JP2008531734A5 - - Google Patents
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- JP2008531734A5 JP2008531734A5 JP2007558320A JP2007558320A JP2008531734A5 JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5 JP 2007558320 A JP2007558320 A JP 2007558320A JP 2007558320 A JP2007558320 A JP 2007558320A JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- substituted
- alkyl
- Prior art date
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Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65865405P | 2005-03-03 | 2005-03-03 | |
| US60/658,654 | 2005-03-03 | ||
| US67708905P | 2005-05-02 | 2005-05-02 | |
| US60/677,089 | 2005-05-02 | ||
| PCT/US2006/007865 WO2006094269A2 (en) | 2005-03-03 | 2006-03-03 | Anti-angiogenic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228959A Division JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531734A JP2008531734A (ja) | 2008-08-14 |
| JP2008531734A5 true JP2008531734A5 (enExample) | 2011-03-03 |
| JP5167473B2 JP5167473B2 (ja) | 2013-03-21 |
Family
ID=36941895
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558320A Expired - Fee Related JP5167473B2 (ja) | 2005-03-03 | 2006-03-03 | 抗血管新生化合物 |
| JP2012228959A Pending JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228959A Pending JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7521425B2 (enExample) |
| EP (2) | EP2292248A3 (enExample) |
| JP (2) | JP5167473B2 (enExample) |
| KR (1) | KR101373140B1 (enExample) |
| CA (1) | CA2598833A1 (enExample) |
| WO (1) | WO2006094269A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040058229A (ko) * | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| JP5167473B2 (ja) * | 2005-03-03 | 2013-03-21 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管新生化合物 |
| AU2011254001B2 (en) * | 2007-01-05 | 2012-08-02 | Covx Technologies Ireland Limited | Glucagon-like protein-1 receptor (GLP-1R) agonist compounds |
| US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| US8293714B2 (en) | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| CN102076331B (zh) | 2008-06-26 | 2013-12-18 | 普罗林科斯有限责任公司 | 具有可控的药物释放速率的前药和药物-大分子轭合物 |
| JP2012517447A (ja) | 2009-02-10 | 2012-08-02 | ザ スクリプス リサーチ インスティチュート | 化学的にプログラムされたワクチン接種法 |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2011094671A2 (en) * | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
| EP2569336A1 (en) | 2010-05-14 | 2013-03-20 | Amgen Inc. | Enhanced death receptor agonists |
| SG186451A1 (en) | 2010-07-12 | 2013-01-30 | Covx Technologies Ireland Ltd | Multifunctional antibody conjugates |
| SG190082A1 (en) | 2010-11-05 | 2013-06-28 | Covx Technologies Ireland Ltd | Anti-diabetic compounds |
| JP2014502607A (ja) | 2011-01-03 | 2014-02-03 | エフ.ホフマン−ラ ロシュ アーゲー | 抗dig抗体およびペプチドと結合体化しているジゴキシゲニンの複合体の薬学的組成物 |
| EP2780039B9 (en) | 2011-11-17 | 2018-04-18 | Pfizer Inc | Cytotoxic peptides and antibody drug conjugates thereof |
| SG11201403324TA (en) * | 2011-12-20 | 2014-07-30 | Pfizer | Improved processes for preparing peptide conjugates and linkers |
| JP6165168B2 (ja) * | 2011-12-22 | 2017-07-19 | ファイザー・インク | 抗糖尿病化合物 |
| EP3539982B1 (en) | 2011-12-23 | 2025-02-19 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| US20130323234A1 (en) | 2012-01-09 | 2013-12-05 | Covx Technologies Ireland Limited | Mutant antibodies and conjugation thereof |
| WO2013148877A1 (en) | 2012-03-28 | 2013-10-03 | Amgen Inc. | Dr5 receptor agonist combinations |
| MX340090B (es) | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| TW201726746A (zh) | 2012-11-07 | 2017-08-01 | 輝瑞股份有限公司 | 抗切口3(anti-notch3)抗體及抗體-藥物共軛體 |
| SG11201605437YA (en) | 2014-01-27 | 2016-08-30 | Pfizer | Bifunctional cytotoxic agents |
| WO2016110662A1 (en) * | 2015-01-09 | 2016-07-14 | Ipsen Bioinnovation Limited | Cationic neurotoxins |
| KR102046862B1 (ko) | 2015-03-20 | 2019-11-20 | 화이자 인코포레이티드 | Cti 약물작용발생단을 함유하는 이관능성 세포독성제 |
| ES2878008T3 (es) * | 2015-09-17 | 2021-11-18 | Scripps Research Inst | Inmunoconjugados de dominio variable dual y usos de los mismos |
| US10689458B2 (en) | 2015-11-30 | 2020-06-23 | Pfizer Inc. | Site specific HER2 antibody drug conjugates |
| CA3012960A1 (en) | 2016-02-01 | 2017-08-10 | Pfizer Inc. | Tubulysin analogs and methods for their preparation |
