JP2008523091A5 - - Google Patents
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- Publication number
- JP2008523091A5 JP2008523091A5 JP2007545664A JP2007545664A JP2008523091A5 JP 2008523091 A5 JP2008523091 A5 JP 2008523091A5 JP 2007545664 A JP2007545664 A JP 2007545664A JP 2007545664 A JP2007545664 A JP 2007545664A JP 2008523091 A5 JP2008523091 A5 JP 2008523091A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- group
- heteroaryl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 74
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 125000000753 cycloalkyl group Chemical group 0.000 description 7
- 125000001188 haloalkyl group Chemical group 0.000 description 7
- 125000000623 heterocyclic group Chemical group 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 125000004966 cyanoalkyl group Chemical group 0.000 description 5
- 125000000392 cycloalkenyl group Chemical group 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 description 4
- 125000004438 haloalkoxy group Chemical group 0.000 description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- -1 cyano, hydroxyl Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63549104P | 2004-12-13 | 2004-12-13 | |
| US60/635,491 | 2004-12-13 | ||
| PCT/US2005/044613 WO2006065646A1 (en) | 2004-12-13 | 2005-12-07 | Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012001109A Division JP2012121887A (ja) | 2004-12-13 | 2012-01-06 | バニロイド受容体サブタイプ１（ｖｒ１）に対するアンタゴニストとして作用するベンズイソチアゾール−１，１−ジオキシドおよびこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008523091A JP2008523091A (ja) | 2008-07-03 |
| JP2008523091A5 true JP2008523091A5 (https=) | 2011-10-06 |
| JP4960254B2 JP4960254B2 (ja) | 2012-06-27 |
Family
ID=36129676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545664A Expired - Fee Related JP4960254B2 (ja) | 2004-12-13 | 2005-12-07 | バニロイド受容体サブタイプ１（ｖｒ１）に対するアンタゴニストとして作用するベンズイソチアゾール−１，１−ジオキシドおよびこれらの使用 |
| JP2012001109A Pending JP2012121887A (ja) | 2004-12-13 | 2012-01-06 | バニロイド受容体サブタイプ１（ｖｒ１）に対するアンタゴニストとして作用するベンズイソチアゾール−１，１−ジオキシドおよびこれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012001109A Pending JP2012121887A (ja) | 2004-12-13 | 2012-01-06 | バニロイド受容体サブタイプ１（ｖｒ１）に対するアンタゴニストとして作用するベンズイソチアゾール−１，１−ジオキシドおよびこれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7615570B2 (https=) |
| EP (1) | EP1836200B1 (https=) |
| JP (2) | JP4960254B2 (https=) |
| CA (1) | CA2591069A1 (https=) |
| MX (1) | MX2007007100A (https=) |
| WO (1) | WO2006065646A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615570B2 (en) * | 2004-12-13 | 2009-11-10 | Abbott Laboratories | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| BRPI0614944A2 (pt) * | 2005-08-19 | 2011-04-26 | Elan Pharm Inc | inibidores sulfonamido n-bicìclicos ponte de gama-secretase |
| JP2009534399A (ja) * | 2006-04-18 | 2009-09-24 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ１型（ｖｒ１）の拮抗薬およびその使用 |
| KR20090107070A (ko) * | 2007-01-26 | 2009-10-12 | 바스프 에스이 | 동물 해충 ⅱ의 퇴치를 위한 3-아미노-1,2-벤즈이소티아졸 화합물 |
| EP2349263B1 (en) * | 2008-10-23 | 2014-04-23 | Vertex Pharmaceuticals Inc. | Modulators of cystic fibrosis transmembrane conductance regulator |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| WO2011092290A1 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| CN102718701B (zh) | 2011-03-30 | 2014-05-07 | 中国中化股份有限公司 | 芳氧基二卤丙烯醚类化合物与应用 |
| AU2014262764B2 (en) | 2013-05-07 | 2018-11-15 | The Regents Of The University Of California | Radiomitigating pharmaceutical formulations |
| CN105707076B (zh) * | 2014-12-05 | 2018-12-14 | 沈阳中化农药化工研发有限公司 | 除草组合物及应用 |
| WO2019185413A1 (en) | 2018-03-27 | 2019-10-03 | Basf Se | Pesticidal substituted cyclopropyl derivatives |
| CN113264900B (zh) * | 2021-06-07 | 2023-05-26 | 南京中医药大学 | 一种苯并异噻唑和苯并噻吩的制备方法及其医药用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US473692A (en) * | 1892-04-26 | Rington | ||
| US4147698A (en) * | 1978-07-13 | 1979-04-03 | E. R. Squibb & Sons, Inc. | 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides |
| US4166910A (en) * | 1978-07-13 | 1979-09-04 | E. R. Squibb & Sons, Inc. | 3-(Nitrogen containing heterocyclic)amino) benzisothiazole-1,1-dioxide |
| US4743692A (en) * | 1986-09-30 | 1988-05-10 | American Home Products Corporation | N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives |
| JP2006526660A (ja) | 2003-06-05 | 2006-11-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｖｒ１レセプターのモジュレーター |
| ATE365167T1 (de) | 2003-07-10 | 2007-07-15 | Neurogen Corp | Aryl-substituierte benzo(d)isothiazol-3-ylamin analoga als capsaicinrezeptormodulatoren |
| US7615570B2 (en) * | 2004-12-13 | 2009-11-10 | Abbott Laboratories | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
-
2005
- 2005-12-05 US US11/294,316 patent/US7615570B2/en not_active Expired - Fee Related
- 2005-12-07 CA CA002591069A patent/CA2591069A1/en not_active Abandoned
- 2005-12-07 MX MX2007007100A patent/MX2007007100A/es active IP Right Grant
- 2005-12-07 JP JP2007545664A patent/JP4960254B2/ja not_active Expired - Fee Related
- 2005-12-07 WO PCT/US2005/044613 patent/WO2006065646A1/en not_active Ceased
- 2005-12-07 EP EP05853514A patent/EP1836200B1/en not_active Expired - Lifetime
-
2012
- 2012-01-06 JP JP2012001109A patent/JP2012121887A/ja active Pending
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