JP2008524158A - カリウムチャネル活性化剤として有用なジフェニル尿素誘導体 - Google Patents

カリウムチャネル活性化剤として有用なジフェニル尿素誘導体 Download PDF

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Publication number
JP2008524158A
JP2008524158A JP2007546052A JP2007546052A JP2008524158A JP 2008524158 A JP2008524158 A JP 2008524158A JP 2007546052 A JP2007546052 A JP 2007546052A JP 2007546052 A JP2007546052 A JP 2007546052A JP 2008524158 A JP2008524158 A JP 2008524158A
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Prior art keywords
phenyl
carbonyl
amino
alkyl
urea
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JP2007546052A
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Japanese (ja)
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JP2008524158A5 (enExample
Inventor
ダール、ビャーネ、エイチ．
クリストファーセン、パッレ
デムニッツ、ヨアキム
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ノイロサーチ アクティーゼルスカブ
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Publication of JP2008524158A publication Critical patent/JP2008524158A/ja
Publication of JP2008524158A5 publication Critical patent/JP2008524158A5/ja
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007546052A 2004-12-17 2005-12-14 カリウムチャネル活性化剤として有用なジフェニル尿素誘導体 Abandoned JP2008524158A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200401953 2004-12-17
US63777504P 2004-12-22 2004-12-22
PCT/EP2005/056766 WO2006064015A2 (en) 2004-12-17 2005-12-14 Diphenylurea derivatives useful as potassium channel activators

Publications (2)

Publication Number Publication Date
JP2008524158A true JP2008524158A (ja) 2008-07-10
JP2008524158A5 JP2008524158A5 (enExample) 2009-01-29

Family

ID=36354109

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007546052A Abandoned JP2008524158A (ja) 2004-12-17 2005-12-14 カリウムチャネル活性化剤として有用なジフェニル尿素誘導体

Country Status (8)

Country Link
US (1) US20070293553A1 (enExample)
EP (1) EP1827411A2 (enExample)
JP (1) JP2008524158A (enExample)
CN (1) CN101287456A (enExample)
AU (1) AU2005315607A1 (enExample)
CA (1) CA2591616A1 (enExample)
MX (1) MX2007007029A (enExample)
WO (1) WO2006064015A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019137678A (ja) * 2018-02-08 2019-08-22 国立大学法人東北大学 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81664C2 (ru) * 2003-06-17 2008-01-25 Ньюросерч А/С Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
EP2121640A1 (en) * 2007-01-18 2009-11-25 NeuroSearch AS Novel semicarbazide and carbonylhydrazide derivatives useful as potassium channel modulators
EP2146971A1 (en) * 2007-05-08 2010-01-27 NeuroSearch A/S Novel benzamidine derivatives useful as potassium channel modulators
EP2148868A1 (en) 2007-05-15 2010-02-03 NeuroSearch A/S Novel aromatic heterocyclic carboxylic acid amide derivatives useful as potassium channel modulators
WO2011053468A1 (en) * 2009-10-30 2011-05-05 Sanofi-Aventis Amino-benzoic acid derivatives for use in the treatment of dihydrogenase-related disorders
BR112018073518A2 (pt) 2016-05-17 2019-03-19 Scandion Oncology A/S métodos para sensibilização de células de câncer a um tratamento anticâncer, para potencialização do efeito terapêutico de um tratamento anticâncer e para tratamento de câncer, composição, modulador de canais de ânion regulados por volume, kit de peças, e, uso de um modulador de canais de ânion regulados por volume
AU2022414087A1 (en) * 2021-12-14 2024-08-01 Trustees Of Tufts College Use of hyperpolarizing agents alone and in combination with other therapeutic agents for treating cancers including glioblastoma
TW202337446A (zh) * 2022-01-28 2023-10-01 韓商鐘根堂股份有限公司 用於預防或治療肺動脈高血壓之組合物
CN117229258B (zh) * 2022-06-07 2024-07-19 杭州壹瑞医药科技有限公司 N-四唑基芳基脲类衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000245A1 (en) * 2001-06-22 2003-01-03 Poseidon Pharmaceuticals A/S Compounds for use in disorders associated with mast cell or basophil activity
US20060160856A1 (en) * 2002-09-05 2006-07-20 Dahl Bjarne H Diarylurea derivatives and their use as chloride channel blockers
DE60327652D1 (de) * 2002-11-21 2009-06-25 Neurosearch As Diarylureidoderivate und deren medizinische verwendung
UA81664C2 (ru) * 2003-06-17 2008-01-25 Ньюросерч А/С Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов
US7851492B2 (en) * 2003-09-04 2010-12-14 Neurosearch A/S ERG channel openers for the treatment of cardiac arrhythmias
WO2005023238A1 (en) * 2003-09-04 2005-03-17 Poseidon Pharmaceuticals A/S Erg channel openers for the treatment of hyperexcitability-related neuronal diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019137678A (ja) * 2018-02-08 2019-08-22 国立大学法人東北大学 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法
JP7111359B2 (ja) 2018-02-08 2022-08-02 国立大学法人東北大学 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法

Also Published As

Publication number Publication date
MX2007007029A (es) 2007-08-08
US20070293553A1 (en) 2007-12-20
CA2591616A1 (en) 2006-06-22
WO2006064015A2 (en) 2006-06-22
WO2006064015A3 (en) 2006-08-03
CN101287456A (zh) 2008-10-15
EP1827411A2 (en) 2007-09-05
AU2005315607A1 (en) 2006-06-22

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