JP2008529745A5 - - Google Patents

Info

Publication number

JP2008529745A5

JP2008529745A5 JP2007556360A JP2007556360A JP2008529745A5 JP 2008529745 A5 JP2008529745 A5 JP 2008529745A5 JP 2007556360 A JP2007556360 A JP 2007556360A JP 2007556360 A JP2007556360 A JP 2007556360A JP 2008529745 A5 JP2008529745 A5 JP 2008529745A5

Authority

JP

Japan

Prior art keywords

polymer

poly

analog

drug

lactone

Prior art date

2006-02-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 polydimethylsiloxane Polymers 0.000 claims 56
• 229920000642 polymer Polymers 0.000 claims 56
• 239000003814 drug Substances 0.000 claims 44
• 229940079593 drug Drugs 0.000 claims 30
• 239000011248 coating agent Substances 0.000 claims 28
• 238000000576 coating method Methods 0.000 claims 28
• 150000002596 lactones Chemical group 0.000 claims 28
• 229920001634 Copolyester Polymers 0.000 claims 14
• 229920002732 Polyanhydride Polymers 0.000 claims 14
• 239000002253 acid Substances 0.000 claims 14
• 229920002678 cellulose Polymers 0.000 claims 14
• 239000004205 dimethyl polysiloxane Substances 0.000 claims 14
• 150000004676 glycans Chemical class 0.000 claims 14
• 239000000203 mixture Substances 0.000 claims 14
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 14
• 229920001693 poly(ether-ester) Polymers 0.000 claims 14
• 229920002627 poly(phosphazenes) Polymers 0.000 claims 14
• 229920000728 polyester Polymers 0.000 claims 14
• 229920001282 polysaccharide Polymers 0.000 claims 14
• 239000005017 polysaccharide Substances 0.000 claims 14
• 229920001343 polytetrafluoroethylene Polymers 0.000 claims 14
• 239000004810 polytetrafluoroethylene Substances 0.000 claims 14
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 14
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 14
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 14
• 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 13
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 12
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 229940124597 therapeutic agent Drugs 0.000 claims 9
• 229940123237 Taxane Drugs 0.000 claims 7
• 230000002209 hydrophobic effect Effects 0.000 claims 6
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 229960003668 docetaxel Drugs 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• LGZKGOGODCLQHG-CYBMUJFWSA-N 5-[(2r)-2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC=C1C[C@@H](O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-CYBMUJFWSA-N 0.000 claims 2
• JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 claims 2
• LGZKGOGODCLQHG-UHFFFAOYSA-N combretastatin Natural products C1=C(O)C(OC)=CC=C1CC(O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-UHFFFAOYSA-N 0.000 claims 2
• QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 claims 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
• 229960002930 sirolimus Drugs 0.000 claims 2
• GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
• 101150065749 Churc1 gene Proteins 0.000 claims 1
• 102100038239 Protein Churchill Human genes 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
• 229940127093 camptothecin Drugs 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1