JP2008524204A5 - - Google Patents

Info

Publication number

JP2008524204A5

JP2008524204A5 JP2007546307A JP2007546307A JP2008524204A5 JP 2008524204 A5 JP2008524204 A5 JP 2008524204A5 JP 2007546307 A JP2007546307 A JP 2007546307A JP 2007546307 A JP2007546307 A JP 2007546307A JP 2008524204 A5 JP2008524204 A5 JP 2008524204A5

Authority

JP

Japan

Prior art keywords

cefepime

amikacin

pharmaceutically acceptable

acceptable salt

antibiotic

Prior art date

2005-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 10
• MMRINLZOZVAPDZ-LSGRDSQZSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;chloride Chemical compound Cl.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 MMRINLZOZVAPDZ-LSGRDSQZSA-N 0.000 claims 9
• 150000003839 salts Chemical class 0.000 claims 9
• 229960004821 amikacin Drugs 0.000 claims 8
• LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 8
• 230000003115 biocidal effect Effects 0.000 claims 8
• 229960002100 cefepime Drugs 0.000 claims 8
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 6
• 239000002253 acid Substances 0.000 claims 6
• 239000003381 stabilizer Substances 0.000 claims 6
• 239000011261 inert gas Substances 0.000 claims 4
• 238000011049 filling Methods 0.000 claims 3
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• 238000002156 mixing Methods 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 229910001873 dinitrogen Inorganic materials 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 229960000318 kanamycin Drugs 0.000 claims 2
• 229930027917 kanamycin Natural products 0.000 claims 2
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 2
• 229930182823 kanamycin A Natural products 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000001243 protein synthesis Methods 0.000 claims 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
• 230000014616 translation Effects 0.000 claims 2
• YWMSSKBMOFPBDM-UHFFFAOYSA-N 4-carbamoylbenzenesulfonyl chloride Chemical compound NC(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 YWMSSKBMOFPBDM-UHFFFAOYSA-N 0.000 claims 1
• 238000012371 Aseptic Filling Methods 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 229930186147 Cephalosporin Natural products 0.000 claims 1
• 229930182566 Gentamicin Natural products 0.000 claims 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
• 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 1
• 229940123573 Protein synthesis inhibitor Drugs 0.000 claims 1
• 229960001656 amikacin sulfate Drugs 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• 229940126574 aminoglycoside antibiotic Drugs 0.000 claims 1
• 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims 1
• 230000000845 anti-microbial effect Effects 0.000 claims 1
• 239000004599 antimicrobial Substances 0.000 claims 1
• 229940090047 auto-injector Drugs 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 claims 1
• 229960005361 cefaclor Drugs 0.000 claims 1
• 229960000927 cefepime hydrochloride Drugs 0.000 claims 1
• 229960004261 cefotaxime Drugs 0.000 claims 1
• AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 claims 1
• 229960000484 ceftazidime Drugs 0.000 claims 1
• ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 claims 1
• 229960004755 ceftriaxone Drugs 0.000 claims 1
• VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 1
• 229960001668 cefuroxime Drugs 0.000 claims 1
• JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 claims 1
• 229940124587 cephalosporin Drugs 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 238000002648 combination therapy Methods 0.000 claims 1
• 239000007789 gas Substances 0.000 claims 1
• 229960002518 gentamicin Drugs 0.000 claims 1
• ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000000007 protein synthesis inhibitor Substances 0.000 claims 1
• 239000002904 solvent Substances 0.000 claims 1
• 229960005322 streptomycin Drugs 0.000 claims 1
• 230000002195 synergetic effect Effects 0.000 claims 1
• 229960000707 tobramycin Drugs 0.000 claims 1
• NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
• -1 β-lactam cephalosporin Chemical class 0.000 claims 1