JP2008530192A - Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体 - Google Patents

Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体 Download PDF

Info

Publication number
JP2008530192A
JP2008530192A JP2007555692A JP2007555692A JP2008530192A JP 2008530192 A JP2008530192 A JP 2008530192A JP 2007555692 A JP2007555692 A JP 2007555692A JP 2007555692 A JP2007555692 A JP 2007555692A JP 2008530192 A JP2008530192 A JP 2008530192A
Authority
JP
Japan
Prior art keywords
alkyl
compound
formula
carbamoyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007555692A
Other languages
English (en)
Japanese (ja)
Inventor
ハル，ケネス・グレゴリー
ビスト，シャンタ
Original Assignee
アストラゼネカ アクチボラグ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アストラゼネカ アクチボラグ filed Critical アストラゼネカ アクチボラグ
Publication of JP2008530192A publication Critical patent/JP2008530192A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007555692A 2005-02-18 2006-02-16 Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体 Pending JP2008530192A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65459605P 2005-02-18 2005-02-18
PCT/GB2006/000530 WO2006087544A2 (en) 2005-02-18 2006-02-16 Pyrrole derivatives as dna gyrase and topoisomerase inhibitors

Publications (1)

Publication Number Publication Date
JP2008530192A true JP2008530192A (ja) 2008-08-07

Family

ID=36916822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007555692A Pending JP2008530192A (ja) 2005-02-18 2006-02-16 Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体

Country Status (4)

Country Link
EP (1) EP1856103A2 (zh)
JP (1) JP2008530192A (zh)
CN (1) CN101163697A (zh)
WO (1) WO2006087544A2 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008531673A (ja) * 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 抗菌活性をもつアゼチジン及びピロールの三環式誘導体

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
CN101163693B (zh) 2005-02-18 2013-03-06 阿斯利康(瑞典)有限公司 抗菌哌啶衍生物
TWI498115B (zh) 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
CA2732618A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Pyrrole carboxylic acid derivatives as antibacterial agents
TW201026695A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Piperidine compounds and uses thereof-596
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
TW201111380A (en) 2009-08-26 2011-04-01 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
RU2737892C1 (ru) 2015-09-30 2020-12-04 Дайити Санкио Компани, Лимитед Гидроксиалкилтиадиазольные производные
TW201840322A (zh) 2017-03-14 2018-11-16 日商第一三共股份有限公司 羥烷基噻二唑衍生物之ｎ－膦醯基氧基甲基前驅藥
US20210323957A1 (en) 2018-09-03 2021-10-21 Univerza V Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
WO2022129327A1 (en) 2020-12-17 2022-06-23 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505092A (ja) * 2003-09-13 2007-03-08 アストラゼネカ アクチボラグ 抗菌活性を有するピロール誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766488B1 (fr) * 1997-07-23 2000-02-18 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505092A (ja) * 2003-09-13 2007-03-08 アストラゼネカ アクチボラグ 抗菌活性を有するピロール誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008531673A (ja) * 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 抗菌活性をもつアゼチジン及びピロールの三環式誘導体

Also Published As

Publication number Publication date
CN101163697A (zh) 2008-04-16
WO2006087544A8 (en) 2007-10-18
WO2006087544A2 (en) 2006-08-24
WO2006087544A3 (en) 2006-12-21
EP1856103A2 (en) 2007-11-21

Similar Documents

Publication Publication Date Title
JP2008530192A (ja) Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体
JP4058106B2 (ja) 抗菌性のピペリジン誘導体
US20080269214A1 (en) Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
US20090253671A1 (en) Tricyclic derivatives of azetidine and pyrrole with antibacterial activity
JP2009520785A (ja) 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン
JP2012511561A (ja) 細菌感染症に抗する２−（ピペリジン−１−イル）−４−ヘテロシクリル−チアゾール−５−カルボン酸誘導体
JP2010511682A (ja) 抗菌性の多環系尿素化合物
JP2011522030A (ja) 複素環式尿素誘導体とその使用の方法
US20100137303A1 (en) New compound 255
JP2010529184A (ja) ピペリジン化合物およびそれらの使用
JP2010500987A (ja) 抗細菌活性を有するピロール誘導体
US20080161306A1 (en) Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
WO2008020227A2 (en) Antibacterial pyrrolecarboxamides
JP2011522026A (ja) 細菌感染の処置用の複素環式尿素誘導体
JP2010531868A (ja) ３−スピロピリミジントリオン−キノリン誘導体と抗菌剤としてのその使用
WO2010142978A1 (en) Heterocyclic urea derivatives and methods of use thereof
KR20110094305A (ko) 박테리아 감염에 대항하는 2-(피페리딘-1-일)-4-아졸릴-티아졸-5-카르복실산 유도체

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090113

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110804

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120403

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120905