JP2008516959A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008516959A5 JP2008516959A5 JP2007536836A JP2007536836A JP2008516959A5 JP 2008516959 A5 JP2008516959 A5 JP 2008516959A5 JP 2007536836 A JP2007536836 A JP 2007536836A JP 2007536836 A JP2007536836 A JP 2007536836A JP 2008516959 A5 JP2008516959 A5 JP 2008516959A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- halogen
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- -1 methylenedioxy Chemical group 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- PXQNLQLMRMROSB-ZDUSSCGKSA-N (3s)-1-(5-bromopyrimidin-2-yl)-n-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-amine Chemical compound ClC1=CC(Cl)=CC=C1CN[C@@H]1CN(C=2N=CC(Br)=CN=2)CC1 PXQNLQLMRMROSB-ZDUSSCGKSA-N 0.000 claims 1
- KRUCDNVZXQNRAZ-HNNXBMFYSA-N (3s)-n-benzyl-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-amine Chemical compound N1=CC(C(F)(F)F)=CC=C1N1C[C@@H](NCC=2C=CC=CC=2)CC1 KRUCDNVZXQNRAZ-HNNXBMFYSA-N 0.000 claims 1
- PXQNLQLMRMROSB-UHFFFAOYSA-N 1-(5-bromopyrimidin-2-yl)-n-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-amine Chemical compound ClC1=CC(Cl)=CC=C1CNC1CN(C=2N=CC(Br)=CN=2)CC1 PXQNLQLMRMROSB-UHFFFAOYSA-N 0.000 claims 1
- ACYGUSYTBTURQK-UHFFFAOYSA-N 1-(5-chloropyrimidin-2-yl)-n-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-amine Chemical compound N1=CC(Cl)=CN=C1N1CC(NCC=2C(=CC(Cl)=CC=2)Cl)CC1 ACYGUSYTBTURQK-UHFFFAOYSA-N 0.000 claims 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 claims 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61978904P | 2004-10-18 | 2004-10-18 | |
| US60/619,789 | 2004-10-18 | ||
| PCT/US2005/036665 WO2006044454A1 (en) | 2004-10-18 | 2005-10-13 | 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mglur3 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516959A JP2008516959A (ja) | 2008-05-22 |
| JP2008516959A5 true JP2008516959A5 (cg-RX-API-DMAC7.html) | 2008-11-06 |
| JP5188807B2 JP5188807B2 (ja) | 2013-04-24 |
Family
ID=35787981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536836A Expired - Fee Related JP5188807B2 (ja) | 2004-10-18 | 2005-10-13 | ｍＧｌｕＲ３受容体アンタゴニストとして用いるための１−（ヘテロ）アリール−３−アミノ−ピロリジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7868014B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1805165B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5188807B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101094846A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE452130T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005295860A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0516602A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2584422A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602005018381D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2336130T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007004661A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006044454A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1757582T3 (en) * | 2004-05-28 | 2016-02-01 | Mitsubishi Tanabe Pharma Corp | Arylalkylamines AND MANUFACTURING METHOD THEREOF |
| FR2928150A1 (fr) | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
| WO2009131196A1 (ja) * | 2008-04-24 | 2009-10-29 | 武田薬品工業株式会社 | 置換ピロリジン誘導体およびその用途 |
| EP2145891A1 (en) | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
| TW201022233A (en) * | 2008-11-04 | 2010-06-16 | Organon Nv | (Pyrrolidin-2-yl)phenyl derivatives |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2016092002A1 (en) | 2014-12-11 | 2016-06-16 | Janssen Pharmaceutica Nv | 1,2,4-triazolo[4,3-a]pyridine compounds and their use as positive allosteric modulators of mglur2 receptors |
| CN113024412A (zh) * | 2021-03-23 | 2021-06-25 | 上海立科化学科技有限公司 | 2,4,6-三氯苯腈的制备方法 |
