JP2008531734A5 - - Google Patents
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- Publication number
- JP2008531734A5 JP2008531734A5 JP2007558320A JP2007558320A JP2008531734A5 JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5 JP 2007558320 A JP2007558320 A JP 2007558320A JP 2007558320 A JP2007558320 A JP 2007558320A JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65865405P | 2005-03-03 | 2005-03-03 | |
| US60/658,654 | 2005-03-03 | ||
| US67708905P | 2005-05-02 | 2005-05-02 | |
| US60/677,089 | 2005-05-02 | ||
| PCT/US2006/007865 WO2006094269A2 (en) | 2005-03-03 | 2006-03-03 | Anti-angiogenic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228959A Division JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531734A JP2008531734A (ja) | 2008-08-14 |
| JP2008531734A5 true JP2008531734A5 (enExample) | 2011-03-03 |
| JP5167473B2 JP5167473B2 (ja) | 2013-03-21 |
Family
ID=36941895
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558320A Expired - Fee Related JP5167473B2 (ja) | 2005-03-03 | 2006-03-03 | 抗血管新生化合物 |
| JP2012228959A Pending JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012228959A Pending JP2013056895A (ja) | 2005-03-03 | 2012-10-16 | 抗血管新生化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20080152660A1 (enExample) |
| EP (2) | EP2292248A3 (enExample) |
| JP (2) | JP5167473B2 (enExample) |
| KR (1) | KR101373140B1 (enExample) |
| CA (1) | CA2598833A1 (enExample) |
| WO (1) | WO2006094269A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040058229A (ko) * | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| JP5167473B2 (ja) * | 2005-03-03 | 2013-03-21 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管新生化合物 |
| US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| AU2011254001B2 (en) * | 2007-01-05 | 2012-08-02 | Covx Technologies Ireland Limited | Glucagon-like protein-1 receptor (GLP-1R) agonist compounds |
| US8293714B2 (en) * | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| EP2306986B1 (en) | 2008-06-26 | 2018-03-21 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| EP2395992A2 (en) | 2009-02-10 | 2011-12-21 | The Scripps Research Institute | Chemically programmed vaccination |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| WO2011094671A2 (en) * | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
| US20130064838A1 (en) | 2010-05-14 | 2013-03-14 | Amgen Inc. | Enhanced death receptor agonists |
| EP2593142B8 (en) | 2010-07-12 | 2018-12-26 | Pfizer Healthcare Ireland | Multifunctional antibody conjugates |
| RU2013118441A (ru) | 2010-11-05 | 2014-12-10 | КовЭкс Текнолоджиз Айэлэнд Лимитед | Антидиабетические соединения |
| CA2822481A1 (en) | 2011-01-03 | 2012-07-12 | F. Hoffmann-La Roche Ag | A pharmaceutical composition of a complex of an anti-dig antibody and digoxigenin that is conjugated to a peptide |
| PT3327027T (pt) | 2011-11-17 | 2021-02-15 | Pfizer | Péptidos citotóxicos e seus conjugados de anticorpos e fármacos |
| CA2860109C (en) | 2011-12-20 | 2016-08-09 | Javier Magano | Improved processes for preparing peptide conjugates and linkers |
| TWI560202B (en) | 2011-12-22 | 2016-12-01 | Pfizer | Anti-diabetic compounds |
| WO2013093809A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| TW201341401A (zh) | 2012-01-09 | 2013-10-16 | Covx Technologies Ireland Ltd | 突變抗體及其共軛 |
| JP6219923B2 (ja) | 2012-03-28 | 2017-10-25 | アムジェン インコーポレイテッド | Dr5受容体アゴニストの組み合わせ |
| RU2618523C2 (ru) | 2012-11-05 | 2017-05-04 | Пфайзер Инк. | Аналоги сплицеостатина |
| BR112015010436A2 (pt) | 2012-11-07 | 2017-08-22 | Pfizer | Anticorpos anti-notch3 e conjugados anticorpo-fármaco |
| KR101871088B1 (ko) | 2014-01-27 | 2018-06-25 | 화이자 인코포레이티드 | 이관능성 세포독성제 |
| DK3242884T3 (da) * | 2015-01-09 | 2021-04-19 | Ipsen Bioinnovation Ltd | Kationiske neurotoksiner |
| KR102046862B1 (ko) | 2015-03-20 | 2019-11-20 | 화이자 인코포레이티드 | Cti 약물작용발생단을 함유하는 이관능성 세포독성제 |
| US11197934B2 (en) * | 2015-09-17 | 2021-12-14 | The Scripps Research Institute | Dual variable domain immunoconjugates and uses thereof |
| TWI778491B (zh) | 2015-11-30 | 2022-09-21 | 美商輝瑞股份有限公司 | 位點專一性her2抗體藥物共軛體 |
