JP2008526715A5 - - Google Patents
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- Publication number
- JP2008526715A5 JP2008526715A5 JP2007548841A JP2007548841A JP2008526715A5 JP 2008526715 A5 JP2008526715 A5 JP 2008526715A5 JP 2007548841 A JP2007548841 A JP 2007548841A JP 2007548841 A JP2007548841 A JP 2007548841A JP 2008526715 A5 JP2008526715 A5 JP 2008526715A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- piperazin
- butyl
- cycloalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CN(CC[n]1c2c*(*)c1)C2=O Chemical compound CN(CC[n]1c2c*(*)c1)C2=O 0.000 description 4
- XCLHLOCMAZPLBT-UHFFFAOYSA-N CN(CCN1C2=Cc3ccccc3C1)C2=O Chemical compound CN(CCN1C2=Cc3ccccc3C1)C2=O XCLHLOCMAZPLBT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500004 | 2005-01-03 | ||
| US64100605P | 2005-01-04 | 2005-01-04 | |
| PCT/EP2006/050001 WO2006072608A2 (en) | 2005-01-03 | 2006-01-02 | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526715A JP2008526715A (ja) | 2008-07-24 |
| JP2008526715A5 true JP2008526715A5 (https=) | 2009-02-19 |
Family
ID=36600734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548841A Pending JP2008526715A (ja) | 2005-01-03 | 2006-01-02 | 神経精神障害の治療のためのアリールピペラジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090238761A1 (https=) |
| EP (1) | EP1836192A2 (https=) |
| JP (1) | JP2008526715A (https=) |
| AU (1) | AU2006204522A1 (https=) |
| CA (1) | CA2593266A1 (https=) |
| NZ (1) | NZ555491A (https=) |
| WO (1) | WO2006072608A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2903986A1 (fr) * | 2006-07-21 | 2008-01-25 | Pierre Fabre Medicament Sa | Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique |
| GB0615809D0 (en) * | 2006-08-09 | 2006-09-20 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| US20100087445A1 (en) * | 2006-10-13 | 2010-04-08 | Universita Degli Studi Di Siena | Aryl piperazine derivatives useful for the treatment of neuropsychiatry disorders |
| CN101616919B (zh) * | 2006-12-28 | 2012-10-10 | 雅培制药有限公司 | 聚（adp核糖）聚合酶抑制剂 |
| WO2008153573A1 (en) * | 2007-06-15 | 2008-12-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 4-phenylpiperazine derivatives with functionalized linkers as dopamine d3 receptor selective ligands and methods of use |
| JP2010531364A (ja) * | 2007-06-25 | 2010-09-24 | ニューロジェン・コーポレーション | ピペラジニルオキソアルキルテトラヒドロ−β−カルボリンおよび関連類似体 |
| EP2238125A1 (en) * | 2008-02-01 | 2010-10-13 | NeuroSearch A/S | Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors |
| WO2010040808A1 (en) * | 2008-10-10 | 2010-04-15 | Neurosearch A/S | Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors |
| SI2825541T1 (sl) | 2012-03-16 | 2016-10-28 | Vitae Pharmaceuticals, Inc. | Modulatorji jetrnega receptorja X |
| ES2607113T3 (es) | 2012-03-16 | 2017-03-29 | Vitae Pharmaceuticals, Inc. | Moduladores de los receptores X del hígado |
| JP6345651B2 (ja) * | 2012-05-09 | 2018-06-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物及びその使用方法 |
| WO2014059265A1 (en) * | 2012-10-11 | 2014-04-17 | Southern Research Institute | Urea and amide derivatives of aminoalkylpiperazines and use thereof |
| ES2786052T3 (es) * | 2013-04-23 | 2020-10-08 | Esteve Pharmaceuticals Sa | Compuestos de pirazino[1,2-a]indol, su preparación y su uso en medicamentos |
| US9598401B2 (en) | 2013-07-29 | 2017-03-21 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| US9714232B2 (en) | 2013-12-20 | 2017-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
| MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| JP2018502158A (ja) * | 2015-01-12 | 2018-01-25 | レビバ ファーマシューティカルズ，インコーポレイティド | パーキンソン病と関連する精神病の治療方法 |
| CN107206007B (zh) * | 2015-01-12 | 2021-08-10 | 雷维瓦药品公司 | 用于治疗肺高血压的方法 |
| CN107249592A (zh) * | 2015-01-12 | 2017-10-13 | 雷维瓦药品公司 | 用于治疗阿尔茨海默病的方法 |
| CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| EP3766885B1 (en) | 2015-06-17 | 2022-05-25 | Pfizer Inc. | Tricyclic compounds and their use as phosphodiesterase inhibitors |
