わせおよびその使用方法 |
| JP2003226639A (ja) * | 2002-01-31 | 2003-08-12 | Hisamitsu Pharmaceut Co Inc | 神経成長因子活性増強剤としてのビタミンｋ類を含む医薬組成物およびその使用 |
| US20030170187A1 (en) | 2002-03-01 | 2003-09-11 | Alfred Marchal | Skin treatments containing nano-sized vitamin K |
| GB0212749D0 (en) * | 2002-06-01 | 2002-07-10 | Boots Co Plc | Personal care compositions |
| GB0220182D0 (en) | 2002-08-30 | 2002-10-09 | Cardiovascular Res Inst Maastr | Organic compounds |
| US7326690B2 (en) * | 2002-10-30 | 2008-02-05 | Bach Pharma, Inc. | Modulation of cell fates and activities by phthalazinediones |
| AU2003230980A1 (en) * | 2003-04-18 | 2004-11-26 | Northeastern University | Micelle delivery system loaded with a pharmaceutical agent |
| JP2005020651A (ja) | 2003-06-30 | 2005-01-20 | Hitachi Ltd | タイムスタンプ情報検証方法 |
| US7320797B2 (en) * | 2003-08-29 | 2008-01-22 | Bioderm Research | Antiaging cosmetic delivery systems |
| BRPI0414907A (pt) | 2003-09-30 | 2006-11-07 | Acusphere Inc | formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas |
| US20050092969A1 (en) * | 2003-10-08 | 2005-05-05 | Kaneka Corporation | Method of stabilizing compound having quinone skeleton and stabilized composition |
| JP2005206521A (ja) | 2004-01-22 | 2005-08-04 | Nippon Menaade Keshohin Kk | 抗菌剤 |
| KR20060002239A (ko) * | 2004-07-01 | 2006-01-09 | 삼성전자주식회사 | 레이저 출력 제어장치 |
| CA2584528A1 (en) | 2004-09-17 | 2006-03-23 | Oystershell Nv | Composition for inhibiting or preventing the formation of a biofilm |
| CA2583315A1 (en) | 2004-10-06 | 2006-06-01 | Tiltan Pharma Ltd. | Method and composition for enhancing anti-angiogenic therapy |
| WO2006107827A1 (en) | 2005-04-05 | 2006-10-12 | Creighton University | Skin bonding process |
| KR101332869B1 (ko) * | 2005-04-15 | 2013-11-25 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 항-ｅｇｆｒ 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 ｋ |
| US20060275504A1 (en) * | 2005-06-07 | 2006-12-07 | Tty Biopharm Company Limited | Methods and compositions for augmenting cancer chemotherapeutic agents |
| US20070025950A1 (en) * | 2005-07-28 | 2007-02-01 | Elson Melvin L | Composition and method for treating cellulite |
| US7252816B1 (en) * | 2006-03-29 | 2007-08-07 | Dow Pharmaceutical Sciences | Topical acne vulgairs medication with a sunscreen |
| WO2007147128A2 (en) | 2006-06-16 | 2007-12-21 | Summa Health System | Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone |
| US7838513B2 (en) | 2006-07-07 | 2010-11-23 | Tiltan Pharma Ltd. | Anti-cancer therapy comprising an H2-blocker, at least one antiinflammatory agent and a cytotoxic agent |
-
2006
- 2006-04-12 KR KR1020077026480A patent/KR101332869B1/ko not_active Expired - Fee Related
- 2006-04-12 CA CA2603785A patent/CA2603785C/en not_active Expired - Fee Related
- 2006-04-12 JP JP2008506765A patent/JP2008536865A/ja not_active Withdrawn
- 2006-04-12 AT AT06750246T patent/ATE492275T1/de active
- 2006-04-12 PT PT06750246T patent/PT1871353E/pt unknown
- 2006-04-12 EP EP11189225A patent/EP2494965A3/en not_active Withdrawn
- 2006-04-12 US US11/886,803 patent/US7745494B2/en not_active Expired - Fee Related
- 2006-04-12 AU AU2006236633A patent/AU2006236633B2/en not_active Ceased
- 2006-04-12 EP EP10195772.8A patent/EP2305224B1/en not_active Expired - Lifetime
- 2006-04-12 ES ES06750246T patent/ES2358528T3/es not_active Expired - Lifetime
- 2006-04-12 EP EP06750246A patent/EP1871353B1/en not_active Expired - Lifetime
- 2006-04-12 CA CA2851079A patent/CA2851079A1/en not_active Abandoned
- 2006-04-12 WO PCT/US2006/014158 patent/WO2006113479A2/en not_active Ceased
- 2006-04-12 DE DE602006019074T patent/DE602006019074D1/de not_active Expired - Lifetime
- 2006-04-12 DK DK06750246.8T patent/DK1871353T3/da active
-
2009
- 2009-05-14 US US12/465,980 patent/US20090239952A1/en not_active Abandoned
-
2010
- 2010-05-26 US US12/788,015 patent/US8283382B2/en not_active Expired - Fee Related
-
2011
- 2011-03-16 CY CY20111100295T patent/CY1111786T1/el unknown
-
2012
- 2012-09-06 JP JP2012196249A patent/JP5620443B2/ja not_active Expired - Fee Related
- 2012-09-20 US US13/623,625 patent/US20130225690A1/en not_active Abandoned
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