JP2008523787A5 - - Google Patents
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- Publication number
- JP2008523787A5 JP2008523787A5 JP2007545789A JP2007545789A JP2008523787A5 JP 2008523787 A5 JP2008523787 A5 JP 2008523787A5 JP 2007545789 A JP2007545789 A JP 2007545789A JP 2007545789 A JP2007545789 A JP 2007545789A JP 2008523787 A5 JP2008523787 A5 JP 2008523787A5
- Authority
- JP
- Japan
- Prior art keywords
- protease
- adam10
- fragment
- adam protease
- adam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000029791 ADAM Human genes 0.000 claims 41
- 108091022885 ADAM Proteins 0.000 claims 41
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 238000006467 substitution reaction Methods 0.000 claims 24
- 235000018102 proteins Nutrition 0.000 claims 23
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 235000018417 cysteine Nutrition 0.000 claims 22
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 22
- 102000036664 ADAM10 Human genes 0.000 claims 20
- 108091007504 ADAM10 Proteins 0.000 claims 20
- 239000012634 fragment Substances 0.000 claims 20
- 102000043279 ADAM17 Human genes 0.000 claims 19
- 108091007505 ADAM17 Proteins 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- 239000000758 substrate Substances 0.000 claims 15
- 239000003112 inhibitor Substances 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000006337 proteolytic cleavage Effects 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 4
- 102100033919 Ephrin-A2 Human genes 0.000 claims 3
- 108010043942 Ephrin-A2 Proteins 0.000 claims 3
- 102100033941 Ephrin-A5 Human genes 0.000 claims 3
- 101000925251 Homo sapiens Ephrin-A5 Proteins 0.000 claims 3
- 108010055191 EphA3 Receptor Proteins 0.000 claims 2
- 108010055334 EphB2 Receptor Proteins 0.000 claims 2
- 102100030324 Ephrin type-A receptor 3 Human genes 0.000 claims 2
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims 2
- 102100031983 Ephrin type-B receptor 4 Human genes 0.000 claims 2
- 102000006396 Ephrin-B2 Human genes 0.000 claims 2
- 108010044090 Ephrin-B2 Proteins 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 108010015255 protransforming growth factor alpha Proteins 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 1
- 101800001224 Disintegrin Proteins 0.000 claims 1
- 102100029837 Probetacellulin Human genes 0.000 claims 1
- 101710186503 Probetacellulin Proteins 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 102000012803 ephrin Human genes 0.000 claims 1
- 108060002566 ephrin Proteins 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000302 molecular modelling Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001603 reducing effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63742504P | 2004-12-17 | 2004-12-17 | |
| US60/637,425 | 2004-12-17 | ||
| PCT/AU2005/001917 WO2006063415A1 (en) | 2004-12-17 | 2005-12-19 | Regulation of metalloprotease cleavage of cell surface proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008523787A JP2008523787A (ja) | 2008-07-10 |
| JP2008523787A5 true JP2008523787A5 (enExample) | 2009-01-29 |
| JP5616572B2 JP5616572B2 (ja) | 2014-10-29 |
Family
ID=36587470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545789A Expired - Fee Related JP5616572B2 (ja) | 2004-12-17 | 2005-12-19 | 哺乳類修飾ａｄａｍ１０プロテアーゼまたはそのフラグメント、単離核酸、遺伝子構築物、宿主細胞、抗体、及び産生方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7960513B2 (enExample) |
| EP (1) | EP1833964B1 (enExample) |
| JP (1) | JP5616572B2 (enExample) |
| AU (1) | AU2005316217A1 (enExample) |
| CA (1) | CA2591659A1 (enExample) |
| NZ (1) | NZ556143A (enExample) |
| WO (1) | WO2006063415A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477932A1 (en) * | 2002-03-08 | 2003-09-18 | Axel Ullrich | Use of egfr transactivation inhibitors in human cancer |
| RU2392961C2 (ru) * | 2004-11-10 | 2010-06-27 | Хубрехт Лабораториум | Лечение аденомы и/или аденокарциномы кишечника с помощью ингибирования активации пути notch |
| JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
| EP2514767A1 (en) * | 2006-12-19 | 2012-10-24 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| WO2010093976A1 (en) * | 2009-02-12 | 2010-08-19 | University Of Southern California | Bioadhesive patch for sutureless closure of soft tissue |
| AR098953A1 (es) * | 2013-12-24 | 2016-06-22 | Pf Medicament | Anticuerpo anti-adam17 (proteína desintegrina y metaloproteinasa-17) y su uso para el tratamiento de cáncer |
| EP3102940B1 (en) | 2014-02-04 | 2019-06-26 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
| US11160873B2 (en) | 2014-02-04 | 2021-11-02 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
| US20180057601A1 (en) * | 2014-12-24 | 2018-03-01 | Pierre Fabre Medicament | Novel humanized adam17 antibody |
| EP3690022A1 (en) | 2016-05-18 | 2020-08-05 | Keio University | Cell culture medium for culturing organoid, culture method, and organoid |
| EP3934418A4 (en) | 2019-03-08 | 2023-01-18 | Memorial Sloan Kettering Cancer Center | ADAM17 BINDING MOLECULES AND THEIR USES |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849338A (en) | 1982-07-16 | 1989-07-18 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4843000A (en) | 1979-12-26 | 1989-06-27 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| AU6136694A (en) | 1993-02-12 | 1994-08-29 | Repligen Corporation | Methods for generating broadly neutralizing anti-hiv antibodies and antigens capable of eliciting same |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| JP3974941B2 (ja) | 1995-11-21 | 2007-09-12 | イェール ユニバーシティ | 単分子セグメントの増幅および検出 |
| US5752019A (en) | 1995-12-22 | 1998-05-12 | International Business Machines Corporation | System and method for confirmationally-flexible molecular identification |
| US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
| JP2000517185A (ja) * | 1996-08-29 | 2000-12-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 新規なメタロプロテアーゼファミリーｋｕｚ |
| US20040224378A1 (en) * | 2002-06-07 | 2004-11-11 | Athersys, Inc. | Methods for using ADAMTS-12, an integrin and metalloprotease with thrombspondin motifs |
| IL150347A (en) | 2002-06-20 | 2008-07-08 | Eci Telecom Ltd | Method and system for span optical power control |
| AU2003900541A0 (en) * | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
-
2005
- 2005-12-19 US US11/721,949 patent/US7960513B2/en not_active Expired - Fee Related
- 2005-12-19 EP EP05818563.8A patent/EP1833964B1/en not_active Expired - Lifetime
- 2005-12-19 NZ NZ556143A patent/NZ556143A/en not_active IP Right Cessation
- 2005-12-19 AU AU2005316217A patent/AU2005316217A1/en not_active Abandoned
- 2005-12-19 JP JP2007545789A patent/JP5616572B2/ja not_active Expired - Fee Related
- 2005-12-19 WO PCT/AU2005/001917 patent/WO2006063415A1/en not_active Ceased
- 2005-12-19 CA CA002591659A patent/CA2591659A1/en not_active Abandoned
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