| CA3061467A1 (en) | 2017-04-28 | 2019-10-24 | Ajinomoto Co., Inc. | Compound having affinity substance to soluble protein, cleavable portionand reactive group, or salt thereof |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| CN108066285B (zh) * | 2017-11-30 | 2019-06-07 | 江南大学 | 一种肝靶向共输送基因/药物的整合纳米系统及制备方法 |
| US20250312472A1 (en) * | 2022-04-29 | 2025-10-09 | University Of Florida Research Foundation, Incorporated | Antibody compounds with reactive cysteine and related antibody drug conjugates |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719667A (en) | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
| US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5216132A (en) | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| ATE155482T1 (de) * | 1990-04-06 | 1997-08-15 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5733757A (en) * | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| AU7382796A (en) * | 1995-09-26 | 1997-04-17 | University Of Washington | Glycoprotein b of the rfhv/kshv subfamily of herpes viruses |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5932545A (en) * | 1997-03-17 | 1999-08-03 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
| GB9722131D0 (en) * | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6326176B1 (en) * | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| US6774211B1 (en) | 1998-05-22 | 2004-08-10 | Abbott Laboratories | Peptide antiangiogenic drugs |
| US6716963B1 (en) | 1998-05-22 | 2004-04-06 | Abbott Laboratories | Peptide antiangiogenic drugs |
| PL200471B1 (pl) | 1998-05-22 | 2009-01-30 | Abbott Lab | Związki peptydowe, kompozycje je zawierające i ich zastosowania |
| AU1190101A (en) | 1999-09-27 | 2001-04-30 | Regents Of The University Of California, The | Engineering antibodies that bind irreversibly |
| US6294374B1 (en) * | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| DE60025648T2 (de) | 1999-11-22 | 2006-09-14 | Abbott Laboratories, Abbott Park | Peptide mit antiangiogener aktivität |
| US6753408B1 (en) | 1999-11-22 | 2004-06-22 | Fortuna Haviv | Peptides having antiangiogenic activity |
| CO5261544A1 (es) | 1999-11-22 | 2003-03-31 | Abbott Lab | Peptidos n-alquilados que tienen actividad antiangiogenica |
| AU1776801A (en) * | 1999-11-24 | 2001-06-04 | Liposome Company, Inc., The | Modular targeted liposomal delivery system |
| US20020183242A1 (en) | 2001-04-11 | 2002-12-05 | Jack Henkin | Peptide antiangiogenic drugs |
| JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| US20030045477A1 (en) | 2001-07-26 | 2003-03-06 | Fortuna Haviv | Peptides having antiangiogenic activity |
| KR20040058229A (ko) * | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| CN1678634A (zh) | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
| CA2511910A1 (en) | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US20050004044A1 (en) * | 2003-04-07 | 2005-01-06 | Board Of Regents | Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en-22-one 16-0-(2-0-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1->3)-(2-0-acetyl-alpha-L-arabinopyranoside)] or OSW-1 and its derivatives for cancer therapeutics |
| WO2004091542A2 (en) * | 2003-04-15 | 2004-10-28 | Covx Pharmaceuticals, Inc. | Nitrogen containing integrin targeting compounds |
| JP5167473B2 (ja) * | 2005-03-03 | 2013-03-21 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管新生化合物 |
-
2006
- 2006-03-03 JP JP2007558320A patent/JP5167473B2/ja not_active Expired - Fee Related
- 2006-03-03 WO PCT/US2006/007865 patent/WO2006094269A2/en not_active Ceased
- 2006-03-03 US US11/368,338 patent/US7521425B2/en not_active Expired - Fee Related
- 2006-03-03 EP EP10190929A patent/EP2292248A3/en not_active Withdrawn
- 2006-03-03 CA CA002598833A patent/CA2598833A1/en not_active Abandoned
- 2006-03-03 US US11/817,668 patent/US20080152660A1/en not_active Abandoned
- 2006-03-03 EP EP06737085A patent/EP1853294A4/en not_active Withdrawn
- 2006-03-03 KR KR1020077020180A patent/KR101373140B1/ko not_active Expired - Fee Related
-
2010
- 2010-10-04 US US12/897,594 patent/US20110087010A1/en not_active Abandoned
-
2012
- 2012-10-16 JP JP2012228959A patent/JP2013056895A/ja active Pending
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