JP2008534467A5 - - Google Patents
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- JP2008534467A5 JP2008534467A5 JP2008502346A JP2008502346A JP2008534467A5 JP 2008534467 A5 JP2008534467 A5 JP 2008534467A5 JP 2008502346 A JP2008502346 A JP 2008502346A JP 2008502346 A JP2008502346 A JP 2008502346A JP 2008534467 A5 JP2008534467 A5 JP 2008534467A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antigen
- immunogenic composition
- oil
- immunogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 48
- 239000000427 antigen Substances 0.000 claims 24
- 102000036639 antigens Human genes 0.000 claims 24
- 108091007433 antigens Proteins 0.000 claims 24
- 230000002163 immunogen Effects 0.000 claims 24
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 10
- 239000007764 o/w emulsion Substances 0.000 claims 9
- 230000000890 antigenic effect Effects 0.000 claims 8
- 239000002671 adjuvant Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 229940087168 alpha tocopherol Drugs 0.000 claims 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 5
- 229920000053 polysorbate 80 Polymers 0.000 claims 5
- 229960000984 tocofersolan Drugs 0.000 claims 5
- 235000004835 α-tocopherol Nutrition 0.000 claims 5
- 239000002076 α-tocopherol Substances 0.000 claims 5
- 244000052769 pathogen Species 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003995 emulsifying agent Substances 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 3
- 238000012770 revaccination Methods 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229930182558 Sterol Natural products 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229940031439 squalene Drugs 0.000 claims 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- 206010059313 Anogenital warts Diseases 0.000 claims 1
- 208000000907 Condylomata Acuminata Diseases 0.000 claims 1
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 claims 1
- 201000004201 anogenital venereal wart Diseases 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 231100000590 oncogenic Toxicity 0.000 claims 1
- 230000002246 oncogenic effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
- 239000000277 virosome Substances 0.000 claims 1
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0505998A GB0505998D0 (en) | 2005-03-23 | 2005-03-23 | Novel compositions |
| GB0506004A GB0506004D0 (en) | 2005-03-23 | 2005-03-23 | Compositions |
| GB0506001A GB0506001D0 (en) | 2005-03-23 | 2005-03-23 | Novel use |
| GB0506000A GB0506000D0 (en) | 2005-03-23 | 2005-03-23 | Novel use |
| GB0505989A GB0505989D0 (en) | 2005-03-23 | 2005-03-23 | Compositions |
| GB0510598A GB0510598D0 (en) | 2005-05-24 | 2005-05-24 | Composition |
| GB0510591A GB0510591D0 (en) | 2005-05-24 | 2005-05-24 | Novel use |
| GB0510593A GB0510593D0 (en) | 2005-05-24 | 2005-05-24 | Novel compositions |
| GB0510589A GB0510589D0 (en) | 2005-05-24 | 2005-05-24 | Novel use |
| GB0510596A GB0510596D0 (en) | 2005-05-24 | 2005-05-24 | Composition |
| GB0603790A GB0603790D0 (en) | 2006-02-24 | 2006-02-24 | Composition |
| GB0603789A GB0603789D0 (en) | 2006-02-24 | 2006-02-24 | Novel use |
| GB0603788A GB0603788D0 (en) | 2006-02-24 | 2006-02-24 | Novel composition |
| PCT/EP2006/002838 WO2006100111A1 (en) | 2005-03-23 | 2006-03-21 | Composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008534467A JP2008534467A (ja) | 2008-08-28 |
| JP2008534467A5 true JP2008534467A5 (OSRAM) | 2008-12-25 |
Family
ID=36441219
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502345A Expired - Fee Related JP5770414B2 (ja) | 2005-03-23 | 2006-03-21 | 新規組成物 |
