CA2592776A1 - Methods and compositions for minimizing accrual of inhalable insulin in the lungs - Google Patents
Methods and compositions for minimizing accrual of inhalable insulin in the lungs Download PDFInfo
- Publication number
- CA2592776A1 CA2592776A1 CA002592776A CA2592776A CA2592776A1 CA 2592776 A1 CA2592776 A1 CA 2592776A1 CA 002592776 A CA002592776 A CA 002592776A CA 2592776 A CA2592776 A CA 2592776A CA 2592776 A1 CA2592776 A1 CA 2592776A1
- Authority
- CA
- Canada
- Prior art keywords
- insulin
- patient
- inhalable
- diketopiperazine
- insulin composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 405
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- 238000000034 method Methods 0.000 title claims abstract description 29
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims description 30
- BBNKIRVUCQNAQR-FETIZUMASA-N (e)-4-[4-[(2s,5s)-5-[4-[[(e)-3-carboxyprop-2-enoyl]amino]butyl]-3,6-dioxopiperazin-2-yl]butylamino]-4-oxobut-2-enoic acid Chemical group OC(=O)\C=C\C(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)\C=C\C(O)=O)NC1=O BBNKIRVUCQNAQR-FETIZUMASA-N 0.000 claims description 21
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
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- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| US64305405P | 2005-01-10 | 2005-01-10 | |
| US60/643,054 | 2005-01-10 | ||
| PCT/US2006/000910 WO2006086107A2 (en) | 2005-01-10 | 2006-01-10 | Methods and compositions for minimizing accrual of inhalable insulin in the lungs |
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| CA2592776A1 true CA2592776A1 (en) | 2006-08-17 |
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| CA002592776A Abandoned CA2592776A1 (en) | 2005-01-10 | 2006-01-10 | Methods and compositions for minimizing accrual of inhalable insulin in the lungs |
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| AU (1) | AU2006213084A1 (enExample) |
| CA (1) | CA2592776A1 (enExample) |
| MX (1) | MX2007008379A (enExample) |
| WO (1) | WO2006086107A2 (enExample) |
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| JP4713798B2 (ja) | 1999-06-29 | 2011-06-29 | マンカインド コーポレイション | ペプチドおよびタンパク質の薬学的因子の精製および安定化 |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ATE385193T1 (de) | 2002-03-20 | 2008-02-15 | Mannkind Corp | Inhalationsgerät |
| US9078866B2 (en) * | 2003-08-01 | 2015-07-14 | Mannkind Corporation | Method for treating hyperglycemia with GLP-1 |
| US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| DE602005024413D1 (de) | 2004-08-20 | 2010-12-09 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| CN104436170B (zh) | 2004-08-23 | 2018-02-23 | 曼金德公司 | 用于药物输送的二酮哌嗪盐 |
| AU2014271222B2 (en) * | 2005-09-14 | 2016-04-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| JP5167133B2 (ja) | 2005-09-14 | 2013-03-21 | マンカインド コーポレイション | 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法 |
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|---|---|---|---|---|
| US2000301A (en) * | 1932-04-02 | 1935-05-07 | Norman Confections Inc | Progressive container |
| US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| JP4713798B2 (ja) * | 1999-06-29 | 2011-06-29 | マンカインド コーポレイション | ペプチドおよびタンパク質の薬学的因子の精製および安定化 |
| NZ548980A (en) * | 2004-01-12 | 2009-10-30 | Mannkind Corp | Reducing serum proinsulin levels in type 2 diabetics |
-
2006
- 2006-01-10 US US11/330,427 patent/US20060153778A1/en not_active Abandoned
- 2006-01-10 CA CA002592776A patent/CA2592776A1/en not_active Abandoned
- 2006-01-10 MX MX2007008379A patent/MX2007008379A/es unknown
- 2006-01-10 EP EP06748159A patent/EP1858486A2/en not_active Withdrawn
- 2006-01-10 WO PCT/US2006/000910 patent/WO2006086107A2/en not_active Ceased
- 2006-01-10 JP JP2007550575A patent/JP2008526893A/ja not_active Withdrawn
- 2006-01-10 AU AU2006213084A patent/AU2006213084A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060153778A1 (en) | 2006-07-13 |
| MX2007008379A (es) | 2008-02-19 |
| JP2008526893A (ja) | 2008-07-24 |
| EP1858486A2 (en) | 2007-11-28 |
| WO2006086107A3 (en) | 2006-11-23 |
| AU2006213084A1 (en) | 2006-08-17 |
| WO2006086107A2 (en) | 2006-08-17 |
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