JP2008524235A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008524235A5 JP2008524235A5 JP2007546882A JP2007546882A JP2008524235A5 JP 2008524235 A5 JP2008524235 A5 JP 2008524235A5 JP 2007546882 A JP2007546882 A JP 2007546882A JP 2007546882 A JP2007546882 A JP 2007546882A JP 2008524235 A5 JP2008524235 A5 JP 2008524235A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- implant
- polar aprotic
- optionally
- octreotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 41
- 239000007943 implant Substances 0.000 claims 19
- 239000007788 liquid Substances 0.000 claims 19
- 229920001169 thermoplastic Polymers 0.000 claims 14
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 12
- 108010016076 Octreotide Proteins 0.000 claims 12
- 229960002700 octreotide Drugs 0.000 claims 12
- 230000009969 flowable effect Effects 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- 229920000728 polyester Polymers 0.000 claims 8
- 210000001124 body fluid Anatomy 0.000 claims 6
- 239000010839 body fluid Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000004416 thermosoftening plastic Substances 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 102000005157 Somatostatin Human genes 0.000 claims 3
- 108010056088 Somatostatin Proteins 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 210000002615 epidermis Anatomy 0.000 claims 3
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 3
- 229960000553 somatostatin Drugs 0.000 claims 3
- 206010007270 Carcinoid syndrome Diseases 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 102000018997 Growth Hormone Human genes 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 2
- 230000003628 erosive effect Effects 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- 208000004652 Cardiovascular Abnormalities Diseases 0.000 claims 1
- 206010065929 Cardiovascular insufficiency Diseases 0.000 claims 1
- 208000010837 Diabetic eye disease Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102000051325 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 108050001286 Somatostatin Receptor Proteins 0.000 claims 1
- 102000011096 Somatostatin receptor Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000001186 cumulative effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 150000001991 dicarboxylic acids Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63627304P | 2004-12-15 | 2004-12-15 | |
| PCT/US2005/045346 WO2006065951A2 (en) | 2004-12-15 | 2005-12-15 | Sustained delivery formulations of octreotide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008524235A JP2008524235A (ja) | 2008-07-10 |
| JP2008524235A5 true JP2008524235A5 (enExample) | 2009-01-29 |
Family
ID=36588524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546882A Pending JP2008524235A (ja) | 2004-12-15 | 2005-12-15 | オクトレオチド化合物の徐放性送達処方物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090092650A1 (enExample) |
| EP (1) | EP1838285A2 (enExample) |
| JP (1) | JP2008524235A (enExample) |
| AU (1) | AU2005316545A1 (enExample) |
| CA (1) | CA2590696A1 (enExample) |
| WO (1) | WO2006065951A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP2079767B1 (en) * | 2006-10-11 | 2014-08-27 | Tolmar Therapeutics, Inc. | Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction |
| EP2907524A1 (en) | 2007-05-25 | 2015-08-19 | RB Pharmaceuticals Limited | Sustained delivery formulations of risperidone compounds |
| CN102112107A (zh) * | 2008-06-03 | 2011-06-29 | 托马医疗科技公司 | 具有改进的释放动力学特征的控制释放共聚物制剂 |
| US20100151033A1 (en) * | 2008-12-15 | 2010-06-17 | Novartis Ag | Octreotide depot formulation with constantly high exposure levels |
| US8815971B2 (en) * | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
| US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US8569421B2 (en) | 2009-04-23 | 2013-10-29 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US9155745B2 (en) * | 2009-06-16 | 2015-10-13 | Universite De Geneve | Bevacizumab formulations with lower aggregation propensity, comprising corticosteroid anti-inflammatory drugs |
| BR112012002341A8 (pt) | 2009-08-06 | 2017-10-10 | Koninklijke Philips Electronics Nv | Semente radioativa para uso na terapia oncológica e método de terapia oncológica |
| WO2011087496A1 (en) * | 2010-01-13 | 2011-07-21 | Oakwood Laboratories LLC | Microspheres for the sustained release of octreotide without an initial time lag |
| WO2011112996A2 (en) * | 2010-03-12 | 2011-09-15 | Surmodics, Inc. | Injectable drug delivery system |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| JP6294885B2 (ja) | 2012-08-30 | 2018-03-14 | エーティーアールピー ソリューションズ インコーポレイテッドＡＴＲＰ Ｓｏｌｕｔｉｏｎｓ，Ｉｎｃ． | 星形高分子、星形高分子組成物および星形高分子の製造方法 |