| JP2008502344A Expired - Fee Related JP5869744B2 (ja) | 2005-03-23 | 2006-03-21 | Cd4t細胞および/または改善された記憶b細胞応答を誘導するためのインフルエンザウイルスおよび水中油型エマルジョンアジュバントの使用 |
| JP2008502346A Pending JP2008534467A (ja) | 2005-03-23 | 2006-03-21 | 組成物 |
| JP2014016254A Pending JP2014129359A (ja) | 2005-03-23 | 2014-01-31 | Cd4t細胞および/または改善された記憶b細胞応答を誘導するためのインフルエンザウイルスおよび水中油型エマルジョンアジュバントの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502345A Expired - Fee Related JP5770414B2 (ja) | 2005-03-23 | 2006-03-21 | 新規組成物 |
| JP2008502344A Expired - Fee Related JP5869744B2 (ja) | 2005-03-23 | 2006-03-21 | Cd4t細胞および/または改善された記憶b細胞応答を誘導するためのインフルエンザウイルスおよび水中油型エマルジョンアジュバントの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016254A Pending JP2014129359A (ja) | 2005-03-23 | 2014-01-31 | Cd4t細胞および/または改善された記憶b細胞応答を誘導するためのインフルエンザウイルスおよび水中油型エマルジョンアジュバントの使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20090081253A1 (OSRAM) |
| EP (4) | EP2397153A1 (OSRAM) |
| JP (4) | JP5770414B2 (OSRAM) |
| KR (5) | KR20160064249A (OSRAM) |
| AR (3) | AR054020A1 (OSRAM) |
| AU (3) | AU2006226458B2 (OSRAM) |
| CA (3) | CA2603180C (OSRAM) |
| CY (1) | CY1117874T1 (OSRAM) |
| DK (1) | DK1861120T3 (OSRAM) |
| EA (3) | EA011393B1 (OSRAM) |
| ES (1) | ES2585810T3 (OSRAM) |
| HR (1) | HRP20160816T1 (OSRAM) |
| HU (1) | HUE027837T2 (OSRAM) |
| IL (3) | IL185906A0 (OSRAM) |
| MA (3) | MA30298B1 (OSRAM) |
| MX (3) | MX2007011775A (OSRAM) |
| NO (3) | NO20074638L (OSRAM) |
| NZ (2) | NZ561822A (OSRAM) |
| PE (3) | PE20061428A1 (OSRAM) |
| PL (1) | PL1861120T3 (OSRAM) |
| PT (1) | PT1861120T (OSRAM) |
| SI (1) | SI1861120T1 (OSRAM) |
| TW (3) | TW200700079A (OSRAM) |
| WO (3) | WO2006100111A1 (OSRAM) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1154790E (pt) * | 1999-02-26 | 2005-03-31 | Chiron Srl | Reforco da actividade bactericida de antigenios contra a neisseria com oligonucleotidos contendo motivos cg |
| GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| US20100221284A1 (en) * | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| PE20061428A1 (es) | 2005-03-23 | 2007-01-16 | Glaxosmithkline Biolog Sa | Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628152C (en) * | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| PT1951300E (pt) | 2005-11-04 | 2011-09-05 | Novartis Vaccines & Diagnostic | Modificação do equilíbrio de th1/th2 em vacinas da influenza fragmentadas com adjuvantes |
| NZ568210A (en) * | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
| CN102755645A (zh) * | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| FR2896162B1 (fr) * | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| US20070224205A1 (en) | 2006-03-07 | 2007-09-27 | Powell Thomas J | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| JP2009534303A (ja) * | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| EP2032163B1 (en) * | 2006-06-15 | 2013-01-23 | Novartis AG | Adjuvant-sparing multi-dose influenza vaccination regimen |
| CA2583555C (en) * | 2006-07-17 | 2020-01-07 | Glaxosmithkline Biologicals S.A. | Influenza vaccine |
| MX2009000660A (es) * | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
| BRPI0621886B1 (pt) * | 2006-07-17 | 2021-09-21 | Glaxosmithkline Biologicals S.A | Composição de vacina contra influenza monovalente, kit, método para a produção de uma composição de vacina contra influenza para uma situação pandêmica ou uma situação pré- pandêmica, e, usos de um antígeno de vírus da influenza ou preparação antigênica do mesmo e de um adjuvante em emulsão óleo-em-água, de um antígeno de vírus da influenza pandêmica ou preparação antigênica do antígeno de hemaglutinina do vírus da influenza e de um adjuvante em emulsão óleo-em-água e de um antígeno ou preparação antigênica de uma primeira cepa de influenza |
