JP2008525518A - 相乗作用を示す１，２−アルカンジオール混合物の皮膚水分調節組成物としての使用 - Google Patents
相乗作用を示す１，２−アルカンジオール混合物の皮膚水分調節組成物としての使用 Download PDFInfo
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- JP2008525518A JP2008525518A JP2007548808A JP2007548808A JP2008525518A JP 2008525518 A JP2008525518 A JP 2008525518A JP 2007548808 A JP2007548808 A JP 2007548808A JP 2007548808 A JP2007548808 A JP 2007548808A JP 2008525518 A JP2008525518 A JP 2008525518A
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- Prior art keywords
- skin moisture
- polyethylene glycol
- mixture
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- alkanediol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NRLLZRJXDKUVHM-UHFFFAOYSA-N tridecyl 7-methyloctanoate Chemical compound CCCCCCCCCCCCCOC(=O)CCCCCC(C)C NRLLZRJXDKUVHM-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63991004P | 2004-12-29 | 2004-12-29 | |
| PCT/EP2005/057057 WO2006069953A1 (en) | 2004-12-29 | 2005-12-21 | Use of synergistically active 1, 2-alkanediol mixtures as skin moisture-regulating compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525518A true JP2008525518A (ja) | 2008-07-17 |
| JP2008525518A5 JP2008525518A5 (enExample) | 2009-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548808A Pending JP2008525518A (ja) | 2004-12-29 | 2005-12-21 | 相乗作用を示す１，２−アルカンジオール混合物の皮膚水分調節組成物としての使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100216892A1 (enExample) |
| EP (1) | EP1835843A1 (enExample) |
| JP (1) | JP2008525518A (enExample) |
| WO (1) | WO2006069953A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016132668A (ja) * | 2015-01-18 | 2016-07-25 | シムライズ アーゲー | 活性混合物 |
| JP2022511328A (ja) * | 2018-09-20 | 2022-01-31 | シムライズ アーゲー | １，２－ペンタンジオールを含む組成物 |
| JP2023552592A (ja) * | 2020-12-09 | 2023-12-18 | シムライズ アーゲー | 親油性化合物および１種または複数の（バイオ）－アルカンジオールを含む組成物 |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006029559A1 (de) * | 2006-06-26 | 2007-12-27 | Beiersdorf Ag | Kosmetische Zubereitung mit besonderer Textur |
| JP2008120743A (ja) * | 2006-11-14 | 2008-05-29 | Mandom Corp | 毛髪処理用組成物 |
| JP5348837B2 (ja) * | 2006-11-20 | 2013-11-20 | 株式会社マンダム | 毛髪処理用組成物 |
| DE102007017851A1 (de) * | 2007-04-16 | 2008-10-23 | Schülke & Mayr GmbH | Zusammensetzung auf Basis von Glycerinether/Polyol-Gemischen |
| DE202008017353U1 (de) * | 2008-07-14 | 2009-06-10 | Beiersdorf Ag | Kosmetische Zubereitung mit neutralisierter 2-Phenylbenzimidazol-5-sulfonsäure |
| EP2269566A1 (en) * | 2009-06-30 | 2011-01-05 | Cognis IP Management GmbH | Ester mixtures and compositions comprising such ester mixtures |
| EP2549993A4 (en) * | 2010-03-23 | 2014-08-06 | Gojo Ind Inc | ANTIMICROBIAL COMPOSITIONS |
| EP2394703B1 (de) * | 2010-06-14 | 2015-12-23 | Symrise AG | Kühlmischungen mit verstärkter Kühlwirkung von 5-Methyl-2-(propan-2-yl)cyclohexyl-N-ethyloxamat |
| US9029415B2 (en) * | 2010-06-14 | 2015-05-12 | Symrise Ag | Cooling mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate |
| EP2286908A3 (de) | 2010-11-19 | 2011-06-01 | Symrise AG | Lösungsvermittler für kosmetische Zubereitungen |
| DE102013222164A1 (de) * | 2013-10-31 | 2015-04-30 | Deb Ip Limited | Stabilisierte multiple Emulsionen als Hautschutzprodukt |
| DE102013112065A1 (de) * | 2013-11-01 | 2015-05-07 | Minasolve Germany Gmbh | Stabile Lösungen mit physiologischem Kühlreagenz und deren Verwendung |
| US11135456B2 (en) * | 2014-03-14 | 2021-10-05 | Gojo Industries, Inc. | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines |
| BR112017004735A2 (pt) | 2014-09-09 | 2017-12-05 | Hydromer Inc | formulação antimicrobiana, e, formulação de concentrado antimicrobiano. |
| DE102015116835A1 (de) | 2015-10-05 | 2017-04-06 | Minasolve Germany Gmbh | Stabile Lösung von Hexamidin-Salzen in Alkandiol-Wasser-Gemischen mit anti-mikrobieller und hautbefeuchtender Wirkung |
| CH711466B1 (de) * | 2015-11-17 | 2017-02-28 | Labo Cosprophar Ag | Dermokosmetische Zusammensetzung zur topischen Anwendung mit penetrationsverstärkenden Eigenschaften und Verfahren zu deren Herstellung. |
| WO2017173240A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11322591A (ja) * | 1998-02-24 | 1999-11-24 | Mandom Corp | 防腐殺菌剤及び人体施用組成物 |
| JP2002053452A (ja) * | 2000-08-10 | 2002-02-19 | Pola Chem Ind Inc | ストレス対応化粧料 |
| WO2003069994A1 (de) * | 2002-02-19 | 2003-08-28 | Symrise Gmbh & Co. Kg | Synergistische mischungen von 1,2-alkandiolen |
| JP2003335658A (ja) * | 2002-05-17 | 2003-11-25 | Pola Chem Ind Inc | 敏感肌用の化粧料 |
| JP2003342146A (ja) * | 2002-05-23 | 2003-12-03 | Pola Chem Ind Inc | 敏感肌用の皮膚外用剤 |
| JP2006045140A (ja) * | 2004-08-06 | 2006-02-16 | Masato Shimizu | 経皮吸収促進性皮膚外用組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4320744A1 (de) * | 1993-06-23 | 1995-01-05 | Dragoco Gerberding Co Gmbh | Verwendung von Alkandiolen in kosmetischen Produkten |
| DE20221386U1 (de) * | 2002-02-19 | 2005-10-06 | Symrise Gmbh & Co. Kg | Synergistische Mischungen von 1,2-Alkandiolen |
| JP2004250332A (ja) * | 2003-02-18 | 2004-09-09 | Pola Chem Ind Inc | 洗浄用の化粧料 |
| DE10341179A1 (de) * | 2003-09-06 | 2005-03-31 | Beiersdorf Ag | Wirkstoffkombination gegen Akne |
-
2005
- 2005-12-21 WO PCT/EP2005/057057 patent/WO2006069953A1/en not_active Ceased
- 2005-12-21 JP JP2007548808A patent/JP2008525518A/ja active Pending
- 2005-12-21 EP EP05823703A patent/EP1835843A1/en not_active Ceased
- 2005-12-21 US US11/721,113 patent/US20100216892A1/en not_active Abandoned
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11322591A (ja) * | 1998-02-24 | 1999-11-24 | Mandom Corp | 防腐殺菌剤及び人体施用組成物 |
| JP2002053452A (ja) * | 2000-08-10 | 2002-02-19 | Pola Chem Ind Inc | ストレス対応化粧料 |
| WO2003069994A1 (de) * | 2002-02-19 | 2003-08-28 | Symrise Gmbh & Co. Kg | Synergistische mischungen von 1,2-alkandiolen |
| JP2005526036A (ja) * | 2002-02-19 | 2005-09-02 | シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト | １，２−アルカンジオールの相乗的混合物 |
| JP2003335658A (ja) * | 2002-05-17 | 2003-11-25 | Pola Chem Ind Inc | 敏感肌用の化粧料 |
| JP2003342146A (ja) * | 2002-05-23 | 2003-12-03 | Pola Chem Ind Inc | 敏感肌用の皮膚外用剤 |
| JP2006045140A (ja) * | 2004-08-06 | 2006-02-16 | Masato Shimizu | 経皮吸収促進性皮膚外用組成物 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016132668A (ja) * | 2015-01-18 | 2016-07-25 | シムライズ アーゲー | 活性混合物 |
| JP2021176906A (ja) * | 2015-01-18 | 2021-11-11 | シムライズ アーゲー | 活性混合物を用いる方法及び使用並びに最終エマルジョンの製造方法 |
| JP7050407B2 (ja) | 2015-01-18 | 2022-04-08 | シムライズ アーゲー | 活性混合物を用いる方法 |
| JP2022511328A (ja) * | 2018-09-20 | 2022-01-31 | シムライズ アーゲー | １，２－ペンタンジオールを含む組成物 |
| JP2024016098A (ja) * | 2018-09-20 | 2024-02-06 | シムライズ アーゲー | １，２－ペンタンジオールを含む組成物 |
| JP7669445B2 (ja) | 2018-09-20 | 2025-04-28 | シムライズ アーゲー | １，２－ペンタンジオールを含む組成物 |
| JP2023552592A (ja) * | 2020-12-09 | 2023-12-18 | シムライズ アーゲー | 親油性化合物および１種または複数の（バイオ）－アルカンジオールを含む組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006069953A1 (en) | 2006-07-06 |
| EP1835843A1 (en) | 2007-09-26 |
| US20100216892A1 (en) | 2010-08-26 |
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