| CA3012960A1 (en) | 2016-02-01 | 2017-08-10 | Pfizer Inc. | Tubulysin analogs and methods for their preparation |
| EP3617235A4 (en) | 2017-04-28 | 2020-12-16 | Ajinomoto Co., Inc. | COMPOUND CONTAINING A SUBSTANCE HAVING AFFINITY FOR A SOLUBLE PROTEIN, CLIVABLE FRACTION, AND REACTIVE GROUP, OR SALT OF THE SAME |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| CN108066285B (zh) * | 2017-11-30 | 2019-06-07 | 江南大学 | 一种肝靶向共输送基因/药物的整合纳米系统及制备方法 |
| US20250312472A1 (en) * | 2022-04-29 | 2025-10-09 | University Of Florida Research Foundation, Incorporated | Antibody compounds with reactive cysteine and related antibody drug conjugates |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719667A (en) * | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
| US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5216132A (en) | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| DE69126871T2 (de) | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5733757A (en) | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US6022542A (en) * | 1995-09-26 | 2000-02-08 | University Of Washington | Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5932545A (en) * | 1997-03-17 | 1999-08-03 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
| GB9722131D0 (en) * | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| US6774211B1 (en) * | 1998-05-22 | 2004-08-10 | Abbott Laboratories | Peptide antiangiogenic drugs |
| CO5080726A1 (es) | 1998-05-22 | 2001-09-25 | Abbott Lab | Drogas antiangiogenicas basadas en peptidos |
| US6716963B1 (en) * | 1998-05-22 | 2004-04-06 | Abbott Laboratories | Peptide antiangiogenic drugs |
| AU1190101A (en) | 1999-09-27 | 2001-04-30 | Regents Of The University Of California, The | Engineering antibodies that bind irreversibly |
| US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| DE60025648T2 (de) | 1999-11-22 | 2006-09-14 | Abbott Laboratories, Abbott Park | Peptide mit antiangiogener aktivität |
| US6753408B1 (en) * | 1999-11-22 | 2004-06-22 | Fortuna Haviv | Peptides having antiangiogenic activity |
| CO5261544A1 (es) | 1999-11-22 | 2003-03-31 | Abbott Lab | Peptidos n-alquilados que tienen actividad antiangiogenica |
| JP2003514843A (ja) * | 1999-11-24 | 2003-04-22 | ザ リポソーム カンパニー、インコーポレーテッド | モジュラー標的化リポソーム送達システム |
| US20020183242A1 (en) * | 2001-04-11 | 2002-12-05 | Jack Henkin | Peptide antiangiogenic drugs |
| DE60237282D1 (de) | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| US20030045477A1 (en) * | 2001-07-26 | 2003-03-06 | Fortuna Haviv | Peptides having antiangiogenic activity |
| KR20040058229A (ko) * | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| DK1517921T3 (da) | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| CA2511910A1 (en) | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| WO2004091484A2 (en) * | 2003-04-07 | 2004-10-28 | Board Of Regents, The University Of Texas System | Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en22-one 16-0-(2-0-4-methoxybenzoyl-beta-d-xylopyranosyl)-(1->3)-(2-0acetyl-alpha-l-arabinopyranoside)] or osw-1 and its derivatives for cancer therapeutics |
| WO2004091542A2 (en) * | 2003-04-15 | 2004-10-28 | Covx Pharmaceuticals, Inc. | Nitrogen containing integrin targeting compounds |
| JP5167473B2 (ja) * | 2005-03-03 | 2013-03-21 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管新生化合物 |
-
2006
- 2006-03-03 JP JP2007558320A patent/JP5167473B2/ja not_active Expired - Fee Related
- 2006-03-03 US US11/817,668 patent/US20080152660A1/en not_active Abandoned
- 2006-03-03 WO PCT/US2006/007865 patent/WO2006094269A2/en not_active Ceased
- 2006-03-03 KR KR1020077020180A patent/KR101373140B1/ko not_active Expired - Fee Related
- 2006-03-03 EP EP10190929A patent/EP2292248A3/en not_active Withdrawn
- 2006-03-03 CA CA002598833A patent/CA2598833A1/en not_active Abandoned
- 2006-03-03 US US11/368,338 patent/US7521425B2/en not_active Expired - Fee Related
- 2006-03-03 EP EP06737085A patent/EP1853294A4/en not_active Withdrawn
-
2010
- 2010-10-04 US US12/897,594 patent/US20110087010A1/en not_active Abandoned
-
2012
- 2012-10-16 JP JP2012228959A patent/JP2013056895A/ja active Pending
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