JP2008525479A - トレフォイル因子およびそれを用いた増殖性疾患の処置方法 - Google Patents

トレフォイル因子およびそれを用いた増殖性疾患の処置方法 Download PDF

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JP2008525479A
JP2008525479A JP2007548477A JP2007548477A JP2008525479A JP 2008525479 A JP2008525479 A JP 2008525479A JP 2007548477 A JP2007548477 A JP 2007548477A JP 2007548477 A JP2007548477 A JP 2007548477A JP 2008525479 A JP2008525479 A JP 2008525479A
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tff3
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ピーター イー. ロビー
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オークランド ユニサービシス リミテッド
ニューレン ファーマシューティカルズ リミテッド
ニューレン ファーマシューティカルズ インコーポレーティッド
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JP2007548477A 2004-12-22 2005-12-22 トレフォイル因子およびそれを用いた増殖性疾患の処置方法 Pending JP2008525479A (ja)

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Application Number Priority Date Filing Date Title
AU2004907226A AU2004907226A0 (en) 2004-12-22 TFF3 antagonists
AU2004907263A AU2004907263A0 (en) 2004-12-22 Methods of treatment
AU2004907262A AU2004907262A0 (en) 2004-12-22 Methods of treatment
PCT/US2005/046634 WO2006069253A2 (en) 2004-12-22 2005-12-22 Trefoil factors and methods of treating proliferation disorders using same

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JP2008525479A5 JP2008525479A5 (https=) 2009-02-12

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015517500A (ja) * 2012-05-09 2015-06-22 ザ ホン コン ユニバーシティ オブ サイエンス アンド テクノロジイ Mcm複合体を阻害するための方法および化合物ならびにガン処置におけるそれらの適用
KR20210008914A (ko) * 2014-01-24 2021-01-25 삼성전자주식회사 c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1
WO2021108511A1 (en) * 2019-11-26 2021-06-03 Alkahest, Inc. Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101743476A (zh) * 2006-10-03 2010-06-16 尼瑞医药品有限公司 结合三叶因子的构象特异性抗体以及使用该抗体治疗癌症以及增殖疾病的方法
US20090304700A1 (en) * 2008-06-06 2009-12-10 Neuren Pharmaceuticals, Ltd. Conformation specific antibodies that bind trefoil factors
WO2011068865A1 (en) * 2009-12-01 2011-06-09 Board Of Trustees Of Southern Illinois University Micro-rna-101 promotes estrogen-independent growth and confers tamoxifen resistance in er-positive cancer cells
CN103096917A (zh) 2010-06-04 2013-05-08 三叶草私人有限公司 用于治疗慢性肺病的三叶因子(tff)
WO2012038825A2 (en) * 2010-09-21 2012-03-29 Auckland Uniservices Limited Methods of increasing radiosensitivity using inhibitors of trefoil factor 1 (tff1)
WO2012150869A1 (en) * 2011-05-05 2012-11-08 Neuren Pharmaceuticals Limited Antibodies that bind trefoil factors and methods of using same
CA3053267A1 (en) * 2017-02-10 2018-08-16 Vivibaba, Inc Compositions and methods for recombinant nerve growth factor
AU2020338947A1 (en) * 2019-08-27 2022-03-31 Tonix Pharma Limited Modified TFF2 polypeptides
AU2022274703A1 (en) * 2021-05-12 2023-08-17 Alkahest, Inc. Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators
CN113721019A (zh) * 2021-09-05 2021-11-30 苏州银湾细胞生物科技有限公司 胆管癌术后生存预测方法、试剂盒以及试剂盒的应用方法
CN116286995A (zh) * 2023-03-24 2023-06-23 清华大学深圳国际研究生院 一种多西霉素浓度梯度依赖性tff3诱导表达质粒及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051628A2 (en) * 2000-01-14 2001-07-19 Millennium Pharmaceuticals, Inc. Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
JP2002516062A (ja) * 1997-12-23 2002-06-04 ザ カーネギー インスチチューション オブ ワシントン 二本鎖rnaによる遺伝子阻害
WO2004039961A2 (en) * 2002-10-31 2004-05-13 The Gi Company, Inc. Trefoil domain-containing polypeptides and uses thereof
JP2004534075A (ja) * 2001-06-14 2004-11-11 ノボ ノルディスク アクティーゼルスカブ Tffダイマーペプチドによる粘膜修復
JP2004534801A (ja) * 2001-06-14 2004-11-18 ノボ ノルディスク アクティーゼルスカブ Tff2ペプチドによる粘膜修復
WO2005042010A1 (en) * 2003-10-30 2005-05-12 Novo Nordisk A/S Use of trefoil polypeptides in the treatment of diabetes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US650559A (en) * 1900-01-31 1900-05-29 American Type Founders Co Gas-burner.
CA2092323A1 (en) 1990-10-01 1992-04-02 George Y. Wu Targeting viruses and cells for selective internalization by cells
CA2103064A1 (en) 1991-05-14 1992-11-15 George Y. Wu Targeted delivery of genes encoding immunogenic proteins
DK0587738T3 (da) 1991-06-05 2000-12-18 Univ Connecticut Destineret levering af gener, som koder for sekretionsproteiner
AU3434393A (en) 1992-01-17 1993-08-03 Regents Of The University Of Michigan, The Targeted virus
EP0633943A4 (en) 1992-04-03 1997-05-02 Alexander T Young GENTHERAPY USING TARGETED VIRAL VECTORS.
US6525018B1 (en) * 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US20030125265A1 (en) * 2001-05-09 2003-07-03 Mien-Chie Hung Anti-estrogen receptor agents for chemotherapy
US20030193682A1 (en) * 2002-04-10 2003-10-16 Parry Travis J. Method and system for partitioning multiple media handling jobs
WO2003004989A2 (en) * 2001-06-21 2003-01-16 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20030215431A1 (en) * 2002-02-11 2003-11-20 Lars Thim Management of mucosal viscosity by TFF monomer peptides
DE10215320A1 (de) * 2002-04-02 2003-10-23 Metagen Pharmaceuticals Gmbh Verwendungen von TFF3 bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen
US20060019256A1 (en) * 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2004263140A1 (en) * 2003-08-07 2005-02-17 Novartis Vaccines And Diagnostics, Inc. Trefoil factor 3 (TFF3) as a target for anti-cancer therapy

