JP2008525468A5 - - Google Patents
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- Publication number
- JP2008525468A5 JP2008525468A5 JP2007548436A JP2007548436A JP2008525468A5 JP 2008525468 A5 JP2008525468 A5 JP 2008525468A5 JP 2007548436 A JP2007548436 A JP 2007548436A JP 2007548436 A JP2007548436 A JP 2007548436A JP 2008525468 A5 JP2008525468 A5 JP 2008525468A5
- Authority
- JP
- Japan
- Prior art keywords
- perfusion
- organ
- tissue
- heart
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000056 organ Anatomy 0.000 claims description 18
- 210000004351 coronary vessel Anatomy 0.000 claims description 14
- 230000000302 ischemic effect Effects 0.000 claims description 9
- 230000010410 reperfusion Effects 0.000 claims description 3
- 230000010412 perfusion Effects 0.000 claims 18
- 210000001519 tissue Anatomy 0.000 claims 12
- 210000002216 heart Anatomy 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- 208000027418 Wounds and injury Diseases 0.000 claims 7
- 230000006378 damage Effects 0.000 claims 7
- 208000014674 injury Diseases 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 210000004204 blood vessel Anatomy 0.000 claims 4
- 230000006835 compression Effects 0.000 claims 4
- 238000007906 compression Methods 0.000 claims 4
- 239000003223 protective agent Substances 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 230000002669 organ and tissue protective effect Effects 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 2
- IWXNYAIICFKCTM-UHFFFAOYSA-N cariporide Chemical compound CC(C)C1=CC=C(C(=O)N=C(N)N)C=C1S(C)(=O)=O IWXNYAIICFKCTM-UHFFFAOYSA-N 0.000 claims 2
- 229950008393 cariporide Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000001508 eye Anatomy 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 210000002027 skeletal muscle Anatomy 0.000 claims 2
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 1
- 101100116570 Caenorhabditis elegans cup-2 gene Proteins 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 108091006146 Channels Proteins 0.000 claims 1
- 101100116572 Drosophila melanogaster Der-1 gene Proteins 0.000 claims 1
- 229940123271 Endothelin 1 antagonist Drugs 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000000158 apoptosis inhibitor Substances 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- FCTRVTQZOUKUIV-MCDZGGTQSA-M potassium;[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound [K+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]1O FCTRVTQZOUKUIV-MCDZGGTQSA-M 0.000 claims 1
- 229940125794 sodium channel blocker Drugs 0.000 claims 1
- 239000003195 sodium channel blocking agent Substances 0.000 claims 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 4
- 229960004373 acetylcholine Drugs 0.000 description 4
- 230000003750 conditioning effect Effects 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 230000008753 endothelial function Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 description 2
- 230000010413 ischemic postconditioning Effects 0.000 description 2
- 230000010411 postconditioning Effects 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63846104P | 2004-12-22 | 2004-12-22 | |
| PCT/US2005/046417 WO2006069170A2 (en) | 2004-12-22 | 2005-12-20 | Therapeutic adjuncts to enhance the organ protective effects of postconditioning |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525468A JP2008525468A (ja) | 2008-07-17 |
| JP2008525468A5 true JP2008525468A5 (https=) | 2009-01-29 |
Family
ID=36602296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548436A Withdrawn JP2008525468A (ja) | 2004-12-22 | 2005-12-20 | ポストコンディショニング臓器保護作用を増強する治療補助薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080097385A1 (https=) |
| EP (1) | EP1827298A4 (https=) |
| JP (1) | JP2008525468A (https=) |
| AU (1) | AU2005319144A1 (https=) |
| CA (1) | CA2592142A1 (https=) |