| WO2008043774A1 (en) * | 2006-10-12 | 2008-04-17 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
| PL2086582T3 (pl) * | 2006-10-12 | 2013-04-30 | Glaxosmithkline Biologicals Sa | Kompozycja zawierająca adiuwant w postaci emulsji typu olej w wodzie |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| EP1923070A1 (en) * | 2006-11-15 | 2008-05-21 | Intervet International BV | Vaccine for vaccinating feline against influenza virus |
| AU2007330494B2 (en) * | 2006-12-06 | 2014-03-13 | Seqirus UK Limited | Vaccines including antigen from four strains of influenza virus |
| EP1938835A1 (en) * | 2006-12-29 | 2008-07-02 | Pevion Biotech AG | Non-specific immunostimulating agents |
| NZ603245A (en) * | 2007-02-23 | 2014-04-30 | Baylor Res Inst | Therapeutic applications of activation of human antigen-presenting cells through dectin-1 |
| US9452209B2 (en) * | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
| SG185294A1 (en) * | 2007-10-12 | 2012-11-29 | Csl Ltd | Method of eliciting an immune response against pandemic influenza virus |
| CA2702871A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| GB0810305D0 (en) † | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| CA2707247A1 (en) * | 2007-12-06 | 2009-06-11 | Glaxosmithkline Biologicals S.A. | Influenza composition |
| TWI376385B (en) * | 2007-12-07 | 2012-11-11 | Nat Health Research Institutes | Production of lipidated proteins in e. coli |
| US8466259B2 (en) * | 2007-12-07 | 2013-06-18 | National Health Research Institutes | Adjuvants |
| EA201071086A1 (ru) * | 2008-03-18 | 2011-04-29 | Новартис Аг | Усовершенствованный способ получения вакцинных антигенов вируса гриппа |
| JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
| GB0905570D0 (en) * | 2009-03-31 | 2009-05-13 | Novartis Ag | Combined vaccines |
| US9421251B2 (en) | 2008-06-25 | 2016-08-23 | Novartis Ag | Rapid responses to delayed booster immunisations |
| US9278126B2 (en) | 2009-02-10 | 2016-03-08 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| AU2010212547B2 (en) | 2009-02-10 | 2015-03-12 | Seqirus UK Limited | Influenza vaccine regimens for pandemic-associated strains |
| AU2015203072B2 (en) * | 2009-02-10 | 2017-05-25 | Seqirus UK Limited | Influenza vaccine regimens for pandemic-associated strains |
| US8287880B2 (en) * | 2009-06-02 | 2012-10-16 | National Health Research Institutes | Lipidated vaccine against dengue virus infection |
| CN102482327B (zh) * | 2009-06-22 | 2014-10-29 | 财团法人卫生研究院 | 脂质化肿瘤相关抗原及其免疫治疗的组成物及方法 |
| EP2289575B1 (de) * | 2009-08-06 | 2017-07-05 | Biotronik VI Patent AG | Medizinisches Implantat enthaltend eine antioxidative Substanz |
| CN102573802A (zh) * | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| EP2308506A1 (en) * | 2009-10-02 | 2011-04-13 | Mucosis B.V. | Adjuvanted intranasal vaccine formulations |
| GB0918830D0 (en) | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
| DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| RS52565B (sr) * | 2009-12-03 | 2013-04-30 | Novartis Ag | Metod interakcije i komore sa povratnim pritiskom za mikrofluidizaciju |
| JP5820390B2 (ja) | 2009-12-03 | 2015-11-24 | ノバルティス アーゲー | エマルジョンの微小流動化中および/または均質化中における成分の循環 |
| KR101616735B1 (ko) * | 2009-12-03 | 2016-04-29 | 노파르티스 아게 | 백신 보조제 제조 중의 친수성 여과 |
| AU2013202690B2 (en) * | 2009-12-03 | 2016-02-11 | Seqirus UK Limited | Hydrophilic filtration during manufacture of vaccine adjuvants |
| DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| JP5894083B2 (ja) * | 2009-12-22 | 2016-03-23 | サノフィ パストゥール リミテッドSanofi Pasteur Limited | 免疫原性組成物 |
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| WO2011088451A1 (en) * | 2010-01-15 | 2011-07-21 | Novavax, Inc. | Uses of influenza virus-like particles (vlps) for characterization of neuraminidase and hemagglutinin activity |
| RU2527688C2 (ru) * | 2010-02-27 | 2014-09-10 | Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" | Способ лечения инфекционных заболеваний, вызванных вирусом гриппа с типом поверхностого антигена н1n1 и лекарственное средство для лечения инфекционных заболеваний, вызванных вирусом гриппа с типом поверхностного антигена н1n1 |
| GB201009673D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009671D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009676D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| US9821051B1 (en) | 2010-10-28 | 2017-11-21 | Seqirus UK Limited | Reducing hospitalization in elderly influenza vaccine recipients |
| TWI507413B (zh) * | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
| TW201221642A (en) | 2010-11-15 | 2012-06-01 | Nat Health Research Institutes | Method of producing lipidated polypeptides |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| MX371154B (es) * | 2012-12-28 | 2020-01-20 | Japan As Represented By Director General Of Nat Institute Of Infectious Diseases | Composicion nasal de vacuna para la influenza. |
| SG11201509265SA (en) * | 2013-05-10 | 2015-12-30 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
| US10080792B2 (en) * | 2013-09-23 | 2018-09-25 | Engen Bio, Inc. | Influenza vaccine and therapy |
| CN104436157A (zh) * | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
| AU2015323334B2 (en) | 2014-09-26 | 2021-02-25 | Seqirus UK Limited | Vaccination of immunocompromised subjects |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| US20200306364A1 (en) * | 2017-11-30 | 2020-10-01 | Ohio State Innovation Foundation | Mucoadhesive nanoparticle entrapped influenza virus vaccine delivery system |
| EP3917567A1 (en) | 2019-01-30 | 2021-12-08 | GlaxoSmithKline Biologicals SA | Oil/surfactant mixtures for self-emulsification |
| EP4076384B9 (de) * | 2019-12-20 | 2025-10-22 | Fresenius Kabi Austria GmbH | Verfahren zur herstellung von öl-in-wasser-emulsionen |
| RU2741003C1 (ru) * | 2020-03-27 | 2021-01-22 | Евгений Дмитриевич Некрасов | Способ производства четырехвалентной субъединичной вакцины против гриппа без адъювантов |
| WO2022002783A1 (en) | 2020-06-29 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Adjuvants |
| IL300632A (en) | 2020-08-24 | 2023-04-01 | Sanofi Pasteur Inc | Vaccines against SARS-COV-2 infections |
| AU2021330836A1 (en) | 2020-08-24 | 2023-05-04 | Glaxosmithkline Biologicals Sa | Covid-19 vaccines with tocopherol-containing squalene emulsion adjuvants |
| KR102270165B1 (ko) | 2020-10-22 | 2021-06-28 | 한국화학연구원 | 세정제 조성물 |
| EP4313137A1 (en) | 2021-03-26 | 2024-02-07 | GlaxoSmithKline Biologicals SA | Immunogenic compositions |
| WO2023274860A1 (en) | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
| RU2766292C1 (ru) * | 2021-08-05 | 2022-03-14 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства (ФГУП СПбНИИВС ФМБА России) | Состав вакцины против covid-19 |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023061993A1 (en) | 2021-10-13 | 2023-04-20 | Glaxosmithkline Biologicals Sa | Polypeptides |
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