| SI3429993T1 (sl) | 2016-03-14 | 2021-09-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer | Selektivni antagonisti/delni agonisti dopaminskega receptorja D3; postopki izdelave; in uporaba le-teh |
| US11299476B2 (en) | 2016-03-14 | 2022-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof |
| US12319659B2 (en) | 2017-02-24 | 2025-06-03 | Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd | Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof |
| EP3608314A4 (en) * | 2017-03-13 | 2020-12-30 | Sumitomo Dainippon Pharma Co., Ltd. | 2,6-DISUBSTITUTED PYRIDINE DERIVATIVE |
| GB201704325D0 (en) * | 2017-03-17 | 2017-05-03 | Argonaut Therapeutics Ltd | Compounds |
| EP3849963A1 (en) | 2018-09-11 | 2021-07-21 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Dopamine d3 receptor selective antagonists/partial agonists and uses thereof |
| WO2021252775A1 (en) | 2020-06-11 | 2021-12-16 | Chdi Foundation, Inc. | Heterocyclic compounds and imaging agents for imaging huntingtin protein |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2777849A (en) * | 1954-07-23 | 1957-01-15 | American Cyanamid Co | 1, 1'-alkylenedipiperazines and methods of preparing same |
| US2837522A (en) * | 1955-10-20 | 1958-06-03 | American Cyanamid Co | Substituted alkylenedipiperazines |
| US3734915A (en) * | 1970-02-02 | 1973-05-22 | American Cyanamid Co | N-(-(4-phenyl-1-piperazinyl)alkyl)benzo(b)thiophene or benzofuran-2-carboxamides |
| US3646047A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | Certain benzo(b)thiophene-2-carboxamide derivatives |
| FR2187311B1 (https=) * | 1972-06-02 | 1975-06-20 | Bouchara Emile | |
| US4803203A (en) * | 1986-11-05 | 1989-02-07 | Warner-Lambert Company | Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| DE3923675A1 (de) * | 1989-07-18 | 1991-01-24 | Basf Ag | Amonoalkylsubstituierte 2-aminothiazole und diese enthaltende therapeutische mittel |
| FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| US6100255A (en) * | 1998-10-28 | 2000-08-08 | Neurogen Corporation | 3-aminoalkylamino-2H-1,4-benzoxazines and 3-aminoalkylamino-2H-1,4-benzothiazines: dopamine receptor subtype specific ligands |
| JP4549452B2 (ja) * | 1997-12-12 | 2010-09-22 | 富山化学工業株式会社 | アルキルエーテル誘導体またはその塩並びにそれらを含有するカルシウム拮抗剤 |
| AU3124100A (en) * | 1998-12-17 | 2000-07-03 | American Home Products Corporation | Piperazine ethylamide derivatives with 5-ht1a receptor activity |
| DE60009154D1 (de) * | 1999-12-30 | 2004-04-22 | Lundbeck & Co As H | Phenylpiperazinyl-derivate |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| ATE354367T1 (de) * | 2002-07-04 | 2007-03-15 | Sanol Arznei Schwarz Gmbh | Heteroarencarboxamide zur verwendung als dopamin- d3 liganden zur behandlung von zns-erkrankungen |
| WO2004024878A2 (en) | 2002-09-14 | 2004-03-25 | Gov't Of The U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Structurally rigid dopamine d3 receptor selective ligands and process for making them |
| DE10248067A1 (de) * | 2002-10-07 | 2004-04-15 | Proteosys Ag | Heteroarylpropyl-Piperazine und Heteroarylpropyl-Piperidine |
| US20070142399A1 (en) * | 2003-06-19 | 2007-06-21 | Psychiatric Genomics, Inc. | Dual function drugs and uses thereof |
| FR2878524B1 (fr) * | 2004-12-01 | 2007-01-19 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
-
2006
- 2006-01-02 CA CA002593266A patent/CA2593266A1/en not_active Abandoned
- 2006-01-02 NZ NZ555491A patent/NZ555491A/en not_active IP Right Cessation
- 2006-01-02 JP JP2007548841A patent/JP2008526715A/ja active Pending
- 2006-01-02 AU AU2006204522A patent/AU2006204522A1/en not_active Abandoned
- 2006-01-02 US US11/794,687 patent/US20090238761A1/en not_active Abandoned
- 2006-01-02 WO PCT/EP2006/050001 patent/WO2006072608A2/en not_active Ceased
- 2006-01-02 EP EP06700234A patent/EP1836192A2/en not_active Withdrawn
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