WO2006087544A3 - Pyrrole derivatives as dna gyrase and topoisomerase inhibitors - Google Patents

Pyrrole derivatives as dna gyrase and topoisomerase inhibitors Download PDF

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Publication number
WO2006087544A3
WO2006087544A3 PCT/GB2006/000530 GB2006000530W WO2006087544A3 WO 2006087544 A3 WO2006087544 A3 WO 2006087544A3 GB 2006000530 W GB2006000530 W GB 2006000530W WO 2006087544 A3 WO2006087544 A3 WO 2006087544A3
Authority
WO
WIPO (PCT)
Prior art keywords
topoisomerase inhibitors
dna gyrase
pyrrole derivatives
formula
pyrrole
Prior art date
Application number
PCT/GB2006/000530
Other languages
French (fr)
Other versions
WO2006087544A8 (en
WO2006087544A2 (en
Inventor
Kenneth Gregory Hull
Shanta Bist
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Kenneth Gregory Hull
Shanta Bist
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Kenneth Gregory Hull, Shanta Bist filed Critical Astrazeneca Ab
Priority to EP06709767A priority Critical patent/EP1856103A2/en
Priority to JP2007555692A priority patent/JP2008530192A/en
Publication of WO2006087544A2 publication Critical patent/WO2006087544A2/en
Publication of WO2006087544A3 publication Critical patent/WO2006087544A3/en
Publication of WO2006087544A8 publication Critical patent/WO2006087544A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I) and their pharmaceutically acceptable salts are described: formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
PCT/GB2006/000530 2005-02-18 2006-02-16 Pyrrole derivatives as dna gyrase and topoisomerase inhibitors WO2006087544A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06709767A EP1856103A2 (en) 2005-02-18 2006-02-16 Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
JP2007555692A JP2008530192A (en) 2005-02-18 2006-02-16 Pyrrole derivatives as inhibitors of DNA gyrase and topoisomerase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65459605P 2005-02-18 2005-02-18
US60/654,596 2005-02-18

Publications (3)

Publication Number Publication Date
WO2006087544A2 WO2006087544A2 (en) 2006-08-24
WO2006087544A3 true WO2006087544A3 (en) 2006-12-21
WO2006087544A8 WO2006087544A8 (en) 2007-10-18

Family

ID=36916822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000530 WO2006087544A2 (en) 2005-02-18 2006-02-16 Pyrrole derivatives as dna gyrase and topoisomerase inhibitors

Country Status (4)

Country Link
EP (1) EP1856103A2 (en)
JP (1) JP2008530192A (en)
CN (1) CN101163697A (en)
WO (1) WO2006087544A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
EP1853586B1 (en) 2005-02-18 2013-07-24 AstraZeneca AB Antibacterial piperidine derivatives
CN101171250A (en) * 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 Tricyclic derivatives of azetidine and pyrrole with antibacterial activity
TWI498115B (en) 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd Imidazole carbonyl compounds
CA2732618A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Pyrrole carboxylic acid derivatives as antibacterial agents
US8071605B2 (en) 2008-12-12 2011-12-06 Astrazeneca Ab Piperidine compounds for use in the treatment of bacterial infections
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
UY32856A (en) 2009-08-26 2011-03-31 Astrazeneca Ab UREA HETEROCYCLIC DERIVATIVES AND METHODS OF USE OF THE SAME
US10399968B2 (en) 2015-09-30 2019-09-03 Daiichi Sankyo Company, Limited Hydroxyalkyl thiadiazole derivatives
EP3596071A1 (en) 2017-03-14 2020-01-22 Daiichi Sankyo Company, Limited N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives
WO2020048949A1 (en) 2018-09-03 2020-03-12 Univerza V Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
WO2022129327A1 (en) 2020-12-17 2022-06-23 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0894805A1 (en) * 1997-07-23 1999-02-03 Hoechst Marion Roussel Ribose substituted aromatic derivatives, their preparation and use as medicaments
WO2005026149A1 (en) * 2003-09-13 2005-03-24 Astrazeneca Ab Pyrrol derivatives with antibacterial activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0894805A1 (en) * 1997-07-23 1999-02-03 Hoechst Marion Roussel Ribose substituted aromatic derivatives, their preparation and use as medicaments
WO2005026149A1 (en) * 2003-09-13 2005-03-24 Astrazeneca Ab Pyrrol derivatives with antibacterial activity

Also Published As

Publication number Publication date
CN101163697A (en) 2008-04-16
WO2006087544A8 (en) 2007-10-18
JP2008530192A (en) 2008-08-07
EP1856103A2 (en) 2007-11-21
WO2006087544A2 (en) 2006-08-24

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