| WO (1) | WO2006069170A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1168912B1 (en) | 1999-03-23 | 2007-05-09 | Hibernation Therapeutics Limited | Organ arrest, protection and preservation |
| WO2003035142A2 (en) | 2001-10-25 | 2003-05-01 | Emory University | Catheter for modified perfusion |
| EP3064242A1 (en) | 2003-04-28 | 2016-09-07 | Advanced Circulatory Systems Inc. | Ventilator and methods for treating head trauma and low blood circulation |
| JP2009538834A (ja) | 2006-05-29 | 2009-11-12 | ハイバーネイション セラピューティクス リミテッド | 組織維持の改善 |
| ES2539762T3 (es) | 2006-07-25 | 2015-07-03 | Hibernation Therapeutics, A Kf Llc | Tratamiento de traumatismos |
| US7717855B2 (en) | 2006-12-06 | 2010-05-18 | The Hospital For Sick Children | System for performing remote ischemic preconditioning |
| WO2008106724A1 (en) | 2007-03-02 | 2008-09-12 | Hibernation Therapeutics Limited | Transplants |
| US20110046039A1 (en) * | 2007-03-09 | 2011-02-24 | George Mason Intellectual Properties Inc. | Post-exposure prophylaxis and treatment of infections |
| US8151790B2 (en) | 2007-04-19 | 2012-04-10 | Advanced Circulatory Systems, Inc. | Volume exchanger valve system and method to increase circulation during CPR |
| US9352111B2 (en) | 2007-04-19 | 2016-05-31 | Advanced Circulatory Systems, Inc. | Systems and methods to increase survival with favorable neurological function after cardiac arrest |
| CN101808509A (zh) * | 2007-07-25 | 2010-08-18 | 低温药理有限公司 | 改进的器官保护、维护和康复 |
| EP2335717A1 (en) * | 2009-11-16 | 2011-06-22 | Institut National De La Recherche Agronomique | PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
| US20110190727A1 (en) * | 2010-02-02 | 2011-08-04 | Boston Scientific Scimed, Inc. | Intervascular catheter, system and method |
| US9724266B2 (en) | 2010-02-12 | 2017-08-08 | Zoll Medical Corporation | Enhanced guided active compression decompression cardiopulmonary resuscitation systems and methods |
| US12016820B2 (en) | 2010-02-12 | 2024-06-25 | Zoll Medical Corporation | Enhanced guided active compression decompression cardiopulmonary resuscitation systems and methods |
| US20120330199A1 (en) * | 2010-07-02 | 2012-12-27 | ResQSystems, Inc. | Methods and systems for reperfusion injury protection after cardiac arrest |
| CA2795053A1 (en) | 2010-03-31 | 2011-10-06 | The Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
| SG10201908576VA (en) | 2010-04-08 | 2019-10-30 | Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
| US9168361B2 (en) | 2010-04-30 | 2015-10-27 | Abbott Cardiovascular Systems Inc. | Balloon catheter exhibiting rapid inflation and deflation |
| US8540669B2 (en) | 2010-04-30 | 2013-09-24 | Abbott Cardiovascular Systems Inc. | Catheter system providing step reduction for postconditioning |
| US8480650B2 (en) | 2010-04-30 | 2013-07-09 | Abbott Cardiovascular Systems Inc. | Method for increased uptake of beneficial agent and ejection fraction by postconditioning procedures |
| US8708996B2 (en) | 2010-04-30 | 2014-04-29 | Abbott Cardiovascular Systems, Inc. | Methods and device for synergistic mitigation of reperfusion injury after an ischemic event |
| CN102939126B (zh) | 2010-04-30 | 2015-09-16 | 雅培心脏血管系统股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
| WO2011136815A1 (en) | 2010-04-30 | 2011-11-03 | Abbott Cardiovascular Systems Inc. | Catheter system having a fluid circuit |
| JP5770512B2 (ja) * | 2011-03-31 | 2015-08-26 | テルモ株式会社 | 肢部圧迫装置 |
| US9533124B2 (en) | 2011-04-14 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Reperfusion injury devices |
| AU2012327224A1 (en) * | 2011-11-18 | 2013-06-06 | Apotex Technologies Inc. | Methods of treatment with deferiprone |
| AU2012358977A1 (en) | 2011-12-19 | 2014-07-24 | ResQSystems, Inc. | Systems and methods for therapeutic intrathoracic pressure regulation |