| CA2899349C (en) | 2013-02-04 | 2021-09-21 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| EP2823808A1 (en) * | 2013-07-09 | 2015-01-14 | Ipsen Pharma S.A.S. | Pharmaceutical composition for a sustained release of lanreotide |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| MX385886B (es) | 2014-07-03 | 2025-03-18 | Pilot Polymer Tech Inc | Macromoleculas estrellas compatibles con tensoactivos. |
| CA2965895C (en) | 2014-11-07 | 2019-08-06 | Indivior Uk Limited | The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders |
| ES2836805T3 (es) * | 2015-08-03 | 2021-06-28 | Tolmar International Ltd | Sistema de administración de polímeros líquidos para la administración extendida de fármacos |
| WO2017083800A1 (en) * | 2015-11-13 | 2017-05-18 | Ohr Pharmaceutical, Inc. | Occult cnv size as a predictor for treatment with squalamine |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| US11690806B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| MX2020012458A (es) | 2018-05-24 | 2021-04-28 | Celanese Eva Performance Polymers Llc | Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular. |
| WO2020087205A1 (en) * | 2018-10-29 | 2020-05-07 | Pujing Chemical Industry Co., Ltd | Polyglycolide copolymer and preparation tehreof |
| CN112469763B (zh) * | 2018-10-29 | 2023-11-24 | 上海浦景化工技术股份有限公司 | 耐高温和耐老化的聚乙交酯共聚物及其组成 |
| CN111214643A (zh) * | 2020-03-11 | 2020-06-02 | 苏州善湾生物医药科技有限公司 | 一种基于皮下凝胶缓释的奥曲肽组合物、制备方法及应用 |
| WO2022231930A1 (en) | 2021-04-26 | 2022-11-03 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| CN113318218A (zh) * | 2021-07-20 | 2021-08-31 | 国药一心制药有限公司 | 一种醋酸奥曲肽注射液及其制备工艺 |
| CN120131956A (zh) * | 2023-12-11 | 2025-06-13 | 中山大学中山眼科中心 | 生长激素抑制剂的用途、和含有生长激素抑制剂的药物组合物、制剂、及其装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6565874B1 (en) * | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| ATE361057T1 (de) * | 2000-12-21 | 2007-05-15 | Alrise Biosystems Gmbh | Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln |
| WO2002058671A1 (en) * | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Burst free pharmaceutical microparticules |
| US20040131595A1 (en) * | 2002-11-05 | 2004-07-08 | Wellstat Biologics Corporation | Treating carcinoid neoplasms with therapeutic viruses |
| CN1713890A (zh) * | 2002-11-06 | 2005-12-28 | 阿尔萨公司 | 控释储库制剂 |
| US20040097419A1 (en) * | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
| US7803781B2 (en) * | 2003-02-28 | 2010-09-28 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| EP1622540A4 (en) * | 2003-03-11 | 2009-12-30 | Qlt Usa Inc | PREPARATIONS OF ANTI-CANCER AGENTS DEPENDENT ON THE CELLULAR PROGRAM |
| EA015793B1 (ru) * | 2005-03-11 | 2011-12-30 | Индевус Фармасеутикалс, Инк. | Способ лечения акромегалии и связанных с ней симптомов и имплант, применяемый в этом способе |
-
2005
- 2005-12-15 JP JP2007546882A patent/JP2008524235A/ja active Pending
- 2005-12-15 CA CA002590696A patent/CA2590696A1/en not_active Abandoned
- 2005-12-15 WO PCT/US2005/045346 patent/WO2006065951A2/en not_active Ceased
- 2005-12-15 EP EP05849725A patent/EP1838285A2/en not_active Withdrawn
- 2005-12-15 US US11/793,296 patent/US20090092650A1/en not_active Abandoned
- 2005-12-15 AU AU2005316545A patent/AU2005316545A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008524235A5 (enExample) | ||
| US20220354956A1 (en) | Biodegradable drug delivery for hydrophobic compositions | |
| CA2822854C (en) | Biodegradable drug delivery compositions | |
| ES2240236T3 (es) | Composicion de polimero biodegradable. | |
| Kempe et al. | In situ forming implants—an attractive formulation principle for parenteral depot formulations | |
| CN101801415B (zh) | 利培酮化合物的持续递送制剂 | |
| JP6061823B2 (ja) | 改良された効力を備えた、ロイプロリドのポリマー送達処方物 | |
| JP4686653B2 (ja) | 低い初期薬物噴出性を有する制御放出性液状デリバリー組成物 | |
| JP2004510807A5 (enExample) | ||
| US20090181068A1 (en) | Low Viscosity Liquid Polymeric Delivery System | |
| JPH05286850A (ja) | 放出を制御されたインプラントに使用する液状混合物、インプラントに好適なポリマーシステム及びそのポリマーシステムを用いた治療方法 | |
| JP2010531807A5 (enExample) | ||
| RS56820B1 (sr) | Injektabilna tečna kompozicija koja sadrži buprenorfin | |
| JP2002537221A (ja) | 成形可能な固体のデリバリーシステム | |
| CN102112107A (zh) | 具有改进的释放动力学特征的控制释放共聚物制剂 | |
| KR20200072322A (ko) | 온도감응형 하이드로겔을 이용한 서방성 약물전달체 제조방법 | |
| ES2370377T3 (es) | Sistema de administración de un líquido polimérico de baja viscosidad. | |
| Singh et al. | In Situ Forming Phase–inversion injectable Hydrogels for Controlled Drug Release |