JP2008517905A - ニトロベンズインドールおよび癌治療におけるそれらの使用 - Google Patents

ニトロベンズインドールおよび癌治療におけるそれらの使用 Download PDF

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JP2008517905A
JP2008517905A JP2007537835A JP2007537835A JP2008517905A JP 2008517905 A JP2008517905 A JP 2008517905A JP 2007537835 A JP2007537835 A JP 2007537835A JP 2007537835 A JP2007537835 A JP 2007537835A JP 2008517905 A JP2008517905 A JP 2008517905A
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indole
benzo
dihydro
chloromethyl
carbonyl
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Japanese (ja)
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JP2008517905A5 (enExample
Inventor
ウィリアム アレキサンダー デニー
ウィリアム ロバート ウィルソン
ラルフ ジェイムズ スティーヴンソン
モアナ タースル
グレアム ジョン アトウェル
シャンジン ヤン
アダム フォルン パターソン
フレデリック バスティアン プルイジン
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オークランド ユニサーヴィスィズ リミテッド
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Publication of JP2008517905A publication Critical patent/JP2008517905A/ja
Publication of JP2008517905A5 publication Critical patent/JP2008517905A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
JP2007537835A 2004-10-22 2005-10-21 ニトロベンズインドールおよび癌治療におけるそれらの使用 Pending JP2008517905A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ536107A NZ536107A (en) 2004-10-22 2004-10-22 Nitrobenzindoles and their use in cancer therapy
PCT/NZ2005/000278 WO2006043839A1 (en) 2004-10-22 2005-10-21 Nitrobenzindoles and their use in cancer therapy

Publications (2)

Publication Number Publication Date
JP2008517905A true JP2008517905A (ja) 2008-05-29
JP2008517905A5 JP2008517905A5 (enExample) 2008-12-04

Family

ID=36203204

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007537835A Pending JP2008517905A (ja) 2004-10-22 2005-10-21 ニトロベンズインドールおよび癌治療におけるそれらの使用

Country Status (14)

Country Link
US (1) US7718688B2 (enExample)
EP (1) EP1809603A4 (enExample)
JP (1) JP2008517905A (enExample)
KR (1) KR20070083806A (enExample)
CN (1) CN101044114B (enExample)
AU (1) AU2005296389B2 (enExample)
BR (1) BRPI0517285A (enExample)
CA (1) CA2584702A1 (enExample)
IL (1) IL182652A0 (enExample)
MX (1) MX2007004596A (enExample)
NZ (1) NZ536107A (enExample)
RU (1) RU2007118938A (enExample)
WO (1) WO2006043839A1 (enExample)
ZA (1) ZA200703699B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013525347A (ja) * 2010-04-21 2013-06-20 シンタルガ・ビーブイ Ｃｃ−１０６５類似体の新規の複合体および二官能性リンカー
US9421278B2 (en) 2014-01-10 2016-08-23 Synthon Biopharmaceuticals B.V. Duocarmycin ADCS showing improved in vivo antitumor activity
US9427480B2 (en) 2014-01-10 2016-08-30 Synthon Biopharmaceuticals B.V. Duocarmycin ADCs for use in treatment of endometrial cancer
WO2019004413A1 (ja) * 2017-06-30 2019-01-03 東レ株式会社 インドリン誘導体及びそれを含む細胞毒性剤
US10266606B2 (en) 2014-01-10 2019-04-23 Synthon Biopharmaceuticals B.V. Method for purifying Cys-linked antibody-drug conjugates

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5346589B2 (ja) * 2006-02-02 2013-11-20 シンタルガ・ビーブイ 水溶性ｃｃ−１０６５類似体及びその接合体
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
HUE025137T2 (en) 2007-08-21 2016-01-28 Senomyx Inc Compositions are bitter taste blocking (blocking) compounds
NZ571028A (en) * 2008-09-03 2011-01-28 Auckland Uniservices Ltd Nitrobenzindole compounds and their use in cancer treatment
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
CN102827061A (zh) * 2012-09-19 2012-12-19 兰州大学 5,6,7-三甲氧基吲哚类衍生物、制备方法及用途
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
DK3160513T3 (da) 2014-06-30 2020-04-06 Glykos Finland Oy Saccharidderivat af en toksisk payload og antistofkonjugater deraf
CN112724068A (zh) * 2020-12-30 2021-04-30 蔡桂坡 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000517292A (ja) * 1996-09-12 2000-12-26 キャンサー リサーチ キャンペーン テクノロジー リミテッド 抗癌剤としての縮合ｎ―アシルインドール
WO2003097635A1 (en) * 2002-05-17 2003-11-27 Auckland Uniservices Limited Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl(amine-derived)] compounds and analogues thereof, and to products obtained therefrom
JP2004522779A (ja) * 2001-02-22 2004-07-29 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ529249A (en) 2003-10-31 2006-04-28 Auckland Uniservices Ltd Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000517292A (ja) * 1996-09-12 2000-12-26 キャンサー リサーチ キャンペーン テクノロジー リミテッド 抗癌剤としての縮合ｎ―アシルインドール
JP2004522779A (ja) * 2001-02-22 2004-07-29 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体
WO2003097635A1 (en) * 2002-05-17 2003-11-27 Auckland Uniservices Limited Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl(amine-derived)] compounds and analogues thereof, and to products obtained therefrom

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013525347A (ja) * 2010-04-21 2013-06-20 シンタルガ・ビーブイ Ｃｃ−１０６５類似体の新規の複合体および二官能性リンカー
US9421278B2 (en) 2014-01-10 2016-08-23 Synthon Biopharmaceuticals B.V. Duocarmycin ADCS showing improved in vivo antitumor activity
US9427480B2 (en) 2014-01-10 2016-08-30 Synthon Biopharmaceuticals B.V. Duocarmycin ADCs for use in treatment of endometrial cancer
US10092659B2 (en) 2014-01-10 2018-10-09 Synthon Biopharmaceuticals B.V. Duocarmycin ADCs for use in treatment of endometrial cancer
US10266606B2 (en) 2014-01-10 2019-04-23 Synthon Biopharmaceuticals B.V. Method for purifying Cys-linked antibody-drug conjugates
US10603387B2 (en) 2014-01-10 2020-03-31 Synthon Biopharmaceuticals B.V. Duocarmycin ADCs showing improved in vivo antitumor activity
US11382982B2 (en) 2014-01-10 2022-07-12 Byondis B.V. Duocarmycin ADCs showing improved in vivo antitumor activity
WO2019004413A1 (ja) * 2017-06-30 2019-01-03 東レ株式会社 インドリン誘導体及びそれを含む細胞毒性剤

Also Published As

Publication number Publication date
CA2584702A1 (en) 2006-04-27
BRPI0517285A (pt) 2008-10-07
RU2007118938A (ru) 2008-11-27
EP1809603A4 (en) 2009-09-02
AU2005296389B2 (en) 2012-03-15
ZA200703699B (en) 2008-10-29
US7718688B2 (en) 2010-05-18
WO2006043839A1 (en) 2006-04-27
MX2007004596A (es) 2007-06-22
AU2005296389A1 (en) 2006-04-27
KR20070083806A (ko) 2007-08-24
CN101044114B (zh) 2012-02-15
CN101044114A (zh) 2007-09-26
IL182652A0 (en) 2007-07-24
NZ536107A (en) 2007-06-29
US20080119442A1 (en) 2008-05-22
EP1809603A1 (en) 2007-07-25

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