JP2008514707A5 - - Google Patents

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Publication number
JP2008514707A5
JP2008514707A5 JP2007534694A JP2007534694A JP2008514707A5 JP 2008514707 A5 JP2008514707 A5 JP 2008514707A5 JP 2007534694 A JP2007534694 A JP 2007534694A JP 2007534694 A JP2007534694 A JP 2007534694A JP 2008514707 A5 JP2008514707 A5 JP 2008514707A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halogen
group
methyl
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JP2007534694A
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English (en)
Japanese (ja)
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JP4953456B2 (ja
JP2008514707A (ja
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Priority claimed from PCT/US2005/034462 external-priority patent/WO2006039243A1/en
Publication of JP2008514707A publication Critical patent/JP2008514707A/ja
Publication of JP2008514707A5 publication Critical patent/JP2008514707A5/ja
Application granted granted Critical
Publication of JP4953456B2 publication Critical patent/JP4953456B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007534694A 2004-09-30 2005-09-26 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体 Expired - Fee Related JP4953456B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61475104P 2004-09-30 2004-09-30
US60/614,751 2004-09-30
PCT/US2005/034462 WO2006039243A1 (en) 2004-09-30 2005-09-26 Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)

Publications (3)

Publication Number Publication Date
JP2008514707A JP2008514707A (ja) 2008-05-08
JP2008514707A5 true JP2008514707A5 (enExample) 2008-11-20
JP4953456B2 JP4953456B2 (ja) 2012-06-13

Family

ID=35825468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007534694A Expired - Fee Related JP4953456B2 (ja) 2004-09-30 2005-09-26 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体

Country Status (10)

Country Link
US (3) US7566733B2 (enExample)
EP (1) EP1805147B1 (enExample)
JP (1) JP4953456B2 (enExample)
CN (1) CN101065363B (enExample)
AR (1) AR050966A1 (enExample)
AU (1) AU2005292345B9 (enExample)
CA (1) CA2582356A1 (enExample)
MY (1) MY147985A (enExample)
TW (1) TW200621725A (enExample)
WO (1) WO2006039243A1 (enExample)

