JP2008523018A5 - - Google Patents
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- Publication number
- JP2008523018A5 JP2008523018A5 JP2007544844A JP2007544844A JP2008523018A5 JP 2008523018 A5 JP2008523018 A5 JP 2008523018A5 JP 2007544844 A JP2007544844 A JP 2007544844A JP 2007544844 A JP2007544844 A JP 2007544844A JP 2008523018 A5 JP2008523018 A5 JP 2008523018A5
- Authority
- JP
- Japan
- Prior art keywords
- angiogenesis
- diseases
- general formula
- angiogenic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004061288A DE102004061288A1 (de) | 2004-12-14 | 2004-12-14 | 3-Amino-Pyrazolo[3,4b]pyridine als Inhibitoren von Proteintyrosinkinasen, deren Herstellung und Verwendung als Arzneimittel |
| US63669004P | 2004-12-17 | 2004-12-17 | |
| PCT/EP2005/013417 WO2006063805A1 (de) | 2004-12-14 | 2005-12-12 | 3-amino-pyrazolo[3,4b]pyridine als inhibitoren von proteintyrosinkinasen zur behandlung von angiogen, hyperproliferativen oder neurodegenerativen erkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008523018A JP2008523018A (ja) | 2008-07-03 |
| JP2008523018A5 true JP2008523018A5 (https=) | 2013-05-23 |
Family
ID=36580240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544844A Pending JP2008523018A (ja) | 2004-12-14 | 2005-12-12 | 脈管形成、高増殖性または神経変性疾患の治療のためのプロテインチロシンキナーゼの阻害剤としての３−アミノ−ピラゾロ［３，４ｂ］ピリジン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7977325B2 (https=) |
| EP (1) | EP1846402B1 (https=) |
| JP (1) | JP2008523018A (https=) |
| AR (1) | AR051794A1 (https=) |
| CA (1) | CA2604463C (https=) |
| DE (1) | DE102004061288A1 (https=) |
| DO (1) | DOP2005000251A (https=) |
| GT (1) | GT200500363A (https=) |
| PA (1) | PA8656401A1 (https=) |
| PE (1) | PE20060737A1 (https=) |
| TW (1) | TW200634012A (https=) |
| UY (1) | UY29253A1 (https=) |
| WO (1) | WO2006063805A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| EP1980561B1 (en) * | 2007-03-30 | 2013-10-09 | Nerviano Medical Sciences S.R.L. | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors |
| US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| CA2704266A1 (en) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153912A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2464647B1 (en) | 2009-08-11 | 2016-09-21 | Bristol-Myers Squibb Company | Azaindazoles as btk kinase modulators and use thereof |
| EP2516437B1 (en) | 2009-12-21 | 2014-01-29 | Novartis AG | Disubstituted heteroaryl-fused pyridines |
| CN103140490A (zh) | 2010-07-15 | 2013-06-05 | 百时美施贵宝公司 | 氮杂吲唑化合物 |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| FR2970967B1 (fr) | 2011-01-27 | 2013-02-15 | Pf Medicament | Derives de type azaindazole ou diazaindazole comme medicament |
| US10138235B2 (en) | 2011-12-14 | 2018-11-27 | Sanofi | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof |
| FR2984325A1 (fr) * | 2011-12-14 | 2013-06-21 | Sanofi Sa | Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique |
| EP2689778A1 (en) * | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindoles or diazaindoles for treating pain |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
| WO2024211708A1 (en) * | 2023-04-06 | 2024-10-10 | Myrobalan Therapeutics, Inc. | Tyk2 inhibitors for treatment of glaucoma |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2160780A1 (de) | 1971-12-08 | 1973-06-14 | Basf Ag | Pyridino-pyrazole |
| DE2238400A1 (de) * | 1972-08-04 | 1974-02-14 | Hoechst Ag | Basische azofarbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| DE2355967A1 (de) | 1973-11-09 | 1975-07-24 | Hoechst Ag | Polycyclische farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| DE2643753A1 (de) * | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
| DE3001498A1 (de) * | 1980-01-17 | 1981-07-23 | Agfa-Gevaert Ag, 5090 Leverkusen | Fotografisches material mit einem stabilisierungsmittel, verfahren zu dessen herstellung, ein entwicklungsverfahren, neue pyrazole, ein verfahren zu deren herstellung sowie zwischenprodukte |
| US5478830A (en) * | 1992-05-29 | 1995-12-26 | The Du Pont Merck Pharmaceutical Company | Fused-ring heterocycles for the treatment of atherosclerosis |
| US6046216A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives |
| PL354241A1 (en) * | 1999-09-17 | 2003-12-29 | Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg | Kinase inhibitors as therapeutic agents |
| JP4251868B2 (ja) * | 2000-08-11 | 2009-04-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ２−アミノピリジン化合物および医薬用途 |
| JP4272338B2 (ja) * | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| FR2827603B1 (fr) | 2001-07-18 | 2003-10-17 | Oreal | Composes derives de diaminopyrazole substitues par un radical heteroaromatique et leur utilisation en teinture d'oxydation des fibres keratiniques |
| DE50207026D1 (de) * | 2001-08-23 | 2006-07-06 | Bayer Cropscience Sa | Substituierte propargylamine |
-
2004
- 2004-12-14 DE DE102004061288A patent/DE102004061288A1/de not_active Ceased
-
2005
- 2005-12-08 DO DO2005000251A patent/DOP2005000251A/es unknown
- 2005-12-08 UY UY29253A patent/UY29253A1/es not_active Application Discontinuation
- 2005-12-12 GT GT200500363A patent/GT200500363A/es unknown
- 2005-12-12 JP JP2007544844A patent/JP2008523018A/ja active Pending
- 2005-12-12 CA CA2604463A patent/CA2604463C/en not_active Expired - Fee Related
- 2005-12-12 WO PCT/EP2005/013417 patent/WO2006063805A1/de not_active Ceased
- 2005-12-12 EP EP05821901.5A patent/EP1846402B1/de not_active Expired - Lifetime
- 2005-12-13 PE PE2005001439A patent/PE20060737A1/es not_active Application Discontinuation
- 2005-12-14 TW TW094144374A patent/TW200634012A/zh unknown
- 2005-12-14 US US11/302,307 patent/US7977325B2/en not_active Expired - Fee Related
- 2005-12-14 PA PA20058656401A patent/PA8656401A1/es unknown
- 2005-12-14 AR ARP050105227A patent/AR051794A1/es not_active Application Discontinuation
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