JP2008525479A - トレフォイル因子およびそれを用いた増殖性疾患の処置方法 - Google Patents
トレフォイル因子およびそれを用いた増殖性疾患の処置方法 Download PDFInfo
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- JP2008525479A JP2008525479A JP2007548477A JP2007548477A JP2008525479A JP 2008525479 A JP2008525479 A JP 2008525479A JP 2007548477 A JP2007548477 A JP 2007548477A JP 2007548477 A JP2007548477 A JP 2007548477A JP 2008525479 A JP2008525479 A JP 2008525479A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2004907226A AU2004907226A0 (en) | 2004-12-22 | TFF3 antagonists | |
| AU2004907263A AU2004907263A0 (en) | 2004-12-22 | Methods of treatment | |
| AU2004907262A AU2004907262A0 (en) | 2004-12-22 | Methods of treatment | |
| PCT/US2005/046634 WO2006069253A2 (en) | 2004-12-22 | 2005-12-22 | Trefoil factors and methods of treating proliferation disorders using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013251639A Division JP2014088393A (ja) | 2004-12-22 | 2013-12-05 | トレフォイル因子およびそれを用いた増殖性疾患の処置方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525479A true JP2008525479A (ja) | 2008-07-17 |
| JP2008525479A5 JP2008525479A5 (https=) | 2009-02-12 |
Family
ID=36602332
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548477A Pending JP2008525479A (ja) | 2004-12-22 | 2005-12-22 | トレフォイル因子およびそれを用いた増殖性疾患の処置方法 |
| JP2013251639A Pending JP2014088393A (ja) | 2004-12-22 | 2013-12-05 | トレフォイル因子およびそれを用いた増殖性疾患の処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013251639A Pending JP2014088393A (ja) | 2004-12-22 | 2013-12-05 | トレフォイル因子およびそれを用いた増殖性疾患の処置方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090022708A1 (https=) |
| EP (1) | EP1833991A4 (https=) |
| JP (2) | JP2008525479A (https=) |
| NZ (1) | NZ556158A (https=) |
| WO (1) | WO2006069253A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015517500A (ja) * | 2012-05-09 | 2015-06-22 | ザ ホン コン ユニバーシティ オブ サイエンス アンド テクノロジイ | Mcm複合体を阻害するための方法および化合物ならびにガン処置におけるそれらの適用 |
| KR20210008914A (ko) * | 2014-01-24 | 2021-01-25 | 삼성전자주식회사 | c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1 |
| WO2021108511A1 (en) * | 2019-11-26 | 2021-06-03 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101743476A (zh) * | 2006-10-03 | 2010-06-16 | 尼瑞医药品有限公司 | 结合三叶因子的构象特异性抗体以及使用该抗体治疗癌症以及增殖疾病的方法 |
| US20090304700A1 (en) * | 2008-06-06 | 2009-12-10 | Neuren Pharmaceuticals, Ltd. | Conformation specific antibodies that bind trefoil factors |
| WO2011068865A1 (en) * | 2009-12-01 | 2011-06-09 | Board Of Trustees Of Southern Illinois University | Micro-rna-101 promotes estrogen-independent growth and confers tamoxifen resistance in er-positive cancer cells |
| CN103096917A (zh) | 2010-06-04 | 2013-05-08 | 三叶草私人有限公司 | 用于治疗慢性肺病的三叶因子(tff) |
| WO2012038825A2 (en) * | 2010-09-21 | 2012-03-29 | Auckland Uniservices Limited | Methods of increasing radiosensitivity using inhibitors of trefoil factor 1 (tff1) |
| WO2012150869A1 (en) * | 2011-05-05 | 2012-11-08 | Neuren Pharmaceuticals Limited | Antibodies that bind trefoil factors and methods of using same |
| CA3053267A1 (en) * | 2017-02-10 | 2018-08-16 | Vivibaba, Inc | Compositions and methods for recombinant nerve growth factor |
| AU2020338947A1 (en) * | 2019-08-27 | 2022-03-31 | Tonix Pharma Limited | Modified TFF2 polypeptides |
| AU2022274703A1 (en) * | 2021-05-12 | 2023-08-17 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators |
| CN113721019A (zh) * | 2021-09-05 | 2021-11-30 | 苏州银湾细胞生物科技有限公司 | 胆管癌术后生存预测方法、试剂盒以及试剂盒的应用方法 |
| CN116286995A (zh) * | 2023-03-24 | 2023-06-23 | 清华大学深圳国际研究生院 | 一种多西霉素浓度梯度依赖性tff3诱导表达质粒及其应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051628A2 (en) * | 2000-01-14 | 2001-07-19 | Millennium Pharmaceuticals, Inc. | Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| JP2002516062A (ja) * | 1997-12-23 | 2002-06-04 | ザ カーネギー インスチチューション オブ ワシントン | 二本鎖rnaによる遺伝子阻害 |
| WO2004039961A2 (en) * | 2002-10-31 | 2004-05-13 | The Gi Company, Inc. | Trefoil domain-containing polypeptides and uses thereof |
| JP2004534075A (ja) * | 2001-06-14 | 2004-11-11 | ノボ ノルディスク アクティーゼルスカブ | Tffダイマーペプチドによる粘膜修復 |
| JP2004534801A (ja) * | 2001-06-14 | 2004-11-18 | ノボ ノルディスク アクティーゼルスカブ | Tff2ペプチドによる粘膜修復 |
