JP2008531467A5 - - Google Patents

Info

Publication number

JP2008531467A5

JP2008531467A5 JP2007541462A JP2007541462A JP2008531467A5 JP 2008531467 A5 JP2008531467 A5 JP 2008531467A5 JP 2007541462 A JP2007541462 A JP 2007541462A JP 2007541462 A JP2007541462 A JP 2007541462A JP 2008531467 A5 JP2008531467 A5 JP 2008531467A5

Authority

JP

Japan

Prior art keywords

glucocorticosteroid

suspension

sterile

heating

liquid excipient

Prior art date

2005-11-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003862 glucocorticoid Substances 0.000 claims 21
• 238000000034 method Methods 0.000 claims 21
• 239000000725 suspension Substances 0.000 claims 17
• 238000010438 heat treatment Methods 0.000 claims 8
• 239000000546 pharmaceutical excipient Substances 0.000 claims 8
• 239000007788 liquid Substances 0.000 claims 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 4
• 239000004094 surface-active agent Substances 0.000 claims 3
• VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 230000000172 allergic effect Effects 0.000 claims 2
• 239000007900 aqueous suspension Substances 0.000 claims 2
• 229940092705 beclomethasone Drugs 0.000 claims 2
• NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 2
• 229960004436 budesonide Drugs 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000008223 sterile water Substances 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 1
• 229960003728 ciclesonide Drugs 0.000 claims 1
• 229960003469 flumetasone Drugs 0.000 claims 1
• WXURHACBFYSXBI-GQKYHHCASA-N flumethasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O WXURHACBFYSXBI-GQKYHHCASA-N 0.000 claims 1
• 229960000676 flunisolide Drugs 0.000 claims 1
• 229940043075 fluocinolone Drugs 0.000 claims 1
• FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 1
• 229960002714 fluticasone Drugs 0.000 claims 1
• MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
• 239000007951 isotonicity adjuster Substances 0.000 claims 1
• 229960001664 mometasone Drugs 0.000 claims 1
• QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 1
• 230000003134 recirculating effect Effects 0.000 claims 1
• 229950004432 rofleponide Drugs 0.000 claims 1
• IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000003381 stabilizer Substances 0.000 claims 1
• 229960005294 triamcinolone Drugs 0.000 claims 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
• 239000000080 wetting agent Substances 0.000 claims 1