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US8123807B2 (en) 2004-10-20 2012-02-28 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US8945183B2 (en) 2004-10-20 2015-02-03 Vertiflex, Inc. Interspinous process spacer instrument system with deployment indicator
US8128662B2 (en) 2004-10-20 2012-03-06 Vertiflex, Inc. Minimally invasive tooling for delivery of interspinous spacer
US8273108B2 (en) 2004-10-20 2012-09-25 Vertiflex, Inc. Interspinous spacer
US9119680B2 (en) 2004-10-20 2015-09-01 Vertiflex, Inc. Interspinous spacer
US8277488B2 (en) 2004-10-20 2012-10-02 Vertiflex, Inc. Interspinous spacer
US8123782B2 (en) 2004-10-20 2012-02-28 Vertiflex, Inc. Interspinous spacer
US7763074B2 (en) 2004-10-20 2010-07-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8152837B2 (en) 2004-10-20 2012-04-10 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8409282B2 (en) 2004-10-20 2013-04-02 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US8613747B2 (en) 2004-10-20 2013-12-24 Vertiflex, Inc. Spacer insertion instrument
US8317864B2 (en) 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8425559B2 (en) 2004-10-20 2013-04-23 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US9161783B2 (en) 2004-10-20 2015-10-20 Vertiflex, Inc. Interspinous spacer
US8167944B2 (en) 2004-10-20 2012-05-01 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8012207B2 (en) 2004-10-20 2011-09-06 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US9023084B2 (en) 2004-10-20 2015-05-05 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for stabilizing the motion or adjusting the position of the spine
ES2318556T3 (es) * 2004-11-02 2009-05-01 Pfizer, Inc. Derivados de sulfonil bencimidazol.
WO2009086010A2 (en) 2004-12-06 2009-07-09 Vertiflex, Inc. Spacer insertion instrument
EA015542B1 (ru) * 2006-01-24 2011-08-30 Янссен Фармацевтика Н.В. Новые 2-замещённые бензимидазолы в качестве селективных модуляторов рецептора андрогена (sarms)
US8845726B2 (en) 2006-10-18 2014-09-30 Vertiflex, Inc. Dilator
CA2684461C (en) 2007-04-16 2015-06-30 Vertiflex Inc. Interspinous spacer
WO2008130669A1 (en) * 2007-04-20 2008-10-30 The Research Foundation Of State University Of New York Benzimidazoles and pharmaceutical compositions thereof
WO2009091922A2 (en) 2008-01-15 2009-07-23 Vertiflex, Inc. Interspinous spacer
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
BRPI0907844B8 (pt) 2008-02-22 2021-05-25 Radius Health Inc compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos
WO2009123164A1 (ja) * 2008-04-02 2009-10-08 塩野義製薬株式会社 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体
US8740948B2 (en) 2009-12-15 2014-06-03 Vertiflex, Inc. Spinal spacer for cervical and other vertebra, and associated systems and methods
US8987319B2 (en) 2010-02-04 2015-03-24 Radius Health, Inc. Selective androgen receptor modulators
PT2568806T (pt) 2010-05-12 2016-08-05 Radius Health Inc Regimes terapêuticos
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
WO2012047617A1 (en) 2010-09-28 2012-04-12 Radius Health, Inc. Selective androgen receptor modulators
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
US9675303B2 (en) 2013-03-15 2017-06-13 Vertiflex, Inc. Visualization systems, instruments and methods of using the same in spinal decompression procedures
US10287617B2 (en) 2014-03-11 2019-05-14 Colorado State University Research Foundation Methods for in vitro—in vivo efficacy determination
PL3122426T3 (pl) 2014-03-28 2023-05-15 Duke University Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
AU2015256024B2 (en) 2014-05-07 2020-03-05 Vertiflex, Inc. Spinal nerve decompression systems, dilation systems, and methods of using the same
US10214529B2 (en) 2015-01-17 2019-02-26 The Board Of Regents Of The University Of Texas System Small molecules for the treatment of primary cancer and cancer metastasis
SMT202200199T1 (it) 2016-06-22 2022-07-21 Ellipses Pharma Ltd Metodi di trattamento del cancro del seno ar+.
EP4374925A3 (en) 2017-01-05 2025-01-15 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
WO2019079691A1 (en) 2017-10-19 2019-04-25 Jean Jiang SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
CN119390714A (zh) 2019-02-12 2025-02-07 雷迪厄斯制药公司 方法和化合物
US12102542B2 (en) 2022-02-15 2024-10-01 Boston Scientific Neuromodulation Corporation Interspinous spacer and methods and systems utilizing the interspinous spacer
US12433646B2 (en) 2023-02-21 2025-10-07 Boston Scientific Neuromodulation Corporation Interspinous spacer with actuator locking arrangements and methods and systems
US12390340B2 (en) 2023-03-15 2025-08-19 Boston Scientific Neuromodulation Corporation Interspinous spacer with a range of deployment positions and methods and systems
CN120230046A (zh) * 2023-12-29 2025-07-01 杭州壹瑞医药科技有限公司 Trpv3抑制剂及其制备和应用

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US3325271A (en) * 1963-07-17 1967-06-13 United States Borax Chem Herbicidal composition and method employing substituted benzimidazoles
US3897432A (en) * 1971-04-21 1975-07-29 Merck & Co Inc Substituted benzimidazole derivatives
SE357932B (enExample) 1972-01-27 1973-07-16 Malaga Ab
US3987182A (en) * 1974-06-17 1976-10-19 Schering Corporation Novel benzimidazoles useful as anti-androgens
NZ221729A (en) 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
JPH05163246A (ja) 1991-12-17 1993-06-29 Nippon Oil & Fats Co Ltd ペルフルオロ−オキサ−アルキル基含有ベンズイミダゾール誘導体及びその製造方法
GB9310069D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Heterocyclic compounds

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