MX2007004596A - Nitrobenzoindoles y su uso en terapia del cancer. - Google Patents
Nitrobenzoindoles y su uso en terapia del cancer.Info
- Publication number
- MX2007004596A MX2007004596A MX2007004596A MX2007004596A MX2007004596A MX 2007004596 A MX2007004596 A MX 2007004596A MX 2007004596 A MX2007004596 A MX 2007004596A MX 2007004596 A MX2007004596 A MX 2007004596A MX 2007004596 A MX2007004596 A MX 2007004596A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer therapy
- nitrobenzindoles
- drugs
- radiosensitizers
- indoles
- Prior art date
Links
- 238000011275 oncology therapy Methods 0.000 title abstract 2
- GNDINQYCDXTGEO-UHFFFAOYSA-N 2-nitro-1h-benzo[g]indole Chemical class C1=CC=CC2=C(NC([N+](=O)[O-])=C3)C3=CC=C21 GNDINQYCDXTGEO-UHFFFAOYSA-N 0.000 title 1
- YJSNSTMRPIVBKY-UHFFFAOYSA-N 1-nitro-2,3-dihydro-1h-benzo[e]indole Chemical class C1=CC=CC2=C3C([N+](=O)[O-])CNC3=CC=C21 YJSNSTMRPIVBKY-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invencion se refiere generalmente a nitro-1,2-dihidro-3H-benzo[e]indoles y analogos relacionados, a su preparacion, y a su uso como farmacos selectivos de hipoxia y radiosensibilizadores para terapia de cancer, ambos juntos o en combinacion con radiacion y/u otros farmacos anticancerigenos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ536107A NZ536107A (en) | 2004-10-22 | 2004-10-22 | Nitrobenzindoles and their use in cancer therapy |
PCT/NZ2005/000278 WO2006043839A1 (en) | 2004-10-22 | 2005-10-21 | Nitrobenzindoles and their use in cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007004596A true MX2007004596A (es) | 2007-06-22 |
Family
ID=36203204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007004596A MX2007004596A (es) | 2004-10-22 | 2005-10-21 | Nitrobenzoindoles y su uso en terapia del cancer. |
Country Status (14)
Country | Link |
---|---|
US (1) | US7718688B2 (es) |
EP (1) | EP1809603A4 (es) |
JP (1) | JP2008517905A (es) |
KR (1) | KR20070083806A (es) |
CN (1) | CN101044114B (es) |
AU (1) | AU2005296389B2 (es) |
BR (1) | BRPI0517285A (es) |
CA (1) | CA2584702A1 (es) |
IL (1) | IL182652A0 (es) |
MX (1) | MX2007004596A (es) |
NZ (1) | NZ536107A (es) |
RU (1) | RU2007118938A (es) |
WO (1) | WO2006043839A1 (es) |
ZA (1) | ZA200703699B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2008009956A (es) * | 2006-02-02 | 2008-12-12 | Syntarga Bv | Analogos de cc-1065 solubles en agua y sus conjugados. |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
US8076491B2 (en) | 2007-08-21 | 2011-12-13 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
CA2696995C (en) | 2007-08-21 | 2017-11-21 | Senomyx, Inc. | Identification of human t2r receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof |
NZ571028A (en) * | 2008-09-03 | 2011-01-28 | Auckland Uniservices Ltd | Nitrobenzindole compounds and their use in cancer treatment |
PL2344478T3 (pl) | 2008-11-03 | 2018-02-28 | Syntarga B.V. | Analogi CC-1065 oraz ich koniugaty |
LT2560645T (lt) * | 2010-04-21 | 2016-10-10 | Syntarga B.V. | Cc-1065 analogų ir bifunkcinių linkerių konjugatai |
CN102827061A (zh) * | 2012-09-19 | 2012-12-19 | 兰州大学 | 5,6,7-三甲氧基吲哚类衍生物、制备方法及用途 |
WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
RU2769700C2 (ru) | 2014-01-10 | 2022-04-05 | Байондис Б.В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
KR20160099725A (ko) | 2014-01-10 | 2016-08-22 | 신톤 바이오파머슈티칼즈 비.브이. | 자궁내막암의 치료에서 사용하기 위한 듀오카르마이신 adc |
KR102323301B1 (ko) | 2014-01-10 | 2021-11-09 | 비온디스 비.브이. | Cys 연결된 항체-약물 접합체의 정제 방법 |
ES2785551T3 (es) | 2014-06-30 | 2020-10-07 | Glykos Finland Oy | Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos |
JPWO2019004413A1 (ja) * | 2017-06-30 | 2020-05-07 | 東レ株式会社 | インドリン誘導体及びそれを含む細胞毒性剤 |
CN112724068A (zh) * | 2020-12-30 | 2021-04-30 | 蔡桂坡 | 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ334344A (en) * | 1996-09-12 | 2000-08-25 | Cancer Res Campaign Tech | benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs |
US7192977B2 (en) * | 2001-02-22 | 2007-03-20 | School Of Pharmacy | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment |
AU2003228173A1 (en) | 2002-05-17 | 2003-12-02 | Auckland Uniservices Limited | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-(ring fused indol-5-yl(amine-derived)) compounds and analogues thereof, and to products obtained therefrom |
NZ529249A (en) | 2003-10-31 | 2006-04-28 | Auckland Uniservices Ltd | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic |
-
2004
- 2004-10-22 NZ NZ536107A patent/NZ536107A/en not_active IP Right Cessation
-
2005
- 2005-10-21 CN CN2005800362035A patent/CN101044114B/zh not_active Expired - Fee Related
- 2005-10-21 KR KR1020077009468A patent/KR20070083806A/ko not_active Application Discontinuation
- 2005-10-21 WO PCT/NZ2005/000278 patent/WO2006043839A1/en active Application Filing
- 2005-10-21 CA CA002584702A patent/CA2584702A1/en not_active Abandoned
- 2005-10-21 MX MX2007004596A patent/MX2007004596A/es not_active Application Discontinuation
- 2005-10-21 RU RU2007118938/04A patent/RU2007118938A/ru not_active Application Discontinuation
- 2005-10-21 JP JP2007537835A patent/JP2008517905A/ja active Pending
- 2005-10-21 BR BRPI0517285-3A patent/BRPI0517285A/pt not_active Application Discontinuation
- 2005-10-21 US US11/666,014 patent/US7718688B2/en not_active Expired - Fee Related
- 2005-10-21 EP EP05800725A patent/EP1809603A4/en not_active Withdrawn
- 2005-10-21 AU AU2005296389A patent/AU2005296389B2/en not_active Ceased
-
2007
- 2007-04-18 IL IL182652A patent/IL182652A0/en unknown
- 2007-05-08 ZA ZA200703699A patent/ZA200703699B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2584702A1 (en) | 2006-04-27 |
US20080119442A1 (en) | 2008-05-22 |
JP2008517905A (ja) | 2008-05-29 |
BRPI0517285A (pt) | 2008-10-07 |
RU2007118938A (ru) | 2008-11-27 |
IL182652A0 (en) | 2007-07-24 |
ZA200703699B (en) | 2008-10-29 |
CN101044114A (zh) | 2007-09-26 |
US7718688B2 (en) | 2010-05-18 |
WO2006043839A1 (en) | 2006-04-27 |
AU2005296389A1 (en) | 2006-04-27 |
EP1809603A4 (en) | 2009-09-02 |
AU2005296389B2 (en) | 2012-03-15 |
EP1809603A1 (en) | 2007-07-25 |
KR20070083806A (ko) | 2007-08-24 |
NZ536107A (en) | 2007-06-29 |
CN101044114B (zh) | 2012-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |