JP2008526893A - 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 - Google Patents

肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 Download PDF

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JP2008526893A
JP2008526893A JP2007550575A JP2007550575A JP2008526893A JP 2008526893 A JP2008526893 A JP 2008526893A JP 2007550575 A JP2007550575 A JP 2007550575A JP 2007550575 A JP2007550575 A JP 2007550575A JP 2008526893 A JP2008526893 A JP 2008526893A
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Prior art keywords
insulin
patient
inhalable
diketopiperazine
insulin composition
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JP2007550575A
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Japanese (ja)
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JP2008526893A5 (enExample
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ゲルバー,コハヴァ
ボス,アンダース
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マンカインド コーポレイション
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Publication of JP2008526893A publication Critical patent/JP2008526893A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2007550575A 2005-01-10 2006-01-10 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 Withdrawn JP2008526893A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64305405P 2005-01-10 2005-01-10
PCT/US2006/000910 WO2006086107A2 (en) 2005-01-10 2006-01-10 Methods and compositions for minimizing accrual of inhalable insulin in the lungs

Publications (2)

Publication Number Publication Date
JP2008526893A true JP2008526893A (ja) 2008-07-24
JP2008526893A5 JP2008526893A5 (enExample) 2009-03-05

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ID=36793549

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007550575A Withdrawn JP2008526893A (ja) 2005-01-10 2006-01-10 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物

Country Status (7)

Country Link
US (1) US20060153778A1 (enExample)
EP (1) EP1858486A2 (enExample)
JP (1) JP2008526893A (enExample)
AU (1) AU2006213084A1 (enExample)
CA (1) CA2592776A1 (enExample)
MX (1) MX2007008379A (enExample)
WO (1) WO2006086107A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500201A (ja) * 2008-08-11 2012-01-05 マンカインド コーポレイション 超速効型インスリンの使用
JP2012514646A (ja) * 2009-01-08 2012-06-28 マンカインド コーポレイション Glp−1を用いる高血糖症の治療方法
JP2012519550A (ja) * 2009-03-04 2012-08-30 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2016028068A (ja) * 2009-06-12 2016-02-25 マンカインド コーポレイション 規定された含量の異性体を有するジケトピペラジン微粒子

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280004B1 (en) 1999-06-29 2016-04-20 MannKind Corporation Pharmaceutical formulations comprising insulin complexed with a diketopiperazine
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1494732B1 (en) 2002-03-20 2008-01-30 MannKind Corporation Inhalation apparatus
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
AU2014271222B2 (en) * 2005-09-14 2016-04-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
KR101736502B1 (ko) * 2007-10-24 2017-05-16 맨카인드 코포레이션 Glp-1에 의한 유해 효과의 예방 방법
SG10201507036TA (en) 2008-06-13 2015-10-29 Mannkind Corp A dry powder inhaler and system for drug delivery
US20190262557A1 (en) * 2010-03-04 2019-08-29 Mannkind Corporation Dry powder drug delivery system
US8485180B2 (en) * 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
US11110151B2 (en) * 2008-08-11 2021-09-07 Mannkind Corporation Composition and method for reducing hypoglycemia events in diabetes treatment
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2014200960B2 (en) * 2009-03-04 2016-02-11 Mannkind Corporation An improved dry powder drug delivery system
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1200318A1 (en) 2011-10-24 2015-08-07 曼金德公司 Methods and compositions for treating pain
EP2872205B1 (en) 2012-07-12 2017-02-08 MannKind Corporation Dry powder drug delivery systems
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2000301A (en) * 1932-04-02 1935-05-07 Norman Confections Inc Progressive container
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
EP2280004B1 (en) * 1999-06-29 2016-04-20 MannKind Corporation Pharmaceutical formulations comprising insulin complexed with a diketopiperazine
AU2005204378B2 (en) * 2004-01-12 2009-01-22 Mannkind Corporation A method of reducing serum proinsulin levels in type 2 diabetics

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500201A (ja) * 2008-08-11 2012-01-05 マンカインド コーポレイション 超速効型インスリンの使用
JP2015143253A (ja) * 2008-08-11 2015-08-06 マンカインド コーポレイション 超速効型インスリンの使用
JP2017226689A (ja) * 2008-08-11 2017-12-28 マンカインド コーポレイション 超速効型インスリン製剤
JP2019196376A (ja) * 2008-08-11 2019-11-14 マンカインド コーポレイション 超速効型インスリン製剤
JP2021167342A (ja) * 2008-08-11 2021-10-21 マンカインド コーポレイション 医薬組成物
JP2012514646A (ja) * 2009-01-08 2012-06-28 マンカインド コーポレイション Glp−1を用いる高血糖症の治療方法
JP2012519550A (ja) * 2009-03-04 2012-08-30 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2015027543A (ja) * 2009-03-04 2015-02-12 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2016028068A (ja) * 2009-06-12 2016-02-25 マンカインド コーポレイション 規定された含量の異性体を有するジケトピペラジン微粒子

Also Published As

Publication number Publication date
MX2007008379A (es) 2008-02-19
US20060153778A1 (en) 2006-07-13
WO2006086107A3 (en) 2006-11-23
EP1858486A2 (en) 2007-11-28
WO2006086107A2 (en) 2006-08-17
CA2592776A1 (en) 2006-08-17
AU2006213084A1 (en) 2006-08-17

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