| WO2005042010A1 (en) * | 2003-10-30 | 2005-05-12 | Novo Nordisk A/S | Use of trefoil polypeptides in the treatment of diabetes |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US650559A (en) * | 1900-01-31 | 1900-05-29 | American Type Founders Co | Gas-burner. |
| CA2092323A1 (en) | 1990-10-01 | 1992-04-02 | George Y. Wu | Targeting viruses and cells for selective internalization by cells |
| CA2103064A1 (en) | 1991-05-14 | 1992-11-15 | George Y. Wu | Targeted delivery of genes encoding immunogenic proteins |
| DK0587738T3 (da) | 1991-06-05 | 2000-12-18 | Univ Connecticut | Destineret levering af gener, som koder for sekretionsproteiner |
| AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
| EP0633943A4 (en) | 1992-04-03 | 1997-05-02 | Alexander T Young | GENTHERAPY USING TARGETED VIRAL VECTORS. |
| US6525018B1 (en) * | 1999-05-17 | 2003-02-25 | The General Hospital Corp. | Treating eye disorders using intestinal trefoil proteins |
| US20030125265A1 (en) * | 2001-05-09 | 2003-07-03 | Mien-Chie Hung | Anti-estrogen receptor agents for chemotherapy |
| US20030193682A1 (en) * | 2002-04-10 | 2003-10-16 | Parry Travis J. | Method and system for partitioning multiple media handling jobs |
| WO2003004989A2 (en) * | 2001-06-21 | 2003-01-16 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20030215431A1 (en) * | 2002-02-11 | 2003-11-20 | Lars Thim | Management of mucosal viscosity by TFF monomer peptides |
| DE10215320A1 (de) * | 2002-04-02 | 2003-10-23 | Metagen Pharmaceuticals Gmbh | Verwendungen von TFF3 bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| AU2004263140A1 (en) * | 2003-08-07 | 2005-02-17 | Novartis Vaccines And Diagnostics, Inc. | Trefoil factor 3 (TFF3) as a target for anti-cancer therapy |
-
2005
- 2005-12-22 JP JP2007548477A patent/JP2008525479A/ja active Pending
- 2005-12-22 WO PCT/US2005/046634 patent/WO2006069253A2/en not_active Ceased
- 2005-12-22 US US11/794,025 patent/US20090022708A1/en not_active Abandoned
- 2005-12-22 NZ NZ556158A patent/NZ556158A/en not_active IP Right Cessation
- 2005-12-22 EP EP05855229A patent/EP1833991A4/en not_active Withdrawn
-
2010
- 2010-01-04 US US12/651,850 patent/US20100129370A1/en not_active Abandoned
-
2013
- 2013-12-05 JP JP2013251639A patent/JP2014088393A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002516062A (ja) * | 1997-12-23 | 2002-06-04 | ザ カーネギー インスチチューション オブ ワシントン | 二本鎖rnaによる遺伝子阻害 |
| WO2001051628A2 (en) * | 2000-01-14 | 2001-07-19 | Millennium Pharmaceuticals, Inc. | Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| JP2004534075A (ja) * | 2001-06-14 | 2004-11-11 | ノボ ノルディスク アクティーゼルスカブ | Tffダイマーペプチドによる粘膜修復 |
| JP2004534801A (ja) * | 2001-06-14 | 2004-11-18 | ノボ ノルディスク アクティーゼルスカブ | Tff2ペプチドによる粘膜修復 |
| WO2004039961A2 (en) * | 2002-10-31 | 2004-05-13 | The Gi Company, Inc. | Trefoil domain-containing polypeptides and uses thereof |
| WO2005042010A1 (en) * | 2003-10-30 | 2005-05-12 | Novo Nordisk A/S | Use of trefoil polypeptides in the treatment of diabetes |
Non-Patent Citations (5)
| Title |
|---|
| JPN6011047107; Food Addit Contam., 21[2] (2004.02) p.134-144 * |
| JPN6011047110; GI Res., 10[3] (2002) p.211-217 * |
| JPN6011047113; FEBS Lett., 408 (1997) p.121-123 * |
| JPN6011047115; BBA., 1578 (2002) p.12-20 * |
| JPN6011047118; 細胞, 32[8] (2000) p.24-27 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015517500A (ja) * | 2012-05-09 | 2015-06-22 | ザ ホン コン ユニバーシティ オブ サイエンス アンド テクノロジイ | Mcm複合体を阻害するための方法および化合物ならびにガン処置におけるそれらの適用 |
| US11648258B2 (en) | 2012-05-09 | 2023-05-16 | The Hong Kong University Of Science And Technology | Method and compounds for inhibiting the MCM complex and their application in cancer treatment |
| KR20210008914A (ko) * | 2014-01-24 | 2021-01-25 | 삼성전자주식회사 | c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1 |
| KR102291465B1 (ko) | 2014-01-24 | 2021-08-18 | 삼성전자주식회사 | c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1 |
| WO2021108511A1 (en) * | 2019-11-26 | 2021-06-03 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006069253A2 (en) | 2006-06-29 |
| US20090022708A1 (en) | 2009-01-22 |
| US20100129370A1 (en) | 2010-05-27 |
| JP2014088393A (ja) | 2014-05-15 |
| EP1833991A2 (en) | 2007-09-19 |
| EP1833991A4 (en) | 2011-11-16 |
| NZ556158A (en) | 2010-04-30 |
| WO2006069253A3 (en) | 2007-08-02 |
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