JP2008533986A - 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用 - Google Patents
変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
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| US66496705P | 2005-03-25 | 2005-03-25 | |
| US69891905P | 2005-07-14 | 2005-07-14 | |
| PCT/IL2006/000372 WO2006100681A2 (en) | 2005-03-25 | 2006-03-23 | Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses |
Publications (2)
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| JP2008533986A true JP2008533986A (ja) | 2008-08-28 |
| JP2008533986A5 JP2008533986A5 (enExample) | 2009-03-12 |
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| US (2) | US8039594B2 (enExample) |
| EP (1) | EP1863846B1 (enExample) |
| JP (1) | JP2008533986A (enExample) |
| AT (1) | ATE437185T1 (enExample) |
| DE (1) | DE602006007967D1 (enExample) |
| WO (1) | WO2006100681A2 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018513135A (ja) * | 2015-03-23 | 2018-05-24 | ザ ジョンズ ホプキンス ユニバーシティー | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JPWO2018092725A1 (ja) * | 2016-11-15 | 2019-10-17 | 学校法人東京理科大学 | ｐ５３分解誘導分子及び医薬組成物 |
| JP2019535241A (ja) * | 2016-10-17 | 2019-12-12 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 抗ｐ５３抗体 |
| US10976306B2 (en) | 2015-06-19 | 2021-04-13 | Tokyo University Of Science Foundation | Protein degradation inducing tag and usage thereof |
| US11052154B2 (en) | 2016-11-15 | 2021-07-06 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008533986A (ja) | 2005-03-25 | 2008-08-28 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用 |
| CN101553567A (zh) * | 2006-07-21 | 2009-10-07 | 台拉维夫大学拉莫特 | 抑制或治疗与细胞内形成蛋白纤维状内含体或聚集体相关的疾病的方法 |
| US20100196403A1 (en) * | 2007-01-29 | 2010-08-05 | Jacob Hochman | Antibody conjugates for circumventing multi-drug resistance |
| CA2705353C (en) * | 2007-11-14 | 2017-07-25 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Methods of treating cancer using anti cd24 antibodies |
| IL208820A0 (en) * | 2010-10-19 | 2011-01-31 | Rachel Teitelbaum | Biologic female contraceptives |
| EP2573565A1 (en) | 2011-09-23 | 2013-03-27 | Gerhard Matthias Kresbach | Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method |
| WO2023060115A1 (en) * | 2021-10-05 | 2023-04-13 | The Penn State Research Foundation | Methods for treating cancers with mutated p53 |
| WO2024015653A1 (en) * | 2022-07-10 | 2024-01-18 | Mbrace Therapeutics, Inc. | Cell-free methods of recombinant antibody production |
| CN115876993B (zh) * | 2022-11-17 | 2024-10-15 | 沈阳农业大学 | 基于生物膜干涉技术检测病原生物凝集素与唾液酸乳糖亲和力方法的建立 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001502553A (ja) * | 1996-10-29 | 2001-02-27 | ローヌ―プーラン・ロレ・エス・アー | 抗ｐ５３一本鎖抗体フラグメント及びその使用 |
| WO2001068801A2 (en) * | 2000-03-16 | 2001-09-20 | Ramot At Tel-Aviv University Ltd. | Single chain antibody against mutant p53 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008533986A (ja) | 2005-03-25 | 2008-08-28 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用 |
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2006
- 2006-03-23 JP JP2008502560A patent/JP2008533986A/ja active Pending
- 2006-03-23 EP EP06711342A patent/EP1863846B1/en not_active Not-in-force
- 2006-03-23 AT AT06711342T patent/ATE437185T1/de not_active IP Right Cessation
- 2006-03-23 DE DE602006007967T patent/DE602006007967D1/de active Active
- 2006-03-23 WO PCT/IL2006/000372 patent/WO2006100681A2/en not_active Ceased
- 2006-03-23 US US11/887,123 patent/US8039594B2/en not_active Expired - Fee Related
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2011
- 2011-07-12 US US13/180,581 patent/US8207309B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001502553A (ja) * | 1996-10-29 | 2001-02-27 | ローヌ―プーラン・ロレ・エス・アー | 抗ｐ５３一本鎖抗体フラグメント及びその使用 |
| WO2001068801A2 (en) * | 2000-03-16 | 2001-09-20 | Ramot At Tel-Aviv University Ltd. | Single chain antibody against mutant p53 |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018513135A (ja) * | 2015-03-23 | 2018-05-24 | ザ ジョンズ ホプキンス ユニバーシティー | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2021121190A (ja) * | 2015-03-23 | 2021-08-26 | ザ ジョンズ ホプキンス ユニバーシティー | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2023085528A (ja) * | 2015-03-23 | 2023-06-20 | ザ ジョンズ ホプキンス ユニバーシティー | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP7304911B2 (ja) | 2015-03-23 | 2023-07-07 | ザ ジョンズ ホプキンス ユニバーシティー | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| US10976306B2 (en) | 2015-06-19 | 2021-04-13 | Tokyo University Of Science Foundation | Protein degradation inducing tag and usage thereof |
| JP2019535241A (ja) * | 2016-10-17 | 2019-12-12 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 抗ｐ５３抗体 |
| JP7173964B2 (ja) | 2016-10-17 | 2022-11-16 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 抗ｐ５３抗体 |
| JPWO2018092725A1 (ja) * | 2016-11-15 | 2019-10-17 | 学校法人東京理科大学 | ｐ５３分解誘導分子及び医薬組成物 |
| US11007269B2 (en) | 2016-11-15 | 2021-05-18 | Tokyo University Of Science Foundation | P53 degradation inducing molecule and pharmaceutical composition |
| US11052154B2 (en) | 2016-11-15 | 2021-07-06 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| JP7061801B2 (ja) | 2016-11-15 | 2022-05-02 | 学校法人東京理科大学 | ｐ５３分解誘導分子及び医薬組成物 |
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
Also Published As
| Publication number | Publication date |
|---|---|
| US8039594B2 (en) | 2011-10-18 |
| US8207309B2 (en) | 2012-06-26 |
| US20110262447A1 (en) | 2011-10-27 |
| WO2006100681A2 (en) | 2006-09-28 |
| WO2006100681A3 (en) | 2007-05-24 |
| EP1863846B1 (en) | 2009-07-22 |
| DE602006007967D1 (de) | 2009-09-03 |
| ATE437185T1 (de) | 2009-08-15 |
| EP1863846A2 (en) | 2007-12-12 |
| US20100074908A1 (en) | 2010-03-25 |
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