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516062A (ja) * 1997-12-23 2002-06-04 ザ カーネギー インスチチューション オブ ワシントン 二本鎖rnaによる遺伝子阻害
WO2001051628A2 (en) * 2000-01-14 2001-07-19 Millennium Pharmaceuticals, Inc. Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
JP2004534075A (ja) * 2001-06-14 2004-11-11 ノボ ノルディスク アクティーゼルスカブ Tffダイマーペプチドによる粘膜修復
JP2004534801A (ja) * 2001-06-14 2004-11-18 ノボ ノルディスク アクティーゼルスカブ Tff2ペプチドによる粘膜修復
WO2004039961A2 (en) * 2002-10-31 2004-05-13 The Gi Company, Inc. Trefoil domain-containing polypeptides and uses thereof
WO2005042010A1 (en) * 2003-10-30 2005-05-12 Novo Nordisk A/S Use of trefoil polypeptides in the treatment of diabetes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6011047107; Food Addit Contam., 21[2] (2004.02) p.134-144 *
JPN6011047110; GI Res., 10[3] (2002) p.211-217 *
JPN6011047113; FEBS Lett., 408 (1997) p.121-123 *
JPN6011047115; BBA., 1578 (2002) p.12-20 *
JPN6011047118; 細胞, 32[8] (2000) p.24-27 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015517500A (ja) * 2012-05-09 2015-06-22 ザ ホン コン ユニバーシティ オブ サイエンス アンド テクノロジイ Mcm複合体を阻害するための方法および化合物ならびにガン処置におけるそれらの適用
US11648258B2 (en) 2012-05-09 2023-05-16 The Hong Kong University Of Science And Technology Method and compounds for inhibiting the MCM complex and their application in cancer treatment
KR20210008914A (ko) * 2014-01-24 2021-01-25 삼성전자주식회사 c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1
KR102291465B1 (ko) 2014-01-24 2021-08-18 삼성전자주식회사 c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1
WO2021108511A1 (en) * 2019-11-26 2021-06-03 Alkahest, Inc. Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators

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WO2006069253A2 (en) 2006-06-29
US20090022708A1 (en) 2009-01-22
US20100129370A1 (en) 2010-05-27
JP2014088393A (ja) 2014-05-15
EP1833991A2 (en) 2007-09-19
EP1833991A4 (en) 2011-11-16
NZ556158A (en) 2010-04-30
WO2006069253A3 (en) 2007-08-02

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