| CA2942614A1 (en) | 2013-03-15 | 2014-10-16 | The Hospital For Sick Children | Methods for modulating autophagy using remote ischemic conditioning |
| WO2014199239A2 (en) | 2013-03-15 | 2014-12-18 | The Hospital For Sick Children | Methods relating to the use of remote ischemic conditioning |
| WO2014140832A2 (en) | 2013-03-15 | 2014-09-18 | The Hospital For Sick Children | Treatment of erectile dysfunction using remote ischemic conditioning |
| US9811634B2 (en) | 2013-04-25 | 2017-11-07 | Zoll Medical Corporation | Systems and methods to predict the chances of neurologically intact survival while performing CPR |
| US20140358047A1 (en) | 2013-05-30 | 2014-12-04 | ResQSystems, Inc. | End-tidal carbon dioxide and amplitude spectral area as non-invasive markers of coronary perfusion pressure and arterial pressure |
| WO2015006831A1 (en) | 2013-07-17 | 2015-01-22 | Hts Therapeutics Pty Ltd | A method for reducing, inflammation, coagulation and adhesions |
| US10265495B2 (en) | 2013-11-22 | 2019-04-23 | Zoll Medical Corporation | Pressure actuated valve systems and methods |
| US10092591B2 (en) * | 2014-02-27 | 2018-10-09 | University Of Alaska Fairbanks | Methods and compositions for the treatment of ischemic injury to tissue using therapeutic hypothermia |
| KR102870840B1 (ko) * | 2018-01-10 | 2025-10-22 | 터프츠 메디컬 센터, 인크 | 심근 경색 치료시 좌심실 언로딩 시스템 및 방법 |
Family Cites Families (76)
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| US4781677A (en) * | 1985-07-17 | 1988-11-01 | Wilcox Gilbert M | Method of treatment utilizing a double balloon nasobiliary occlusion catheter |
| US4691708A (en) * | 1986-03-10 | 1987-09-08 | Cordis Corporation | Optical pressure sensor for measuring blood pressure |
| US4769010A (en) * | 1987-02-11 | 1988-09-06 | Strato Medical Corporation | Catheter needle assembly with adjustable height support |
| US4901731A (en) * | 1988-04-27 | 1990-02-20 | Millar Instruments, Inc. | Single sensor pressure differential device |
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| US4943277A (en) * | 1989-03-24 | 1990-07-24 | Bolling Steven F | Retrograde coronary sinus cardioplegia cannula and method for using same in heart surgery |
| US5129891A (en) * | 1989-05-19 | 1992-07-14 | Strato Medical Corporation | Catheter attachment device |
| DE4003425A1 (de) * | 1990-02-06 | 1991-08-08 | Beyersdorf Friedhelm Dr Med | Reperfusionsvorrichtung |
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| US20050187221A1 (en) * | 2003-09-08 | 2005-08-25 | Japan Tobacco Inc. | Method of treating ischemia reperfusion injury |
| US20060029589A1 (en) * | 2004-06-01 | 2006-02-09 | Hartmut Weiler | Induction of heterozygous FV Leiden carrier status to reduce mortality in sepsis and to prevent organ damage caused by inflammation and/or ischemia-reperfusion injury |
| US7304073B2 (en) * | 2004-08-20 | 2007-12-04 | Wyeth | Method of treating myocardial ischemia-reperfusion injury using NF-kB inhibitors |
| US20060136023A1 (en) * | 2004-08-26 | 2006-06-22 | Dobak John D Iii | Method and apparatus for patient temperature control employing administration of anti-shivering agents |
| US7332159B2 (en) * | 2004-09-30 | 2008-02-19 | Board Of Regents Of The University Of Nebraska | Method and composition for inhibiting reperfusion injury in the brain |
-
2005
- 2005-12-20 CA CA002592142A patent/CA2592142A1/en not_active Abandoned
- 2005-12-20 JP JP2007548436A patent/JP2008525468A/ja not_active Withdrawn
- 2005-12-20 WO PCT/US2005/046417 patent/WO2006069170A2/en not_active Ceased
- 2005-12-20 EP EP05855042A patent/EP1827298A4/en not_active Withdrawn
- 2005-12-20 AU AU2005319144A patent/AU2005319144A1/en not_active Abandoned
- 2005-12-20 US US11/793,508 patent/US20080097385A1/en not_active Abandoned
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