JP2008518900A5 - - Google Patents
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- Publication number
- JP2008518900A5 JP2008518900A5 JP2007538537A JP2007538537A JP2008518900A5 JP 2008518900 A5 JP2008518900 A5 JP 2008518900A5 JP 2007538537 A JP2007538537 A JP 2007538537A JP 2007538537 A JP2007538537 A JP 2007538537A JP 2008518900 A5 JP2008518900 A5 JP 2008518900A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- aryl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000006239 protecting group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- HUCVOHYBFXVBRW-UHFFFAOYSA-M caesium hydroxide Chemical compound [OH-].[Cs+] HUCVOHYBFXVBRW-UHFFFAOYSA-M 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 claims 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62463504P | 2004-11-02 | 2004-11-02 | |
| US71707105P | 2005-09-14 | 2005-09-14 | |
| PCT/IB2005/003297 WO2006048744A1 (en) | 2004-11-02 | 2005-10-21 | Methods of preparing indazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518900A JP2008518900A (ja) | 2008-06-05 |
| JP2008518900A5 true JP2008518900A5 (cg-RX-API-DMAC10.html) | 2008-11-06 |
Family
ID=35744929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538537A Withdrawn JP2008518900A (ja) | 2004-11-02 | 2005-10-21 | インダゾール化合物の調製方法 |
Country Status (14)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2134702B2 (en) * | 2007-04-05 | 2023-08-30 | Pfizer Products Inc. | Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole suitable for the treatment of abnormal cell growth in mammals |
| JP5348725B2 (ja) | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| EP2163544A1 (en) * | 2008-09-16 | 2010-03-17 | Pfizer, Inc. | Methods of preparing indazole compounds |
| PE20141317A1 (es) * | 2009-01-08 | 2014-09-26 | Merck Patent Gmbh | Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil}-6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion |
| WO2013046133A1 (en) | 2011-09-30 | 2013-04-04 | Pfizer Inc. | Pharmaceutical compositions of n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide |
| KR20140088556A (ko) | 2011-11-11 | 2014-07-10 | 화이자 인코포레이티드 | 만성 골수성 백혈병을 치료하기 위한 n-메틸-2-[3-((e)-2-피리딘-2-일-비닐)-1h-인다졸-6-일설파닐]-벤즈아미드 |
| US9899120B2 (en) | 2012-11-02 | 2018-02-20 | Nanotek Instruments, Inc. | Graphene oxide-coated graphitic foil and processes for producing same |
| US10087073B2 (en) | 2013-02-14 | 2018-10-02 | Nanotek Instruments, Inc. | Nano graphene platelet-reinforced composite heat sinks and process for producing same |
| EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
| WO2015067224A1 (en) | 2013-11-08 | 2015-05-14 | Zentiva, K.S. | Salts of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethanyl] indazole |
| PT3077397T (pt) * | 2013-12-06 | 2020-01-22 | Vertex Pharma | Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo |
| WO2015119930A1 (en) | 2014-02-04 | 2015-08-13 | Pfizer Inc. | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer |
| RU2667486C2 (ru) * | 2014-03-31 | 2018-09-20 | Сэндзю Фармацевтикал Ко., Лтд. | Производное алкинилиндазола и его применение |
| WO2016032927A1 (en) | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| WO2016108106A1 (en) * | 2014-12-29 | 2016-07-07 | Shilpa Medicare Limited | An improved process for preparation of axitinib |
| RU2714233C2 (ru) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Ингибиторы pd-1 / pd-l1 для лечения рака |
| US9580406B2 (en) | 2015-04-28 | 2017-02-28 | Signa S.A. De C.V. | Processes for the preparation of axitinib |
| MX390878B (es) | 2015-06-16 | 2025-03-21 | Merck Patent Gmbh | Usos medicos de antagonista de ligando 1 de muerte programada (pd-l1). |
| IL265762B2 (en) | 2016-10-06 | 2024-04-01 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
| WO2020128893A1 (en) | 2018-12-21 | 2020-06-25 | Pfizer Inc. | Combination treatments of cancer comprising a tlr agonist |
| ES2982700T3 (es) | 2019-04-18 | 2024-10-17 | Synthon Bv | Proceso para preparar axitinib, proceso para purificar el producto intermedio 2-((3-yodo-1H-indazol-6-il)tio)-n-metilbenzamida, proceso para purificar axitinib a través de la sal HCI de axitinib, forma sólida de la sal HCI de axitinib |
| CA3253467A1 (en) | 2022-03-03 | 2023-09-07 | Pfizer Inc. | MULTISPECIFIC ANTIBODIES AND THEIR USES |
| WO2025157389A1 (en) | 2024-01-22 | 2025-07-31 | Iomx Therapeutics Ag | Combinations of halogenated heterocyclic kinase inhibitors and vegfr inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| CA2517517C (en) * | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| KR20050119671A (ko) * | 2003-04-03 | 2005-12-21 | 화이자 인코포레이티드 | Ａｇ013736을 포함하는 제형 |
| WO2006123223A1 (en) | 2005-05-19 | 2006-11-23 | Pfizer Inc. | Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor |
-
2005
- 2005-10-21 WO PCT/IB2005/003297 patent/WO2006048744A1/en not_active Ceased
- 2005-10-21 MX MX2007005291A patent/MX2007005291A/es not_active Application Discontinuation
- 2005-10-21 AU AU2005300310A patent/AU2005300310A1/en not_active Abandoned
- 2005-10-21 KR KR1020077009848A patent/KR20070058690A/ko not_active Ceased
- 2005-10-21 CA CA002586174A patent/CA2586174A1/en not_active Abandoned
- 2005-10-21 JP JP2007538537A patent/JP2008518900A/ja not_active Withdrawn
- 2005-10-21 EP EP05804650A patent/EP1809621A1/en not_active Withdrawn
- 2005-10-21 BR BRPI0518203-4A patent/BRPI0518203A2/pt not_active IP Right Cessation
- 2005-10-21 RU RU2007116107/04A patent/RU2007116107A/ru not_active Application Discontinuation
- 2005-10-28 TW TW094137922A patent/TWI294421B/zh active
- 2005-10-31 US US11/264,440 patent/US7232910B2/en not_active Expired - Fee Related
- 2005-11-01 AR ARP050104568A patent/AR051754A1/es unknown
-
2007
- 2007-03-28 NO NO20071619A patent/NO20071619L/no not_active Application Discontinuation
- 2007-04-19 IL IL182693A patent/IL182693A0/en unknown