JP2008526893A - 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 - Google Patents

肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 Download PDF

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Publication number
JP2008526893A
JP2008526893A JP2007550575A JP2007550575A JP2008526893A JP 2008526893 A JP2008526893 A JP 2008526893A JP 2007550575 A JP2007550575 A JP 2007550575A JP 2007550575 A JP2007550575 A JP 2007550575A JP 2008526893 A JP2008526893 A JP 2008526893A
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Japan
Prior art keywords
insulin
patient
inhalable
diketopiperazine
insulin composition
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JP2007550575A
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English (en)
Japanese (ja)
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JP2008526893A5 (cg-RX-API-DMAC10.html
Inventor
ゲルバー,コハヴァ
ボス,アンダース
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マンカインド コーポレイション
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Publication of JP2008526893A publication Critical patent/JP2008526893A/ja
Publication of JP2008526893A5 publication Critical patent/JP2008526893A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2007550575A 2005-01-10 2006-01-10 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物 Withdrawn JP2008526893A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64305405P 2005-01-10 2005-01-10
PCT/US2006/000910 WO2006086107A2 (en) 2005-01-10 2006-01-10 Methods and compositions for minimizing accrual of inhalable insulin in the lungs

Publications (2)

Publication Number Publication Date
JP2008526893A true JP2008526893A (ja) 2008-07-24
JP2008526893A5 JP2008526893A5 (cg-RX-API-DMAC10.html) 2009-03-05

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ID=36793549

Family Applications (1)

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JP2007550575A Withdrawn JP2008526893A (ja) 2005-01-10 2006-01-10 肺における吸入可能なインスリンの自然増加を最少化するための方法及び組成物

Country Status (7)

Country Link
US (1) US20060153778A1 (cg-RX-API-DMAC10.html)
EP (1) EP1858486A2 (cg-RX-API-DMAC10.html)
JP (1) JP2008526893A (cg-RX-API-DMAC10.html)
AU (1) AU2006213084A1 (cg-RX-API-DMAC10.html)
CA (1) CA2592776A1 (cg-RX-API-DMAC10.html)
MX (1) MX2007008379A (cg-RX-API-DMAC10.html)
WO (1) WO2006086107A2 (cg-RX-API-DMAC10.html)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2012500201A (ja) * 2008-08-11 2012-01-05 マンカインド コーポレイション 超速効型インスリンの使用
JP2012514646A (ja) * 2009-01-08 2012-06-28 マンカインド コーポレイション Glp−1を用いる高血糖症の治療方法
JP2012519550A (ja) * 2009-03-04 2012-08-30 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2016028068A (ja) * 2009-06-12 2016-02-25 マンカインド コーポレイション 規定された含量の異性体を有するジケトピペラジン微粒子

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ES2395096T3 (es) 1999-06-29 2013-02-08 Mannkind Corporation Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
AU2014271222B2 (en) * 2005-09-14 2016-04-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
KR101736502B1 (ko) * 2007-10-24 2017-05-16 맨카인드 코포레이션 Glp-1에 의한 유해 효과의 예방 방법
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
US8485180B2 (en) * 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US20190262557A1 (en) * 2010-03-04 2019-08-29 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
US11110151B2 (en) * 2008-08-11 2021-09-07 Mannkind Corporation Composition and method for reducing hypoglycemia events in diabetes treatment
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2014200960B2 (en) * 2009-03-04 2016-02-11 Mannkind Corporation An improved dry powder drug delivery system
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
AU2010259943C1 (en) * 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

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US2000301A (en) * 1932-04-02 1935-05-07 Norman Confections Inc Progressive container
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
ES2395096T3 (es) * 1999-06-29 2013-02-08 Mannkind Corporation Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas
US20050153874A1 (en) * 2004-01-12 2005-07-14 Mannkind Corporation Method of reducing serum proinsulin levels in type 2 diabetics

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500201A (ja) * 2008-08-11 2012-01-05 マンカインド コーポレイション 超速効型インスリンの使用
JP2015143253A (ja) * 2008-08-11 2015-08-06 マンカインド コーポレイション 超速効型インスリンの使用
JP2017226689A (ja) * 2008-08-11 2017-12-28 マンカインド コーポレイション 超速効型インスリン製剤
JP2019196376A (ja) * 2008-08-11 2019-11-14 マンカインド コーポレイション 超速効型インスリン製剤
JP2021167342A (ja) * 2008-08-11 2021-10-21 マンカインド コーポレイション 医薬組成物
JP2012514646A (ja) * 2009-01-08 2012-06-28 マンカインド コーポレイション Glp−1を用いる高血糖症の治療方法
JP2012519550A (ja) * 2009-03-04 2012-08-30 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2015027543A (ja) * 2009-03-04 2015-02-12 マンカインド コーポレイション 改善された乾燥粉末薬物送達システム
JP2016028068A (ja) * 2009-06-12 2016-02-25 マンカインド コーポレイション 規定された含量の異性体を有するジケトピペラジン微粒子

Also Published As

Publication number Publication date
WO2006086107A3 (en) 2006-11-23
CA2592776A1 (en) 2006-08-17
US20060153778A1 (en) 2006-07-13
MX2007008379A (es) 2008-02-19
EP1858486A2 (en) 2007-11-28
WO2006086107A2 (en) 2006-08-17
AU2006213084A1 (en) 2006-08-17

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