| CN114149297A (zh) * | 2021-12-07 | 2022-03-08 | 北京中医药大学 | 一种微波辅助的选择性芳基甲醛的绿色合成方法 |
| CN115368283A (zh) * | 2022-09-15 | 2022-11-22 | 丽水绿氟科技有限公司 | 一种手性结构或非手性结构的顺式-3-氟-4-羟基吡咯烷及其衍生物的制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| US4785119A (en) * | 1985-10-11 | 1988-11-15 | Tokyo Kasei Kogyo Co., Ltd. | 3-aminopyrrolidine compound and process for preparation thereof |
| US5232929A (en) | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| WO1991009844A1 (en) | 1990-01-04 | 1991-07-11 | Pfizer Inc. | Substance p antagonists |
| US5332817A (en) * | 1990-01-04 | 1994-07-26 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles |
| TW202432B (cg-RX-API-DMAC7.html) * | 1991-06-21 | 1993-03-21 | Pfizer | |
| US5686482A (en) * | 1994-04-28 | 1997-11-11 | Yamanouchi Pharmaceutical Co., Ltd. | N-(3-pyrrolidinyl) benzamide derivative |
| ES2079323B1 (es) * | 1994-06-21 | 1996-10-16 | Vita Invest Sa | Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes. |
| DE19524765A1 (de) * | 1995-07-07 | 1997-01-09 | Boehringer Mannheim Gmbh | Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| ES2237788T3 (es) | 1996-01-22 | 2005-08-01 | Eli Lilly And Company | Derivados de indano para composiciones antipsicoticas. |
| AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| US5891889A (en) * | 1996-04-03 | 1999-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2001515839A (ja) * | 1997-07-18 | 2001-09-25 | ジョージタウン・ユニバーシティ | 二環式向代謝性グルタミン酸受容体リガンド |
| JP2001510797A (ja) | 1997-07-22 | 2001-08-07 | イーライ・リリー・アンド・カンパニー | 医薬化合物 |
| US20010006972A1 (en) | 1998-04-21 | 2001-07-05 | Stephen A. Williams | Nk-1 receptor antagonists for the treatment of symptoms of irritable bowel syndrome |
| WO1999064396A1 (en) * | 1998-06-09 | 1999-12-16 | Neurogen Corporation | Substituted 1-aryl-3-benzylaminopyrrolidine: dopamine receptor subtype specific ligands |
| AU2002342414A1 (en) * | 2001-05-10 | 2002-11-25 | Aventis Pharma Deutschland Gmbh | Novel processes for the preparation of adenosine compounds and intermediates thereto |
| WO2004060308A2 (en) * | 2002-12-27 | 2004-07-22 | Chiron Corporation | Thiosemicarbazones as anti-virals and immunopotentiators |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ES2305776T3 (es) | 2003-06-17 | 2008-11-01 | Pfizer Inc. | Derivados de n-pirrolidin-3-il-amida como inhibidores de la re-captacion de serotonina y noradrenalina. |
| US7348434B2 (en) * | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| CA2539335A1 (en) * | 2003-10-31 | 2005-05-12 | Otsuka Pharmaceutical Co., Ltd. | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis |
| DK1757582T3 (en) * | 2004-05-28 | 2016-02-01 | Mitsubishi Tanabe Pharma Corp | Arylalkylamines AND MANUFACTURING METHOD THEREOF |
-
2005
- 2005-10-13 AT AT05804465T patent/ATE452130T1/de not_active IP Right Cessation
- 2005-10-13 JP JP2007536836A patent/JP5188807B2/ja not_active Expired - Fee Related
- 2005-10-13 CA CA002584422A patent/CA2584422A1/en not_active Abandoned
- 2005-10-13 DE DE602005018381T patent/DE602005018381D1/de not_active Expired - Lifetime
- 2005-10-13 ES ES05804465T patent/ES2336130T3/es not_active Expired - Lifetime
- 2005-10-13 MX MX2007004661A patent/MX2007004661A/es not_active Application Discontinuation
- 2005-10-13 EP EP05804465A patent/EP1805165B1/en not_active Expired - Lifetime
- 2005-10-13 WO PCT/US2005/036665 patent/WO2006044454A1/en not_active Ceased
- 2005-10-13 CN CNA200580035313XA patent/CN101094846A/zh active Pending
- 2005-10-13 BR BRPI0516602-0A patent/BRPI0516602A/pt not_active IP Right Cessation
- 2005-10-13 US US11/576,960 patent/US7868014B2/en not_active Expired - Fee Related
- 2005-10-13 AU AU2005295860A patent/AU2005295860A1/en not_active Abandoned