JP2008521928A5 - - Google Patents
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- Publication number
- JP2008521928A5 JP2008521928A5 JP2007544545A JP2007544545A JP2008521928A5 JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5 JP 2007544545 A JP2007544545 A JP 2007544545A JP 2007544545 A JP2007544545 A JP 2007544545A JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- medicament
- group
- medicament according
- chemotherapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000010099 disease Diseases 0.000 claims description 10
- 230000001613 neoplastic Effects 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 108010034143 Inflammasomes Proteins 0.000 claims description 5
- 101700079133 KLK7 Proteins 0.000 claims description 4
- 101700076891 PAPA Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 239000011885 synergistic combination Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 32
- 201000011510 cancer Diseases 0.000 claims 18
- 239000002246 antineoplastic agent Substances 0.000 claims 12
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 9
- 201000009251 multiple myeloma Diseases 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 7
- 239000000460 chlorine Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 210000003169 Central Nervous System Anatomy 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 229910052740 iodine Chemical group 0.000 claims 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 4
- 239000011630 iodine Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- GXJABQQUPOEUTA-RDJZCZTQSA-N Bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
- 210000000133 Brain Stem Anatomy 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960003957 Dexamethasone Drugs 0.000 claims 3
- 229960004679 Doxorubicin Drugs 0.000 claims 3
- 206010017758 Gastric cancer Diseases 0.000 claims 3
- 206010024324 Leukaemias Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010025650 Malignant melanoma Diseases 0.000 claims 3
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 3
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 3
- 206010025310 Other lymphomas Diseases 0.000 claims 3
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 3
- 206010038038 Rectal cancer Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- UEJJHQNACJXSKW-UHFFFAOYSA-N Thalidomide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 3
- 229960003433 Thalidomide Drugs 0.000 claims 3
- 206010046766 Uterine cancer Diseases 0.000 claims 3
- 229960001467 bortezomib Drugs 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 201000011231 colorectal cancer Diseases 0.000 claims 3
- 230000002124 endocrine Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 201000003733 ovarian melanoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 201000001275 rectum cancer Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 201000009381 skin hemangioma Diseases 0.000 claims 3
- 201000003708 skin melanoma Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002195 synergetic Effects 0.000 claims 1
- 0 CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O Chemical compound CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O 0.000 description 8
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63316104P | 2004-12-03 | 2004-12-03 | |
| US60/633,161 | 2004-12-03 | ||
| PCT/US2005/043668 WO2006060676A1 (en) | 2004-12-03 | 2005-12-02 | Compositions and methods for treating neoplastic diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Division JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Division JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521928A JP2008521928A (ja) | 2008-06-26 |
| JP2008521928A5 true JP2008521928A5 (US20040106767A1-20040603-C00005.png) | 2009-01-22 |
| JP5676071B2 JP5676071B2 (ja) | 2015-02-25 |
Family
ID=36118298
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544545A Active JP5676071B2 (ja) | 2004-12-03 | 2005-12-02 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2012198263A Active JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Active JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Active JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Active JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Country Status (18)
Families Citing this family (40)
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| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| CA2532066C (en) * | 2003-06-20 | 2015-07-28 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
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| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| CN101155582B (zh) * | 2004-12-03 | 2013-04-24 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的组合物和方法 |
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| US10402927B2 (en) | 2011-12-30 | 2019-09-03 | Elwha Llc | Evidence-based healthcare information management protocols |
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| US10475142B2 (en) | 2011-12-30 | 2019-11-12 | Elwha Llc | Evidence-based healthcare information management protocols |
| KR20150087270A (ko) * | 2012-11-05 | 2015-07-29 | 프로나이 테라퓨틱스, 인코포레이티드 | Bcl2 발현 조절에 의한 암치료용 바이오마커 이용 방법 |
| CN108883081A (zh) * | 2015-11-06 | 2018-11-23 | 阿克西制药有限公司 | 蛋白酶体抑制剂治疗眼部疾病的用途 |
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| ES2923022T3 (es) * | 2017-01-31 | 2022-09-22 | Univ Leland Stanford Junior | Agentes que inhiben Ngly1 y métodos de uso de los mismos |
| JP7498475B2 (ja) * | 2020-01-31 | 2024-06-12 | 株式会社セラバイオファーマ | 多発性骨髄腫の治療剤 |
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| BRPI0909661A2 (pt) | 2008-03-07 | 2015-08-11 | Nereus Pharmaceuticals Inc | Composto e métodos de síntese química e de formação ou preparação de compostos |
| CA2723465A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Proteasome inhibitors |
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