ATE437185T1 - Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon - Google Patents

Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon

Info

Publication number
ATE437185T1
ATE437185T1 AT06711342T AT06711342T ATE437185T1 AT E437185 T1 ATE437185 T1 AT E437185T1 AT 06711342 T AT06711342 T AT 06711342T AT 06711342 T AT06711342 T AT 06711342T AT E437185 T1 ATE437185 T1 AT E437185T1
Authority
AT
Austria
Prior art keywords
mutant
applications
single chain
directed against
chain antibodies
Prior art date
Application number
AT06711342T
Other languages
German (de)
English (en)
Inventor
Beka Solomon
Sara Orgad
Itai Benhar
Ronit Rosenfeld
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Application granted granted Critical
Publication of ATE437185T1 publication Critical patent/ATE437185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06711342T 2005-03-25 2006-03-23 Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon ATE437185T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66496705P 2005-03-25 2005-03-25
US69891905P 2005-07-14 2005-07-14
PCT/IL2006/000372 WO2006100681A2 (en) 2005-03-25 2006-03-23 Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses

Publications (1)

Publication Number Publication Date
ATE437185T1 true ATE437185T1 (de) 2009-08-15

Family

ID=36617330

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06711342T ATE437185T1 (de) 2005-03-25 2006-03-23 Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon

Country Status (6)

Country Link
US (2) US8039594B2 (enExample)
EP (1) EP1863846B1 (enExample)
JP (1) JP2008533986A (enExample)
AT (1) ATE437185T1 (enExample)
DE (1) DE602006007967D1 (enExample)
WO (1) WO2006100681A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008533986A (ja) 2005-03-25 2008-08-28 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用
CN101553567A (zh) * 2006-07-21 2009-10-07 台拉维夫大学拉莫特 抑制或治疗与细胞内形成蛋白纤维状内含体或聚集体相关的疾病的方法
US20100196403A1 (en) * 2007-01-29 2010-08-05 Jacob Hochman Antibody conjugates for circumventing multi-drug resistance
CA2705353C (en) * 2007-11-14 2017-07-25 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Methods of treating cancer using anti cd24 antibodies
IL208820A0 (en) * 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives
EP2573565A1 (en) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method
EP3286222A4 (en) * 2015-03-23 2018-08-08 The Johns Hopkins University Hla-restricted epitopes encoded by somatically mutated genes
BR112017027246A2 (pt) 2015-06-19 2018-08-28 Miyamoto Etsuko marcador de indução de degradação de proteína e uso do mesmo
GB201617564D0 (en) 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
JP7061801B2 (ja) * 2016-11-15 2022-05-02 学校法人東京理科大学 ｐ５３分解誘導分子及び医薬組成物
JP7061800B2 (ja) 2016-11-15 2022-05-02 学校法人東京理科大学 Ｒａｓタンパク質分解誘導分子及び医薬組成物
EP3635000A4 (en) 2017-05-16 2021-04-14 The Johns Hopkins University Manabodies and methods of using
WO2023060115A1 (en) * 2021-10-05 2023-04-13 The Penn State Research Foundation Methods for treating cancers with mutated p53
WO2024015653A1 (en) * 2022-07-10 2024-01-18 Mbrace Therapeutics, Inc. Cell-free methods of recombinant antibody production
CN115876993B (zh) * 2022-11-17 2024-10-15 沈阳农业大学 基于生物膜干涉技术检测病原生物凝集素与唾液酸乳糖亲和力方法的建立

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
JP2008533986A (ja) 2005-03-25 2008-08-28 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用

Also Published As

Publication number Publication date
US8039594B2 (en) 2011-10-18
US8207309B2 (en) 2012-06-26
US20110262447A1 (en) 2011-10-27
WO2006100681A2 (en) 2006-09-28
WO2006100681A3 (en) 2007-05-24
EP1863846B1 (en) 2009-07-22
JP2008533986A (ja) 2008-08-28
DE602006007967D1 (de) 2009-09-03
EP1863846A2 (en) 2007-12-12
US20100074908A1 (en) 2010-03-25

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